All language subtitles for Through.the.Wormhole.S05E06.Is.a.Zombie.Apocalypse.Possible.720p.HDTV.x264-DHD

af Afrikaans
ak Akan
sq Albanian
am Amharic
ar Arabic Download
hy Armenian
az Azerbaijani
eu Basque
be Belarusian
bem Bemba
bn Bengali
bh Bihari
bs Bosnian
br Breton
bg Bulgarian
km Cambodian
ca Catalan
ceb Cebuano
chr Cherokee
ny Chichewa
zh-CN Chinese (Simplified)
zh-TW Chinese (Traditional)
co Corsican
hr Croatian
cs Czech
da Danish
nl Dutch
en English
eo Esperanto
et Estonian
ee Ewe
fo Faroese
tl Filipino
fi Finnish
fr French Download
fy Frisian
gaa Ga
gl Galician
ka Georgian
de German
el Greek
gn Guarani
gu Gujarati
ht Haitian Creole
ha Hausa
haw Hawaiian
iw Hebrew
hi Hindi
hmn Hmong
hu Hungarian
is Icelandic
ig Igbo
id Indonesian
ia Interlingua
ga Irish
it Italian
ja Japanese
jw Javanese
kn Kannada
kk Kazakh
rw Kinyarwanda
rn Kirundi
kg Kongo
ko Korean
kri Krio (Sierra Leone)
ku Kurdish
ckb Kurdish (Soranî)
ky Kyrgyz
lo Laothian
la Latin
lv Latvian
ln Lingala
lt Lithuanian
loz Lozi
lg Luganda
ach Luo
lb Luxembourgish
mk Macedonian
mg Malagasy
ms Malay
ml Malayalam
mt Maltese
mi Maori
mr Marathi
mfe Mauritian Creole
mo Moldavian
mn Mongolian
my Myanmar (Burmese)
sr-ME Montenegrin
ne Nepali
pcm Nigerian Pidgin
nso Northern Sotho
no Norwegian
nn Norwegian (Nynorsk)
oc Occitan
or Oriya
om Oromo
ps Pashto
fa Persian
pl Polish
pt-BR Portuguese (Brazil)
pt Portuguese (Portugal)
pa Punjabi
qu Quechua
ro Romanian
rm Romansh
nyn Runyakitara
ru Russian
sm Samoan
gd Scots Gaelic
sr Serbian
sh Serbo-Croatian
st Sesotho
tn Setswana
crs Seychellois Creole
sn Shona
sd Sindhi
si Sinhalese
sk Slovak
sl Slovenian
so Somali
es Spanish Download
es-419 Spanish (Latin American)
su Sundanese
sw Swahili
sv Swedish
tg Tajik
ta Tamil
tt Tatar
te Telugu
th Thai
ti Tigrinya
to Tonga
lua Tshiluba
tum Tumbuka
tr Turkish
tk Turkmen
tw Twi
ug Uighur
uk Ukrainian
ur Urdu
uz Uzbek
vi Vietnamese
cy Welsh
wo Wolof
xh Xhosa
yi Yiddish
yo Yoruba
zu Zulu
Would you like to inspect the original subtitles? These are the user uploaded subtitles that are being translated: 1 00:00:01,150 --> 00:00:04,369 Freeman: It is a nightmare that has stalked us for centuries. 2 00:00:06,855 --> 00:00:10,024 Hordes of human beings transformed 3 00:00:10,026 --> 00:00:12,794 into mindless, bloodthirsty monsters, 4 00:00:12,796 --> 00:00:16,364 and civilization collapses. [ Siren wailing ] 5 00:00:18,000 --> 00:00:20,802 Could this nightmare become reality? 6 00:00:26,809 --> 00:00:30,762 Scientists have discovered parasites that turn the living 7 00:00:30,764 --> 00:00:34,048 into the walking dead, 8 00:00:34,050 --> 00:00:40,405 and new strains of deadly pathogens attack us every year. 9 00:00:40,407 --> 00:00:44,058 Neuroscientists are learning how to take over our minds. 10 00:00:44,060 --> 00:00:49,731 Will we someday lose control of our bodies and souls? 11 00:00:49,733 --> 00:00:53,451 Is a zombie apocalypse possible? 12 00:00:58,791 --> 00:01:03,712 Space, time, life itself... 13 00:01:05,798 --> 00:01:10,385 The secrets of the cosmos lie through the wormhole. 14 00:01:10,387 --> 00:01:14,387 ♪ Through the Wormhole 05x06 ♪ Is a Zombie Apocalypse Possible? Original Air Date on June 25, 2014 15 00:01:14,388 --> 00:01:20,388 == sync, corrected by elderman == @elder_man 16 00:01:23,363 --> 00:01:25,498 According to Haitian folklore, 17 00:01:25,978 --> 00:01:28,845 certain priests had magical powders... 18 00:01:28,847 --> 00:01:33,367 [ Thunderclap ] That could transform a corpse... 19 00:01:33,369 --> 00:01:35,569 into a puppet. 20 00:01:35,571 --> 00:01:40,040 Our popular culture has turned that zombie legend 21 00:01:40,042 --> 00:01:42,743 into an apocalyptic nightmare, 22 00:01:42,745 --> 00:01:46,046 a contagious virus that turns the infected 23 00:01:46,048 --> 00:01:49,333 into violent monsters with rotting flesh. 24 00:01:49,335 --> 00:01:50,867 [ Thunderclap ] 25 00:01:50,869 --> 00:01:53,470 We are all just one bite away 26 00:01:53,472 --> 00:01:59,343 from joining the mindless legions of walking dead. 27 00:01:59,345 --> 00:02:02,096 All of these are myths, of course. 28 00:02:02,098 --> 00:02:03,380 [ Thunderclap ] 29 00:02:03,382 --> 00:02:07,484 But every myth has a grain of truth. 30 00:02:07,486 --> 00:02:08,902 Could our imaginations 31 00:02:08,904 --> 00:02:12,990 be telling us something about our future? 32 00:02:12,992 --> 00:02:14,725 [ Thunderclap ] 33 00:02:14,727 --> 00:02:17,227 Freeman: A long time ago, 34 00:02:17,229 --> 00:02:18,996 my friends and I saw a movie... [ Door creaks ] 35 00:02:18,998 --> 00:02:21,565 that gave us nightmares... [ All gasp ] 36 00:02:21,567 --> 00:02:23,534 "The Mummy." 37 00:02:23,536 --> 00:02:25,419 [ Children screaming ] In that story, 38 00:02:25,421 --> 00:02:27,788 ancient magic made a corpse walk the earth again. 39 00:02:29,624 --> 00:02:33,927 Could such a mindless monster ever exist in the real world? 40 00:02:38,416 --> 00:02:41,719 David Hughes is an entomologist. 41 00:02:41,721 --> 00:02:44,054 He has a long history 42 00:02:44,056 --> 00:02:47,057 with the dark side of that science. 43 00:02:47,059 --> 00:02:48,308 When I was a kid 44 00:02:48,310 --> 00:02:50,361 I had a rather personal relationship with a fungus. 45 00:02:50,363 --> 00:02:52,696 We didn't know exactly what it was at the beginning, 46 00:02:52,698 --> 00:02:54,431 and over the course of months, 47 00:02:54,433 --> 00:02:57,701 this fungus creeped its way across my scalp, 48 00:02:57,703 --> 00:02:59,486 uh, making me half bald. 49 00:03:00,989 --> 00:03:02,906 Freeman: David survived, 50 00:03:02,908 --> 00:03:06,994 but his fungus was not the worst nature has cooked up. 51 00:03:06,996 --> 00:03:11,448 Some funguses turned the bodies of their hosts into piles of rot 52 00:03:11,450 --> 00:03:14,785 and enslave their minds. 53 00:03:16,971 --> 00:03:19,840 David is the foremost expert on a fungus 54 00:03:19,842 --> 00:03:23,560 that turns its victims into the walking dead, 55 00:03:23,562 --> 00:03:28,298 or to be more accurate, the crawling dead. 56 00:03:28,300 --> 00:03:30,300 The fungus, like all organisms on the planet, 57 00:03:30,302 --> 00:03:31,518 has a scientific name. 58 00:03:31,520 --> 00:03:34,855 This one's called ophiocordyceps unitlateralis. 59 00:03:34,857 --> 00:03:37,741 But colloquially, it's known as the zombie ant fungi. 60 00:03:37,743 --> 00:03:40,160 Freeman: While foraging for food, 61 00:03:40,162 --> 00:03:41,578 an unsuspecting ant 62 00:03:41,580 --> 00:03:45,282 will pick up a spore of the zombie fungus. 63 00:03:45,284 --> 00:03:48,819 The fungus bores through the ant's body. 64 00:03:48,821 --> 00:03:51,955 It multiplies and infects the ant's brain, 65 00:03:51,957 --> 00:03:53,290 where it releases 66 00:03:53,292 --> 00:03:56,043 powerful mind-controlling chemicals. 67 00:03:57,429 --> 00:04:00,764 The zombified ant bites the underside of a leaf 68 00:04:00,766 --> 00:04:02,833 and dies. 69 00:04:02,835 --> 00:04:05,886 Well, sort of. 70 00:04:05,888 --> 00:04:08,505 Death is really the starting point for the parasite. 71 00:04:08,507 --> 00:04:10,524 Fungi are rather interesting 72 00:04:10,526 --> 00:04:13,393 in that they require the host to die, 73 00:04:13,395 --> 00:04:17,013 and then, from its tissues, they grow and they reproduce. 74 00:04:17,015 --> 00:04:18,315 And so, at this stage, 75 00:04:18,317 --> 00:04:21,685 the whole ant body is completely transformed. 76 00:04:23,905 --> 00:04:25,856 Freeman: The zombie ant fungus continues to control 77 00:04:25,858 --> 00:04:27,908 the dead creature's mind, 78 00:04:27,910 --> 00:04:31,695 keeping the insect's jaw locked onto the leaf. 79 00:04:31,697 --> 00:04:33,046 The fungus multiplies, 80 00:04:33,048 --> 00:04:35,365 building pressure inside the ant's skull 81 00:04:35,367 --> 00:04:40,053 until...it breaks open. 82 00:04:40,055 --> 00:04:43,807 Out comes a fungal stock that sprays down deadly spores 83 00:04:43,809 --> 00:04:47,311 on the fungus's next victims. 84 00:04:47,313 --> 00:04:49,980 The cycle repeats. 85 00:04:49,982 --> 00:04:52,516 The fungal spores need to be shot out, launched, 86 00:04:52,518 --> 00:04:56,103 from an area high above the foraging trail. 87 00:04:56,105 --> 00:04:58,555 And so the fungus has evolved the ability 88 00:04:58,557 --> 00:05:02,276 to control the mind of its host. 89 00:05:02,278 --> 00:05:06,730 Freeman: Inside their nests, ants are hygienic. 90 00:05:06,732 --> 00:05:08,699 But when they're out foraging, 91 00:05:08,701 --> 00:05:11,785 they are vulnerable to infection. 92 00:05:11,787 --> 00:05:15,005 David believes the fungus evolved the ability 93 00:05:15,007 --> 00:05:18,458 to strike the ants during this moment of weakness. 94 00:05:18,460 --> 00:05:23,213 The zombie ant fungus could never infect us. 95 00:05:23,215 --> 00:05:26,099 Our brains are too different from those of ants. 96 00:05:26,101 --> 00:05:30,687 But could a similar pathogen ever find its way into our mind? 97 00:05:30,689 --> 00:05:33,524 So fungi have clearly evolved the ability 98 00:05:33,526 --> 00:05:36,059 to control the behavior of animals. 99 00:05:36,061 --> 00:05:41,031 Our brains are animal brains, and there's no reason, 100 00:05:41,033 --> 00:05:43,867 theoretically, why we couldn't have our behavior controlled. 101 00:05:48,573 --> 00:05:52,576 Freeman: If a mind-enslaving pathogen ever strikes humanity, 102 00:05:52,578 --> 00:05:54,244 it will most likely jump to us 103 00:05:54,246 --> 00:05:57,648 from our close genetic relatives. 104 00:05:59,417 --> 00:06:04,788 Microbiologist Kartik Chandran studies the Ebola virus... 105 00:06:06,341 --> 00:06:09,760 A pathogen from our worst nightmares. 106 00:06:09,762 --> 00:06:11,261 Within weeks of infection, 107 00:06:11,263 --> 00:06:16,934 most patients leak blood from every orifice and die. 108 00:06:16,936 --> 00:06:19,486 Kartik is leading a team to find out 109 00:06:19,488 --> 00:06:24,691 how deadly viruses like Ebola evolve to infect humans. 110 00:06:26,194 --> 00:06:29,980 As far as we know, Ebola lives in bats, 111 00:06:29,982 --> 00:06:31,331 and every once in a while, 112 00:06:31,333 --> 00:06:34,150 this virus can break out from bats into other animals, 113 00:06:34,152 --> 00:06:37,537 including primates and apes and humans. 114 00:06:42,326 --> 00:06:44,378 Freeman: Kartik is investigating 115 00:06:44,380 --> 00:06:48,599 how Ebola made the jump from bats to us. 116 00:06:48,601 --> 00:06:51,685 He's imagining what it's like 117 00:06:51,687 --> 00:06:55,973 to be one of the microscopic bad guys. 118 00:06:57,225 --> 00:06:58,508 [ Static, door creaks ] 119 00:06:58,510 --> 00:07:00,176 The human body is a lot like a building 120 00:07:00,178 --> 00:07:02,062 where our cells are rooms. 121 00:07:02,064 --> 00:07:06,366 Viruses infect us by breaking and entering. 122 00:07:08,786 --> 00:07:10,904 So you might ask me, why does this little room 123 00:07:10,906 --> 00:07:12,706 in this storage facility have a lock? 124 00:07:12,708 --> 00:07:14,291 And so the answer is obvious -- 125 00:07:14,293 --> 00:07:16,693 because somebody needs to go in and out. 126 00:07:16,695 --> 00:07:19,162 This is an attempt to secure the entrance 127 00:07:19,164 --> 00:07:22,132 so that only the authorized individuals can get in. 128 00:07:22,134 --> 00:07:23,417 And cells are the same way. 129 00:07:23,419 --> 00:07:25,368 You know, cells need to bring stuff in, 130 00:07:25,370 --> 00:07:26,586 they need to export stuff, 131 00:07:26,588 --> 00:07:28,755 and viruses have really evolved to exploit 132 00:07:28,757 --> 00:07:31,141 this sort of entry and access ways. 133 00:07:31,143 --> 00:07:33,977 Freeman: Viruses mimic the shape of nutrients 134 00:07:33,979 --> 00:07:35,846 that the cell needs to survive, 135 00:07:35,848 --> 00:07:39,266 just like a lockpick mimics the shape of a key. 136 00:07:39,268 --> 00:07:42,235 [ Click, door rattling ] 137 00:07:42,237 --> 00:07:44,521 Freeman: Once inside the cell, 138 00:07:44,523 --> 00:07:48,058 the virus inserts its malicious genetic code. 139 00:07:48,060 --> 00:07:51,244 The host cell becomes an enslaved factory, 140 00:07:51,246 --> 00:07:54,448 producing countless copies of the invader. 141 00:07:54,450 --> 00:07:56,700 [ Screeching sound ] 142 00:07:56,702 --> 00:07:58,702 A multiplying virus can build so much pressure 143 00:07:58,704 --> 00:08:03,040 inside the host cell that it explodes... 144 00:08:03,042 --> 00:08:04,708 [ Explosion ] 145 00:08:04,710 --> 00:08:10,213 ...ejecting millions of viral clones to infect other cells. 146 00:08:11,916 --> 00:08:15,302 For a virus to jump from animal to human, 147 00:08:15,304 --> 00:08:19,056 it has to find a piece of biological machinery 148 00:08:19,058 --> 00:08:22,258 shared by both the animal and the human cell. 149 00:08:22,260 --> 00:08:25,062 Like you often see with viruses and other parasites, 150 00:08:25,064 --> 00:08:28,331 they evolve to co-opt these common cellular mechanisms, 151 00:08:28,333 --> 00:08:31,601 and Ebola has done just that. 152 00:08:31,603 --> 00:08:33,653 Freeman: Kartik made a groundbreaking discovery. 153 00:08:33,655 --> 00:08:39,826 Ebola relies on a protein called npc1 to infect cells. 154 00:08:39,828 --> 00:08:44,831 NPC1 is found in both bat and human cells. 155 00:08:44,833 --> 00:08:47,501 [ Chirping ] 156 00:08:47,503 --> 00:08:49,836 Bats and humans may seem very different, 157 00:08:49,838 --> 00:08:54,841 but their cells use remarkably similar molecular machinery. 158 00:08:54,843 --> 00:08:59,312 Most viruses that infect bats can also jump to humans. 159 00:08:59,314 --> 00:09:04,401 All a virus has to do is find those common keys. 160 00:09:04,403 --> 00:09:07,187 So, I mean, I think it's a probability thing. 161 00:09:07,189 --> 00:09:10,407 The more closely related you are to another organism, 162 00:09:10,409 --> 00:09:13,110 the more likely you are to pick up a virus. 163 00:09:13,112 --> 00:09:15,145 Freeman: A virus that turns human beings 164 00:09:15,147 --> 00:09:21,651 into violent, unconscious monsters already exists... 165 00:09:21,653 --> 00:09:22,653 Rabies. 166 00:09:22,654 --> 00:09:24,421 People that have rabies 167 00:09:24,423 --> 00:09:27,374 go through a phase where they're highly violent and belligerent, 168 00:09:27,376 --> 00:09:28,625 and they can foam at the mouth. 169 00:09:28,627 --> 00:09:30,093 These are changes that are -- 170 00:09:30,095 --> 00:09:32,328 clearly seem to benefit the virus 171 00:09:32,330 --> 00:09:34,347 in terms of its ability to spread 172 00:09:34,349 --> 00:09:38,101 from one infected host to a naive host. 173 00:09:39,687 --> 00:09:41,054 Freeman: A rabies infection 174 00:09:41,056 --> 00:09:44,775 does not spread easily from person to person. 175 00:09:44,777 --> 00:09:47,727 But if a virus like rabies mutated 176 00:09:47,729 --> 00:09:50,697 to have influenza-like properties, 177 00:09:50,699 --> 00:09:54,067 it could spread like wildfire. 178 00:10:00,625 --> 00:10:02,358 [ Coughing ] 179 00:10:02,360 --> 00:10:05,629 Freeman: The infected would mistake it for a common cold... 180 00:10:07,331 --> 00:10:09,416 ...until it's too late... 181 00:10:09,418 --> 00:10:12,702 [ Coughing ] 182 00:10:12,704 --> 00:10:15,722 Freeman: ...and they fall into a mindless rage. 183 00:10:23,481 --> 00:10:26,933 They would become violent and attack without warning. 184 00:10:26,935 --> 00:10:29,186 [ Strangled yell ] 185 00:10:29,188 --> 00:10:30,386 [ Stabbing sound ] 186 00:10:32,773 --> 00:10:35,725 [ Panting ] 187 00:10:35,727 --> 00:10:36,860 [ Gasps ] [ Banging on door ] 188 00:10:36,862 --> 00:10:40,747 Freeman: Open wounds would benefit the virus. 189 00:10:40,749 --> 00:10:45,168 It would easily transmit through airborne particles. 190 00:10:48,539 --> 00:10:50,507 [ Elevator bell dings ] 191 00:10:50,509 --> 00:10:54,094 Ironically, our own vigilant immune systems 192 00:10:54,096 --> 00:10:57,631 could help bring this virus into existence. 193 00:11:01,185 --> 00:11:02,919 Once a virus infects a cell, 194 00:11:02,921 --> 00:11:05,889 there is sort of this hardwired immune response 195 00:11:05,891 --> 00:11:08,925 that makes all these new machines in the cell 196 00:11:08,927 --> 00:11:10,977 that can try to stop the virus from infecting, 197 00:11:10,979 --> 00:11:12,646 and so the virus has got to evolve 198 00:11:12,648 --> 00:11:16,283 so it can get around these sort of antiviral proteins. 199 00:11:16,285 --> 00:11:19,035 Freeman: In the never-ending arms race 200 00:11:19,037 --> 00:11:22,272 between the virus and the host's immune system, 201 00:11:22,274 --> 00:11:24,741 both sides keep upping their game. 202 00:11:24,743 --> 00:11:28,778 As viruses mutate, they develop an array of evasive talents. 203 00:11:28,780 --> 00:11:33,884 In some mutations, viruses learn to become invisible. 204 00:11:33,886 --> 00:11:36,503 [ Switch clicks ] 205 00:11:36,505 --> 00:11:39,339 Other times, they evolve chemical tools 206 00:11:39,341 --> 00:11:43,293 that allow them to disable the body's infection monitors. 207 00:11:43,295 --> 00:11:45,362 [ Static ] 208 00:11:45,364 --> 00:11:49,099 Or if the virus mutates just right, 209 00:11:49,101 --> 00:11:54,854 it can permanently evade the immune system with a decoy. 210 00:11:57,308 --> 00:12:01,828 Eventually, a new form of the virus will evolve 211 00:12:01,830 --> 00:12:05,699 that can slip past the body's defenses. 212 00:12:05,701 --> 00:12:07,867 And that virus is selected because it's the only one 213 00:12:07,869 --> 00:12:10,420 that's able to grow and replicate itself 214 00:12:10,422 --> 00:12:12,005 in these cells, and so, all of a sudden, 215 00:12:12,007 --> 00:12:13,540 it takes over the whole population. 216 00:12:13,542 --> 00:12:17,260 So you go through these sort of, like, bursts of selection 217 00:12:17,262 --> 00:12:18,461 that completely change the -- 218 00:12:18,463 --> 00:12:20,380 sort of the structure of the viral population. 219 00:12:20,382 --> 00:12:23,166 And this can happen very quickly. 220 00:12:23,168 --> 00:12:25,468 Freeman: As long as we rely on our immune systems 221 00:12:25,470 --> 00:12:30,506 to keep us healthy, new viruses will constantly evolve. 222 00:12:30,508 --> 00:12:33,343 But a zombie virus may also 223 00:12:33,345 --> 00:12:37,230 one day be created in a laboratory. 224 00:12:37,232 --> 00:12:39,232 We should be able to design viruses 225 00:12:39,234 --> 00:12:40,617 that do different things. 226 00:12:40,619 --> 00:12:42,118 In principle, it seems to me 227 00:12:42,120 --> 00:12:44,354 that if you know what buttons to push, 228 00:12:44,356 --> 00:12:47,157 you could make a virus that could do those things. 229 00:12:47,159 --> 00:12:48,992 Freeman: Kartik, of course, 230 00:12:48,994 --> 00:12:52,078 wants to stop a zombie virus, not create one. 231 00:12:52,080 --> 00:12:55,198 But nothing is preventing the wrong minds 232 00:12:55,200 --> 00:12:56,549 from pursuing it. 233 00:12:56,551 --> 00:12:58,534 Is a zombie virus possible? 234 00:12:58,536 --> 00:13:00,670 I mean, I suppose there's really nothing in the laws of physics 235 00:13:00,672 --> 00:13:02,538 that says it's impossible, 236 00:13:02,540 --> 00:13:04,207 although I would say that it could be 237 00:13:04,209 --> 00:13:05,508 some sort of combination 238 00:13:05,510 --> 00:13:08,311 of different viruses that we know about. 239 00:13:08,313 --> 00:13:11,982 Freeman: A hybrid virus that turns human beings 240 00:13:11,984 --> 00:13:15,652 into deadly, contagious monsters is not likely, 241 00:13:15,654 --> 00:13:18,405 but it is possible. 242 00:13:18,407 --> 00:13:20,940 It could come from a laboratory, 243 00:13:20,942 --> 00:13:24,894 or could be born from the crucible of evolution. 244 00:13:24,896 --> 00:13:29,949 If this virus breaks out, what happens next? 245 00:13:31,731 --> 00:13:35,317 When you get the flu, what do you do? 246 00:13:36,319 --> 00:13:41,405 Go home, get in bed, and hope no one bothers you. 247 00:13:41,407 --> 00:13:43,491 But imagine a disease that spreads 248 00:13:43,493 --> 00:13:47,311 by making its victims violent. 249 00:13:47,313 --> 00:13:51,198 Such a disease could emerge someday. 250 00:13:51,200 --> 00:13:56,087 Could we keep it from becoming a global pandemic? 251 00:13:57,655 --> 00:13:59,090 In Ottawa, Canada, 252 00:13:59,092 --> 00:14:02,543 a scientist is taking on the zombie apocalypse 253 00:14:02,545 --> 00:14:04,879 before it happens. 254 00:14:04,881 --> 00:14:07,381 [ Beeps ] 255 00:14:07,383 --> 00:14:14,722 A scientist who always seems to have a question on his mind. 256 00:14:14,724 --> 00:14:16,673 I added the question mark because my name was very boring, 257 00:14:16,675 --> 00:14:18,609 and I was getting confused with all kinds of Robert Smiths, 258 00:14:18,611 --> 00:14:20,811 so I thought it'd be a cool thing to add to my name. 259 00:14:20,813 --> 00:14:23,680 And because I have my question mark which helps me 260 00:14:23,682 --> 00:14:25,232 be distinguished from other Robert Smiths 261 00:14:25,234 --> 00:14:28,619 in my specific field of disease modeling by mathematics. 262 00:14:33,041 --> 00:14:35,042 Freeman: Diseases are everywhere. 263 00:14:35,044 --> 00:14:36,911 [ Coughs ] Robert wants to log 264 00:14:36,913 --> 00:14:39,296 every moment in his life... [ Cell phone rings, beeps ] 265 00:14:39,298 --> 00:14:42,699 When he can pick up a pathogen from an infected person, 266 00:14:42,701 --> 00:14:46,637 even when the infected aren't around. 267 00:14:46,639 --> 00:14:48,756 [ Water streaming ] If a disease is airborne, 268 00:14:48,758 --> 00:14:50,341 then the air that we share 269 00:14:50,343 --> 00:14:52,676 is obviously something that's potentially quite toxic. 270 00:14:52,678 --> 00:14:54,478 [ Cell phone rings, beeps ] And the closer you are, 271 00:14:54,480 --> 00:14:55,712 of course, the more likely. 272 00:14:55,714 --> 00:14:57,714 But then other things become transmissible as well. 273 00:14:57,716 --> 00:15:00,985 So doorknobs and, you know... [ Cell phone rings ] 274 00:15:00,987 --> 00:15:03,554 [ Beep ] The handle of whatever it is 275 00:15:03,556 --> 00:15:05,856 that I'm touching or breathing on. 276 00:15:05,858 --> 00:15:07,191 [ Cell phone rings ] 277 00:15:07,193 --> 00:15:11,895 [ Beeping ] 278 00:15:11,897 --> 00:15:13,697 Freeman: Robert is using this data 279 00:15:13,699 --> 00:15:16,534 to build mathematical models to predict 280 00:15:16,536 --> 00:15:20,737 how quickly infectious diseases can spread. 281 00:15:20,739 --> 00:15:22,289 And with the help of his students, 282 00:15:22,291 --> 00:15:27,411 he's creating live human versions of those models. 283 00:15:27,413 --> 00:15:29,630 Just like any human community, 284 00:15:29,632 --> 00:15:33,184 the virus has many chances to find a new host. 285 00:15:33,186 --> 00:15:36,253 Okay, in these beakers, most of them are just plain water. 286 00:15:36,255 --> 00:15:37,555 One of them has been infected 287 00:15:37,557 --> 00:15:40,391 with something that's gonna simulate a virus. 288 00:15:40,393 --> 00:15:43,027 Freeman: The rules are simple. 289 00:15:43,029 --> 00:15:45,813 No student can take more than five steps. 290 00:15:45,815 --> 00:15:47,781 Ready? And go. [ Blows whistle ] 291 00:15:47,783 --> 00:15:49,933 Freeman: They have 30 seconds to mix 292 00:15:49,935 --> 00:15:52,403 with as many other students as possible, 293 00:15:52,405 --> 00:15:54,938 and no one knows who has the beaker 294 00:15:54,940 --> 00:15:56,490 with the infection. 295 00:15:56,492 --> 00:16:02,446 Robert wants to see how many people patient zero can infect. 296 00:16:02,448 --> 00:16:05,782 [ Toot ] 297 00:16:05,784 --> 00:16:08,302 Okay, now please return your beakers to the middle. 298 00:16:09,671 --> 00:16:11,005 Freeman: At the end of the game, 299 00:16:11,007 --> 00:16:13,924 Robert drops a chemical into each beaker. 300 00:16:13,926 --> 00:16:16,627 If a student mixed with the infected, 301 00:16:16,629 --> 00:16:18,596 their water will turn yellow. 302 00:16:18,598 --> 00:16:20,297 Even though patient zero 303 00:16:20,299 --> 00:16:23,901 could only have direct contact with a few neighbors, 304 00:16:23,903 --> 00:16:25,802 those neighbors passed the disease along, 305 00:16:25,804 --> 00:16:29,306 and about half the group ends up infected. 306 00:16:29,308 --> 00:16:35,479 But Robert believes the math desperately needs an update. 307 00:16:35,481 --> 00:16:37,281 So recently, we tried to update models, 308 00:16:37,283 --> 00:16:39,533 and we have much more powerful ways of understanding 309 00:16:39,535 --> 00:16:41,952 the network of connections that different people have. 310 00:16:41,954 --> 00:16:43,287 [ Film projector whirring ] 311 00:16:43,289 --> 00:16:45,923 Freeman: The old models focused on human beings 312 00:16:45,925 --> 00:16:48,626 and their local communities. 313 00:16:48,628 --> 00:16:52,162 But we now live in a global society 314 00:16:52,164 --> 00:16:54,465 and are on the move like never before. 315 00:16:54,467 --> 00:16:59,169 On an average day, approximately 22.8 million of us 316 00:16:59,171 --> 00:17:03,340 travel someplace far away. 317 00:17:05,393 --> 00:17:08,729 Robert repeats the game with the same rules, 318 00:17:08,731 --> 00:17:10,514 but this time, the students are allowed 319 00:17:10,516 --> 00:17:13,150 to take as many steps as they wish 320 00:17:13,152 --> 00:17:16,570 to account for the ease with which we travel. 321 00:17:16,572 --> 00:17:18,289 [ Toot ] 322 00:17:25,714 --> 00:17:27,364 [ Toot ] 323 00:17:30,585 --> 00:17:33,053 Freeman: At the end of the 30-second round, 324 00:17:33,055 --> 00:17:36,707 Robert tests each beaker again. 325 00:17:39,094 --> 00:17:42,212 Every student is infected. 326 00:17:42,214 --> 00:17:44,381 Robert has calculated 327 00:17:44,383 --> 00:17:48,051 the infection rate for a disease that doesn't yet exist. 328 00:17:48,053 --> 00:17:52,323 He imagines a virus that spreads easily through the air, 329 00:17:52,325 --> 00:17:53,524 like the flu. 330 00:17:53,526 --> 00:17:55,159 But unlike influenza, 331 00:17:55,161 --> 00:17:58,028 the disease does not make its victims 332 00:17:58,030 --> 00:17:59,896 want to stay home in bed. 333 00:17:59,898 --> 00:18:03,450 Instead, they become zombies, 334 00:18:03,452 --> 00:18:07,338 and they take to the streets in a mindless rage. 335 00:18:07,340 --> 00:18:08,672 [ Snarls ] 336 00:18:08,674 --> 00:18:10,040 So if we actually had a zombie virus, 337 00:18:10,042 --> 00:18:11,508 then the mathematics predicts 338 00:18:11,510 --> 00:18:13,377 that we're not gonna do very well. 339 00:18:13,379 --> 00:18:16,013 [ Sirens wailing ] 340 00:18:16,015 --> 00:18:19,133 Freeman: If just one person is infected with this zombie virus, 341 00:18:19,135 --> 00:18:23,086 Robert predicts an epidemic is inevitable. 342 00:18:23,088 --> 00:18:26,256 Cities would be overrun in weeks. 343 00:18:26,258 --> 00:18:27,858 [ Crowd shouting indistinctly ] 344 00:18:27,860 --> 00:18:29,476 Freeman: As refugees escape, 345 00:18:29,478 --> 00:18:33,564 some of them inadvertently bring the disease along. 346 00:18:33,566 --> 00:18:36,066 Global civilization as we know it 347 00:18:36,068 --> 00:18:39,603 would be brought to its knees in a matter of months. 348 00:18:39,605 --> 00:18:44,575 We have completely eradicated only two infectious diseases -- 349 00:18:44,577 --> 00:18:46,943 cattle plague and smallpox. 350 00:18:46,945 --> 00:18:50,164 Finding a cure for this hypothetical zombie virus 351 00:18:50,166 --> 00:18:53,167 is very unlikely. 352 00:18:53,169 --> 00:18:56,286 But if a zombie outbreak does happen, 353 00:18:56,288 --> 00:18:58,005 Robert's calculations 354 00:18:58,007 --> 00:19:01,842 show how humans can avoid total annihilation... 355 00:19:02,960 --> 00:19:06,630 by getting our hands dirty. 356 00:19:06,632 --> 00:19:09,066 Probably the best way that we found to deal with zombies 357 00:19:09,068 --> 00:19:11,185 was to basically hit them hard and hit them often. 358 00:19:12,737 --> 00:19:15,972 So the idea is that you try and wipe the zombies out in one go, 359 00:19:15,974 --> 00:19:17,274 and of course, you're not gonna be successful at that, 360 00:19:17,276 --> 00:19:19,643 so, next day, you try and wipe them out again, 361 00:19:19,645 --> 00:19:21,645 using the knowledge that you learned from the last time. 362 00:19:21,647 --> 00:19:23,146 So we get better at it, 363 00:19:23,148 --> 00:19:26,333 and so then the third day, we're now even better. 364 00:19:26,335 --> 00:19:30,087 Freeman: To stop a zombie plague from becoming an apocalypse, 365 00:19:30,089 --> 00:19:33,657 we may only have one horrifying option -- 366 00:19:33,659 --> 00:19:39,046 to kill every single infected person. 367 00:19:39,048 --> 00:19:45,769 Just one surviving zombie could trigger another epidemic. 368 00:19:45,771 --> 00:19:48,171 Our best hope to stop a super virus 369 00:19:48,173 --> 00:19:51,174 is to catch it in time. 370 00:19:51,176 --> 00:19:54,027 Virus hunters are scouring the microscopic world, 371 00:19:54,029 --> 00:19:55,946 looking for an invisible enemy 372 00:19:55,948 --> 00:20:00,367 that may have already made its first move. 373 00:20:02,883 --> 00:20:06,152 During the four years of World War I, 374 00:20:06,154 --> 00:20:10,756 almost 15 million people died. 375 00:20:10,758 --> 00:20:12,925 In the two years that followed, 376 00:20:12,927 --> 00:20:18,664 a single flu virus claimed three times that many lives. 377 00:20:18,666 --> 00:20:21,634 The virus had spread around the world 378 00:20:21,636 --> 00:20:24,387 before anyone detected it. 379 00:20:24,389 --> 00:20:27,256 There are millions of microbes out there, 380 00:20:27,258 --> 00:20:29,875 most of them harmless. 381 00:20:29,877 --> 00:20:33,512 How can we find the next deadly pandemic, 382 00:20:33,514 --> 00:20:35,681 perhaps a zombie virus... 383 00:20:35,683 --> 00:20:38,550 [ Imitates gunshot ] 384 00:20:38,552 --> 00:20:42,104 ...before it sweeps the globe? 385 00:20:42,106 --> 00:20:44,657 [ Blows air ] 386 00:20:44,659 --> 00:20:48,461 [ Wind blowing loudly ] 387 00:20:48,463 --> 00:20:50,930 Hello? 388 00:20:50,932 --> 00:20:53,399 Hello? 389 00:20:53,401 --> 00:20:54,934 Freeman: According to Ian Lipkin, 390 00:20:54,936 --> 00:20:57,569 the world's leading virus hunter, 391 00:20:57,571 --> 00:21:02,407 our civilization runs a terrible risk of global pandemic. 392 00:21:02,409 --> 00:21:05,377 I'm standing in the middle of Times Square, 393 00:21:05,379 --> 00:21:07,346 and it's completely deserted. 394 00:21:07,348 --> 00:21:10,916 It looks like something that you might see in a movie, 395 00:21:10,918 --> 00:21:12,968 but, in fact, it's a real possibility. 396 00:21:14,754 --> 00:21:16,138 Freeman: Ian is the director 397 00:21:16,140 --> 00:21:18,590 for the Center for Infection and Immunity 398 00:21:18,592 --> 00:21:21,093 at Columbia University. 399 00:21:21,095 --> 00:21:23,229 His team is on the front lines, 400 00:21:23,231 --> 00:21:27,599 hunting for deadly viruses before they become pandemics. 401 00:21:27,601 --> 00:21:30,236 In 2003, his lab was the first 402 00:21:30,238 --> 00:21:33,405 to identify the lethal S.A.R.S. virus. 403 00:21:33,407 --> 00:21:38,294 That early discovery saved countless lives. 404 00:21:38,296 --> 00:21:41,964 Nature herself is continually evolving new bacteria, 405 00:21:41,966 --> 00:21:44,750 new viruses that are more pathogenic, 406 00:21:44,752 --> 00:21:48,120 that escape the antivirals, the antibacterials, 407 00:21:48,122 --> 00:21:51,674 the vaccines that we create to hold them in check. 408 00:21:51,676 --> 00:21:52,758 [ Coughs ] 409 00:21:52,760 --> 00:21:54,760 Freeman: There are more 410 00:21:54,762 --> 00:21:59,398 than 10,000 trillion trillion trillion viruses on earth. 411 00:21:59,400 --> 00:22:03,486 Pinpointing a deadly virus in a sea of its benign cousins 412 00:22:03,488 --> 00:22:06,655 is just about impossible, 413 00:22:06,657 --> 00:22:10,943 unless you lure the virus out of hiding. 414 00:22:10,945 --> 00:22:13,245 When a patient falls ill somewhere in the world 415 00:22:13,247 --> 00:22:15,080 with an unknown virus, 416 00:22:15,082 --> 00:22:16,982 blood and other biological samples 417 00:22:16,984 --> 00:22:19,818 are often sent to Ian's lab. 418 00:22:19,820 --> 00:22:25,708 He then gets to work by going fishing with D.N.A. 419 00:22:28,845 --> 00:22:32,381 D.N.A. makes for the perfect virus bait, 420 00:22:32,383 --> 00:22:33,966 because viruses contain genetic code 421 00:22:33,968 --> 00:22:38,387 that binds to matching sequences of D.N.A. 422 00:22:38,389 --> 00:22:41,974 So then if that virus is present within that sample, 423 00:22:41,976 --> 00:22:44,009 it will be caught on the hook, 424 00:22:44,011 --> 00:22:47,279 and I'll be able to reel it in, and I'll see it. 425 00:22:47,281 --> 00:22:50,950 Freeman: Ian can cast thousands of genetic lures 426 00:22:50,952 --> 00:22:52,234 into the sample. 427 00:22:53,853 --> 00:22:57,189 Each one is tailored to attract a known virus. 428 00:22:57,191 --> 00:22:58,407 [ Screeches ] 429 00:22:58,409 --> 00:23:00,543 Freeman: Biological samples from sick patients 430 00:23:00,545 --> 00:23:04,663 are oceans filled with microbes that ignore the lure, 431 00:23:04,665 --> 00:23:07,532 except for the virus that is a match 432 00:23:07,534 --> 00:23:09,752 for the lure's D.N.A. sequence. 433 00:23:11,304 --> 00:23:13,872 The virus lines up its genetic code -- 434 00:23:13,874 --> 00:23:18,594 A binds to T, C binds to G. 435 00:23:18,596 --> 00:23:20,095 Once it's hooked... Uh-oh. 436 00:23:20,097 --> 00:23:22,264 The weight of the lure changes, 437 00:23:22,266 --> 00:23:25,017 and Ian can reel in the virus. 438 00:23:25,019 --> 00:23:26,551 [ Seagulls crying ] 439 00:23:26,553 --> 00:23:27,987 [ Click ] 440 00:23:27,989 --> 00:23:31,323 Now, if that method works, then we can get an answer 441 00:23:31,325 --> 00:23:33,943 very, very quickly, very inexpensively, 442 00:23:33,945 --> 00:23:37,746 probably in a matter of four to six hours at the outside. 443 00:23:37,748 --> 00:23:39,615 Freeman: But viral and genetic code 444 00:23:39,617 --> 00:23:41,667 can evolve rapidly. 445 00:23:41,669 --> 00:23:44,670 Sometimes new viruses have changed so much 446 00:23:44,672 --> 00:23:47,406 that they no longer stick to the lure. 447 00:23:47,408 --> 00:23:50,876 In that case, Ian switches to another technique -- 448 00:23:50,878 --> 00:23:53,128 grab all the D.N.A. he can. 449 00:23:53,130 --> 00:23:54,413 I have a net. 450 00:23:54,415 --> 00:23:57,749 This is essentially a D.N.A. sequence. 451 00:23:57,751 --> 00:24:00,519 When we don't know precisely what we're looking for, 452 00:24:00,521 --> 00:24:02,805 we use a high-throughput sequencer 453 00:24:02,807 --> 00:24:05,924 that allows us to characterize all of the genetic material 454 00:24:05,926 --> 00:24:08,727 that'd be present within a sample. 455 00:24:08,729 --> 00:24:10,613 We pull everything in, and then we compare that 456 00:24:10,615 --> 00:24:13,482 with a database of all known sequences. 457 00:24:13,484 --> 00:24:15,534 That allows us to identify anything 458 00:24:15,536 --> 00:24:18,487 which is potentially a microbial agent. 459 00:24:18,489 --> 00:24:19,989 Freeman: Ian and his team 460 00:24:19,991 --> 00:24:23,375 then grow colonies of the isolated virus 461 00:24:23,377 --> 00:24:25,377 and attempt either to identify a drug 462 00:24:25,379 --> 00:24:31,383 that can fight the infection or to develop a vaccine. 463 00:24:31,385 --> 00:24:35,454 We and our colleagues can begin testing drugs for efficacy, 464 00:24:35,456 --> 00:24:37,673 drugs that will be able to prevent this agent 465 00:24:37,675 --> 00:24:39,558 from reproducing itself. 466 00:24:39,560 --> 00:24:41,260 And then, ultimately, 467 00:24:41,262 --> 00:24:43,962 because drugs are frequently too expensive, 468 00:24:43,964 --> 00:24:46,131 we try to collaborate with people 469 00:24:46,133 --> 00:24:48,300 who know how to develop vaccines. 470 00:24:48,302 --> 00:24:49,935 Freeman: No matter how quickly 471 00:24:49,937 --> 00:24:52,354 they identify new viruses, however, 472 00:24:52,356 --> 00:24:56,641 there will always be a lag time between detection and treatment, 473 00:24:56,643 --> 00:24:59,244 a time when the virus can spread. 474 00:24:59,246 --> 00:25:03,499 The major time lag is not at the level of the laboratory. 475 00:25:03,501 --> 00:25:05,451 It's really in the field. 476 00:25:05,453 --> 00:25:09,654 It's recognizing the appearance of something as new. 477 00:25:09,656 --> 00:25:11,540 Then that has to percolate 478 00:25:11,542 --> 00:25:15,928 through the ether until it reaches people like us. 479 00:25:15,930 --> 00:25:18,330 Freeman: Ian's team could prevent 480 00:25:18,332 --> 00:25:20,599 millions if not billions of us 481 00:25:20,601 --> 00:25:23,886 from succumbing to a highly infectious disease. 482 00:25:23,888 --> 00:25:26,722 But if a virus evolves that is sufficiently different 483 00:25:26,724 --> 00:25:29,692 from the viruses we know today, 484 00:25:29,694 --> 00:25:32,778 Ian's team will not be able to fish it out. 485 00:25:32,780 --> 00:25:34,229 [ Beeping ] 486 00:25:34,231 --> 00:25:40,819 In humanity's war on viruses, we need a new strategy. 487 00:25:40,821 --> 00:25:43,288 We can hunt viruses down, 488 00:25:43,290 --> 00:25:48,410 and we can try to vaccinate ourselves against them. 489 00:25:48,412 --> 00:25:54,500 But once they infect us, we're at their mercy. 490 00:25:54,502 --> 00:25:58,721 What if we turn a virus into a zombie 491 00:25:58,723 --> 00:26:05,177 that works for us and make it kill a zombie virus? 492 00:26:06,058 --> 00:26:07,325 Modern medicine 493 00:26:07,327 --> 00:26:11,429 has conquered many diseases in the past century. 494 00:26:11,931 --> 00:26:16,334 Viruses, however, remain elusive targets. 495 00:26:16,336 --> 00:26:21,539 Because they hijack the vital genetic machinery of our cells, 496 00:26:21,541 --> 00:26:24,375 killing them is tricky. 497 00:26:24,377 --> 00:26:29,446 The solution may require a pair of these, 498 00:26:29,448 --> 00:26:34,085 shrunk down to the size of our D.N.A. 499 00:26:34,087 --> 00:26:35,887 [ Snip ] 500 00:26:35,889 --> 00:26:40,341 Viruses are party crashers. 501 00:26:40,343 --> 00:26:42,760 They do everything possible to blend in with healthy cells... 502 00:26:42,762 --> 00:26:44,512 Aah! [ Snarling ] 503 00:26:44,514 --> 00:26:46,297 Freeman: ...All the while 504 00:26:46,299 --> 00:26:49,300 relentlessly infecting the invited guests. 505 00:26:49,302 --> 00:26:51,102 For severe infections, 506 00:26:51,104 --> 00:26:54,605 our best medical treatments today are crude. 507 00:26:54,607 --> 00:26:59,410 They work by chopping up the harmful invaders... 508 00:26:59,412 --> 00:27:00,528 Party's over. 509 00:27:00,530 --> 00:27:02,146 [ Motor revs, women scream ] 510 00:27:02,148 --> 00:27:05,533 [ Saw buzzing ] ...And all the healthy cells 511 00:27:05,535 --> 00:27:06,867 in their vicinity. 512 00:27:06,869 --> 00:27:09,754 But a new treatment that only goes after the bad guys 513 00:27:09,756 --> 00:27:12,790 could be right around the corner. 514 00:27:14,159 --> 00:27:17,511 As the director of the Center for Nanomedicine 515 00:27:17,513 --> 00:27:19,130 at U.C. Santa Barbara, 516 00:27:19,132 --> 00:27:22,049 Jamey Marth thinks it should be possible 517 00:27:22,051 --> 00:27:24,051 to make an antiviral drug 518 00:27:24,053 --> 00:27:30,942 out of a class of chemicals that we all have in our stomachs. 519 00:27:30,944 --> 00:27:33,344 The food that I have on this plate right now 520 00:27:33,346 --> 00:27:37,481 is what I need to keep me alive and mostly healthy. 521 00:27:37,483 --> 00:27:39,650 [ Crunching ] 522 00:27:39,652 --> 00:27:42,353 But for my body to use this material, 523 00:27:42,355 --> 00:27:45,323 it has to convert it into different forms, 524 00:27:45,325 --> 00:27:51,028 and it does that by using small natural machines called enzymes. 525 00:27:51,030 --> 00:27:55,466 Freeman: Enzymes are the power tools of microbiology. 526 00:27:55,468 --> 00:28:00,671 In the stomach, they break apart our food into digestible forms. 527 00:28:00,673 --> 00:28:03,874 Jamey and his colleagues are working 528 00:28:03,876 --> 00:28:07,094 with an enzyme called C.R.E. Recombinase. 529 00:28:07,096 --> 00:28:10,881 This enzyme has remarkable utility. 530 00:28:10,883 --> 00:28:14,718 It can cut out any section of D.N.A. 531 00:28:14,720 --> 00:28:16,854 And neatly staple back together 532 00:28:16,856 --> 00:28:19,323 the two adjoining genetic pieces. 533 00:28:19,325 --> 00:28:21,275 It's allowed us to do things 534 00:28:21,277 --> 00:28:24,495 that we haven't been able to do before -- 535 00:28:24,497 --> 00:28:27,665 to remove specific genes from specific cells 536 00:28:27,667 --> 00:28:29,834 at different times. 537 00:28:32,204 --> 00:28:34,955 Freeman: Inside every cell in our body, 538 00:28:34,957 --> 00:28:37,625 there is a forest of D.N.A. 539 00:28:37,627 --> 00:28:40,344 Viruses sneak foreign genes 540 00:28:40,346 --> 00:28:44,248 into this forest and hijack our cellular machinery. 541 00:28:44,250 --> 00:28:49,253 A drug based on Jamey's C.R.E. Recombinase enzyme 542 00:28:49,255 --> 00:28:53,924 could chop down viral infections at their root 543 00:28:53,926 --> 00:28:56,644 by weeding out their D.N.A. 544 00:28:58,263 --> 00:29:01,265 The enzyme needs to find a specific sequence 545 00:29:01,267 --> 00:29:05,436 of 34 genetic letters at either end of the cut. 546 00:29:05,438 --> 00:29:08,489 And that sequence can be customized. 547 00:29:08,491 --> 00:29:12,443 So once you know the genetic sequence of a virus, 548 00:29:12,445 --> 00:29:14,628 you can program C.R.E. Recombinase 549 00:29:14,630 --> 00:29:19,884 to latch onto the first and last parts of this D.N.A. code. 550 00:29:19,886 --> 00:29:23,387 This represents viral D.N.A. -- 551 00:29:23,389 --> 00:29:25,139 D.N.A. that's foreign to the cell 552 00:29:25,141 --> 00:29:27,291 and has integrated itself into the genome. 553 00:29:27,293 --> 00:29:30,895 An enzyme like the C.R.E. Recombinase 554 00:29:30,897 --> 00:29:33,931 is capable of removing this precisely 555 00:29:33,933 --> 00:29:35,766 from the cell's genome. 556 00:29:35,768 --> 00:29:39,070 It does this with precision. 557 00:29:39,072 --> 00:29:40,104 [ Snip ] 558 00:29:40,106 --> 00:29:42,022 And then, what the enzyme will do 559 00:29:42,024 --> 00:29:43,908 is it will stitch back together 560 00:29:43,910 --> 00:29:46,527 the ends of the normal D.N.A. 561 00:29:46,529 --> 00:29:50,314 So that the cell is effectively cured... 562 00:29:50,316 --> 00:29:52,366 [ Stapler clicks ] 563 00:29:52,368 --> 00:29:54,452 ...of the disease. 564 00:29:54,454 --> 00:29:57,204 Freeman: Jamey is laying the groundwork 565 00:29:57,206 --> 00:30:02,126 for what could be a cure for all infectious viruses. 566 00:30:02,128 --> 00:30:04,211 H.I.V. A.I.D.S... 567 00:30:04,213 --> 00:30:05,662 [ Snip, click ] 568 00:30:05,664 --> 00:30:06,931 ...influenza... 569 00:30:06,933 --> 00:30:08,432 [ Snip, click ] 570 00:30:08,434 --> 00:30:10,184 ...even the common cold... 571 00:30:10,186 --> 00:30:11,835 [ Snip, click ] 572 00:30:11,837 --> 00:30:15,639 ...will all only exist in history books. 573 00:30:15,641 --> 00:30:19,193 And the delivery vehicle for this life-saving drug 574 00:30:19,195 --> 00:30:22,897 is the last thing you would expect -- 575 00:30:22,899 --> 00:30:24,565 another virus. 576 00:30:24,567 --> 00:30:30,070 We could reprogram that virus so that once that virus 577 00:30:30,072 --> 00:30:32,189 binds and goes inside the cell, 578 00:30:32,191 --> 00:30:35,126 instead of releasing a disease-causing payload, 579 00:30:35,128 --> 00:30:37,128 it will instead release a cargo 580 00:30:37,130 --> 00:30:40,664 that allows us to cure those cells. 581 00:30:40,666 --> 00:30:44,301 [ Screaming and crying ] 582 00:30:44,303 --> 00:30:45,536 Freeman: Our best weapon against a virus 583 00:30:45,538 --> 00:30:48,389 that turns humans into zombies 584 00:30:48,391 --> 00:30:52,593 could be a virus that we turn into our zombie slave. 585 00:30:52,595 --> 00:30:53,978 [ Roars ] 586 00:30:53,980 --> 00:30:55,479 Freeman: This harmful virus 587 00:30:55,481 --> 00:30:58,048 would be stripped of its disease payload 588 00:30:58,050 --> 00:31:00,684 and instead be filled 589 00:31:00,686 --> 00:31:04,888 with reprogrammed C.R.E. Recombinase enzymes, 590 00:31:04,890 --> 00:31:08,192 which can search throughout our entire bodies 591 00:31:08,194 --> 00:31:13,164 and only eliminate the unwanted invaders. 592 00:31:13,166 --> 00:31:14,865 [ Clinking ] 593 00:31:14,867 --> 00:31:17,535 But finding a universal cure for viruses may not save us 594 00:31:17,537 --> 00:31:20,204 from a world filled with zombies. 595 00:31:20,206 --> 00:31:24,175 A zombie takeover is already underway in a lab 596 00:31:24,177 --> 00:31:27,127 in North Carolina, where living creatures 597 00:31:27,129 --> 00:31:32,299 are turned into zombie drones at the press of a button. 598 00:31:34,319 --> 00:31:37,121 If I told you to run off a cliff, 599 00:31:37,423 --> 00:31:40,791 you wouldn't do it, would you? 600 00:31:40,793 --> 00:31:44,728 But what if I took control of the neurons in your brain 601 00:31:44,730 --> 00:31:48,832 and made your legs run straight off the edge? 602 00:31:48,834 --> 00:31:53,170 Turning a conscious person into a mindless zombie 603 00:31:53,172 --> 00:31:55,004 may only be a matter of finding 604 00:31:55,006 --> 00:31:57,307 and controlling the right circuits in the brain. 605 00:31:57,309 --> 00:31:59,008 [ Electricity crackling ] 606 00:31:59,010 --> 00:32:01,561 [ Chuckles ] 607 00:32:03,698 --> 00:32:08,852 How do you get a living mind to completely surrender its will? 608 00:32:11,789 --> 00:32:14,858 Electrical engineer Alper Bozkurt 609 00:32:14,860 --> 00:32:16,993 thinks we've been doing it for centuries 610 00:32:16,995 --> 00:32:19,796 by domesticating wild animals. 611 00:32:19,798 --> 00:32:22,699 The horses open themselves to our control 612 00:32:22,701 --> 00:32:27,003 thanks to this mutual beneficial relation that we have with them, 613 00:32:27,005 --> 00:32:30,373 and it took a long time for us to be able to train them, 614 00:32:30,375 --> 00:32:32,425 uh, basically to condition them 615 00:32:32,427 --> 00:32:34,761 with different rewards or punishments. 616 00:32:36,180 --> 00:32:39,382 Freeman: Alper looks at animals as electrical circuits. 617 00:32:39,384 --> 00:32:40,650 As a horse moves, 618 00:32:40,652 --> 00:32:41,885 its brain sends 619 00:32:41,887 --> 00:32:44,905 an elaborate series of commands to its muscles 620 00:32:44,907 --> 00:32:47,557 through the electrical wiring of its nerve cells. 621 00:32:47,559 --> 00:32:48,909 [ Electricity crackling ] 622 00:32:48,911 --> 00:32:51,862 But convincing a horse to make these complex movements 623 00:32:51,864 --> 00:32:54,965 only requires a simple input. 624 00:32:54,967 --> 00:32:58,118 So when the rider wants the horse to go to left, 625 00:32:58,120 --> 00:33:00,453 she just pulls the reins to left... 626 00:33:00,455 --> 00:33:01,671 [ Nickers ] 627 00:33:01,673 --> 00:33:04,791 ...and the horse starts going in that direction. 628 00:33:04,793 --> 00:33:06,543 And then, she wants it to go right. 629 00:33:06,545 --> 00:33:07,794 She just pulls it to right, 630 00:33:07,796 --> 00:33:09,796 and we see that horse is going on the right. 631 00:33:09,798 --> 00:33:11,298 [ Nickering ] 632 00:33:11,300 --> 00:33:13,300 And then she wants it to go forward. 633 00:33:13,302 --> 00:33:17,137 She just provides a gentle kick with her heels, 634 00:33:17,139 --> 00:33:19,356 and the horse knows that it needs to go forward, 635 00:33:19,358 --> 00:33:20,590 and it does it. 636 00:33:20,592 --> 00:33:23,092 [ Blusters ] 637 00:33:23,094 --> 00:33:26,696 Freeman: The horse obeys because of its training. 638 00:33:26,698 --> 00:33:28,431 But Alper thinks he can get 639 00:33:28,433 --> 00:33:30,483 the same results in other creatures 640 00:33:30,485 --> 00:33:33,653 without conditioning by replacing mechanical commands 641 00:33:33,655 --> 00:33:37,273 with electrical signals sent directly to the brain. 642 00:33:37,275 --> 00:33:39,826 I have a set of domino stones here 643 00:33:39,828 --> 00:33:43,279 representing a neural network like in any brain. 644 00:33:43,281 --> 00:33:46,583 A brain is a set of electrical relay networks. 645 00:33:46,585 --> 00:33:51,254 It is composed of excitable cells called neurons. 646 00:33:51,256 --> 00:33:54,424 Freeman: When neurons become electrically excited, 647 00:33:54,426 --> 00:33:57,126 they pass a signal on to their neighbors, 648 00:33:57,128 --> 00:33:59,563 which in turn pass the signal along. 649 00:33:59,565 --> 00:34:03,683 Alper only needs to stimulate one neuron, 650 00:34:03,685 --> 00:34:07,136 and the entire neural circuit will activate, 651 00:34:07,138 --> 00:34:11,491 resulting in a complex bodily action. 652 00:34:15,913 --> 00:34:18,782 It's a principle that should work in any brain, 653 00:34:18,784 --> 00:34:21,534 but Alper is starting with a simple mind -- 654 00:34:21,536 --> 00:34:24,371 the cockroach. 655 00:34:24,373 --> 00:34:27,657 Alper implanted electrodes into the sockets 656 00:34:27,659 --> 00:34:31,544 where a roach's antennae connect to its brain. 657 00:34:31,546 --> 00:34:33,129 [ Clicking ] 658 00:34:33,131 --> 00:34:35,932 When he sends an electronic pulse to the neurons inside, 659 00:34:35,934 --> 00:34:38,268 the roach becomes... 660 00:34:38,270 --> 00:34:42,338 a zombie. 661 00:34:42,340 --> 00:34:44,641 It goes wherever the electronic pulse 662 00:34:44,643 --> 00:34:50,647 tells it to go, and it even turns on a dime. 663 00:34:50,649 --> 00:34:54,017 So when we stimulate the right antenna of the insect, 664 00:34:54,019 --> 00:34:56,736 insect thinks there there's an obstacle in front of it, 665 00:34:56,738 --> 00:34:58,622 and it tries to make a left turn. 666 00:34:58,624 --> 00:35:01,291 And when we stimulate the left antenna, 667 00:35:01,293 --> 00:35:03,293 it tries to make a right turn. 668 00:35:08,582 --> 00:35:10,333 Freeman: Alper thinks his zombie bugs 669 00:35:10,335 --> 00:35:13,386 will one day save lives. 670 00:35:13,388 --> 00:35:17,373 He envisions cockroach cyborgs outfitted with cameras 671 00:35:17,375 --> 00:35:18,925 and G.P.S. chips 672 00:35:18,927 --> 00:35:23,763 so they can locate survivors under collapsed buildings. 673 00:35:23,765 --> 00:35:26,983 But his breakthrough could be the beginning of a world 674 00:35:26,985 --> 00:35:29,819 where no mind is safe. 675 00:35:29,821 --> 00:35:34,607 Theoretically, even a human could be zombified. 676 00:35:37,445 --> 00:35:39,112 We know how neurons work, 677 00:35:39,114 --> 00:35:41,731 and, uh, we can communicate with them. 678 00:35:41,733 --> 00:35:43,199 When we stimulate the insect, 679 00:35:43,201 --> 00:35:45,201 it is the same stimulation principle 680 00:35:45,203 --> 00:35:47,954 that is used in deep brain stimulation patients 681 00:35:47,956 --> 00:35:49,956 with Parkinson's disease. 682 00:35:49,958 --> 00:35:52,042 So these are all the same principles. 683 00:35:52,044 --> 00:35:56,046 It's relatively easy with cockroaches 684 00:35:56,048 --> 00:35:59,015 to make them follow our command signals. 685 00:35:59,017 --> 00:36:02,218 But with higher organisms, with vertebrates, 686 00:36:02,220 --> 00:36:05,772 it is much complicated, although it's not impossible. 687 00:36:05,774 --> 00:36:09,476 Freeman: Technology may soon exist that, in the wrong hands, 688 00:36:09,478 --> 00:36:12,812 could turn us into zombies. 689 00:36:12,814 --> 00:36:17,734 If our minds are taken over, will we even know it? 690 00:36:17,736 --> 00:36:21,654 A zombie apocalypse may already be happening today. 691 00:36:21,656 --> 00:36:25,158 In fact, this neuroscientist thinks 692 00:36:25,160 --> 00:36:27,610 we're already 98% zombie. 693 00:36:30,886 --> 00:36:32,153 In fiction, 694 00:36:32,155 --> 00:36:35,256 the nightmare of a zombie apocalypse 695 00:36:35,258 --> 00:36:39,177 is constantly taking on new forms, 696 00:36:39,179 --> 00:36:42,430 but they all have a common theme -- 697 00:36:42,432 --> 00:36:47,669 the infected don't even know they are zombies. 698 00:36:47,671 --> 00:36:52,156 If, right now, we were zombies in the midst of an apocalypse, 699 00:36:52,158 --> 00:36:54,409 would we even know it? 700 00:36:56,695 --> 00:36:59,647 [ Birds chirping ] 701 00:36:59,649 --> 00:37:01,499 Neuroscientist Scott Grafton 702 00:37:01,501 --> 00:37:03,985 believes that in sports like golf, 703 00:37:03,987 --> 00:37:08,006 it pays to be a zombie. 704 00:37:08,008 --> 00:37:09,290 I was watching this tournament 705 00:37:09,292 --> 00:37:12,010 where Fuzzy Zoeller was winning. 706 00:37:12,012 --> 00:37:13,094 [ Whack ] 707 00:37:13,096 --> 00:37:14,963 Announcer runs up to him and says, 708 00:37:14,965 --> 00:37:17,265 "Fuzzy, how did you do it? How did you win?" 709 00:37:17,267 --> 00:37:21,069 He says, "Well, I've been brain-dead all week." 710 00:37:21,071 --> 00:37:22,503 [ Whack ] 711 00:37:22,505 --> 00:37:27,341 Freeman: After enough practice, a good swing is automatic. 712 00:37:27,343 --> 00:37:31,362 In fact, nearly everything that our bodies do 713 00:37:31,364 --> 00:37:34,515 requires little, if any, thought. 714 00:37:34,517 --> 00:37:37,685 Almost all of our actions are actually unconscious. 715 00:37:37,687 --> 00:37:41,239 We can pretend we access our muscle. 716 00:37:41,241 --> 00:37:43,074 You know, when I hold a golf club, 717 00:37:43,076 --> 00:37:44,492 I can grip it, and then I can think, 718 00:37:44,494 --> 00:37:48,496 okay, flex this muscle, extend this muscle, 719 00:37:48,498 --> 00:37:52,867 turn my shoulders, turn my waist, so forth. 720 00:37:52,869 --> 00:37:58,806 But actually, I have very, very poor access to those muscles. 721 00:37:58,808 --> 00:38:03,311 It's much easier to visualize what you'd like to happen, 722 00:38:03,313 --> 00:38:06,064 and the swing just takes care of itself. 723 00:38:07,215 --> 00:38:09,150 [ Whack ] 724 00:38:09,152 --> 00:38:12,219 Freeman: Our brains are goal-oriented. 725 00:38:12,221 --> 00:38:14,221 We think of an end result, 726 00:38:14,223 --> 00:38:18,526 and our bodies mindlessly follow a program to achieve it. 727 00:38:18,528 --> 00:38:21,362 Freeman: For Scott, this is evidence 728 00:38:21,364 --> 00:38:24,916 that our willpower is not as strong as we think. 729 00:38:24,918 --> 00:38:29,337 On a good day, I think we're about, uh...97% zombie, 730 00:38:29,339 --> 00:38:35,126 and on a bad day, 98% zombie, and the rest of the 2 or 3% 731 00:38:35,128 --> 00:38:37,411 is us having actually willful control 732 00:38:37,413 --> 00:38:39,580 over our daily activities. 733 00:38:41,800 --> 00:38:43,417 Freeman: Scott is running an experiment 734 00:38:43,419 --> 00:38:49,107 to momentarily rob his subject, misty, of the other 2%. 735 00:38:50,726 --> 00:38:52,226 He uses a technique 736 00:38:52,228 --> 00:38:55,313 called transcranial magnetic stimulation, 737 00:38:55,315 --> 00:38:57,398 or T.M.S., to induce 738 00:38:57,400 --> 00:38:59,651 a harmless electrical current in her brain. 739 00:38:59,653 --> 00:39:01,069 [ Click ] Oh. 740 00:39:01,071 --> 00:39:04,706 T.M.S. is a method for 741 00:39:04,708 --> 00:39:08,493 very briefly turning off a small part of your brain, 742 00:39:08,495 --> 00:39:12,213 so it's a copper coil that goes against the skull, 743 00:39:12,215 --> 00:39:14,949 and you induce a current through that, 744 00:39:14,951 --> 00:39:16,334 and during that time, 745 00:39:16,336 --> 00:39:19,620 you essentially have a virtual lesion in your brain. 746 00:39:19,622 --> 00:39:20,622 [ Clicking ] 747 00:39:20,623 --> 00:39:22,456 Freeman: Scott calibrates the device 748 00:39:22,458 --> 00:39:26,427 by stimulating the neurons that control her right hand. 749 00:39:26,429 --> 00:39:31,966 He then moves the device to focus on her parietal cortex. 750 00:39:33,969 --> 00:39:36,821 This region of the brain is believed to be responsible 751 00:39:36,823 --> 00:39:41,075 for making sure that our actions match our intentions, 752 00:39:41,077 --> 00:39:45,079 like trying to touch an illuminated dot. 753 00:39:45,081 --> 00:39:47,749 In the first round of Scott's experiment, 754 00:39:47,751 --> 00:39:50,585 there is no T.M.S. pulse. 755 00:39:50,587 --> 00:39:52,453 As soon as their hand starts moving, 756 00:39:52,455 --> 00:39:56,708 we jump that second light to the right a few inches, 757 00:39:56,710 --> 00:40:01,929 and their hand quickly corrects for that jump, 758 00:40:01,931 --> 00:40:06,167 and it smoothly goes over and pursues that new location. 759 00:40:06,169 --> 00:40:07,969 Freeman: But in the second round, 760 00:40:07,971 --> 00:40:13,107 right as misty's finger moves, Scott zaps her parietal cortex. 761 00:40:13,109 --> 00:40:14,341 Oh. 762 00:40:14,343 --> 00:40:16,060 Freeman: She doesn't feel the pulse 763 00:40:16,062 --> 00:40:17,845 but loses the ability to consciously 764 00:40:17,847 --> 00:40:20,698 correct her action for a brief moment. 765 00:40:20,700 --> 00:40:22,483 They react, essentially, 766 00:40:22,485 --> 00:40:25,319 as a zombie and go to the original location, 767 00:40:25,321 --> 00:40:26,654 that second light, 768 00:40:26,656 --> 00:40:28,790 and they're unable to correct themselves on the fly. 769 00:40:28,792 --> 00:40:31,826 So when we turn off the parietal lobe, 770 00:40:31,828 --> 00:40:35,413 we're essentially making a person a full zombie 771 00:40:35,415 --> 00:40:37,832 for just a second or so. 772 00:40:37,834 --> 00:40:38,883 And during that time, 773 00:40:38,885 --> 00:40:40,034 they're just carrying out a movement 774 00:40:40,036 --> 00:40:41,969 that they no longer can control. 775 00:40:41,971 --> 00:40:45,590 Freeman: Scott believes we evolved to be 98% zombie 776 00:40:45,592 --> 00:40:48,843 so that the intellectual parts of our brains 777 00:40:48,845 --> 00:40:52,680 could be freed up from thinking about the menial tasks 778 00:40:52,682 --> 00:40:55,850 that take up most of our time. 779 00:40:55,852 --> 00:40:58,886 For all of its evolutionary advantages, 780 00:40:58,888 --> 00:41:03,024 the intelligent human brain may come with a cost. 781 00:41:03,026 --> 00:41:05,943 I think we're a hair's breadth away from a zombie apocalypse 782 00:41:05,945 --> 00:41:09,230 in the sense that most of what we do, 783 00:41:09,232 --> 00:41:10,865 we can accomplish without thinking about it. 784 00:41:10,867 --> 00:41:13,668 Just think about how many willful choices 785 00:41:13,670 --> 00:41:15,753 you've made in the last week. 786 00:41:15,755 --> 00:41:18,005 It's probably maybe one or two. 787 00:41:18,007 --> 00:41:21,709 Everything else you did was essentially automatic behavior. 788 00:41:21,711 --> 00:41:25,346 So now you think of something, it takes away that last 2%. 789 00:41:25,348 --> 00:41:29,217 You're already prepared to live as a zombie. 790 00:41:29,219 --> 00:41:32,053 Freeman: By the time we reach adulthood, 791 00:41:32,055 --> 00:41:34,972 most of our daily lives are spent engaging 792 00:41:34,974 --> 00:41:37,525 in activities that require little conscious thought. 793 00:41:37,527 --> 00:41:42,396 If we were to lose our ability to make conscious decisions, 794 00:41:42,398 --> 00:41:45,533 life just might continue as normal. 795 00:41:45,535 --> 00:41:48,486 Certainly, we wouldn't recognize it in ourselves, 796 00:41:48,488 --> 00:41:51,155 and the scary thing is whether you could recognize it 797 00:41:51,157 --> 00:41:52,907 in anyone else. 798 00:41:52,909 --> 00:41:55,409 If there was a zombie apocalypse, 799 00:41:55,411 --> 00:41:58,112 I don't think it would be like "World War Z." 800 00:41:58,114 --> 00:42:00,631 I think we would be plain old normal human beings, 801 00:42:00,633 --> 00:42:02,667 except we'd be a little bit different. 802 00:42:02,669 --> 00:42:05,286 We'd be more like "invasion of the body snatchers," 803 00:42:05,288 --> 00:42:09,857 where we're ourselves, but we're not ourselves anymore. 804 00:42:17,533 --> 00:42:21,686 We humans love our free will. 805 00:42:21,688 --> 00:42:23,938 As bizarre as it may seem, 806 00:42:23,940 --> 00:42:27,525 it is entirely possible that a microscopic parasite 807 00:42:27,527 --> 00:42:29,810 or technology run wild 808 00:42:29,812 --> 00:42:34,815 could take away the free will we cherish so dearly. 809 00:42:34,817 --> 00:42:37,168 All of this talk of zombie apocalypse 810 00:42:37,170 --> 00:42:40,454 raises one final question -- 811 00:42:40,456 --> 00:42:45,543 why do we enjoy scaring ourselves half to death? 812 00:42:45,545 --> 00:42:47,762 Maybe that's what we need to do 813 00:42:47,764 --> 00:42:50,965 in order to prepare for the worst. 814 00:42:50,967 --> 00:42:55,816 I'm not scared, because science is our best defense. 815 00:42:55,817 --> 00:43:01,817 == sync, corrected by elderman == @elder_man 64086

Can't find what you're looking for?
Get subtitles in any language from opensubtitles.com, and translate them here.