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[Alice laughs]

There, now this is completely painless.

It will only take a few seconds, okay?

[Alice chuckles]

Question.

[Dr. Feldshue] Yes?

Could Jack do that?

Well, legally, no.

No, I'm sorry.

Oh, it's all right.

But he can put his hand on top of mine if...

How do you feel about that, Jack?

So, we'd be hold...

We'd be holding hands?

[Dr. Feldshue] Yeah, just on top.

For this bit?

No, not for this bit, no.

No, for the next bit.

Yeah, okay.

Yeah, that'll be, yeah, that'll be, yeah...

Absolutely, yeah, no problem, yeah.

Thanks.

Right.

- Question. - Yes?

Could Jack and I have a moment alone?

Oh, well of course,

yeah, no, I'll just pop out.

Thanks.

You okay?

Thank you.

[mattress squeaking]

[Jack groans]

[mattress thumping]

[Jack groans]

[mattress squeaking] [mattress thumping]

[Maya] Scone?

[floor thuds] Okay, wow.

[mattress squeaking] [Jack and Alice groan]

[Alice chuckling]

[Jack exhales]

Not exactly how I expected the day going.

No.

Do you think anybody's ever done that in here before?

Oh, God, I hope not.

[both chuckling]

D'you think we should--

Yeah, yeah,

they probably have another appointment.

Yeah.

God, what a colossal waste of money.

We could have gone to fucking Borneo.

[Jack chuckling]

[Alice exhales] - Shh, shh...

Be careful.

Bye now.

Thanks very much.

Fingers crossed.

Lovely to meet you.

[gentle piano music]

[traffic whirring]

[horn beeps]

[water rushing] - [Jack] Here we go.

Caffeine-free, obviously,

plus a little something to keep your glucose up.

Thank you, but can you please calm down?

[Jack laughs]

If it is a pregnancy,

definitionally, it's a high-risk one, so...

Those definitions are ageist.

So's life.

Works both ways.

My little guys need all the help they can get too.

Your poor old-man sperm,

struggling to navigate upstream.

Yeah, all right.

Is there anything else?

No, thank you very much

and please go home.

And I'll call you in 12-14 days with the results.

I'll also call you, like, 50 times between now and then.

I'm happy to stay.

I'm sure the couch is comfortable.

Do you like fussing over me?

Of course I do.

If I was laid up, you'd wait on me hand and foot.

[Alice] No, I wouldn't!

But I would hire someone.

And I'd be there also.

That's close enough.

Just think of me like any other possibly pregnant lady.

[Jack] Not a chance.

[Alice laughs]

Jack?

[Jack] Yeah?

Do you want to talk about what happened today?

[Jack] No.

[water rushing]

Okay.

Bye!

[Alice] Jack?

Yeah?

[Alice] Actually, can you stay on the couch?

Yeah.

[Alice] Thank you.

[gentle piano music]

[Jack exhales]

[gentle piano music]

[indistinct chatter]

[phone vibrates]

I didn't hear from you yesterday.

[Jack] I know, I'm sorry.

I was worried it had gone south or something.

[Jack] Yeah, no, it...

It was...

It went oddly.

Yeah, it took an interesting turn.

Well, now you're gonna have to say.

[Jack exhales]

Alice and I made love on the insemination table.

[Donna] [laughs] Okey-dokey.

Um, golly.

[Jack] Hmm, yeah, I know.

Yeah, I...

I don't really know how it happened,

or what it means, or if it even really means anything.

It could have been a one-off,

a valedictory,

or maybe we crossed a Rubicon again,

or maybe we crossed it only for a few minutes

and now we'll cross back again,

or maybe...

So you're not sure.

[Jack] Not sure, yeah.

But a non-clean slate just got non-cleaner.

So, I wonder if maybe we're...

[dog barking]

[traffic whirring]

[cell phone ringing]

[cell phone whooshes]

Hello.

Are you all right?

So funny. [laughs]

Your guys can swim.

Whoo-hoo!

Whoa, Alice! [Alice laughing]

Comhgairdeachas, comhgairdeachas,

comhgairdeachas, comhgairdeachas!

What are you saying?

That's Irish for congratulations.

[Alice] Jesus, that takes so long to say.

I know!

I know.

[Alice] Jack?

What?

I think...

I think I'm getting good at it.

- [Jack] You're good at what? - Like, real life.

If that's something that you're interested in,

or anything that you want to take a risk over?

Oh.

[gentle piano music]

Can we think about it?

When have we ever not thought about it?

[gentle piano music]

Never.

[gentle piano music]

[door bell buzzes]

My food's here, I've gotta...

I love you.

[gentle piano music]

[bright music]

Whoo!

[bright music]

How are you feeling, love?

I'm feeling very well, thank you.

Am I right in thinking the baby is like the size of a fig?

That's right, yeah.

Next week, a lime.

[Alice chuckling]

So, we did the standard 10-week work-up

and I need to tell you that

it showed some genetic abnormalities

that could be indicative of an illness.

What kind of illness?

They could be indicative of cancer.

But then...

I mean, cancer?

[Dr. Feldshue] Yeah.

Yeah. - How can they detect that

when the baby's so small?

It's not the baby.

[Dr. Feldshue] No. it's not the baby.

It's you.

[somber piano music]

[Jack] Hi, everybody, thanks for being here.

Okay, this is Stage 4 Bile Duct Cancer

with distant metastases.

The 5-year survival rate is 2%.

Conventional therapy is already underway

at the point of attack, but there are so many...

[Jack clears throat]

Sorry, there are so many points of attack

that I believe the only way to save this patient's life

is to harness her own immune system.

Luckily, we have some experience in that area,

in related areas.

Okay, this is CTLA-4.

It switches off our T-Cells

after they've killed an infection,

but before they start attacking healthy tissue.

Without CTLA-4,

our bodies would basically murder themselves.

Cancer cells are clever fuckers.

They use CTLA-4 to fool our immune system

into thinking everything's okay,

and then the cancer cells take over.

So, what we are looking for

is a substance that stops our T-Cell's from being fooled:

a tumor-specific form of Anti-CTLA-4.

[Paul] Even if your theory is right

and the formulation exists and somehow we find it,

we'd still have to work out how to deliver it

and then put it through trials and then get it approved.

Someone'll do it someday.

Yes, maybe,

if they've spent a lifetime in cancer research.

You don't just swoop in

and cure the worst disease in human history--

You don't if you don't try.

We did something similar on Hashimoto's.

We knew where to look on Hashimoto's.

And we got very lucky.

On this, we're in a fucking rowing boat on an open ocean

looking for a drop of water with a--

We've got lightning-fast computers now.

They can process literally hundreds of candidates a second.

You're not being rational.

You're tilting at windmills, mate.

I've never known what that means.

That this is not gonna work.

And you're taking people and machines away from Dengue Fever

and half a dozen other projects we're this close on.

What are you telling me to do?

Are you telling me to let her go?

I'm telling you to let the doctors do what they do.

They'll fail, Paul.

Their science is old.

Blast away with chemicals and radiation

and hope for the best.

Meanwhile, the person suffers and withers in front of you

and almost always dies anyway.

That can't happen to Alice.

If there's anything that I can do, I'm gonna do it.

What if there isn't?

Then I'll die trying, okay?

I'll die trying.

[Paul] Look, it's not that I don't understand.

I'm sure I'd feel the same way if,

God forbid, it were Donna.

If this was Donna, we wouldn't even be talking about it

'cause I would've been in from the start.

[Paul] Okay.

Okay?

Okay.

Good man.

[Paul] I'll start the moment I get back upstairs.

Good man.

[Paul] Just don't get your hopes up

in that way that you do.

This is still insane.

I have to have hope.

Okay, well hope, just don't believe.

[Jack] I have to believe.

[gentle music]

[siren blares]

[siren whirring] [gentle music]

[Alice chuckling]

Hello, Miss, can I walk you home?

[Alice] Yeah, you certainly can!

You shouldn't have done this in the middle of a workday.

Ah, I'd spend every minute with you if you'd let me.

Oh, that's creepy.

Yeah.

How'd it go in there?

You know.

We're all terminal,

I'm just a little more terminal than most.

Okay.

I called around about your doctors and they all check out,

but people seem especially keen on Dr. Anthony Cedarbaum

because, apparently, he rolls with the punches

and he's a student of the game,

so that's good.

How are you?

I'm fine.

- Mmm-hmm? - Mmm-hmm.

Yeah, when was the last time you slept?

Can we please not worry about me right now?

Why not?

It's a fucking excellent change of pace.

Okay, the other thing, all the shit online.

Do not Google late at night,

but if you do Google late at night,

as I admit, maybe I was doing recently,

don't get caught up in stupid fucking papers written by...

Written by stupid people

with these ridiculous axes to grind.

It's a waste of time and it will drive you mad, so...

[Jack exhales]

Jack?

[Jack] Yeah?

You wanna go somewhere?

Sure, yeah.

Where do you wanna go?

You know where.

[gentle piano music]

Cuba?

Our roof.

It's a long trip for you, Alice.

Yeah.

Yeah, of course, I'll set it up.

[Alice chuckles]

[gentle piano music]

[engine whirring] [gentle piano music]

[cell phone ringing]

Hey, I've been...

Yeah, sorry, I've been waiting for you.

I was gonna say that my instinct is

it's gotta be a protein, right?

[Paul] Mine too,

because the monoclonal antibodies are proteins.

Yeah.

Yeah, yeah, so that's the place to start then.

[Paul] Okay. [Jack grunts]

That's gotta be the place to start, right?

[Paul] Are you okay?

[Jack exhales]

[exhales] Yeah, sorry.

Traffic is...

[Jack panting]

Uh, I'll call you back.

Just, you keep...

You keep doing what you're doing, yeah?

[Jack breathing heavily] [dialing tone ringing]

[Lynn] Jack?

[panting] Hey, Lynn...

[Jack sighs]

Thanks for letting me ruin your week.

Oh, well.

We circle the wagons, Cyril.

How are you feeling?

[exhales] I'm grand.

It's probably just stress.

Yeah, yeah, exactly.

I mean, I'm sure we'll see.

Uh, how's Alice?

It's weird, Lynn.

I can tell she's, like,

resigned herself to the worst already,

which I hate, but makes sense.

She's always been one for the odds.

But she's still putting herself through the chemo

and God knows what else after that.

I just...

I just can't work out why.

Well, for you, obviously.

Thanks for asking after her.

Aye, yeah, well, I can't go around hating people.

Except for you, of course.

Of course.

You know, if you ever actually met her,

I think that you will really like each other.

I mean, let's not go crazy.

[Lynn chuckles]

You know, I'm good and over you, Jack,

I can promise you that,

but it doesn't mean I don't love you.

And it doesn't mean I don't want you wandering the earth

making someone else miserable.

[door opens]

[Dr. Pell] Good morning to you, Mr. & Mrs. Caine.

[Lynn] Oh, it's Mr. Caine and Ms. Mixon.

We're not married.

Well, we were, but not anymore.

I married someone else.

You have Ehlers Danlos Syndrome,

a genetic disorder of the connective tissue,

in your case, of this piece right here

where the artery meets your heart.

Okay, that sounds bad.

That looks bad.

[Dr. Pell] Because it's an aortic aneurysm

which, had it gone undetected, might have led to dissection,

which would have led to death.

But now that we know about it,

we can keep it from killing you.

Jesus Christ.

Okay.

[Dr. Pell] Your medical history

says that both your parents died of heart attacks.

Mmm, they did.

No, they didn't.

So, what are my odds?

Assuming you behave yourself 100%...

100, 100, okay.

As I said, it's a syndrome, not a disease.

You did say that, yeah.

[Lynn laughs]

Sorry to laugh.

Just...

That was a lot to, you know...

It's bad news, but it's not...

It's not terrible...

News.

- News. - Yeah.

You see all this?

This is you and me passing into obsolescence.

Ah, we've still got some time left.

Oh, really?

Have you looked in the mirror recently?

Because I did, and the ghost of Marie Curie looked back

and told me I was fucked.

Each of these servers is looking at

a different set of combinations and permutations.

Normal proteins, novel proteins, synthetic proteins,

a smorgasbord of proteins.

As you can see, I chose yellow for failure,

just for nostalgia's sake.

All we need is one that turns red.

Essentially, that's it.

The programs are up and running.

All that remains for the humans to do

is to stare at the screen,

contemplating their technological unemployment

and maybe shout if anything good happens.

And not even that, really,

because about 85 alerts will just go off.

So, you may as well just go home and recuperate.

I don't like the word "aneurysm."

Alice wants to go on a trip.

So go on a trip. That's a good idea.

I'll keep you updated.

I feel like I should be here.

Again, that's ego and neurosis.

She thinks it's gonna be her last one.

You haven't told her, have you?

About the Ehlers Danlos?

No, not yet.

I will.

No, about this, Jack.

About everything we're doing here.

If it works, she'll be my first phone call, believe me.

And what if--

If it...

If it doesn't and I told her,

then I will spend the rest of my life

wishing that I hadn't, okay?

Yeah, okay.

[suitcase rattling]

[Maya] Right, so, the Paris leg

will be a piece of gateau, obviously,

and on the layover an agent named Capucine or Capucina,

I got tired of asking her, she'll be there to take you

to the fancy-person section of the lounge.

And on the second leg, the long leg,

all your meals have been pre-loaded.

And I checked.

Of the 100-or-so in-flight films,

at least seven aren't based on comic books.

All your documents are in your bag,

in the order you'll be needing them.

Don't get clever at immigration

because you might wind up in the slammer

and then there's nothing I can do.

Um, at the hotel, tip like a sailor.

Bottled water only and the internet is still 3G.

So, yep, no public swearing.

[laughs] Thank you.

You didn't need to do all of that.

It's just muscle memory.

I love you.

What?

I said I'm not paying you.

[Maya chuckles]

Out of my way. [laughs]

All yours, move over.

[Alice chuckles]

You all right? [Alice chuckles]

Yeah.

Okay.

[strains] Oh, Jesus!

[both chuckling]

[somber piano music]

What's wrong?

Nothing.

I don't like leaving Paul in the lurch.

Makes me anxious.

Honestly, I don't feel anxious about anything right now.

Really?

What's that like?

It's good--

[car thuds] [driver grunts]

[Driver] Oh, for fuck sake.

What about now, are you anxious now?

No.

[train whooshes]

Do you think he's hurt?

He didn't even spill his coffee.

Well, then what's taking so long?

What are they talking about?

[traffic whirring] [horn blares]

Come on, lads.

Someone's not in holiday mode.

Because we're not yet on holiday.

We're watching these two fellas have a chat.

Jesus Christ, this is...

Oh, man, this is not good.

You're looking at traffic.

It looks like my phone is bleeding.

It says if we leave now, we get to Heathrow in April.

[Jack exclaims]

Jack, if we miss the flight,

we'll just get the next flight.

There's...

No, there's like... The next one's in two days.

[Jack exhales]

I just wanna be with you.

[traffic whirring] [indistinct chatter]

I just wanna be with you too.

Good.

Why don't I ask the driver

to take our luggage back to my apartment?

I don't understand.

What do we...

What do we do?

Whatever we want.

[horn blares]

[horns blaring]

[Alice laughs]

Yeah.

- Okay? - Yeah.

[Alice chuckling]

[Alice] So, how are your tension levels?

Was a nine.

Now a seven.

Oh, great. [Jack laughs]

Seven and a half.

[Alice chuckling]

Oh, my goodness, do you know what's on this street?

What?

My favorite house.

Where?

It's there.

It's that white one with those windows.

Oh, beautiful, yeah.

Not your usual taste though, I wouldn't have thought.

I dunno, I feel like I would've been ready

for something different, you know?

[Jack] Yeah.

Something warmer.

I would've liked to have tried to have kids again.

With you.

Yeah.

[Alice] I wouldn't have wanted to raise them

in my refrigerator of an apartment, though.

I like your flat.

[Alice laughs]

Yeah, there's a time in life for everything, isn't there?

But I feel like a kid

needs a window in the bathroom, for fuck sake.

- That's fair enough. - Yeah.

I can see us, though.

Two kids.

Them windows. [chuckles]

Can you?

Boys or girls?

Either.

Well, one of each, if I could choose.

[laughs] Agreed.

Celia would have siblings.

Yeah.

The Caine-Long kids.

Hmm... - [laughs] Yeah.

Polite, charming, more than usually funny.

Nice.

My God, do you want a fizzy drink?

Do you?

Fuck yeah, I want a fizzy drink.

Might be my last one.

My farewell fizzy drink.

I'll buy you one.

No, I'll buy you one.

- Let me buy you one. - No, I'll buy you one.

Alice come on, Jesus Christ. [Alice chuckling]

- I'll buy you one. - No, I'll get it.

- No, it's okay. - I just wanna...

Please don't do this!

[Alice laughing]

- Hello. - Hi.

I'm gonna, I'm about to pay for

two fizzy drinks, please. - Two fizzy drinks.

[gentle piano music]

[Jack] Mmm-hmm.

[Alice] When the kids are old enough

for us not to go totally bananas and lose our minds,

we take them on holiday.

Where do we go?

Skiing?

No.

I've only been skiing once.

I nearly killed myself and a bunch of other people.

[Alice chuckling]

It's not funny.

I think I need a friction-based relationship

between myself and the earth's surface.

I need that with people.

I know exactly what you mean.

I'm aware. [Alice laughs]

[Alice] Um, okay, no skiing.

But we'll go somewhere. - Mmm-hmm.

We'll travel somewhere.

Where?

America.

No!

Fucking America.

Donegal.

We certainly can.

I've never been.

Yeah, amazing beaches, amazing people,

amazing coastline, amazing fiddle music.

It's amazing!

Oh!

[Jack] And if you know where to go,

there's nobody else around

apart from sheep and a few goats.

Okay, and on day one,

the kids learn to not...

To stay away from the goats.

Hmm, you make friends, but at a distance.

[Jack] Yeah.

They'll be good at that if it's hereditary.

Fucking stop.

[chuckling] It's true!

And so, what are we doing

while the kids are avoiding goats?

We're gambolling.

You what?

Gambling?

No, we're gambolling.

Gambolling?

Gambolling! - Yeah!

Gambolling, right. - Show me your gambol.

I'll do a gambol if you do a gambol.

All right.

- Yeah? - Mmm-hmm.

Okay.

Finished with your fizzy drink?

[Alice] What in the actual fuck?

[both laughing]

You do it then, go on.

No, I'll do you gambolling.

Don't do me gambolling.

You do you gambolling.

[exhales] Okay, this is you gambolling.

- That's... - Oh, I'm just gambolling!

I do the accent, all right!

You do you gambolling then.

I would just...

I would just gambol you know, like cool...

That's not fucking gambolling!

You gotta put some spirit into it.

[Alice] I'll never go back to finance.

[Jack] What do you do?

[Alice] Charge ahead with philanthropy,

trying bit by bit to erase the moral stain of wealth.

You?

I'm a lab rat til the day I die.

You'll have to drag me out by my ankles.

[chuckles] I'd like to see that.

And then we see just little enough of each other

that when we do it's, you know, it's still thrilling.

It's always thrilling, Alice.

People say at some point the excitement fades away

but, with you, it never has.

[seagulls squawking]

I feel like that about skiing.

And you, I should have led with that.

[Jack chuckling]

Maybe my mistake with skiing

was the same as my mistake with you.

I never learned to slow down.

[gentle piano music]

Well, I wouldn't wanna be

one of those couples who sits in silence

having run out of things to say 25 bloody years ago.

That's like a living death, isn't it?

Which is arguably worse than a dying death.

Maybe they're just content.

I don't trust content, you know.

Isn't content like the younger cousin of bored shitless?

- No! - No?

What about when we're older?

Like when we're 70, or 80, or 90?

Oh well, when we're 70, 80, or 90,

we begin in a very entertaining way,

to totally lose our wits.

Mmm-hmm, chaos.

[Alice] Absolute chaos.

[both chuckling]

[gentle piano music]

How's your tension level?

When I'm 90 I hope it's zero.

I hope.

[Alice laughs]

[gentle piano music]

[Alice] Do you know where we are now?

Yeah, we're a couple streets from Celia's school.

Which you know

because you've snuck over there once or twice.

Which I do know

because I might have snuck over there once or twice.

Imagine her when we're 90?

Oh, my God, she'll have had her dance career

and she'll have been all over the world.

And she'll be a diplomat.

A diplomat?

I think she'd be really good at it.

Oh, 'cause she's had the training.

Right, yeah.

I blame myself for that.

I blame me.

She's been well-loved, though,

and there's definitely worse things than that.

Yes, there are.

Oh, my God.

Oh, my God!

What's she...

What's she doing?

Well, she's meeting a boy, Jack.

She didn't tell me about that.

You think?

[indistinct chatter]

Do you think she'll be happy?

[Alice] Yeah.

Do you think she'll see less trouble than we did?

Yeah.

Maybe I should just nip over and say hello?

[Alice] No!

Unless you want to be reviled for the rest of time.

[Jack] Why don't you...

Why don't you go over and say hello?

She loves you. - Nice try.

She doesn't want to see me either, Jack.

[Alice chuckles]

[Jack] Can we go and get a proper drink?

[Alice] Oh, yeah.

Can we get five?

Yes, we can.

Okay.

[Alice] Okay, so we're 100 years old.

[exhales] Well done us.

- Whoo-hoo! [laughs] - Yeah.

[Alice] And you're fine.

You're like a field horse, but I'm on the fade.

What do we do?

We go for a walk

and we have a fizzy drink

and we do what we did today but in reverse.

We reminisce.

And you know how I would feel?

[Jack] No.

I would feel exactly the same as today

which is that, because you're here, it's too soon.

It's too soon.

[Alice exhales]

Do you think these hipsters are looking at us

thinking we've run out of things to say?

If they are, they are morons.

[lips smack]

Maybe content is okay, eh?

[Jack] Why are you not angry, Alice?

[Jack sighs]

Because I'm apoplectic.

[Alice] Do you know what I thought

when they first gave me my diagnosis?

No.

I thought, "These people are thieves.

They're thieves of time."

But...

I don't want to spend the days that I've got left

just being angry about the ones I'm not gonna have.

Jack?

Are you gonna be all right

if I'm not one of these, you know, two-percenters?

No.

Are you?

Jack, I'm gonna be dead.

I think...

Technically, I think dead's the opposite of all right.

Yeah, yeah, sorry. [laughs]

Can I tell you a secret now?

Whatever happens, I think we're gonna see each other again.

- You think so? - Mmm-hmm.

Do you think I'm absolutely crackers for believing that?

[Jack] No.

You don't think it's like the desperate delusions

of a nearly-expired human?

No.

Do you remember that first night that we met?

I do remember the first time we met, yeah.

[Alice] Do you remember what I asked you?

Yeah, you asked me fucking everything.

You asked me everything all in a row like this.

[Alice laughs]

Do you remember when I asked you if you were religious?

[Jack] Mmm-hmm.

I asked you back.

You never answered.

So, are you you religious now? - No!

May...

I mean, maybe, I don't know.

I mean, it's hard to find proof, isn't it?

[Alice chuckles] - Mmm.

[Alice sighs]

But I think there are hints.

You're saying you've had a hint?

I am saying that, yeah.

And what was the hint?

I'm looking at him.

[cell phone ringing]

That's Paul's ring.

[Alice laughs]

Just take...

Go on, take it. - Do you want the same again?

Oh, yeah, please, yeah, thanks.

[cell phone ringing]

Paul.

[Paul] Oh, it's you.

I thought you'd be on a plane.

I was expecting to leave a message.

No.

Do you...

Do you have news?

No, mate.

I'm sorry.

I was just calling to tell you

we're through the first hundred-million candidates.

I was just keeping you apprised.

I'm sorry.

It's all right.

But, look, a hundred million down,

but billions to go.

So, this is only the first

of approximately 17,000 phone calls.

[Jack] She wouldn't want this, Paul.

What?

It's not gonna work, is it?

We should spend her time more wisely.

[sighs] Stop it.

Go back to the other projects.

Stand down.

Are you sure?

[Jack] Yeah.

Okay.

Okay.

[somber piano music]

[indistinct chatter] [somber piano music]

[somber piano music]

[Alice] Just in time. [Jack exhales]

Thank you.

[somber piano music]

To us.

Mmm.

[glasses clinking]

[somber piano music]