All language subtitles for Unnatural.Selection.S01E03.Changing.an.Entire.Species.720p.NF.WEB-DL.DDP5.1.x264-NTG

So, where were we?

I know we stopped in, like,
the middle of chapter two.

"Her daemon's name was Pantalaimon,

and he was currently
in the form of a moth,

then cat, snake, rat, fox,
bird, wolf, cheetah, lizard,

polecat, porcupine.

After a moment or two, the daemon flicked
from shape to shape more quickly

than Emma had ever seen
a daemon change before."

Um, wait, wait, wait. So...

...her daemon is a...
is like a moth or something.

That does not seem very useful.

So, her daemon can change forms
whenever he wants.

Oh!

Yeah, so he's just a moth right now
'cause it's sneaky.

What would my daemon be?

I don't know.

Mine would probably be, like, a magpie.

- 26,000 views. It's crazy.
- There we go.

This is bigger than HIV, right?

This is about people
being able to control their own genome.

So far, all right, nothing is red

- or irritated.
- People will know

the results one way or another.

You'll be able to update us?

- Correct.
- Right.

I'm surprised to see Aaron there
because he... he should not be there.

That's not smart. Um...

He should, um...

It should just be Tristan.

Like, this should be about Tristan.

Through our company,
we take these to manufacturing,

and we are finding a way... to deliver it.

My understanding of it was

this is what Tristan wants to do,

and Aaron's trying to reframe it
as being about Ascendance.

Go to www.ascendance.io.

That's... first of all,
a stupid mistake, legally.

But also, it... it reframes
the whole thing ethically too.

We are taking, you know,
what has been so effective...

He's blowing it way out of proportion.

He's pushing these things as cures

when they... we don't even know
if it's gonna work.

Our timeline is to have this available
by January 1st.

With or without the consent of the...
the state.

He shouldn't be selling it yet.
It's not ready.

You'll see more of that from us
and more of that

- from our company itself.
- The entire biohacking community.

Right? Like, it's not just us.

We are just one part of a wave
that is about to crash onto society.

So, you can either ride with the wave
or try to adopt a resistance to it,

- but it's coming.
- Yeah.

I should've been more skeptical.

I mean, he hasn't harmed anyone yet.

Uh, though I don't think
he's unwilling to risk it.

And I'm concerned about that.

We're on the verge
of a technological breakthrough

that could change the future of mankind.

Most people have no idea
how rapidly things are changing.

We're now changing the DNA,
the code of life.

It's amazing, the sorts of things
that we could do with this.

The question is, should we?

What happens if diseases
were just eradicated?

All technology is inherently
about changing away from what is natural.

Have you ever thought
about how inefficient it all is?

Like, trees having to grow up?

It's purely in competition
with other trees, right?

There's no actual need for it,
in terms of photosynthetic efficiency.

Like, there's a reason why
a sheet of solar panels

is just a sheet of solar panels.
It doesn't...

You don't need to put them on towers.

It's competition with other trees.

It's that dog-eat-dog aspect of nature
that forces trees to grow up.

I mean, if only things could cooperate.

But how do you determine
with whom to trust enough to cooperate?

I first got into evolution

because it's the fastest way
to change the world...

at least, in science.

So, to everyone who knew anything
about genome engineering,

CRISPR was the starting gun.

CRISPR has become the tool for biologists,

regardless of organism
they're working with,

because it does seem to work
in every organism

and lets you edit just about any gene.

Sometime around then,
I was walking through...

the Emerald Necklace here in Boston,

this beautiful stream
and surrounding forest...

looking at all the living things.

There were some ducks and some ducklings.

Then, at some point, I realized,
"Wait a minute.

What if you program an organism
to do genome editing on its own?

What if you insert a CRISPR system...

into it?"

That is, encode the instructions
for how to do the editing

along with the gene we want to replace,

and it all went into the genome...

as one piece.

Then, the real magic happens

when that organism mates

with a wild organism, not engineered.

Because then, in the offspring,
editing would happen again.

And all of its offspring
would be guaranteed to inherit the change.

And the process would happen
again and again and again.

So, this is called a CRISPR-based
gene-drive system,

a system capable of copying itself

by genome editing in the wild...

and very possibly spreading
through every population of that species

everywhere in the world.

So, this was a striking realization.

It has tremendous promise
for doing good in the world.

It also means that...

we have a problem.

In an organism like a mosquito,

um, gene drive could be very good, right?

As a way of, um,

making, uh, mosquitoes unable to pass on
all sorts of dreaded diseases

that we've been trying for decades,
if not longer, to eradicate.

Gene drive is a new and risky

genetic-engineering technology

where the goal is to drive a single trait

through a population, through a species,
for all generations to come.

What you're saying is,

"I'm not just going to engineer
this single organism.

As a result,
I'm gonna engineer an entire population,

and thereby, an entire ecosystem."

Um, that's an immense amount of power.

And the implications of being able
to do that, if you can do that, are huge.

To me,
it's the most high-leverage technology

I've seen, after, maybe, nuclear power.

For example,

you might try to drive a lethal trait
through a species

to make them extinct.

Ultimately, you could describe it

as an extinction technology.

So, what... what are the implications
of an ecosystem

that has its mosquito population,

or at least one species
of its mosquito population, crash?

Uh, we... we don't know the answer
to that question.

How much do we have to know
before we jump off that cliff?

In the end, this is on my shoulders.

It was on me to decide
to share this with the world,

for good or for ill.

Yes, there's abundant reason
for caution and humility.

But we also need to remember

that the problems
that we're trying to solve

are real problems today.

In the last three minutes,
malaria has infected 1,000 people.

And two of those are going to die.

Leonce... Leonce?

How are you?

Where did she say it hurt this morning?

- She was vomiting.
- Mmm.

- And she couldn't sleep.
- Mmm.

Your hand.

I will come again later this afternoon
to give her another treatment.

Mm-hmm.

How many months have you been pregnant?

Almost three months.

- Yeah?
- Mm-hmm.

That's it.

Hmm?

The results show you have malaria.

So, how do people get malaria?

Mm...

Mmm...

- Don't be shy.
- Isn't it bad food?

- Mmm?
- Isn't it from bad food?

It's mosquitoes that give malaria.

Malaria is very dangerous
for pregnant women.

It attacks your pregnancy.

Do you know
what a mosquito net is? Huh?

I used to sleep in a mosquito net,

- Mm-hmm.
- but one side was torn,

and we took it down.

We'll find a mosquito net for you.

Every day you must sleep
in a mosquito net.

Do you understand?

I will prescribe some malaria medicines.
You'll take them, you understand?

God willing, you'll recover.

In the village here, at minimum,

people will contract malaria once a year.

Children are especially at risk.

At least twice a year,
they'll contract malaria.

So, if I was to attack one disease,

it's the first disease I would attack.

Give me the chalk.

Do the exercise.

As Africans, we are
really living the huge burden of malaria,

and this has been
for centuries and centuries.

I'm done.

Give me five then.

Very good.

I lived it when I was a kid,

I'm living it as a scientist today,

and I'm living it as a father.

I can still remember seeing myself
laying down on the floor.

I think I was probably
around two or three years old,

and it was really, really tough, sweating.

And fortunately, really, for me,

we had a very good doctor at that time
in my village.

If I would not have that,

I'm really not sure I would have made it,
you know, today.

Étienne, dinner.

Come and eat.

All my brothers and sisters,

they have all been through malaria.

I don't even know a single person
who was born here

and has never experienced malaria.

I just don't know any single person.

These are mosquitoes
that are locally collected

here in Burkina Faso.

This is the DNA of mosquito
that has been amplified yesterday.

From the reading,

uh, this is the kind of picture
that you will get.

If you look at the genome
of the mosquitoes

and you look at the profile,

you have the mutation,

making that the insecticide
cannot bind anymore.

These mosquitoes is adapting
to the changing environment.

It has a kind of plasticity in its genome,

making it really very difficult
for insecticide to be efficient.

Unfortunately, the resistance just jumped.

Conventional tools have really reached
their protective limit.

If we don't have new tools,
just forget it.

We will not be able to eliminate malaria.

This is the painting that shows
the Roman Campagna

in, uh, probably in 1840, 1845.

But, as you can see,
there is no houses there.

Because people didn't want to live there.

It was all swamps.

Malaria affected Italy for...
for centuries.

And they didn't even know
the cause of the disease.

Ever since Grassi,
in Italy,

and Ross, in India, proved in 1898

that certain mosquitoes carried malaria,

mosquitoes have been under attack
in most of the regions of the world.

There is no malaria without mosquito.

It's very simple.

We have eliminated malaria from Europe
thanks to the insecticides.

Eradication using the insecticide DDT

All water surfaces were sprayed
to kill larvae.

However, you need to sustain this effort

over a long, long period of time.

You need a lot of, uh, support.
You need a lot of money.

You need political stability.

It's a bit sad to say,

but you need a technology
that overcomes human nature.

Now, in the lab,
we have gene-drive mosquitoes

that are very, very promising.

Mosquitoes are the deadliest animal
on the planet,

responsible for millions of deaths
every year.

Not only malaria,

there are many, many diseases
transmitted by mosquitoes.

Just, yeah, look at them, they are...

look like from a different world.

They look a bit aliens.

But they are very... terrestrial.

We inject CRISPR
that we engineered in the lab

in a specific location in the embryo

that will develop
into the sexual organs of the mosquito.

Once you get
your first transgenic mosquito,

it's kind of amazing.

This is the brain,
the optical nerve, and... and the eyes.

The gene drive will be fluorescent,

and the non-gene drive will be
without the fluorescence.

You can clearly see
which one have been modified

and which ones are not.

Gene drive can generate
mosquitoes that produce only males,

and this is very important
for two reasons.

One is that males don't bite,
and they don't transmit a disease.

And the second one,
you will have more and more males

and less and less females

to the point
that the population will crash.

At the beginning,
we looked at this technology

with a... with a healthy skepticism.

Personally,
I think a scientist has to be skeptical.

We can mimic environmental condition
in the tropics.

Let's say a particular location
in Burkina Faso, in Africa, or Angola.

We can reproduce, very, very precisely,
temperature, humidity, light cycle.

This allow us to predict what will happen
when these mosquito are released.

Now, I must say, I'm, uh...
I'm convinced that the technology works.

I'm not dead yet,
but I also don't know if it's worked yet.

So, the title of this is

"Experimental Data Revealing
for the N6 HIV Genetic Plasma Therapy."

All right, this is up.

I got all the data.

Um...

Uh...

Yeah, my viral load went up.
So, all right.

Yeah, this was not
what we were hoping for, right?

But...

it's very rare that a therapy that's new
works the first time.

I'm pretty sure we just used
too small of a dose.

We did a very, very small dose.

I mean, this was 1/100th
of what we had available in December.

We all wanted to be absolutely careful

to ensure
that the minimal effective dose...

- Mm-hmm.
- You know.

The future doses, um...

will have about 50 to 100 times,
I believe...

We're developing something

that we believe will be both, uh,
more potent, but also...

it will last longer within the human body.

Um, but I am glad that with the general...
Yeah, the proof of concept...

We didn't... We didn't kill anybody.

What Tristan experimented with
in phase one...

is approximately 250
to 500 times lower in potency

than what he will experiment with
next Saturday.

We've got N6 going right now,

the actual production run.

Should be ready to be purified
in the next couple days.

HIV is a very...

sneaky, and pernicious,
and quickly evolving, uh, virus.

That said,
we think we can respond back to HIV.

It... It's a living entity.

It's gonna throw us
some more curveballs

as it always has in the past,

um, but the fight's not over
just because we lost the first round.

You know, we're not giving up.

If everything goes according to plan,
and it will,

then we will have
all the data that we need

to show that we've developed treatments.

Then we're moving forward
at a lightning pace.

You're listening to Radiolab.

This is Radiolab.

Kevin Esvelt, he is a scientist
who's talking to our producers...

...about a gene-editing technology
that... that can reshape life, actually.

I'm Kevin Esvelt.

- Esvelt.
- He's very svelte.

I think of myself
as an evolutionary engineer.

And Kevin has his idea,

which is to use CRISPR
to create something called...

Gene drive.

Gene drive.

Let's say that you want to change
a gene inside the mosquitoes.

- That'd be great.
- A great thing,

'cause malaria is a bad thing.

With gene drive, that gene does the work
on its own, on autopilot.

You're putting, like,
a spare scissors or something?

And then that baby passes the scissors
to the next baby,

- snip, snip, snip...
- Yup.

And it is like a chain reaction?

- Yeah.
- Dude.

Things are moving very fast.

Uh, what kinds of things?

So, we might be able to use
gene drive to remove rats in New Zealand.

Wait, what?

When I first heard of gene drive,

it was actually a bit worrying,

'cause it's...
...it's at a scale of molecular editing

that we haven't even seen before.

But the threat we're facing
is so incredibly aggressive.

It's the stuff of nightmares.

New Zealand's preparing
for a rat population explosion

of biblical proportions.

Warm weather has created
ideal breeding conditions

for forest predators.

Predators like this
kill 25 million native birds a year,

and these vulnerable species
are at even greater threat

because the vermin population
is about to explode.

The US military is enlisting
six million dollars in research

into gene technology
to control the spread of rats.

Researchers want to use our islands
for the study,

which would see rat DNA edited
to control breeding.

New Zealand
was one of the last places

in the world colonized by people.

Since humans have arrived,

nearly half of New Zealand
land bird species have gone extinct.

Birds like this
were the rulers of the land.

They didn't have any, uh, need to learn
how to evade furry mammals.

When humans brought these rats
and other predators,

they just made a meal out of
all of these birds

who had no evolutionary adaptation.

The choice is either to have birds
like this or to have rats like this.

It's one or the other.
There's no equilibrium.

If we make active choices,
we can steer the world

in a particular direction
that we might want it to go in.

And otherwise, we just end up
with a... a world overrun by rats.

We are here today
to ask for your guidance

in whether you believe
it is useful to even consider

these potential methods

to protect the native species' ecosystems

by painlessly removing
these invasive predators.

And the overall, this kind of phenomenon
is called gene drive.

The goal of this
would be to remove all of the rats.

So, yes, it involves...
engineering the rats,

but the goal is to have
all the rats go away,

and so there would be
no engineered genes left,

- if this is successful.
- Um...

You remove a rat from the ecosystem,
what takes its place?

You're making room for something else,
and then here we go again,

the humans saying,
"Well, we'll play God today,

and bugger the consequences."

We have enough problems in the world.

It's frightening

what you can do to alter, um,

God's creation.

You cannot question,

compromise, with spirit.

I cannot say how that will affect
the spirit of the animal.

I cannot say how will it affect
the spirit of the environment,

but evolution is a game of numbers.

And that is something that we can measure.

Every day that we don't do anything,

there is one indigenous bird
going by the wayside.

We can't just sit here and say,
"Oh no, we're not gonna try that."

We've been using poison
for the last 50, 60 years.

- And it's not working.
- No, it's not.

- Nothing we're doing is working.
- So let's be honest about that

and say, "Look, we're gonna be open
to look at other ways."

Yes.

Ecologically, in terms of sustainably,
the world is broken.

We have broken it.

Is it...

Is it our place to try to fix it?

God made an order.

And Noah...

he did have two rats on that ark.

We have no right to try and eradicate
one of those species

unless we want to pay a severe price.

I speak for me.
I wouldn't dare try to do that.

The challenge is that explaining
how things are

to people, according to science,
has no effect on their actual opinions...

because their opinions about the world
are not shaped by their grasp of facts.

They're shaped by their values.

If you're really playing God,
you don't care what other people think.

So, we're gonna do just the opposite.

We want to learn all of those reasons
why they think it is a terrible idea.

♪ Ah, ya, ya, ya... ♪

...the government planning
to get rid of all the rats in New Zealand.

In fact, the prime minister says,
all going well,

there will be no rats, stoats, or possums

anywhere in New Zealand by 2050.

♪ Bombs to set the world on fire ♪

♪ Suffering in the land... ♪

Going back to the '70s
with that number, "Sufferin' in the Land."

We've got a special guest in the studio,
Bryce Smith.

Uh, we're talking about a big topic.
It's genetic engineering.

The government want to get rid
of all pests by 2050

and may be using
what they call a "gene drive."

I mean, what are your thoughts on that?

I personally don't think
we should be doing that.

This type of technology has the ability
to change our way of life significantly,

and there are a lot of, um...
issues around it,

for us as...
...people of the land,

on how we're going to deal with it.

And I suppose, the thing about this,
I mean, where's it going to end?

I mean, we might talk about this
as a way of getting rid of the pests,

but I mean, the long-term ramifications
of this type of thing.

We need to consider,
if they can do that to that,

then the same tool can be used
on other animals.

At the moment, they've got tools there
to create, um, sterile possums.

What other tools are gonna be needed
to create sterile humans?

You know, our elders never got excited
about technology

manipulating our Maori world.

There's one here for you.

There's a couple more here.

Can I have that knife?

Yep.

Okay.

This is a native breed of taro.

You can just slice them up and cook them
as they are like a potato.

Some of the old people
use it to make bread. You can grate them.

And this particular patch here
has been here

for about six or seven generations,
from what we know of.

This particular plant needs
a moist piece of land.

You can look at the soil here.

It's years and years of, um,
of black mud and...

...if you smell it, it's, uh...
may not be appealing to smell,

but it needs to have that smell
because in that...

in that smell is the food.

My father was a... a great supporter
of our natural whakapapa.

Another nice little one.

Um, whakapapa isn't
an easy word to understand.

It's a relationship
that sustains one another.

Two parties or three parties
in this particular environment here,

you're gonna be at 18 different parties
working together.

One is creating an environment
for the other one to live happily.

One of the critical points is to be sure

that you know exactly
what's going to happen

when you make changes.

And be very, very careful
when you don't have all the information.

When we talk about conserving these birds,

we're not just talking about it
for their charisma

or for the aesthetic value they have.

These are important parts
of the ecosystem.

They pollinate plants,

they regulate invertebrate communities.

If we have too many of these species
go extinct,

it could just unravel the ecosystem.

Just, it's... it's a duty, it's a job
to have to remove these rats

in the entirety of the country.

So we're looking at a map here,
at the Eastern Bay of Islands.

It's a collection of islands here
that they eradicated rats from in 2009

with toxins and aerial rat poison.

But there's a constant pressure of rats
swimming out to the island group.

Got four rats on the loose at the moment.

We're just not sure where these rats are.
They could be running anywhere.

So it's all hands on deck
trying to get hold of these rats

using detection dogs
and tracking devices and traps.

You said you've got four on the run
at the moment?

Four animals on the loose
at the moment

across four separate islands.

So they come swimming,
and they come on people's boats.

You really only have to miss one.

If you miss a pregnant female,

you go from one rat to,
"Holy crap, we're in trouble."

Can see their little, um, footprints there

and also where
they've been dragging their tail along.

When you've got a species
that can breed that quickly,

one rat can devastate our environment.

It's an incredible challenge.

The effort that it takes to catch one rat

is just not sustainable
over the long term.

So if we're serious

of actually making
the whole of New Zealand pest-free,

we've gotta come up with new stuff.

It's the 21st century.
We've put men on the moon.

Surely we can manage this.

It sucks
to have to kill something

to save something else,

but we're well past the situation
where we can leave nature to be.

The impact of humans is well beyond
that where you can say,

"Let's just lock it away in preservation
in a national park,"

and expect it to be protected.

Invasive species are reaching
the furthest corner of the planet.

That's why I support eradication so much,
even though in one instance,

it's killing everything at once,
which sounds horrific.

It's done.
And after it's done, the killing stops.

And the birds come back,
and the life comes back.

Come on, ladies.

- Great. That's a good photo. Yeah.
- Real good.

Here, over here, look.

It's always been
my favorite place to come,

and you just feel at rest...

when you come up here
and just watch over the harbor.

And so, that's what I really like
about coming here.

I think of my ancestors, and...

this is what they left behind.

They protected it
so that it could be left behind like this.

All my role is today
is to continue doing what they did.

Do scientists really believe
they can control the environment?

Do they really believe
they can control this?

Do they really believe
that they can manage this?

Today, we have
some incredible talks, debates,

and a three-day celebration
of human enhancement,

transhumanism, and biohacking.

Oh, wow.

Oh my God. I have to take a video.
I have to take a video.

Hello, I'm Aaron Traywick.
We represent Ascendance Biomedical.

We're a small group of people scattered
around the world with a lot of talent,

developing gene therapy applications.

You have likely heard of us from, um...

our work in live testing
the first gene-therapy cure for HIV.

It's really interesting,
but when we think about HIV,

we think also something similar
to what happens with flu.

Each year it's gonna mutate,
and HIV mutates really fast.

Of course.

So, the, uh, the solution there

is to study the presence
of the N6 antibody in the body,

and ensure that it is staying
at peak concentrations.

The only way to do that
is with blood samples,

and that will be done on a weekly,
ongoing basis for the next six months

with Tristan Roberts, following phase two.

And we'll make sure that raw human data
is available as quickly as possible.

Richter, guard!

Good boy!

Good boy!

Walk with the line?

Swing. Do it again.

There we go.

When you're fighting a living organism,

uh, you've gotta...
you've gotta factor in evolution.

You've gotta factor in the fact
that it's gonna fight back.

In a case like Tristan's,
the key thing to rememberis that his...

his infection is alive.

You know, it's a living,
evolving organism inside his body.

So, if you... if you hit it with something
that will wipe it out,

then you've... you've stopped it.

But if you hit it with something
that just challenges it,

it'll adapt.

And you challenge it a little more
and challenge it a little more,

and you keep sort of piecemealing your way
towards a cure.

You may get lots of useful information,
but the cost may be

that when you finally find
a... a functional cure for HIV,

Tristan's not a candidate for it anymore.

You know,
real biology takes time and effort.

Aaron's problem is he wants it to be now,

regardless of whether it's finished.

All right, so, you're of the opinion that

there's a good chance
of a resistance developing.

Um...

There's risk every time.

So, did...

Was it your version of the N6
that was sent to the lab?

The first version, yes.

Okay.

But I wanted to talk to you a little bit.

Who's, like, adding transfection reagents

and measuring, and all that stuff,
and doing all that?

I... I don't know, actually.

Okay, so, somebody needs to...
measure it, and do the math,

and get it at the right concentrations.

At the wrong concentrations,

either it won't transfect,
or it'll be cytotoxic.

That is... concerning.

It's like, I wanna help you
do what you wanna do.

- Yeah.
- Um...

But you've gotta be really, really careful
with something like that.

There's no reason to push this timetable.

Mmm.

From... From where I'm looking at it,
it's your experiment, right?

So, Ascendance has to accept
that... that one of two things is true:

Either...

you're Tristan doing the experiment,
in charge of what you're doing,

because this is a self-experiment

and Ascendance
is just trying to facilitate you,

or you're their human test subject,
and that's deception.

Genetic modification
is a new topic for a lot of people...

so if you're doing this kind of work,
you have to engage with the community.

We cannot just go there to the village
and then start working.

We have to explain what we are doing
so that the community can understand,

and so this is really
a very big challenge.

Hello.

Hello, hello.

Please clap your hands for the people
of Target Malaria project.

They are working on mosquitoes.

Working on mosquitoes?
How is that possible?

Their work is simple.
They catch mosquitoes.

After they catch the mosquitoes,
where do they take them?

They call it a laboratory.

Ah, laboratory.

The technologies are quite complex,

so it's not easy
for everybody to understand

the specific detail of what you're doing.

We are a kind of small country,

but we have about 60 dialect.

Some of these scientific word
is not easy.

Isn't it malaria?

Can you tell us
what you see in the picture?

- Mosquitoes.
- Mosquitoes.

Not to mention
if you want to translate it

from French to the local language.

If you look
at the picture,

the female's mouth is stretched.

It looks like a needle.

Yesterday morning they told me
that my friend's son died from malaria.

Today, it's my own sister
who's died from malaria.

Every day and night,
mosquitoes are causing damage.

If we don't wake up,
things will get worse!

We can't let the mosquitoes
keep killing us.

I have my rifle at home.
I'll kill all the mosquitoes.

I'm ready, let's go! I'll kill them all!

This is Anopheles gambiae,

the species that transmit
the disease malaria.

You can see some of these mosquitoes
are already blood fed.

This means that they have taken
the blood meal,

so they can fly around
and transmit the disease.

This one is the male.

We genetically modify the male.

When it mates with a female...

Hmm.

...they lay eggs.

- Eggs.
- Mosquito eggs.

But these eggs, they can't hatch.

Because you modified its thing.

This is what we are doing.

That's the type of mosquito
we have in our laboratory.

This is what we're seeking permission for.

If the people of Bana give us permission,

then we are going to release
the mosquitoes

here in Bana.

- I want to do it.
- I want to do it, too.

We must all be a part of it!

You see everyone has raised their hands.
Do you all agree?

We all agree. We all agree.
Let's raise our hands!

We have scientists going into communities,

claiming that they have a solution
for very grave problems.

But you can't base the consent

of releasing a risky,

genetically engineered organism
into the wild

based on one single community.

I think we need more, uh,
to hear the voice

of people living in endemic country
where malaria is a problem.

The opinion of somebody
that is sitting comfortably in a nice desk

overlooking the bay of San Diego
in Southern California, for me...

I mean, I respect it,
but for me, it has a different weight

than somebody in Africa.

These are genetically modified mosquitoes.

These have been brought, uh, from Italy.

I wouldn't sit here today and say

that this technology
is completely free of risk.

It's a new technology.
It has never been done.

But we are taking a phased approach.

We have compiled a dossier,

and we have submitted it
to the National Agency of Biosecurity.

So, not a single
genetically modified mosquito

is going to be released in the field

if we are not confident
about the concern that people have.

We're often told the story
in the context of the best possible use.

Maybe
you could genetically engineer a mosquito

to not carry malaria.

But clearly, this is a very good vector

for spreading bioweapons
and for other offensive uses.

We should never assess a new technology
just by its best possible use.

We have to assess it
against all the ways it's gonna be used.

What is it doing beyond this thing
that I see in front of me?

What's it doing behind the scenes?

DARPA. DARPA takes on

the most difficult technical challenges
for the Department of Defense.

DARPA, the US Defense Advanced
Research Projects Agency,

seem to be putting millions upon
millions of dollars into gene drives.

That's, frankly, terrifying.

And there's a range of other ways
in which it could be used.

There is a patent on the idea
of using gene drives in bees

so that, uh,
you could then control those bees,

using light sources,

to drive it to particular crops.

So, controlling pollination...

if... if a company could do that,

would be, uh, extremely powerful,

and... and they would use that
in the marketplace.

The unexpected mutations
and the unintended consequences

have profound and dangerous impacts
on our environment.

It is irresponsible
for a small group of scientists

to be making decisions
on behalf of the entire planet.

People may think
that it's wrong to, uh...

to play God with environment,

which is very respectable.

But this is a different conversation.
This is a conversation on value.

You have to have a hierarchy of value.

In everything.

Otherwise, you cannot distinguish
what is good and what is bad.

I think it's the keystone of morality.
You have to have a hierarchy of value.

You can't put all the value
on the same level.

So what is at the top...

Life is on top of it.

Social stability is on top of it.

Progress, well-being.

Malaria is a disease of poverty
and social instability.

My objective is to solve
a great health problem,

so everybody will benefit,

irrespective of their social condition
or their beliefs or their income.

We are no different
from any other species.

I mean, species compete with each other.

We are competing with mosquitoes.

We need to win.

♪ To the speaking mountains ♪

♪ To the echoing cliffs ♪

♪ That flow to the sea ♪

♪ Call us ♪

♪ Call us ♪

♪ Call us ♪

♪ I acknowledge you
Who spoke of the celestial knowledge ♪

♪ Knowledge of the heavens
And the terrestrial knowledge ♪

♪ Earthly knowledge ♪

♪ And the prayers you delivered
Will be heard day and night ♪

♪ Stand like the kahikatea tree ♪

♪ To brave the storm ♪

♪ Embrace and receive each other ♪

♪ We are one together ♪

Every scientist that's spoken to us,

and I've got a good 30-year experience,

not one...

has ever provided an antidote
or a formula to undo the mistake

they usually end up with.

So, we will tell you
what we think is possible.

Our best idea to date
is a form of local gene drive

that can stop and go away.

It can be made to be reversible

and, in fact, it can be made
to be reversible on its own.

Or at least, that's the idea.

We're currently working on the first one,

and we're reasonably confident
that it will likely work.

I can't promise that,

but that's my best expectation.

You've come here
wanting to talk about pest eradication,

and yet, you yourself realize
this is dangerous.

So I just wanted to stand
and tell you to your face

I cannot support you

when I see, in actual fact,
that your main supporter of finance

is the Americans' war weapon company,
DARPA.

Why are they spending
all that many millions of dollars?

The only sort of logical conclusion
I could come to

is that DARPA, the war weapons
organization in the United States,

is looking for biological warfare.

Is DARPA actually going to use that,
use you?

I personally am against that.

In terms of weapons,
I refuse to do any work in secret.

And so, after some negotiations,
they agreed,

and that...
that was my unbreakable requirement,

that I will accept military funding
for this,

to understand how these systems work,

but only insofar as everything we do
is in the open.

And I hold myself morally responsible

for all of the consequences
that will ensue.

You know, we've heard
lots and lots of nice words

from the colonizers over the...
over the millennia...

uh, that have proven to be... hollow...

because underneath it
is those hidden agendas.

In a sense, historically,

you're a little bit like the missionary
coming with a good story,

but behind you is a whole lot of fellas
with some rifles, you know?

You understand what I'm saying?

So, it's... it's not just you personally
we're talking about.

It's your ilk, as a whole,
coming to this land.

That's what science does.
It creates urgency in our minds,

and I'm not gonna be tricked by that.

Given the technology and the way
it's racing down the train track,

um, it would be advisable to look at
the natural environment a bit longer,

to make sure that we do need
to intervene or not.

Thank you.

What do you do?

Do you sit and do nothing
or just talk about it?

A lot of our cognate species
are going extinct,

and we don't even know.

What's been happening at the moment
is quite alarming.

What kind of regulations
have gotta be put in place

to actually curb your enthusiasm for it?

I don't have enthusiasm for gene...

What kind of regulations do we need?

In my view, I think, as... as a country,
we need to have a discussion about it.

But I think science, in and of itself,
is just like a book,

and I think it would be dangerous
if we didn't open the book.

I think we need better ways
to control rats.

I don't like poison coming out of the sky
as much as the next person.

The people that are resourcing
this kind of technology,

a military force, they're after the tools.

The kind of technology
they're wanting from Kevin

isn't the technology
that he's talking to us about,

but it's, in fact, the evolving technology
in Kevin's little tool bag...

that can be used for other things.

It's the mightiest fucking military force
on the planet.

They don't bullshit
about weapons of mass destruction.

I'm just going on their track record,
that's all.

Research on a radical new way
to combat malaria

and other insect-borne diseases
could be severely hampered

if proposals to introduce a UN moratorium
on the work go ahead.

Ladies and gentlemen and dear colleagues,

welcome to the 22nd meeting
of the Biodiversity Convention.

The risks of humans undermining
their own existence are very real,

and it is time for the voice of scientists
on biodiversity

to be heard as loud and clear.

No gene drives! No gene drives!
No gene drives!

These are the experts
from around the world for governments

who decide what happens
around genetic engineering.

CBD, don't let the gene drives out!

And the big topic under discussion here
is going to be gene drives.

Mass extinction!

Is not a solution!

Gene drives are a crazy idea,
but militaries are interested.

There are a number
of agriculture companies interested.

There needs to be rules internationally
saying a moratorium.

Don't put gene drives into the wild,
into the field, out of the lab.

- GMO mosquitoes!
- Go way!

- GMO mosquitoes!
- Go way!

- Say no to GMO!
- Say no to GMO!

- Say no to GMO!
- Say no to GMO!

Genetic engineering brings up
the question of control.

Who is profiting?
Who is controlling the technology?

GMO mosquitoes!

- Go away!
- GMO mosquitoes!

Go away!

Agribusiness companies,

chemical companies,

mega companies
around the world are interested

because it allows them to control nature.

Look how many people,
thousands and thousands,

gathered in the capital to say no to GMOs,

to say no to modified mosquitoes,

to say yes to our sovereignty
over our food and health.

Everyone against GMO mosquitoes,
raise your hands!

NGO 2112,
please make the statements very short.

We see proposals proliferating
for gene-drive bees,

cats, mice, parasitic worms,

fruit flies, and more.

There should be no release
of gene-drive organisms at this time,

and we would like to suggest text
that makes this clear.

Gene drives could cause
irreversible ecological damage.

There must be a moratorium

on any environmental
and commercial release.

I think that would be a disgrace,
a moratorium.

The first consequence of a prohibition
is that somebody will do it anyhow

and will be not transparent.

The moratorium will have
exactly the opposite effect,

so I think, actually, it's dangerous.

It would be desirable
if there is a regional agreement,

but I think the people
that have the problem

have the right to implement.

I don't think you need
total agreement of everybody.

It is New Zealand’s view

that we should assist
each application of gene drive

based on its own positive
and adverse effects.

Germany cannot support the text
that can be interpreted as a moratorium.

There's no blueprint
for how we govern, oversee, control,

uh, an advancing, emerging biotechnology
across the globe. None.

Bolivia observes with profound worry

the advancements in gene drives.

South Africa
is of the view that gene drives

may pose new risk assessment challenges.

Given the current uncertainties
regarding engineered gene drives,

the Philippines urges parties
to take a precautionary approach.

We might think of treaties,

but treaties tend to be very difficult
to enforce across countries,

and good luck with that, frankly.

New Zealand does not support
the reference in paragraphs four and five.

The focus should be
on an adequate risk assessment.

Prioritization of risk assessment

and risk management, as well as...

Risk assessments...

We are not comfortable
with the recommendations

in paragraph four, five...

We'd like to propose amendments
to paragraph...

Lines two and three in paragraph seven.

If you were to say, "Where have we been
successful in that in the past?"

- Paragraphs four...
- Paragraph...

- Paragraph nine.
- Paragraph six.

There isn't an example.

The thing that we shouldn't forget

is that Africa is really suffering
from this burden.

At the human level,
we are the ones suffering from this thing.

Every single minute,
one kid is dying from malaria.

How many people are you going to lose?

I was born here in Burkina,
grew up in Burkina,

and I know what is the burden of malaria.

This is really my hope
ever since I have been in this world.

Will we be able to eradicate it
in two years or three years?

I just can't give you an answer.

But I'm absolutely confident

that bearing the burden of malaria
is not the fate of Africa.

I do have concerns about...

whether or not I'm making
the right decision.

Ensuring that I'm not wrecking
my body further...

isn't something I can do
a hundred percent.

I could impact the virus itself...

creating an even stronger opponent.

Tristan's concerns...

his feelings...

everything has to be taken into account.

He can't be disregarded.

At the same time,

the most important thing to do
is to keep moving forward,

because if we stop working,
then our value...

goes away. It drops off.

The way I put it is like, there's, like,
a maybe...

Let's say there's a one percent chance
that it works

and it can positively benefit
thousands of people.

Like, how do you balance out
those two extremes, the two tails?

At what point is it not worth the risk,
right?

Look at all that.
That water is pretty close to boiling.

And yet...

it clearly doesn't care about the heat.

Life finds a way.

Science is explicitly about...

learning to understand the things
that we can see and measure.

So as soon as people bring up
the spiritual,

that's not directly relevant to science.

But the same is true for ethics.

Soon as people bring up the question
of what we should do,

that's not a scientific question.

Often, the technology is the easy part.

It's always dealing with other people,
other complex, evolving creatures

with their own evolving ideas
in competition with ours.

But you can't just hide out in your lab

and invent things
without thinking about the consequences.

I still have nightmares about boxes...

in the Pandora's box sense.

Because we need to keep opening boxes.

Our civilization is not sustainable.

But we're not so hot at telling
which ones will help

and which ones are dangerous.

So...

to me, that is the challenge,
more than anything else.

How do we coordinate our efforts

to ensure that the dangerous ones
are not opened?

You see how calm they are?

In the evening,
the bees are nice and calm and settled,

and they don't mind being disturbed
as much as they normally would,

and it's easier for us to harvest.

We don't need any protective gear.

Okay.

There are more options
that are available to us.

The natural environment has options
on its own.

Science needs to study
natural environments,

not to change them.

Because science isn't meant to do
what Kevin's done,

creating a Pandora's box
where anything can be used,

anything can be done
with this gene editing.