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Freeman: It is a nightmare that
has stalked us for centuries.
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00:00:06,855 --> 00:00:10,024
Hordes of human beings
transformed
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00:00:10,026 --> 00:00:12,794
into mindless,
bloodthirsty monsters,
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00:00:12,796 --> 00:00:16,364
and civilization collapses.
[ Siren wailing ]
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00:00:18,000 --> 00:00:20,802
Could this nightmare
become reality?
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00:00:26,809 --> 00:00:30,762
Scientists have discovered
parasites that turn the living
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00:00:30,764 --> 00:00:34,048
into the walking dead,
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00:00:34,050 --> 00:00:40,405
and new strains of deadly
pathogens attack us every year.
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00:00:40,407 --> 00:00:44,058
Neuroscientists are learning how
to take over our minds.
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00:00:44,060 --> 00:00:49,731
Will we someday lose control
of our bodies and souls?
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00:00:49,733 --> 00:00:53,451
Is a zombie apocalypse possible?
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00:00:58,791 --> 00:01:03,712
Space, time, life itself...
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The secrets of the cosmos
lie through the wormhole.
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♪ Through the Wormhole 05x06 ♪
Is a Zombie Apocalypse Possible?
Original Air Date on June 25, 2014
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== sync, corrected by elderman ==
@elder_man
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According to Haitian folklore,
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certain priests
had magical powders...
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[ Thunderclap ]
That could transform a corpse...
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into a puppet.
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Our popular culture has turned
that zombie legend
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into an apocalyptic nightmare,
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a contagious virus
that turns the infected
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into violent monsters
with rotting flesh.
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[ Thunderclap ]
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We are all just one bite away
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from joining the mindless
legions of walking dead.
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All of these are myths,
of course.
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00:02:02,098 --> 00:02:03,380
[ Thunderclap ]
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00:02:03,382 --> 00:02:07,484
But every myth
has a grain of truth.
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00:02:07,486 --> 00:02:08,902
Could our imaginations
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be telling us something
about our future?
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[ Thunderclap ]
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Freeman: A long time ago,
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my friends and I saw a movie...
[ Door creaks ]
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that gave us nightmares...
[ All gasp ]
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"The Mummy."
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[ Children screaming ]
In that story,
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ancient magic made a corpse walk
the earth again.
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Could such a mindless monster
ever exist in the real world?
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00:02:38,416 --> 00:02:41,719
David Hughes is an entomologist.
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He has a long history
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with the dark side
of that science.
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When I was a kid
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I had a rather personal
relationship with a fungus.
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We didn't know exactly
what it was at the beginning,
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and over the course of months,
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this fungus creeped its way
across my scalp,
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uh, making me half bald.
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Freeman: David survived,
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but his fungus was not the worst
nature has cooked up.
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Some funguses turned the bodies
of their hosts into piles of rot
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and enslave their minds.
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David is the foremost expert
on a fungus
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that turns its victims
into the walking dead,
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or to be more accurate,
the crawling dead.
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The fungus, like all organisms
on the planet,
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has a scientific name.
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This one's called
ophiocordyceps unitlateralis.
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But colloquially, it's known
as the zombie ant fungi.
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Freeman:
While foraging for food,
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an unsuspecting ant
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will pick up a spore
of the zombie fungus.
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The fungus bores
through the ant's body.
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It multiplies and infects
the ant's brain,
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where it releases
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powerful mind-controlling
chemicals.
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The zombified ant bites
the underside of a leaf
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and dies.
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00:04:02,835 --> 00:04:05,886
Well, sort of.
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Death is really the starting
point for the parasite.
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Fungi are rather interesting
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in that they require
the host to die,
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and then, from its tissues,
they grow and they reproduce.
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And so, at this stage,
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the whole ant body
is completely transformed.
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Freeman: The zombie ant fungus
continues to control
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the dead creature's mind,
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keeping the insect's jaw
locked onto the leaf.
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The fungus multiplies,
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building pressure
inside the ant's skull
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until...it breaks open.
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Out comes a fungal stock
that sprays down deadly spores
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on the fungus's next victims.
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The cycle repeats.
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The fungal spores need to be
shot out, launched,
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from an area high above
the foraging trail.
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And so the fungus
has evolved the ability
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to control the mind
of its host.
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Freeman: Inside their nests,
ants are hygienic.
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00:05:06,732 --> 00:05:08,699
But when they're out foraging,
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they are vulnerable
to infection.
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David believes the fungus
evolved the ability
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to strike the ants
during this moment of weakness.
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The zombie ant fungus
could never infect us.
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Our brains are too different
from those of ants.
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But could a similar pathogen
ever find its way into our mind?
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So fungi have clearly
evolved the ability
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to control the behavior
of animals.
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Our brains are animal brains,
and there's no reason,
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theoretically, why we couldn't
have our behavior controlled.
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Freeman: If a mind-enslaving
pathogen ever strikes humanity,
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it will most likely jump to us
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from our close genetic
relatives.
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Microbiologist Kartik Chandran
studies the Ebola virus...
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00:06:06,341 --> 00:06:09,760
A pathogen
from our worst nightmares.
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Within weeks of infection,
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most patients leak blood
from every orifice and die.
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00:06:16,936 --> 00:06:19,486
Kartik is leading a team
to find out
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how deadly viruses like Ebola
evolve to infect humans.
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As far as we know,
Ebola lives in bats,
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and every once in a while,
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this virus can break out
from bats into other animals,
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including primates and apes
and humans.
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Freeman:
Kartik is investigating
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how Ebola made the jump
from bats to us.
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He's imagining what it's like
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to be one
of the microscopic bad guys.
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[ Static, door creaks ]
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The human body is a lot like
a building
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where our cells are rooms.
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Viruses infect us
by breaking and entering.
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00:07:08,786 --> 00:07:10,904
So you might ask me,
why does this little room
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in this storage facility
have a lock?
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00:07:12,708 --> 00:07:14,291
And so the answer
is obvious --
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because somebody needs
to go in and out.
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This is an attempt
to secure the entrance
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so that only the authorized
individuals can get in.
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00:07:22,134 --> 00:07:23,417
And cells are the same way.
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You know,
cells need to bring stuff in,
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they need to export stuff,
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and viruses have really
evolved to exploit
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this sort of entry
and access ways.
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Freeman: Viruses mimic
the shape of nutrients
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that the cell needs to survive,
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just like a lockpick
mimics the shape of a key.
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[ Click, door rattling ]
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Freeman: Once inside the cell,
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the virus inserts
its malicious genetic code.
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The host cell becomes
an enslaved factory,
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00:07:51,246 --> 00:07:54,448
producing countless copies
of the invader.
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00:07:54,450 --> 00:07:56,700
[ Screeching sound ]
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A multiplying virus can build
so much pressure
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inside the host cell
that it explodes...
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00:08:03,042 --> 00:08:04,708
[ Explosion ]
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...ejecting millions of viral
clones to infect other cells.
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00:08:11,916 --> 00:08:15,302
For a virus to jump
from animal to human,
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00:08:15,304 --> 00:08:19,056
it has to find a piece
of biological machinery
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shared by both the animal
and the human cell.
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Like you often see with
viruses and other parasites,
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they evolve to co-opt these
common cellular mechanisms,
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00:08:28,333 --> 00:08:31,601
and Ebola has done
just that.
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Freeman: Kartik made
a groundbreaking discovery.
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Ebola relies on a protein
called npc1 to infect cells.
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NPC1 is found in both bat
and human cells.
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[ Chirping ]
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Bats and humans may seem
very different,
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but their cells use remarkably
similar molecular machinery.
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00:08:54,843 --> 00:08:59,312
Most viruses that infect bats
can also jump to humans.
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00:08:59,314 --> 00:09:04,401
All a virus has to do
is find those common keys.
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00:09:04,403 --> 00:09:07,187
So, I mean, I think
it's a probability thing.
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00:09:07,189 --> 00:09:10,407
The more closely related
you are to another organism,
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the more likely you are
to pick up a virus.
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Freeman: A virus that turns
human beings
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into violent, unconscious
monsters already exists...
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Rabies.
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People that have rabies
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go through a phase where they're
highly violent and belligerent,
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00:09:27,376 --> 00:09:28,625
and they can foam
at the mouth.
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These are changes that are --
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clearly seem to benefit
the virus
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in terms of its ability
to spread
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from one infected host
to a naive host.
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Freeman: A rabies infection
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does not spread easily
from person to person.
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But if a virus like rabies
mutated
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to have
influenza-like properties,
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it could spread like wildfire.
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[ Coughing ]
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00:10:02,360 --> 00:10:05,629
Freeman: The infected would
mistake it for a common cold...
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00:10:07,331 --> 00:10:09,416
...until it's too late...
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00:10:09,418 --> 00:10:12,702
[ Coughing ]
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00:10:12,704 --> 00:10:15,722
Freeman: ...and they fall
into a mindless rage.
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00:10:23,481 --> 00:10:26,933
They would become violent
and attack without warning.
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00:10:26,935 --> 00:10:29,186
[ Strangled yell ]
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00:10:29,188 --> 00:10:30,386
[ Stabbing sound ]
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00:10:32,773 --> 00:10:35,725
[ Panting ]
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00:10:35,727 --> 00:10:36,860
[ Gasps ]
[ Banging on door ]
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Freeman: Open wounds
would benefit the virus.
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00:10:40,749 --> 00:10:45,168
It would easily transmit
through airborne particles.
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00:10:48,539 --> 00:10:50,507
[ Elevator bell dings ]
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00:10:50,509 --> 00:10:54,094
Ironically,
our own vigilant immune systems
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00:10:54,096 --> 00:10:57,631
could help bring this virus
into existence.
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00:11:01,185 --> 00:11:02,919
Once a virus infects a cell,
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00:11:02,921 --> 00:11:05,889
there is sort of this hardwired
immune response
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00:11:05,891 --> 00:11:08,925
that makes all these
new machines in the cell
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00:11:08,927 --> 00:11:10,977
that can try to stop the virus
from infecting,
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00:11:10,979 --> 00:11:12,646
and so the virus
has got to evolve
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00:11:12,648 --> 00:11:16,283
so it can get around these
sort of antiviral proteins.
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00:11:16,285 --> 00:11:19,035
Freeman:
In the never-ending arms race
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between the virus
and the host's immune system,
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00:11:22,274 --> 00:11:24,741
both sides
keep upping their game.
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00:11:24,743 --> 00:11:28,778
As viruses mutate, they develop
an array of evasive talents.
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00:11:28,780 --> 00:11:33,884
In some mutations, viruses learn
to become invisible.
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00:11:33,886 --> 00:11:36,503
[ Switch clicks ]
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00:11:36,505 --> 00:11:39,339
Other times,
they evolve chemical tools
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00:11:39,341 --> 00:11:43,293
that allow them to disable
the body's infection monitors.
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00:11:43,295 --> 00:11:45,362
[ Static ]
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00:11:45,364 --> 00:11:49,099
Or if the virus
mutates just right,
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00:11:49,101 --> 00:11:54,854
it can permanently evade
the immune system with a decoy.
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00:11:57,308 --> 00:12:01,828
Eventually, a new form
of the virus will evolve
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00:12:01,830 --> 00:12:05,699
that can slip
past the body's defenses.
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00:12:05,701 --> 00:12:07,867
And that virus is selected
because it's the only one
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00:12:07,869 --> 00:12:10,420
that's able to grow
and replicate itself
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00:12:10,422 --> 00:12:12,005
in these cells,
and so, all of a sudden,
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00:12:12,007 --> 00:12:13,540
it takes over
the whole population.
216
00:12:13,542 --> 00:12:17,260
So you go through these sort of,
like, bursts of selection
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00:12:17,262 --> 00:12:18,461
that completely change the --
218
00:12:18,463 --> 00:12:20,380
sort of the structure
of the viral population.
219
00:12:20,382 --> 00:12:23,166
And this can happen
very quickly.
220
00:12:23,168 --> 00:12:25,468
Freeman: As long as we rely on
our immune systems
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00:12:25,470 --> 00:12:30,506
to keep us healthy, new viruses
will constantly evolve.
222
00:12:30,508 --> 00:12:33,343
But a zombie virus may also
223
00:12:33,345 --> 00:12:37,230
one day be created
in a laboratory.
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00:12:37,232 --> 00:12:39,232
We should be able
to design viruses
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00:12:39,234 --> 00:12:40,617
that do different things.
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00:12:40,619 --> 00:12:42,118
In principle,
it seems to me
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00:12:42,120 --> 00:12:44,354
that if you know what
buttons to push,
228
00:12:44,356 --> 00:12:47,157
you could make a virus
that could do those things.
229
00:12:47,159 --> 00:12:48,992
Freeman: Kartik, of course,
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00:12:48,994 --> 00:12:52,078
wants to stop a zombie virus,
not create one.
231
00:12:52,080 --> 00:12:55,198
But nothing is preventing
the wrong minds
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00:12:55,200 --> 00:12:56,549
from pursuing it.
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00:12:56,551 --> 00:12:58,534
Is a zombie virus possible?
234
00:12:58,536 --> 00:13:00,670
I mean, I suppose there's really
nothing in the laws of physics
235
00:13:00,672 --> 00:13:02,538
that says it's impossible,
236
00:13:02,540 --> 00:13:04,207
although I would say
that it could be
237
00:13:04,209 --> 00:13:05,508
some sort of combination
238
00:13:05,510 --> 00:13:08,311
of different viruses
that we know about.
239
00:13:08,313 --> 00:13:11,982
Freeman: A hybrid virus
that turns human beings
240
00:13:11,984 --> 00:13:15,652
into deadly, contagious monsters
is not likely,
241
00:13:15,654 --> 00:13:18,405
but it is possible.
242
00:13:18,407 --> 00:13:20,940
It could come from a laboratory,
243
00:13:20,942 --> 00:13:24,894
or could be born
from the crucible of evolution.
244
00:13:24,896 --> 00:13:29,949
If this virus breaks out,
what happens next?
245
00:13:31,731 --> 00:13:35,317
When you get the flu,
what do you do?
246
00:13:36,319 --> 00:13:41,405
Go home, get in bed,
and hope no one bothers you.
247
00:13:41,407 --> 00:13:43,491
But imagine a disease
that spreads
248
00:13:43,493 --> 00:13:47,311
by making its victims violent.
249
00:13:47,313 --> 00:13:51,198
Such a disease could emerge
someday.
250
00:13:51,200 --> 00:13:56,087
Could we keep it from becoming
a global pandemic?
251
00:13:57,655 --> 00:13:59,090
In Ottawa, Canada,
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00:13:59,092 --> 00:14:02,543
a scientist is taking on
the zombie apocalypse
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before it happens.
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[ Beeps ]
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00:14:07,383 --> 00:14:14,722
A scientist who always seems
to have a question on his mind.
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I added the question mark
because my name was very boring,
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and I was getting confused
with all kinds of Robert Smiths,
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00:14:18,611 --> 00:14:20,811
so I thought it'd be
a cool thing to add to my name.
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And because I have
my question mark which helps me
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00:14:23,682 --> 00:14:25,232
be distinguished
from other Robert Smiths
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00:14:25,234 --> 00:14:28,619
in my specific field of
disease modeling by mathematics.
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Freeman:
Diseases are everywhere.
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[ Coughs ]
Robert wants to log
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every moment in his life...
[ Cell phone rings, beeps ]
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When he can pick up a pathogen
from an infected person,
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even when the infected
aren't around.
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[ Water streaming ]
If a disease is airborne,
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then the air that we share
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is obviously something that's
potentially quite toxic.
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[ Cell phone rings, beeps ]
And the closer you are,
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of course, the more likely.
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But then other things become
transmissible as well.
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So doorknobs and, you know...
[ Cell phone rings ]
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00:15:00,987 --> 00:15:03,554
[ Beep ]
The handle of whatever it is
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that I'm touching
or breathing on.
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[ Cell phone rings ]
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[ Beeping ]
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Freeman:
Robert is using this data
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to build mathematical models
to predict
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how quickly infectious diseases
can spread.
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00:15:20,739 --> 00:15:22,289
And with the help
of his students,
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he's creating live
human versions of those models.
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Just like any human community,
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the virus has many chances
to find a new host.
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00:15:33,186 --> 00:15:36,253
Okay, in these beakers, most of
them are just plain water.
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One of them has been infected
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with something that's gonna
simulate a virus.
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Freeman: The rules are simple.
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No student can take more
than five steps.
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Ready? And go.
[ Blows whistle ]
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Freeman:
They have 30 seconds to mix
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with as many other students
as possible,
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and no one knows
who has the beaker
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with the infection.
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Robert wants to see how many
people patient zero can infect.
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00:16:02,448 --> 00:16:05,782
[ Toot ]
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00:16:05,784 --> 00:16:08,302
Okay, now please return
your beakers to the middle.
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00:16:09,671 --> 00:16:11,005
Freeman:
At the end of the game,
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Robert drops a chemical
into each beaker.
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00:16:13,926 --> 00:16:16,627
If a student mixed
with the infected,
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00:16:16,629 --> 00:16:18,596
their water will turn yellow.
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00:16:18,598 --> 00:16:20,297
Even though patient zero
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00:16:20,299 --> 00:16:23,901
could only have direct contact
with a few neighbors,
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those neighbors
passed the disease along,
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00:16:25,804 --> 00:16:29,306
and about half the group
ends up infected.
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00:16:29,308 --> 00:16:35,479
But Robert believes the math
desperately needs an update.
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00:16:35,481 --> 00:16:37,281
So recently,
we tried to update models,
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00:16:37,283 --> 00:16:39,533
and we have much more
powerful ways of understanding
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00:16:39,535 --> 00:16:41,952
the network of connections
that different people have.
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00:16:41,954 --> 00:16:43,287
[ Film projector whirring ]
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00:16:43,289 --> 00:16:45,923
Freeman: The old models
focused on human beings
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and their local communities.
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00:16:48,628 --> 00:16:52,162
But we now live
in a global society
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and are on the move
like never before.
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00:16:54,467 --> 00:16:59,169
On an average day,
approximately 22.8 million of us
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travel someplace far away.
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00:17:05,393 --> 00:17:08,729
Robert repeats the game
with the same rules,
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00:17:08,731 --> 00:17:10,514
but this time,
the students are allowed
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00:17:10,516 --> 00:17:13,150
to take as many steps
as they wish
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00:17:13,152 --> 00:17:16,570
to account for the ease
with which we travel.
321
00:17:16,572 --> 00:17:18,289
[ Toot ]
322
00:17:25,714 --> 00:17:27,364
[ Toot ]
323
00:17:30,585 --> 00:17:33,053
Freeman: At the end
of the 30-second round,
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Robert tests each beaker again.
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00:17:39,094 --> 00:17:42,212
Every student is infected.
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00:17:42,214 --> 00:17:44,381
Robert has calculated
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00:17:44,383 --> 00:17:48,051
the infection rate for a disease
that doesn't yet exist.
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00:17:48,053 --> 00:17:52,323
He imagines a virus that spreads
easily through the air,
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00:17:52,325 --> 00:17:53,524
like the flu.
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00:17:53,526 --> 00:17:55,159
But unlike influenza,
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00:17:55,161 --> 00:17:58,028
the disease does not make
its victims
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want to stay home in bed.
333
00:17:59,898 --> 00:18:03,450
Instead, they become zombies,
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00:18:03,452 --> 00:18:07,338
and they take to the streets
in a mindless rage.
335
00:18:07,340 --> 00:18:08,672
[ Snarls ]
336
00:18:08,674 --> 00:18:10,040
So if we actually had
a zombie virus,
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00:18:10,042 --> 00:18:11,508
then the mathematics predicts
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00:18:11,510 --> 00:18:13,377
that we're not gonna do
very well.
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00:18:13,379 --> 00:18:16,013
[ Sirens wailing ]
340
00:18:16,015 --> 00:18:19,133
Freeman: If just one person is
infected with this zombie virus,
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00:18:19,135 --> 00:18:23,086
Robert predicts an epidemic
is inevitable.
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00:18:23,088 --> 00:18:26,256
Cities would be overrun
in weeks.
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00:18:26,258 --> 00:18:27,858
[ Crowd shouting indistinctly ]
344
00:18:27,860 --> 00:18:29,476
Freeman: As refugees escape,
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00:18:29,478 --> 00:18:33,564
some of them inadvertently
bring the disease along.
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00:18:33,566 --> 00:18:36,066
Global civilization
as we know it
347
00:18:36,068 --> 00:18:39,603
would be brought to its knees
in a matter of months.
348
00:18:39,605 --> 00:18:44,575
We have completely eradicated
only two infectious diseases --
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00:18:44,577 --> 00:18:46,943
cattle plague and smallpox.
350
00:18:46,945 --> 00:18:50,164
Finding a cure for this
hypothetical zombie virus
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00:18:50,166 --> 00:18:53,167
is very unlikely.
352
00:18:53,169 --> 00:18:56,286
But if a zombie outbreak
does happen,
353
00:18:56,288 --> 00:18:58,005
Robert's calculations
354
00:18:58,007 --> 00:19:01,842
show how humans can avoid
total annihilation...
355
00:19:02,960 --> 00:19:06,630
by getting our hands dirty.
356
00:19:06,632 --> 00:19:09,066
Probably the best way that
we found to deal with zombies
357
00:19:09,068 --> 00:19:11,185
was to basically hit them hard
and hit them often.
358
00:19:12,737 --> 00:19:15,972
So the idea is that you try and
wipe the zombies out in one go,
359
00:19:15,974 --> 00:19:17,274
and of course, you're not
gonna be successful at that,
360
00:19:17,276 --> 00:19:19,643
so, next day, you try
and wipe them out again,
361
00:19:19,645 --> 00:19:21,645
using the knowledge that you
learned from the last time.
362
00:19:21,647 --> 00:19:23,146
So we get better at it,
363
00:19:23,148 --> 00:19:26,333
and so then the third day,
we're now even better.
364
00:19:26,335 --> 00:19:30,087
Freeman: To stop a zombie plague
from becoming an apocalypse,
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00:19:30,089 --> 00:19:33,657
we may only have
one horrifying option --
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00:19:33,659 --> 00:19:39,046
to kill
every single infected person.
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00:19:39,048 --> 00:19:45,769
Just one surviving zombie
could trigger another epidemic.
368
00:19:45,771 --> 00:19:48,171
Our best hope to stop
a super virus
369
00:19:48,173 --> 00:19:51,174
is to catch it in time.
370
00:19:51,176 --> 00:19:54,027
Virus hunters are
scouring the microscopic world,
371
00:19:54,029 --> 00:19:55,946
looking for
an invisible enemy
372
00:19:55,948 --> 00:20:00,367
that may have already made
its first move.
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00:20:02,883 --> 00:20:06,152
During the four years
of World War I,
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00:20:06,154 --> 00:20:10,756
almost 15 million people died.
375
00:20:10,758 --> 00:20:12,925
In the two years that followed,
376
00:20:12,927 --> 00:20:18,664
a single flu virus claimed
three times that many lives.
377
00:20:18,666 --> 00:20:21,634
The virus had spread
around the world
378
00:20:21,636 --> 00:20:24,387
before anyone detected it.
379
00:20:24,389 --> 00:20:27,256
There are millions
of microbes out there,
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00:20:27,258 --> 00:20:29,875
most of them harmless.
381
00:20:29,877 --> 00:20:33,512
How can we find
the next deadly pandemic,
382
00:20:33,514 --> 00:20:35,681
perhaps a zombie virus...
383
00:20:35,683 --> 00:20:38,550
[ Imitates gunshot ]
384
00:20:38,552 --> 00:20:42,104
...before it sweeps the globe?
385
00:20:42,106 --> 00:20:44,657
[ Blows air ]
386
00:20:44,659 --> 00:20:48,461
[ Wind blowing loudly ]
387
00:20:48,463 --> 00:20:50,930
Hello?
388
00:20:50,932 --> 00:20:53,399
Hello?
389
00:20:53,401 --> 00:20:54,934
Freeman:
According to Ian Lipkin,
390
00:20:54,936 --> 00:20:57,569
the world's leading
virus hunter,
391
00:20:57,571 --> 00:21:02,407
our civilization runs a terrible
risk of global pandemic.
392
00:21:02,409 --> 00:21:05,377
I'm standing in the middle
of Times Square,
393
00:21:05,379 --> 00:21:07,346
and it's completely deserted.
394
00:21:07,348 --> 00:21:10,916
It looks like something that
you might see in a movie,
395
00:21:10,918 --> 00:21:12,968
but, in fact,
it's a real possibility.
396
00:21:14,754 --> 00:21:16,138
Freeman: Ian is the director
397
00:21:16,140 --> 00:21:18,590
for the Center
for Infection and Immunity
398
00:21:18,592 --> 00:21:21,093
at Columbia University.
399
00:21:21,095 --> 00:21:23,229
His team is on the front lines,
400
00:21:23,231 --> 00:21:27,599
hunting for deadly viruses
before they become pandemics.
401
00:21:27,601 --> 00:21:30,236
In 2003, his lab was the first
402
00:21:30,238 --> 00:21:33,405
to identify
the lethal S.A.R.S. virus.
403
00:21:33,407 --> 00:21:38,294
That early discovery saved
countless lives.
404
00:21:38,296 --> 00:21:41,964
Nature herself is continually
evolving new bacteria,
405
00:21:41,966 --> 00:21:44,750
new viruses
that are more pathogenic,
406
00:21:44,752 --> 00:21:48,120
that escape the antivirals,
the antibacterials,
407
00:21:48,122 --> 00:21:51,674
the vaccines that we create
to hold them in check.
408
00:21:51,676 --> 00:21:52,758
[ Coughs ]
409
00:21:52,760 --> 00:21:54,760
Freeman: There are more
410
00:21:54,762 --> 00:21:59,398
than 10,000 trillion trillion
trillion viruses on earth.
411
00:21:59,400 --> 00:22:03,486
Pinpointing a deadly virus
in a sea of its benign cousins
412
00:22:03,488 --> 00:22:06,655
is just about impossible,
413
00:22:06,657 --> 00:22:10,943
unless you lure the virus
out of hiding.
414
00:22:10,945 --> 00:22:13,245
When a patient falls ill
somewhere in the world
415
00:22:13,247 --> 00:22:15,080
with an unknown virus,
416
00:22:15,082 --> 00:22:16,982
blood
and other biological samples
417
00:22:16,984 --> 00:22:19,818
are often sent to Ian's lab.
418
00:22:19,820 --> 00:22:25,708
He then gets to work
by going fishing with D.N.A.
419
00:22:28,845 --> 00:22:32,381
D.N.A. makes
for the perfect virus bait,
420
00:22:32,383 --> 00:22:33,966
because viruses contain
genetic code
421
00:22:33,968 --> 00:22:38,387
that binds to matching sequences
of D.N.A.
422
00:22:38,389 --> 00:22:41,974
So then if that virus
is present within that sample,
423
00:22:41,976 --> 00:22:44,009
it will be caught on the hook,
424
00:22:44,011 --> 00:22:47,279
and I'll be able to reel it in,
and I'll see it.
425
00:22:47,281 --> 00:22:50,950
Freeman: Ian can cast thousands
of genetic lures
426
00:22:50,952 --> 00:22:52,234
into the sample.
427
00:22:53,853 --> 00:22:57,189
Each one is tailored to attract
a known virus.
428
00:22:57,191 --> 00:22:58,407
[ Screeches ]
429
00:22:58,409 --> 00:23:00,543
Freeman: Biological samples
from sick patients
430
00:23:00,545 --> 00:23:04,663
are oceans filled with microbes
that ignore the lure,
431
00:23:04,665 --> 00:23:07,532
except for the virus
that is a match
432
00:23:07,534 --> 00:23:09,752
for the lure's D.N.A. sequence.
433
00:23:11,304 --> 00:23:13,872
The virus lines up
its genetic code --
434
00:23:13,874 --> 00:23:18,594
A binds to T,
C binds to G.
435
00:23:18,596 --> 00:23:20,095
Once it's hooked...
Uh-oh.
436
00:23:20,097 --> 00:23:22,264
The weight of the lure changes,
437
00:23:22,266 --> 00:23:25,017
and Ian can reel in the virus.
438
00:23:25,019 --> 00:23:26,551
[ Seagulls crying ]
439
00:23:26,553 --> 00:23:27,987
[ Click ]
440
00:23:27,989 --> 00:23:31,323
Now, if that method works,
then we can get an answer
441
00:23:31,325 --> 00:23:33,943
very, very quickly,
very inexpensively,
442
00:23:33,945 --> 00:23:37,746
probably in a matter of four
to six hours at the outside.
443
00:23:37,748 --> 00:23:39,615
Freeman:
But viral and genetic code
444
00:23:39,617 --> 00:23:41,667
can evolve rapidly.
445
00:23:41,669 --> 00:23:44,670
Sometimes new viruses
have changed so much
446
00:23:44,672 --> 00:23:47,406
that they no longer
stick to the lure.
447
00:23:47,408 --> 00:23:50,876
In that case, Ian switches
to another technique --
448
00:23:50,878 --> 00:23:53,128
grab all the D.N.A. he can.
449
00:23:53,130 --> 00:23:54,413
I have a net.
450
00:23:54,415 --> 00:23:57,749
This is essentially
a D.N.A. sequence.
451
00:23:57,751 --> 00:24:00,519
When we don't know precisely
what we're looking for,
452
00:24:00,521 --> 00:24:02,805
we use
a high-throughput sequencer
453
00:24:02,807 --> 00:24:05,924
that allows us to characterize
all of the genetic material
454
00:24:05,926 --> 00:24:08,727
that'd be present
within a sample.
455
00:24:08,729 --> 00:24:10,613
We pull everything in,
and then we compare that
456
00:24:10,615 --> 00:24:13,482
with a database
of all known sequences.
457
00:24:13,484 --> 00:24:15,534
That allows us
to identify anything
458
00:24:15,536 --> 00:24:18,487
which is potentially
a microbial agent.
459
00:24:18,489 --> 00:24:19,989
Freeman: Ian and his team
460
00:24:19,991 --> 00:24:23,375
then grow colonies
of the isolated virus
461
00:24:23,377 --> 00:24:25,377
and attempt either
to identify a drug
462
00:24:25,379 --> 00:24:31,383
that can fight the infection
or to develop a vaccine.
463
00:24:31,385 --> 00:24:35,454
We and our colleagues can begin
testing drugs for efficacy,
464
00:24:35,456 --> 00:24:37,673
drugs that will be able
to prevent this agent
465
00:24:37,675 --> 00:24:39,558
from reproducing itself.
466
00:24:39,560 --> 00:24:41,260
And then, ultimately,
467
00:24:41,262 --> 00:24:43,962
because drugs are frequently
too expensive,
468
00:24:43,964 --> 00:24:46,131
we try to collaborate
with people
469
00:24:46,133 --> 00:24:48,300
who know how
to develop vaccines.
470
00:24:48,302 --> 00:24:49,935
Freeman: No matter how quickly
471
00:24:49,937 --> 00:24:52,354
they identify new viruses,
however,
472
00:24:52,356 --> 00:24:56,641
there will always be a lag time
between detection and treatment,
473
00:24:56,643 --> 00:24:59,244
a time
when the virus can spread.
474
00:24:59,246 --> 00:25:03,499
The major time lag is not
at the level of the laboratory.
475
00:25:03,501 --> 00:25:05,451
It's really in the field.
476
00:25:05,453 --> 00:25:09,654
It's recognizing the appearance
of something as new.
477
00:25:09,656 --> 00:25:11,540
Then that has to percolate
478
00:25:11,542 --> 00:25:15,928
through the ether until
it reaches people like us.
479
00:25:15,930 --> 00:25:18,330
Freeman:
Ian's team could prevent
480
00:25:18,332 --> 00:25:20,599
millions if not billions of us
481
00:25:20,601 --> 00:25:23,886
from succumbing
to a highly infectious disease.
482
00:25:23,888 --> 00:25:26,722
But if a virus evolves
that is sufficiently different
483
00:25:26,724 --> 00:25:29,692
from the viruses we know today,
484
00:25:29,694 --> 00:25:32,778
Ian's team will not be able
to fish it out.
485
00:25:32,780 --> 00:25:34,229
[ Beeping ]
486
00:25:34,231 --> 00:25:40,819
In humanity's war on viruses,
we need a new strategy.
487
00:25:40,821 --> 00:25:43,288
We can hunt viruses down,
488
00:25:43,290 --> 00:25:48,410
and we can try to vaccinate
ourselves against them.
489
00:25:48,412 --> 00:25:54,500
But once they infect us,
we're at their mercy.
490
00:25:54,502 --> 00:25:58,721
What if we turn a virus
into a zombie
491
00:25:58,723 --> 00:26:05,177
that works for us
and make it kill a zombie virus?
492
00:26:06,058 --> 00:26:07,325
Modern medicine
493
00:26:07,327 --> 00:26:11,429
has conquered many diseases
in the past century.
494
00:26:11,931 --> 00:26:16,334
Viruses, however,
remain elusive targets.
495
00:26:16,336 --> 00:26:21,539
Because they hijack the vital
genetic machinery of our cells,
496
00:26:21,541 --> 00:26:24,375
killing them is tricky.
497
00:26:24,377 --> 00:26:29,446
The solution may require
a pair of these,
498
00:26:29,448 --> 00:26:34,085
shrunk down to the size
of our D.N.A.
499
00:26:34,087 --> 00:26:35,887
[ Snip ]
500
00:26:35,889 --> 00:26:40,341
Viruses are party crashers.
501
00:26:40,343 --> 00:26:42,760
They do everything possible to
blend in with healthy cells...
502
00:26:42,762 --> 00:26:44,512
Aah!
[ Snarling ]
503
00:26:44,514 --> 00:26:46,297
Freeman: ...All the while
504
00:26:46,299 --> 00:26:49,300
relentlessly infecting
the invited guests.
505
00:26:49,302 --> 00:26:51,102
For severe infections,
506
00:26:51,104 --> 00:26:54,605
our best medical treatments
today are crude.
507
00:26:54,607 --> 00:26:59,410
They work by chopping up
the harmful invaders...
508
00:26:59,412 --> 00:27:00,528
Party's over.
509
00:27:00,530 --> 00:27:02,146
[ Motor revs, women scream ]
510
00:27:02,148 --> 00:27:05,533
[ Saw buzzing ]
...And all the healthy cells
511
00:27:05,535 --> 00:27:06,867
in their vicinity.
512
00:27:06,869 --> 00:27:09,754
But a new treatment that
only goes after the bad guys
513
00:27:09,756 --> 00:27:12,790
could be
right around the corner.
514
00:27:14,159 --> 00:27:17,511
As the director
of the Center for Nanomedicine
515
00:27:17,513 --> 00:27:19,130
at U.C. Santa Barbara,
516
00:27:19,132 --> 00:27:22,049
Jamey Marth
thinks it should be possible
517
00:27:22,051 --> 00:27:24,051
to make an antiviral drug
518
00:27:24,053 --> 00:27:30,942
out of a class of chemicals that
we all have in our stomachs.
519
00:27:30,944 --> 00:27:33,344
The food that I have
on this plate right now
520
00:27:33,346 --> 00:27:37,481
is what I need to keep me alive
and mostly healthy.
521
00:27:37,483 --> 00:27:39,650
[ Crunching ]
522
00:27:39,652 --> 00:27:42,353
But for my body
to use this material,
523
00:27:42,355 --> 00:27:45,323
it has to convert it
into different forms,
524
00:27:45,325 --> 00:27:51,028
and it does that by using small
natural machines called enzymes.
525
00:27:51,030 --> 00:27:55,466
Freeman: Enzymes are
the power tools of microbiology.
526
00:27:55,468 --> 00:28:00,671
In the stomach, they break apart
our food into digestible forms.
527
00:28:00,673 --> 00:28:03,874
Jamey and his colleagues
are working
528
00:28:03,876 --> 00:28:07,094
with an enzyme called
C.R.E. Recombinase.
529
00:28:07,096 --> 00:28:10,881
This enzyme
has remarkable utility.
530
00:28:10,883 --> 00:28:14,718
It can cut out any section
of D.N.A.
531
00:28:14,720 --> 00:28:16,854
And neatly staple back together
532
00:28:16,856 --> 00:28:19,323
the two adjoining
genetic pieces.
533
00:28:19,325 --> 00:28:21,275
It's allowed us
to do things
534
00:28:21,277 --> 00:28:24,495
that we haven't been
able to do before --
535
00:28:24,497 --> 00:28:27,665
to remove specific genes
from specific cells
536
00:28:27,667 --> 00:28:29,834
at different times.
537
00:28:32,204 --> 00:28:34,955
Freeman:
Inside every cell in our body,
538
00:28:34,957 --> 00:28:37,625
there is a forest of D.N.A.
539
00:28:37,627 --> 00:28:40,344
Viruses sneak foreign genes
540
00:28:40,346 --> 00:28:44,248
into this forest and hijack
our cellular machinery.
541
00:28:44,250 --> 00:28:49,253
A drug based on Jamey's
C.R.E. Recombinase enzyme
542
00:28:49,255 --> 00:28:53,924
could chop down viral infections
at their root
543
00:28:53,926 --> 00:28:56,644
by weeding out their D.N.A.
544
00:28:58,263 --> 00:29:01,265
The enzyme needs to find
a specific sequence
545
00:29:01,267 --> 00:29:05,436
of 34 genetic letters
at either end of the cut.
546
00:29:05,438 --> 00:29:08,489
And that sequence
can be customized.
547
00:29:08,491 --> 00:29:12,443
So once you know
the genetic sequence of a virus,
548
00:29:12,445 --> 00:29:14,628
you can program
C.R.E. Recombinase
549
00:29:14,630 --> 00:29:19,884
to latch onto the first and last
parts of this D.N.A. code.
550
00:29:19,886 --> 00:29:23,387
This represents
viral D.N.A. --
551
00:29:23,389 --> 00:29:25,139
D.N.A. that's foreign
to the cell
552
00:29:25,141 --> 00:29:27,291
and has integrated itself
into the genome.
553
00:29:27,293 --> 00:29:30,895
An enzyme like
the C.R.E. Recombinase
554
00:29:30,897 --> 00:29:33,931
is capable
of removing this precisely
555
00:29:33,933 --> 00:29:35,766
from the cell's genome.
556
00:29:35,768 --> 00:29:39,070
It does this
with precision.
557
00:29:39,072 --> 00:29:40,104
[ Snip ]
558
00:29:40,106 --> 00:29:42,022
And then, what the enzyme
will do
559
00:29:42,024 --> 00:29:43,908
is it will stitch
back together
560
00:29:43,910 --> 00:29:46,527
the ends
of the normal D.N.A.
561
00:29:46,529 --> 00:29:50,314
So that the cell is
effectively cured...
562
00:29:50,316 --> 00:29:52,366
[ Stapler clicks ]
563
00:29:52,368 --> 00:29:54,452
...of the disease.
564
00:29:54,454 --> 00:29:57,204
Freeman: Jamey is laying
the groundwork
565
00:29:57,206 --> 00:30:02,126
for what could be a cure
for all infectious viruses.
566
00:30:02,128 --> 00:30:04,211
H.I.V. A.I.D.S...
567
00:30:04,213 --> 00:30:05,662
[ Snip, click ]
568
00:30:05,664 --> 00:30:06,931
...influenza...
569
00:30:06,933 --> 00:30:08,432
[ Snip, click ]
570
00:30:08,434 --> 00:30:10,184
...even the common cold...
571
00:30:10,186 --> 00:30:11,835
[ Snip, click ]
572
00:30:11,837 --> 00:30:15,639
...will all only exist
in history books.
573
00:30:15,641 --> 00:30:19,193
And the delivery vehicle
for this life-saving drug
574
00:30:19,195 --> 00:30:22,897
is the last thing
you would expect --
575
00:30:22,899 --> 00:30:24,565
another virus.
576
00:30:24,567 --> 00:30:30,070
We could reprogram that virus
so that once that virus
577
00:30:30,072 --> 00:30:32,189
binds and goes
inside the cell,
578
00:30:32,191 --> 00:30:35,126
instead of releasing
a disease-causing payload,
579
00:30:35,128 --> 00:30:37,128
it will instead release
a cargo
580
00:30:37,130 --> 00:30:40,664
that allows us
to cure those cells.
581
00:30:40,666 --> 00:30:44,301
[ Screaming and crying ]
582
00:30:44,303 --> 00:30:45,536
Freeman:
Our best weapon against a virus
583
00:30:45,538 --> 00:30:48,389
that turns humans into zombies
584
00:30:48,391 --> 00:30:52,593
could be a virus that we turn
into our zombie slave.
585
00:30:52,595 --> 00:30:53,978
[ Roars ]
586
00:30:53,980 --> 00:30:55,479
Freeman: This harmful virus
587
00:30:55,481 --> 00:30:58,048
would be stripped
of its disease payload
588
00:30:58,050 --> 00:31:00,684
and instead be filled
589
00:31:00,686 --> 00:31:04,888
with reprogrammed
C.R.E. Recombinase enzymes,
590
00:31:04,890 --> 00:31:08,192
which can search throughout
our entire bodies
591
00:31:08,194 --> 00:31:13,164
and only eliminate
the unwanted invaders.
592
00:31:13,166 --> 00:31:14,865
[ Clinking ]
593
00:31:14,867 --> 00:31:17,535
But finding a universal cure
for viruses may not save us
594
00:31:17,537 --> 00:31:20,204
from a world
filled with zombies.
595
00:31:20,206 --> 00:31:24,175
A zombie takeover is already
underway in a lab
596
00:31:24,177 --> 00:31:27,127
in North Carolina,
where living creatures
597
00:31:27,129 --> 00:31:32,299
are turned into zombie drones
at the press of a button.
598
00:31:34,319 --> 00:31:37,121
If I told you
to run off a cliff,
599
00:31:37,423 --> 00:31:40,791
you wouldn't do it, would you?
600
00:31:40,793 --> 00:31:44,728
But what if I took control
of the neurons in your brain
601
00:31:44,730 --> 00:31:48,832
and made your legs
run straight off the edge?
602
00:31:48,834 --> 00:31:53,170
Turning a conscious person
into a mindless zombie
603
00:31:53,172 --> 00:31:55,004
may only be a matter
of finding
604
00:31:55,006 --> 00:31:57,307
and controlling
the right circuits in the brain.
605
00:31:57,309 --> 00:31:59,008
[ Electricity crackling ]
606
00:31:59,010 --> 00:32:01,561
[ Chuckles ]
607
00:32:03,698 --> 00:32:08,852
How do you get a living mind to
completely surrender its will?
608
00:32:11,789 --> 00:32:14,858
Electrical engineer
Alper Bozkurt
609
00:32:14,860 --> 00:32:16,993
thinks we've been doing it
for centuries
610
00:32:16,995 --> 00:32:19,796
by domesticating wild animals.
611
00:32:19,798 --> 00:32:22,699
The horses open themselves
to our control
612
00:32:22,701 --> 00:32:27,003
thanks to this mutual beneficial
relation that we have with them,
613
00:32:27,005 --> 00:32:30,373
and it took a long time for us
to be able to train them,
614
00:32:30,375 --> 00:32:32,425
uh, basically
to condition them
615
00:32:32,427 --> 00:32:34,761
with different rewards
or punishments.
616
00:32:36,180 --> 00:32:39,382
Freeman: Alper looks at animals
as electrical circuits.
617
00:32:39,384 --> 00:32:40,650
As a horse moves,
618
00:32:40,652 --> 00:32:41,885
its brain sends
619
00:32:41,887 --> 00:32:44,905
an elaborate series of commands
to its muscles
620
00:32:44,907 --> 00:32:47,557
through the electrical wiring
of its nerve cells.
621
00:32:47,559 --> 00:32:48,909
[ Electricity crackling ]
622
00:32:48,911 --> 00:32:51,862
But convincing a horse
to make these complex movements
623
00:32:51,864 --> 00:32:54,965
only requires a simple input.
624
00:32:54,967 --> 00:32:58,118
So when the rider wants
the horse to go to left,
625
00:32:58,120 --> 00:33:00,453
she just pulls
the reins to left...
626
00:33:00,455 --> 00:33:01,671
[ Nickers ]
627
00:33:01,673 --> 00:33:04,791
...and the horse starts
going in that direction.
628
00:33:04,793 --> 00:33:06,543
And then, she wants it
to go right.
629
00:33:06,545 --> 00:33:07,794
She just pulls it to right,
630
00:33:07,796 --> 00:33:09,796
and we see that horse
is going on the right.
631
00:33:09,798 --> 00:33:11,298
[ Nickering ]
632
00:33:11,300 --> 00:33:13,300
And then
she wants it to go forward.
633
00:33:13,302 --> 00:33:17,137
She just provides
a gentle kick with her heels,
634
00:33:17,139 --> 00:33:19,356
and the horse knows
that it needs to go forward,
635
00:33:19,358 --> 00:33:20,590
and it does it.
636
00:33:20,592 --> 00:33:23,092
[ Blusters ]
637
00:33:23,094 --> 00:33:26,696
Freeman: The horse obeys
because of its training.
638
00:33:26,698 --> 00:33:28,431
But Alper thinks he can get
639
00:33:28,433 --> 00:33:30,483
the same results
in other creatures
640
00:33:30,485 --> 00:33:33,653
without conditioning
by replacing mechanical commands
641
00:33:33,655 --> 00:33:37,273
with electrical signals
sent directly to the brain.
642
00:33:37,275 --> 00:33:39,826
I have a set
of domino stones here
643
00:33:39,828 --> 00:33:43,279
representing a neural network
like in any brain.
644
00:33:43,281 --> 00:33:46,583
A brain is a set of
electrical relay networks.
645
00:33:46,585 --> 00:33:51,254
It is composed of excitable
cells called neurons.
646
00:33:51,256 --> 00:33:54,424
Freeman: When neurons
become electrically excited,
647
00:33:54,426 --> 00:33:57,126
they pass a signal
on to their neighbors,
648
00:33:57,128 --> 00:33:59,563
which in turn
pass the signal along.
649
00:33:59,565 --> 00:34:03,683
Alper only needs
to stimulate one neuron,
650
00:34:03,685 --> 00:34:07,136
and the entire neural circuit
will activate,
651
00:34:07,138 --> 00:34:11,491
resulting
in a complex bodily action.
652
00:34:15,913 --> 00:34:18,782
It's a principle that should
work in any brain,
653
00:34:18,784 --> 00:34:21,534
but Alper is starting
with a simple mind --
654
00:34:21,536 --> 00:34:24,371
the cockroach.
655
00:34:24,373 --> 00:34:27,657
Alper implanted electrodes
into the sockets
656
00:34:27,659 --> 00:34:31,544
where a roach's antennae
connect to its brain.
657
00:34:31,546 --> 00:34:33,129
[ Clicking ]
658
00:34:33,131 --> 00:34:35,932
When he sends an electronic
pulse to the neurons inside,
659
00:34:35,934 --> 00:34:38,268
the roach becomes...
660
00:34:38,270 --> 00:34:42,338
a zombie.
661
00:34:42,340 --> 00:34:44,641
It goes wherever
the electronic pulse
662
00:34:44,643 --> 00:34:50,647
tells it to go,
and it even turns on a dime.
663
00:34:50,649 --> 00:34:54,017
So when we stimulate
the right antenna of the insect,
664
00:34:54,019 --> 00:34:56,736
insect thinks there there's
an obstacle in front of it,
665
00:34:56,738 --> 00:34:58,622
and it tries
to make a left turn.
666
00:34:58,624 --> 00:35:01,291
And when we stimulate
the left antenna,
667
00:35:01,293 --> 00:35:03,293
it tries to make
a right turn.
668
00:35:08,582 --> 00:35:10,333
Freeman:
Alper thinks his zombie bugs
669
00:35:10,335 --> 00:35:13,386
will one day save lives.
670
00:35:13,388 --> 00:35:17,373
He envisions cockroach cyborgs
outfitted with cameras
671
00:35:17,375 --> 00:35:18,925
and G.P.S. chips
672
00:35:18,927 --> 00:35:23,763
so they can locate survivors
under collapsed buildings.
673
00:35:23,765 --> 00:35:26,983
But his breakthrough could be
the beginning of a world
674
00:35:26,985 --> 00:35:29,819
where no mind is safe.
675
00:35:29,821 --> 00:35:34,607
Theoretically, even a human
could be zombified.
676
00:35:37,445 --> 00:35:39,112
We know how neurons work,
677
00:35:39,114 --> 00:35:41,731
and, uh, we can communicate
with them.
678
00:35:41,733 --> 00:35:43,199
When we stimulate the insect,
679
00:35:43,201 --> 00:35:45,201
it is the same stimulation
principle
680
00:35:45,203 --> 00:35:47,954
that is used in deep brain
stimulation patients
681
00:35:47,956 --> 00:35:49,956
with Parkinson's disease.
682
00:35:49,958 --> 00:35:52,042
So these are all
the same principles.
683
00:35:52,044 --> 00:35:56,046
It's relatively easy
with cockroaches
684
00:35:56,048 --> 00:35:59,015
to make them follow
our command signals.
685
00:35:59,017 --> 00:36:02,218
But with higher organisms,
with vertebrates,
686
00:36:02,220 --> 00:36:05,772
it is much complicated,
although it's not impossible.
687
00:36:05,774 --> 00:36:09,476
Freeman: Technology may soon
exist that, in the wrong hands,
688
00:36:09,478 --> 00:36:12,812
could turn us into zombies.
689
00:36:12,814 --> 00:36:17,734
If our minds are taken over,
will we even know it?
690
00:36:17,736 --> 00:36:21,654
A zombie apocalypse may already
be happening today.
691
00:36:21,656 --> 00:36:25,158
In fact,
this neuroscientist thinks
692
00:36:25,160 --> 00:36:27,610
we're already 98% zombie.
693
00:36:30,886 --> 00:36:32,153
In fiction,
694
00:36:32,155 --> 00:36:35,256
the nightmare
of a zombie apocalypse
695
00:36:35,258 --> 00:36:39,177
is constantly taking on
new forms,
696
00:36:39,179 --> 00:36:42,430
but they all have
a common theme --
697
00:36:42,432 --> 00:36:47,669
the infected don't even know
they are zombies.
698
00:36:47,671 --> 00:36:52,156
If, right now, we were zombies
in the midst of an apocalypse,
699
00:36:52,158 --> 00:36:54,409
would we even know it?
700
00:36:56,695 --> 00:36:59,647
[ Birds chirping ]
701
00:36:59,649 --> 00:37:01,499
Neuroscientist Scott Grafton
702
00:37:01,501 --> 00:37:03,985
believes
that in sports like golf,
703
00:37:03,987 --> 00:37:08,006
it pays to be a zombie.
704
00:37:08,008 --> 00:37:09,290
I was watching
this tournament
705
00:37:09,292 --> 00:37:12,010
where Fuzzy Zoeller
was winning.
706
00:37:12,012 --> 00:37:13,094
[ Whack ]
707
00:37:13,096 --> 00:37:14,963
Announcer runs up to him
and says,
708
00:37:14,965 --> 00:37:17,265
"Fuzzy, how did you do it?
How did you win?"
709
00:37:17,267 --> 00:37:21,069
He says, "Well, I've been
brain-dead all week."
710
00:37:21,071 --> 00:37:22,503
[ Whack ]
711
00:37:22,505 --> 00:37:27,341
Freeman: After enough practice,
a good swing is automatic.
712
00:37:27,343 --> 00:37:31,362
In fact, nearly everything
that our bodies do
713
00:37:31,364 --> 00:37:34,515
requires little,
if any, thought.
714
00:37:34,517 --> 00:37:37,685
Almost all of our actions
are actually unconscious.
715
00:37:37,687 --> 00:37:41,239
We can pretend we access
our muscle.
716
00:37:41,241 --> 00:37:43,074
You know, when I hold
a golf club,
717
00:37:43,076 --> 00:37:44,492
I can grip it,
and then I can think,
718
00:37:44,494 --> 00:37:48,496
okay, flex this muscle,
extend this muscle,
719
00:37:48,498 --> 00:37:52,867
turn my shoulders,
turn my waist, so forth.
720
00:37:52,869 --> 00:37:58,806
But actually, I have very, very
poor access to those muscles.
721
00:37:58,808 --> 00:38:03,311
It's much easier to visualize
what you'd like to happen,
722
00:38:03,313 --> 00:38:06,064
and the swing
just takes care of itself.
723
00:38:07,215 --> 00:38:09,150
[ Whack ]
724
00:38:09,152 --> 00:38:12,219
Freeman:
Our brains are goal-oriented.
725
00:38:12,221 --> 00:38:14,221
We think of an end result,
726
00:38:14,223 --> 00:38:18,526
and our bodies mindlessly follow
a program to achieve it.
727
00:38:18,528 --> 00:38:21,362
Freeman:
For Scott, this is evidence
728
00:38:21,364 --> 00:38:24,916
that our willpower
is not as strong as we think.
729
00:38:24,918 --> 00:38:29,337
On a good day, I think
we're about, uh...97% zombie,
730
00:38:29,339 --> 00:38:35,126
and on a bad day, 98% zombie,
and the rest of the 2 or 3%
731
00:38:35,128 --> 00:38:37,411
is us having actually
willful control
732
00:38:37,413 --> 00:38:39,580
over our daily activities.
733
00:38:41,800 --> 00:38:43,417
Freeman: Scott is running
an experiment
734
00:38:43,419 --> 00:38:49,107
to momentarily rob his subject,
misty, of the other 2%.
735
00:38:50,726 --> 00:38:52,226
He uses a technique
736
00:38:52,228 --> 00:38:55,313
called transcranial magnetic
stimulation,
737
00:38:55,315 --> 00:38:57,398
or T.M.S., to induce
738
00:38:57,400 --> 00:38:59,651
a harmless electrical current
in her brain.
739
00:38:59,653 --> 00:39:01,069
[ Click ]
Oh.
740
00:39:01,071 --> 00:39:04,706
T.M.S. is a method for
741
00:39:04,708 --> 00:39:08,493
very briefly turning off
a small part of your brain,
742
00:39:08,495 --> 00:39:12,213
so it's a copper coil
that goes against the skull,
743
00:39:12,215 --> 00:39:14,949
and you induce a current
through that,
744
00:39:14,951 --> 00:39:16,334
and during that time,
745
00:39:16,336 --> 00:39:19,620
you essentially have a virtual
lesion in your brain.
746
00:39:19,622 --> 00:39:20,622
[ Clicking ]
747
00:39:20,623 --> 00:39:22,456
Freeman:
Scott calibrates the device
748
00:39:22,458 --> 00:39:26,427
by stimulating the neurons
that control her right hand.
749
00:39:26,429 --> 00:39:31,966
He then moves the device to
focus on her parietal cortex.
750
00:39:33,969 --> 00:39:36,821
This region of the brain
is believed to be responsible
751
00:39:36,823 --> 00:39:41,075
for making sure that our actions
match our intentions,
752
00:39:41,077 --> 00:39:45,079
like trying to touch
an illuminated dot.
753
00:39:45,081 --> 00:39:47,749
In the first round
of Scott's experiment,
754
00:39:47,751 --> 00:39:50,585
there is no T.M.S. pulse.
755
00:39:50,587 --> 00:39:52,453
As soon as their hand
starts moving,
756
00:39:52,455 --> 00:39:56,708
we jump that second light
to the right a few inches,
757
00:39:56,710 --> 00:40:01,929
and their hand quickly
corrects for that jump,
758
00:40:01,931 --> 00:40:06,167
and it smoothly goes over
and pursues that new location.
759
00:40:06,169 --> 00:40:07,969
Freeman:
But in the second round,
760
00:40:07,971 --> 00:40:13,107
right as misty's finger moves,
Scott zaps her parietal cortex.
761
00:40:13,109 --> 00:40:14,341
Oh.
762
00:40:14,343 --> 00:40:16,060
Freeman:
She doesn't feel the pulse
763
00:40:16,062 --> 00:40:17,845
but loses the ability
to consciously
764
00:40:17,847 --> 00:40:20,698
correct her action
for a brief moment.
765
00:40:20,700 --> 00:40:22,483
They react, essentially,
766
00:40:22,485 --> 00:40:25,319
as a zombie and go
to the original location,
767
00:40:25,321 --> 00:40:26,654
that second light,
768
00:40:26,656 --> 00:40:28,790
and they're unable to correct
themselves on the fly.
769
00:40:28,792 --> 00:40:31,826
So when we turn off
the parietal lobe,
770
00:40:31,828 --> 00:40:35,413
we're essentially
making a person a full zombie
771
00:40:35,415 --> 00:40:37,832
for just a second or so.
772
00:40:37,834 --> 00:40:38,883
And during that time,
773
00:40:38,885 --> 00:40:40,034
they're just carrying out
a movement
774
00:40:40,036 --> 00:40:41,969
that they no longer
can control.
775
00:40:41,971 --> 00:40:45,590
Freeman: Scott believes
we evolved to be 98% zombie
776
00:40:45,592 --> 00:40:48,843
so that the intellectual parts
of our brains
777
00:40:48,845 --> 00:40:52,680
could be freed up from thinking
about the menial tasks
778
00:40:52,682 --> 00:40:55,850
that take up most of our time.
779
00:40:55,852 --> 00:40:58,886
For all of
its evolutionary advantages,
780
00:40:58,888 --> 00:41:03,024
the intelligent human brain
may come with a cost.
781
00:41:03,026 --> 00:41:05,943
I think we're a hair's breadth
away from a zombie apocalypse
782
00:41:05,945 --> 00:41:09,230
in the sense
that most of what we do,
783
00:41:09,232 --> 00:41:10,865
we can accomplish
without thinking about it.
784
00:41:10,867 --> 00:41:13,668
Just think about
how many willful choices
785
00:41:13,670 --> 00:41:15,753
you've made
in the last week.
786
00:41:15,755 --> 00:41:18,005
It's probably
maybe one or two.
787
00:41:18,007 --> 00:41:21,709
Everything else you did was
essentially automatic behavior.
788
00:41:21,711 --> 00:41:25,346
So now you think of something,
it takes away that last 2%.
789
00:41:25,348 --> 00:41:29,217
You're already prepared
to live as a zombie.
790
00:41:29,219 --> 00:41:32,053
Freeman: By the time
we reach adulthood,
791
00:41:32,055 --> 00:41:34,972
most of our daily lives
are spent engaging
792
00:41:34,974 --> 00:41:37,525
in activities that require
little conscious thought.
793
00:41:37,527 --> 00:41:42,396
If we were to lose our ability
to make conscious decisions,
794
00:41:42,398 --> 00:41:45,533
life just might continue
as normal.
795
00:41:45,535 --> 00:41:48,486
Certainly, we wouldn't
recognize it in ourselves,
796
00:41:48,488 --> 00:41:51,155
and the scary thing is whether
you could recognize it
797
00:41:51,157 --> 00:41:52,907
in anyone else.
798
00:41:52,909 --> 00:41:55,409
If there was
a zombie apocalypse,
799
00:41:55,411 --> 00:41:58,112
I don't think it would be
like "World War Z."
800
00:41:58,114 --> 00:42:00,631
I think we would be
plain old normal human beings,
801
00:42:00,633 --> 00:42:02,667
except we'd be
a little bit different.
802
00:42:02,669 --> 00:42:05,286
We'd be more like "invasion
of the body snatchers,"
803
00:42:05,288 --> 00:42:09,857
where we're ourselves, but we're
not ourselves anymore.
804
00:42:17,533 --> 00:42:21,686
We humans love our free will.
805
00:42:21,688 --> 00:42:23,938
As bizarre as it may seem,
806
00:42:23,940 --> 00:42:27,525
it is entirely possible
that a microscopic parasite
807
00:42:27,527 --> 00:42:29,810
or technology run wild
808
00:42:29,812 --> 00:42:34,815
could take away the free will
we cherish so dearly.
809
00:42:34,817 --> 00:42:37,168
All of this talk
of zombie apocalypse
810
00:42:37,170 --> 00:42:40,454
raises one final question --
811
00:42:40,456 --> 00:42:45,543
why do we enjoy scaring
ourselves half to death?
812
00:42:45,545 --> 00:42:47,762
Maybe that's what we need to do
813
00:42:47,764 --> 00:42:50,965
in order to prepare
for the worst.
814
00:42:50,967 --> 00:42:55,816
I'm not scared, because science
is our best defense.
815
00:42:55,817 --> 00:43:01,817
== sync, corrected by elderman ==
@elder_man
64086
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