All language subtitles for GD710

How long have you known?

About a week or two.

My doctor found it
on the yearly scan.

Did they give you
a sense of how long?

- Three to six.
- Years?

Months.

What's your plan?

Is there a surgery or chemo?

No. This is my plan right here.

You. You're it.

You're the plan.

And you.

And that one.

And maybe some bowling.

I have to go to work.

Last time, you also said
it was inoperable. Goodbye.

He just took your medical file.

Yeah.

I'm so sorry, Glassy.

Me too.

Despite having you on
vancomycin and ceftriaxone,

your post-op infection
is still progressing.

We're waiting for
the cultures to grow out,

but we suspect MRSA.

I'm thinking we debride
the infected tissue,

then flush antibiotics
directly into the wound

and put in drains.

Good call.

I'll put it on the schedule,

and leave you two alone.

I guess we weren't
exactly subtle.

No.

You said you wanted more
than a one-night stand.

I did.

But, uh,

how would we do that?

I don't know.

But...

I would like to make it work.

Me too.

Oh, it's Shaun. He wants me in
the Residents' Lounge, stat.

The patient is a 68-year-old man

diagnosed with grade IV
butterfly glioblastoma,

from the left
frontotemporal lobe.

Do we have
a full medical record?

Patient history?

Or a name?

Successful surgical resection
for glioma five years ago,

followed by chemo and radiation.

And within the past year,

several minor strokes.

Glioma and strokes.

Are those Glassman's?

His cancer's back?

The patient's identity
isn't medically relevant.

How is he? How are you, Shaun?

The patient's identity
isn't medically relevant.

Shaun, did Dr. Glassman
ask you to develop a treatment?

No, he didn't.
Otherwise, he'd be here.

The patient is reluctant
to pursue treatment,

but the patient is also
not aware of new developments.

You and Jordan go do
Claire's debridement.

I'm sorry, Shaun. I can't.

Looking at the axial images
with contrast...

How's Claire?

Looks like MRSA. We've got her
on vanc and ceftriaxone.

Rack 'em up.

Said the woman who
hates the fact that there's

a pool table in
the president's lounge

to a dying man?

Shaun?

He's got a group brainstorming
a treatment plan for you.

- I'll rejoin them if you want me to.
- No.

Thank you.

Hey, look at the bright side.

When I'm gone,
no more co-presidency.

You can run this joint
however you want.

I never wanted it
in the first place.

Stop. You're a natural.

Even if you are overly invested
and too accessible...

In every other way,
you're amazing.

This sucks.

Shut up and rack 'em.

No sign of any more
devascularized tissue.

Proceeding with
antibiotic irrigation.

Looked like you two were
reconnecting last night.

Yeah.

Did that...
Does that bother you?

It caught me off guard a little.

You could have told me you two
had unfinished business.

You're with Perez.

Danny and I are texting a lot,

and, yes, I do hope and pray
my future is with him.

That's why I backed off
and stopped flirting with you.

You and me, we're friends.

Placing the drain.

Thing about friends is,
no holding out.

I told you about me and Danny,
you tell me

when your ex you're not over
is back in town.

I can close.

Deal.

To both.

I'll go check on the cultures,

see which antibiotics
are working.

Shaun, have you tried calling
the Tisch Brain Tumor Center

or Cleveland Clinic about
their in-progress GBM trials?

That is an excellent idea.

I'll keep things rolling here.

Come on, guys, I need some energy,
some enthusiasm.

Stop pitching the same idea.
Start pitching any idea.

I ran out an hour ago.

How long are we supposed
to keep doing this?

Until Shaun accepts
what we already know.

That there is no treatment.

- What do you got?
- Nothing's working.

Not a single antibiotic made
a dent in Claire's infection.

It's not MRSA.

We cleared out
all the infected tissue,

but initial cultures confirm
you don't have MRSA.

You have acinetobacter.

It's resistant to everything.

One of the antibiotic combos
slowed growth a little.

We'll try that.

But mostly, we need your immune system
to beat this thing.

Are you scared?

I heard about Glassman.
How's he holding up?

Better than the rest of us,
I think.

At least, he's acting like it.

Congratulations.

I assume they'll
offer you the presidency.

Look,

it is a terrible way
to get the offer,

but it is still
a huge accomplishment.

There's another offer.

Chief of surgery at the hospital

where Clay's doing
his fellowship in Chicago.

I'd get to focus
on surgery again,

be with Clay again.

But?

How did you know it was
the right choice

to move to Guatemala?

It made me want to throw up.

It was so terrifying.

But in an exhilarating
kind of way.

What?

You're sweating.

I'm looking for
stuff to scavenge.

Oh, well, help yourself.

Just stay away from the scotch.
I'm gonna need that.

Tell me about your bucket list.

Bucket list? Hmm.

Criss-cross the Serengeti with
a backpack and a pitch tent.

Wrestle an alligator and win.

Or go bowling.

I didn't take you
for a Pin Prince.

A bowler?

I'm kind of
a Strike Siren myself.

Park and I are in a league.

I wasn't expecting that.

I know what I want.

When you were treating
my rheumatoid arthritis,

there was this

one day when you were
going over my

X-rays and blood work

and medical history,

all this stupid paperwork
about me and my stupid hands,

and it all felt so overwhelming.

And then you gathered it up
into this nice, neat pile,

and you
paper-clipped it together.

And all of a sudden,
it felt manageable, like,

maybe I would be okay.

Also, I can use it to jimmy open

the filing cabinet in my office.

I can't find the key.

Thank you.

I sense you've cracked it.

No, we've made
no progress at all.

Shaun, we've been
at this all day.

It's only 3:15.

We've been at this
for over seven hours,

with six people
looking non-stop.

If there was
a miracle cure to find,

- I think we would've...
- I found something!

A maximal resection
would debulk the tumor

down to a one-centimeter margin.

Minimally invasive techniques
could be used.

You would only be in the hospital
for one to two nights,

and overall recovery
would be faster

because they wouldn't be
operating in the brain stem.

The surgery would be followed

by an experimental
ultrasound therapy.

Thank you. An experimental
ultrasound therapy,

breaking down
the blood-brain barrier

to increase chemo penetration,
allowing for a lower dose.

There would still be
some side effects,

but we could take
more edibles together

and eat Mallomars. Mm.

It could give you
as much as a year.

Maybe more, if you respond well.

Claire is in septic shock.
I have to go.

I will be back later
to answer any questions.

Temp's 103.

BP's low, cardiac output
is declining.

We could do another
wound debridement.

It's in her blood. The wound is
not the biggest issue anymore.

But clearing it out
allows her immune system

to focus its resources
elsewhere.

Not enough. We could try
a hyperbaric oxygen chamber.

Guys.

We all know the answer.

You have to put me in a coma.

- No.
- We're not there yet.

We are.

Shutting down your
other metabolic demands

will allow your body to

focus on fighting the infection.

I know, once you put me under,

that may be...

But this is my best chance
to beat this thing.

Hey.

Have you looked over
the materials?

I highlighted relevant sections.

I have, and I appreciate

what you're trying to do, Shaun.

Yes. It is a very good plan.

I'm not going to do it.

I don't want to spend my remaining days
sick and in pain.

I might not be able
to talk normally.

I might not be able
to walk normally.

I'll have memory loss.

Oh, there is
a less than 20% chance.

I don't want to take
that chance.

But it could give you more time.

A year, maybe,

and in and out of hospitals
half the time.

Or, Shaun,

or I could do nothing

and have six good months.

I could spend those good months

with you and Lea

and Steve.

Please don't touch anything.

Glassman rejected the plan.

His three concerns were
impairment of motor and speech,

loss of memory,
side effects of the chemo.

I just need to find ways
to mitigate those risks.

You are just standing there.

You are here to tell me
to stop working

on Dr. Glassman's case.

No, Shaun.

It's your choice.

The rocuronium will
temporarily paralyze you

to make intubation easier.

Once the tube is in, we'll do
a continuous propofol drip.

You ready?

I forgot a med.

I can't say goodbye.

Just got you back.

I love you.

I...

I'm so sorry

we lost so much time.

Hey.

We needed that time
to get back here.

We weren't ready before.

We were too dumb.

We were so dumb.

But I did tell you
that I think, one day,

we'd both be very happy.

I just didn't realize
it would be together.

I love you, too, Claire Browne.

And I really wish
I could kiss you right now.

Where is Shaun?

Claire's asking for you.

I am working on her case.

Currently, I'm working
on Dr. Glassman's,

but I will switch back
in 3 minutes and 27 seconds.

She might not wake up, Shaun.

She wants to say goodbye.

I will find a way
to save them both.

Oncolytic viruses
have been used to infect

and destroy cancer cells,
but the viruses won't work

because Dr. Glassman's tumor
was previously EGFR negative...

- Shaun. - ...so there is no target
for the virus to attach to,

- but if I could find a different receptor...
- Shaun.

Your very good friend,
who might die,

is asking for
a few minutes of your time,

but you're too busy ignoring
the expressed wishes

of your other friend
who's dying.

I know you're scared.

But you're being a bad friend

when the people you love
could really use a good one.

I know how to save Claire.

Hello. We can use viruses

to cure Claire's
bacterial infection.

Bacteriophages, to be precise.

They are viruses
that attack and infiltrate

only bacteria, and then
destroy them from the inside.

Every bacteriophage only
infects certain kinds of bacteria.

All we need to do is find one

that will attack
Claire's infection.

There are billions of phages.

Are any of them known
to work on acinetobacter?

- No.
- So, we're searching

through a billion haystacks
for one needle?

Not exactly.

Each phage can attack
more than one kind of bacteria,

so it is more like searching
a billion haystacks

for a million needles.

And where are
we supposed to find these

haystacks, or needles?

Bacteriophages. The metaphor
is not helping.

We need to collect the phages,

as many as we can,
as fast as we can.

Phage therapy is experimental.

We would need a compassionate
use authorization from the FDA,

- but they've...
- But that's tomorrow's problem.

Today, we've got to find
the right phage.

According to
the microbiology department

of the CDC,
the most common sources

of bacteriophages are swamps,

farms, storm drains,
and sewage plants.

I noticed her left forearm
felt cold with a weak pulse.

- Septic emboli?
- Poor blood flow.

Already showing signs
of ischemia.

We can do a thrombectomy,

try to remove the clot
and slow progress of infection.

Her body's putting a ton of
resources into saving this arm,

which is taking energy away
from saving her vital organs.

She can live without an arm.

Let's try
the thrombectomy first.

We need transport.

I have taken your concerns
into account

and formed a new treatment plan.

I don't want
a new treatment plan, Shaun.

You don't know.
You haven't looked.

We will do a fluorescence-guided

awake brain surgery
with cortical stimulation.

Shaun, I appreciate that
you're doing this out of,

you know, love.

But sometimes
when you love someone,

you don't have to
fight every fight.

You don't have to persevere
to the ends of the earth.

Sometimes, when you
love someone,

you just, you know,
take 'em bowling.

Six years ago,
you didn't give up,

and you got to see me
get married.

You got to meet your grandson.

You got to save more lives.

You were wrong then,

- and you are wrong now.
- Shaun, look at me, please.

Listen to me.
Look at me, please!

Is my tumor recurrent,
yes or no?

Yes.

Is it aggressive?
Is it even more aggressive?

There are better treatments now.

We just need to
buy you some time.

I shouldn't have told you.

You are being selfish.

And you are a coward.

You could keep fighting
and have more time with me

and with Lea and with Steve,
but you are giving up.

You are giving up on all of us.

If you are giving up on me...

then I have to give up on you.

The thrombectomy didn't
fully clear the blood clot.

It's obstructing blood flow,

and the arm is showing
signs of necrosis.

I think we need to amputate.

Or we could try
an open thrombectomy.

It'll give us better access
to the clot.

It'll also risk seeding
the infection to other places.

We could start a heparin drip,

see if it'll give us
better blood flow.

The arm is taking resources

the rest of her body
desperately needs.

Her creatinine and LFTs
are trending up.

Her liver and her kidney
are starting to fail.

Putting off amputation
any longer,

it risks her life.

She wouldn't be
a surgeon anymore.

She loves her job
and is very good at it.

I know.

But what she loves

is the young girl in Guatemala
who walked half a day

to the hospital
with a broken ankle.

And the old man who
just lost his wife of 52 years

and needed someone
to hold his hand.

And the first-year
surgical resident

who was different,

but she saw something
special in him.

Claire loves people,

and she will find a way
to take care of people,

no matter what.

And I think,
if she was here right now,

listening to all of this,
she would tell us

to take her damn arm

and trust that she will find
a way forward,

because she...

she always has.

Prep the OR.

I thought you could use
some baby snuggles.

You have no idea.

Mm.

Come here.

Come here. I gotcha.

I gotcha.

Hi.

Hi. I gotcha. I gotcha.

I said no to

Shaun's plan twice.

I thought he'd be ready to

accept this eventually.

Well, "eventually" probably
means more than 48 hours.

I spent a couple of decades
trying to prepare him

for when I

wasn't going
to be around anymore.

Apparently, that wasn't enough.

Glassy...

I love you.

You are the first-wisest

and second-smartest person
I know,

but if you think you
haven't done enough for Shaun,

then I am sorry,
but you are a ginormous idiot.

Look at who you're holding.

That baby is here
because of what you did.

I'm here
because of what you did.

You saw who he was,
who he could be.

You saved his life,
and he knows it.

He will come around...

eventually.

Hi.

He doesn't have
a whole lot of time.

10-blade.

We've concluded our tour
of the most disgusting barns

in Northern California.

I have received hundreds
of phages from the CDC.

Charlie and Dom
are on their way with 87.

Have any showed promise so far?

None whatsoever.

Shaun, uh, can I talk to you?

I have samples to test.

Uh, it's important.

We'll keep gathering.

I know of
a slaughterhouse nearby.

- You know of a slaughterhouse?
- Mm-hmm.

You can't shut Glassman out.

I presented him with two plans.

He doesn't want them.
That's his choice.

His choice is wrong.

No, it isn't, Shaun.

I know how hard it is
for you to accept.

I know you don't want
to face any of this,

but Glassman is dying, Shaun.

And all this work you've
been doing to try to save him

is really for you.

You need a new plan.

A plan to say goodbye.

Right now, you can't
make yourself feel okay

about Glassman's decision,
and that is okay.

You don't have to.

But...

he is going to die,

and if you are not with him
for his final days,

you will regret it
for the rest of your life.

So...

you need to plan

for your final days
with your father.

You are a very good friend.

I should have come earlier.

I am sorry.

Goodbye, Claire.

We've got it!

We've got it!

- The bacteriophage?
- Yes!

The right bacteriophage?

I said, "We've got it."
What else would I have meant?

Oh-ye!

I told you. I was not wrong.

I was not wrong
to not say goodbye.

I will see you very soon.

You have the data.
It's in the green folders.

Stress the time frame,

the bacterial lysis times
were very striking,

and there were low levels
of endotoxins.

Oh, also, uh, her amputated arm
isn't strictly relevant,

but because we're applying
for a compassionate use,

anything that'll make her appear

more sympathetic
will be helpful.

We can appeal.

But the whole point
of a compassionate use

is to allow people
with no other option.

They can take risks.

I am so angry.

Are you not angry?

Go back to the hospital

and prep Claire for
the bacteriophage treatment.

Are you going to...

I don't know. I need to think.

Are you okay, Shaun?

Is Claire going to be okay?
Why did you text us?

I texted you

because when I have
important news,

you two are the people
I need to share it with.

On the day the copper pipes

in the old building
smelled like burnt food...

my brother taught me

that just because you
love somebody doesn't mean

you get to love them forever.

But I was okay

because I had you,
Dr. Glassman.

And on the day that...

On the day
that you go to heaven...

I will have Lea.

I will have little Steve.

And on the day
the carousel smelled like oil,

the carousel you used
to go to with Maddie,

I told you I would go there

and think of you
after you're gone, and I will.

But I want to go
before then too.

I will go there with you.

And I will go bowling.
I will go bowling with you.

I will make a plan.
But I can't today because...

Because on the day you stood up
for me, I met Claire.

And she believed me.

And I spoke to people
in this room,

and I told them
I want to save people

so they can become adults

and have children
and love those children.

But I don't...

I don't need to save everyone.

I just need to save Claire.

The FDA did not approve
her treatment.

But I am going to give it
to her anyway.

And then I won't be
a doctor anymore.

And that's okay.

No. No.

No, Shaun, that's not okay.

Thank you.

I am Dr. Shaun Murphy.

I am Chief of Surgery

at San Jose
Saint Bonaventure Hospital.

I have autism spectrum disorder,

which is part of the reason
that I remember the names

of all 1,524 people
whose lives I've helped save.

There were a lot of people

who did not want me
to be a surgeon

at Saint Bonaventure Hospital,
or anywhere,

because I was different.

I couldn't make eye contact.

I didn't know how to lie.
I made people uncomfortable.

But someone believed in me.

Dr. Aaron Glassman...

was my friend.

I love you, Dr. Glassman.

I love you more, Dr. Murphy.

But you don't
even speak Ukrainian.

They have translators, Mom.

I'm proud of you.

Thanks.

We have to go.

Dr. Claire Browne

is my friend.

Hello.

Dr. Glassman and I
saved her life.

Dr. Glassman saved
over 4,000 lives.

He would say less,
but I give him credit

for all the lives
that I have saved,

because he taught me

a mnemonic for remembering

the effects
of organophosphate poisoning,

and he taught me that

if you just palm grip
the needle driver,

you will get way more maneuverability,
and force control.

And he taught me...

that when you touch one life,

you don't just touch one life.

You touch every life
that that life touches.

Dr. Glassman said
many wise things. Yes.

And over the years, I have
tried to write them down.

"Think about what people can do,

not about
what people can't do."

"Hear what I have to say,

and then decide
if it's bad advice."

"Questions are good."

"Leads to awareness
and understanding."

"And, who knows,
maybe even acceptance."

And when he wanted the board
to hire me, he said,

"We will be a better hospital
for hiring him."

"We will be better people
for hiring him."

And then he slammed
the desk with his hand,

because that is
how you communicate

that you really mean
what you are saying.

He always knew people
were looking to him,

that they might
take lessons from him.

And if they did,

he always wanted
that lesson to be...

"Don't be an ass."

"Don't be an ass."

It's not always easy.

Together, we planned,

and six months after he died,

I started...

the Dr. Aaron Glassman
Foundation

for Neurodiversity in Medicine,

which is today run by myself
and Dr. Claire Browne,

and has affiliations
with 17 hospitals

and 32 medical schools.

I wanted to help people

and save lives.

And I wanted to make
a lot of money

so that I could buy
a television.

But because of Dr. Glassman,

I have much more than that.

I have many friends.

And I have a family.

And I have two televisions.