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Freeman:
The end of life.
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It's a reality that terrifies us
and motivates us.
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Now cutting-edge science embarks
on a bold mission
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to extend human life.
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[ Engine revs ]
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Some think the answer lies
in biology.
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Some believe
it might be in our brains.
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And others claim
that immortality would mean
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the end of humanity.
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Will death remain inevitable?
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Or can we live forever?
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[ Crying ]
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Freeman:
Space, time, life itself.
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The secrets of the cosmos
lie through the wormhole.
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? Through the Wormhole 2x08 ?
Can We Live Forever?
Original Air Date on July 27, 2011
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== sync, corrected by elderman ==
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The sands of time run swiftly,
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a reminder
that life is fleeting;
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death is a humbling reality.
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But what if life had no end?
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In just the past 200 years,
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the average life-span
has doubled
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from about 40
to almost 80 years.
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Breakthroughs
in biology and physics
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could soon bring immortality
within our grasp.
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For better or worse, many of you
watching me right now
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may live to see the day
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when aging and death itself
are relics of a distant past.
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I remember rummaging through
my grandmother's trunk once,
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happening upon objects that
had been stored away for years.
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Everything was
faded, curled, rusted.
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I couldn't help but wonder,
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when would
the same decay happen to me?
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Michio Kaku,
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a theoretical physicist
at City College of New York,
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is fascinated with
the big questions in science,
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like whether the laws of physics
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require that
all living things die.
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One of the iron laws of physics
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is the second law
of thermodynamics,
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which says
that everything rusts,
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everything decays, falls apart.
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We're all made out of atoms,
and these atoms, in turn,
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obey the second law
of thermodynamics.
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Freeman: Anything and everything
in the Universe
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has the tendency to go
from order to disorder.
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And once the damage is done,
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it's extremely difficult to
reverse things and un-mix them.
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It's a process known as entropy.
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If I mix coffee,
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I realize that when I put cream
into coffee, I increase entropy.
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I increase disorder.
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In fact, to see this milk jump
out and reform in this cup
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is such a preposterous event
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that you would
have to wait longer
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than the lifetime of
the Universe to see it happen.
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Freeman: The second law of thermodynamics
is an unremitting force.
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Nothing is immune
to the power of entropy,
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not even the cells in our body.
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Kaku:
And that's why we age.
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In fact, that's why we die.
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But it turns out that there is a
loophole to the law of entropy.
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There is a way to restore order
from disorder.
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Kaku: Imagine that each one
represents an atom.
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Now, if I apply the second law
of thermodynamics,
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it means that entropy increases.
It mixes. Chaos reigns.
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Watch this.
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Freeman: The candy on the tray starts off
organized and color-coded.
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But if the tray
begins to vibrate,
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the second law takes over.
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Kaku: Even though
this is entropy in action,
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I can reverse entropy by adding
energy from the outside.
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But the price is, I have to
constantly be on alert,
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constantly add
energy from the outside.
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I mean, this is hard work.
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Freeman:
With energy and concentration,
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Michio can step in
and stop the chaos.
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But reversing entropy
in a tray of vibrating candy
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is far less complicated than
reversing entropy in our bodies.
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Where would we even begin?
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[ Engine revving ]
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Valter Longo is searching
for the answer.
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He is a Professor of Gerontology
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at the University
of Southern California.
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He knows that many things
live fast and die young,
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and he believes the road
to reversing entropy in the body
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starts where things get
the hottest -- in the engine.
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Longo: In the engine,
the gasoline gets oxidized,
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and that's a combustion process,
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and this provides energy
to the car.
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But because of the combustion,
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the engine itself
can become damaged,
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and eventually, you
have to rebuild the engine.
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Freeman:
Every cell in our bodies
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have tiny engines
called mitochondria.
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Mitochondria are
double-membraned structures
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whose job is to provide energy.
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But when these powerhouses
wear down,
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our body begins
to decay and age.
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And so, you can imagine
in the cells, instead,
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you have hundreds
of these mitochondria,
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these little engines.
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And these hundreds of engines
provide the energy locally
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to every single cell
in our body.
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Freeman:
But Valter has found a way
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to reverse
this deterioration process
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and rejuvenate mitochondria
in one tiny organism.
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He has extended the life
of baker's yeast --
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the kind you use to make bread
and beer -- to 10 weeks.
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That's 10 times the yeast's
normal life-span of 6 days.
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It may not sound
like a long time,
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but it's equivalent
to 800 human years.
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The yeast's longevity occurred
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when two genes,
R.A.S.2 and S.C.H.9,
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were removed from its DNA.
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Longo: So these pathways
that we've identified in yeast,
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in addition to promoting aging,
they also promote DNA damage
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and the damage
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of a variety of different
systems within the cells.
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Freeman: Valter wondered if
this fountain of youth for yeast
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might apply
to more complex life-forms.
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And so he began looking
for the equivalent genes
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in a much larger organism --
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mice.
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When he knocked out
those two genes,
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these mice doubled
their life expectancy.
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Longo:
This is very encouraging
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because if you look
at the similarities
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between a mouse and a human,
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we are over 90% identical
in many ways.
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A mouse lives for 2 years,
and people live for 100 years.
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So, you can see,
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with just a small modification
of the genome,
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you can go
from 2 years to 100 years.
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There's no law of physics
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that prevents us from finding
the secret of longevity,
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the secret, perhaps,
even of immortality.
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If you take, for example, the
genome of millions of old people
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and the genome of millions
of young people --
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which we will do in the coming
years -- and subtract,
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you will then find the genes
where aging is concentrated.
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Already,
we've identified over 60 genes
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involved in the aging process.
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Longo:
Now, the question is,
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how do you reprogram a human
that lives 100 years
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to be now a 2,000-
or 3,000-year-old person?
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[ Engine revving ]
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Freeman: Valter's mission to
keep our engines running forever
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has just begun, and he's in it
for the long haul.
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Suppose we do find a way
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to keep our engines running
for hundreds of years or more.
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We would all be very old
for a very long time.
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But this scientist
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is digging for ways to keep us
not just eternally alive...
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But eternally young.
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Take our current life-span
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and stretch it 5
or even 10 times longer.
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The joys of our youth would
endure like an endless summer.
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But imagine suffering decade
after decade with fragile bones,
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failing eyesight,
and an ever-more-feeble mind.
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If we want to become immortal,
we can't just extend life.
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We need to discover how to keep
our bodies eternally youthful.
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Aubrey de Grey thinks of himself
as a modern-day Methuselah.
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He has dedicated his career
to fighting aging.
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Aubrey believes that
many people who are born today
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could live to be 1,000 years old
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and remain physically young
for most of that time.
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The key is a matter of good
biological housekeeping --
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taking the trash out
of ourselves.
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So, what happens, indeed,
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is that certain types
of material in the body
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just accumulate junk.
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Certain types of junk accumulate
inside cells and between cells
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and stuff that we would not
think of as junk, like DNA,
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accumulates randomness,
which is a type of junk.
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Freeman:
Cells have the important job
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of constantly breaking down
waste,
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and they're mostly pretty good
at it.
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But sometimes a cell
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comes across things
that are so weird...
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None of this degradation
machinery works on them.
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That's when the junk
gets re-routed
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to what's called the lysosome,
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a vessel that houses
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the most powerful degradation
machinery in the cell.
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And if the garbage
can't be broken down,
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it stays there forever.
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Aubrey believes that
the accumulation of garbage
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in the lysosomal storage unit
is what causes aging.
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And he wants to free our bodies
of these buildups.
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He realized the most logical way
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was to take a close look
at waste itself.
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And he wondered, "In nature,
what likes to eat junk?"
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Longo:
We're working on an idea
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that we might be able to find
other species,
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especially bacteria,
that are able to break down
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the substances that accumulate
in the human body.
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Freeman: Aubrey's hunt
for the fountain of youth
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led him to a final
resting place -- graveyards.
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Since graveyards are riddled
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with the waste
of decomposing bodies,
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he suspected
he might find microbes
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who live to feast on death.
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[De Grey] And if we can find the genes
and enzymes that they are using
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to actually perform
that function,
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then we might be able to put
those genes and enzymes
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into our own cells
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so that our own cells
can break stuff down
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that they could not
naturally break down.
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Freeman: The secret to longevity
might be 6 feet under.
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Aubrey and his team are still
digging for the right microbe
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that will work
in mammalian cells.
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And when they find it,
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he believes we will all live
like 25-year-olds forever.
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[De Grey] I think that we have
maybe a 50/50 chance
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in the next 25 years or so
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of developing what I think of
as the first generation
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of bona fide
rejuvenation biotechnology.
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In other words,
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technologies that are
sufficiently comprehensive
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that we can give them
to middle-aged people,
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people 60 or 70 or so,
and fix them up well enough
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that they don't become
biologically 60 or 70 again
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until 30 years later
or something like that.
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Freeman: Aubrey is looking for the magic
bullet that will fight aging,
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but synthetic biologist
Chris Voigt
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is looking to build
an entire army
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out of various parts
from all over nature.
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Voigt: All right.
Let's give this a shot.
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One of the things
we're often trying to do
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in synthetic biology
is create new functions
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out of parts that already exist
in nature for other reason
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so we're often having to go out
and grab those components
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from different organisms
and put them together.
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Freeman: Chris searches
for microorganisms
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throughout biology
to find the right parts.
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And they end up at his lab
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at the University of California,
San Francisco,
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where biology meets mechanics.
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Voigt: When you look
at being able to fight disease,
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whether it's identifying
malignant cells
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and killing them,
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we're trying to go through the
garbage of all the functions
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that are out
in the natural world
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and identify those
that are useful to us
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in trying to be able to identify
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a correct disease state
in the body.
248
00:14:03,257 --> 00:14:07,092
Freeman: To build a bio robot that
can detect its surroundings,
249
00:14:07,094 --> 00:14:11,063
Chris and his team needed to
find an organism with a sensor.
250
00:14:11,065 --> 00:14:15,300
And they found it...
In pond scum...
251
00:14:15,302 --> 00:14:20,272
Where they discovered that algae
are equipped with light sensors.
252
00:14:20,274 --> 00:14:23,508
Voigt: We took a bacterium that
normally lives in your gut --
253
00:14:23,510 --> 00:14:26,111
so it's not used
to the Sun shining --
254
00:14:26,113 --> 00:14:29,147
and we put in a light sensor
out of an algae.
255
00:14:29,149 --> 00:14:32,951
Freeman: Inside Chris'
bacterial darkroom,
256
00:14:32,953 --> 00:14:35,087
colonies of bacteria
257
00:14:35,089 --> 00:14:36,888
that are now implanted
with algae light sensors
258
00:14:36,890 --> 00:14:40,258
are able to take photographs
of slide-projected images.
259
00:14:42,495 --> 00:14:45,197
Freeman: It might look
like bacterial art,
260
00:14:45,199 --> 00:14:47,332
but this is the first big step
261
00:14:47,334 --> 00:14:50,636
toward creating programmable
biological robots
262
00:14:50,638 --> 00:14:53,305
that will keep our bodies
healthy forever.
263
00:14:53,307 --> 00:14:56,842
Voigt: There are bacteria
all throughout our bodies,
264
00:14:56,844 --> 00:14:59,945
and we can reprogram
those bacteria
265
00:14:59,947 --> 00:15:03,148
in order to be able to implement
therapeutic effects
266
00:15:03,150 --> 00:15:06,618
for just about any disease
that you can imagine.
267
00:15:06,620 --> 00:15:10,555
The possibilities are limitless.
268
00:15:10,557 --> 00:15:13,258
Freeman:
Chris' photographic bacteria
269
00:15:13,260 --> 00:15:15,494
are able to turn themselves
on and off
270
00:15:15,496 --> 00:15:16,962
like the flip of a switch.
271
00:15:16,964 --> 00:15:18,530
But the question is,
272
00:15:18,532 --> 00:15:23,969
can Chris figure out how to
program and control that switch?
273
00:15:23,971 --> 00:15:26,071
We'd like to see
the programming of cells
274
00:15:26,073 --> 00:15:28,006
be the same
as programming a computer
275
00:15:28,008 --> 00:15:29,541
or designing an electronic chip,
276
00:15:29,543 --> 00:15:32,210
where, as programmers,
we would write out
277
00:15:32,212 --> 00:15:35,380
the exact function
that we'd want the cells to do.
278
00:15:35,382 --> 00:15:38,283
And then that would be
automatically compiled
279
00:15:38,285 --> 00:15:39,584
into a DNA sequence
280
00:15:39,586 --> 00:15:41,687
in the same way
that a computer program
281
00:15:41,689 --> 00:15:45,123
gets compiled, ultimately,
into ones and zeroes.
282
00:15:45,125 --> 00:15:46,458
That's the dream.
283
00:15:46,460 --> 00:15:48,994
[ Gulp! ]
284
00:15:48,996 --> 00:15:52,097
Freeman: Bio robots may one day
roam our blood streams,
285
00:15:52,099 --> 00:15:56,635
police our organs, and respond
to our internal 911 calls,
286
00:15:56,637 --> 00:16:00,672
keeping us
free from the threat of disease.
287
00:16:02,341 --> 00:16:05,610
Chris Voigt's
and Aubrey de Grey's research
288
00:16:05,612 --> 00:16:07,846
to keep our bodies healthy
for eternity
289
00:16:07,848 --> 00:16:09,915
is still
in the beginning stages.
290
00:16:09,917 --> 00:16:13,051
But what does this mean
for us mere mortals
291
00:16:13,053 --> 00:16:15,620
who will never live
to see the day
292
00:16:15,622 --> 00:16:18,056
when immortality
is within reach?
293
00:16:18,058 --> 00:16:21,193
There is
one chilling possibility
294
00:16:21,195 --> 00:16:27,699
that will give us all a chance
to hang on, even after we die.
295
00:16:31,873 --> 00:16:34,675
We're all genetically programmed
296
00:16:34,677 --> 00:16:38,412
to lust for life
and to flee from death.
297
00:16:38,414 --> 00:16:43,284
Eventually, we will discover
the secret of immortality,
298
00:16:43,286 --> 00:16:45,586
but we're not there yet.
299
00:16:45,588 --> 00:16:50,691
To cheat death right now,
we need to put aging on ice
300
00:16:50,693 --> 00:16:55,129
and be ready to grasp
eternal life
301
00:16:55,131 --> 00:16:58,466
long after life abandons us.
302
00:17:01,636 --> 00:17:04,405
Greg Fahy is a cryobiologist.
303
00:17:04,407 --> 00:17:09,977
The goal of his team at biotech
outfit 21st Century Medicine
304
00:17:09,979 --> 00:17:13,147
is to freeze human organs
and tissues
305
00:17:13,149 --> 00:17:17,852
so that they can be revived,
undamaged, centuries from now.
306
00:17:19,454 --> 00:17:22,022
Fahy: Cryopreservation is the
preservation of living systems
307
00:17:22,024 --> 00:17:23,858
at very low temperatures.
308
00:17:23,860 --> 00:17:27,328
We usually are referring to
temperatures that are low enough
309
00:17:27,330 --> 00:17:30,598
that you can store the system
as long as you wish
310
00:17:30,600 --> 00:17:32,233
before you use it again.
311
00:17:32,235 --> 00:17:34,502
Cryopreservation is essential
312
00:17:34,504 --> 00:17:36,937
to get a cell or a tissue,
an organ,
313
00:17:36,939 --> 00:17:39,940
from one place in time
to another place in time
314
00:17:39,942 --> 00:17:43,844
without allowing that system
to change in the process.
315
00:17:43,846 --> 00:17:46,113
Freeman:
Scientists have been trying
316
00:17:46,115 --> 00:17:48,816
to preserve whole organs
for decades.
317
00:17:48,818 --> 00:17:52,653
But it's a lot harder than
throwing food in the freezer.
318
00:17:52,655 --> 00:17:58,526
When biological material
freezes, ice crystals form,
319
00:17:58,528 --> 00:18:02,129
which push the cells out
of their normal position.
320
00:18:02,131 --> 00:18:06,467
When you thaw the organ, it may
look okay from the outside,
321
00:18:06,469 --> 00:18:10,871
but on the inside,
it's damaged beyond repair.
322
00:18:12,941 --> 00:18:16,110
The biggest problem, we think,
is really mechanical.
323
00:18:16,112 --> 00:18:18,679
It's the formation of ice
between cells.
324
00:18:18,681 --> 00:18:21,849
If the cells are dislodged
from their normal locations,
325
00:18:21,851 --> 00:18:23,083
then you can destroy
326
00:18:23,085 --> 00:18:25,753
the function of that structure
as a whole
327
00:18:25,755 --> 00:18:27,421
even if the cells survive.
328
00:18:29,591 --> 00:18:32,626
Freeman: Greg and his team
decided to focus their efforts
329
00:18:32,628 --> 00:18:34,528
on preventing bodily fluids
from freezing
330
00:18:34,530 --> 00:18:36,630
and eventually
developed a way
331
00:18:36,632 --> 00:18:41,502
to turn those fluids into
a form of biological glass --
332
00:18:41,504 --> 00:18:45,472
a technique he calls
vitrification.
333
00:18:45,474 --> 00:18:48,709
Fahy: Vitrification
is the formation of a glass.
334
00:18:48,711 --> 00:18:52,112
So if you take water and you mix
it with various chemicals
335
00:18:52,114 --> 00:18:54,348
in high-enough concentrations
of chemical
336
00:18:54,350 --> 00:18:56,850
and then cool it down
to low temperatures,
337
00:18:56,852 --> 00:18:59,987
the system will never freeze
no matter how low you go.
338
00:18:59,989 --> 00:19:01,455
Freeman:
To test whether
339
00:19:01,457 --> 00:19:05,759
vitrification actually preserves
the function of whole organs,
340
00:19:05,761 --> 00:19:09,897
Greg's team vitrified
a rabbit kidney.
341
00:19:09,899 --> 00:19:13,233
Fahy: This is
the kidney profusion lab.
342
00:19:13,235 --> 00:19:15,402
What John is doing
in the background
343
00:19:15,404 --> 00:19:18,539
is delivering...through the
vascular system of the kidney
344
00:19:18,541 --> 00:19:20,908
so the kidney becomes
unfreezable.
345
00:19:20,910 --> 00:19:24,078
The kidney is sitting
in a special chamber.
346
00:19:24,080 --> 00:19:25,546
The chamber
is temperature-conditioned
347
00:19:25,548 --> 00:19:26,914
to minimize toxicity.
348
00:19:26,916 --> 00:19:28,749
And at the end of the process,
349
00:19:28,751 --> 00:19:30,851
the kidney's taken out
and is transplanted.
350
00:19:30,853 --> 00:19:33,454
Freeman: This kidney,
351
00:19:33,456 --> 00:19:38,559
even though it has been stored
at minus-22 degrees celsius,
352
00:19:38,561 --> 00:19:41,362
works just as well
as a normal kidney.
353
00:19:41,364 --> 00:19:42,529
It's proof
354
00:19:42,531 --> 00:19:46,000
that Greg's vitrification
technique actually works
355
00:19:46,002 --> 00:19:47,401
and might be the key
356
00:19:47,403 --> 00:19:52,539
to preserving human organs
far into the future.
357
00:19:52,541 --> 00:19:56,410
So if you cool to below that
glass-transition temperature,
358
00:19:56,412 --> 00:19:59,179
our calculations indicate
you can store a system
359
00:19:59,181 --> 00:20:00,948
for tens of thousands of years.
360
00:20:00,950 --> 00:20:05,486
Freeman: Imagine being able
to put your body on ice
361
00:20:05,488 --> 00:20:10,290
and then being revived
10,000 years from now.
362
00:20:10,292 --> 00:20:12,793
You could wake up
and find yourself
363
00:20:12,795 --> 00:20:17,631
in an age when science
has made immortality possible.
364
00:20:17,633 --> 00:20:20,000
Greg Fahy
may be just a few years
365
00:20:20,002 --> 00:20:24,605
from giving a few select people
a shot at eternal life.
366
00:20:24,607 --> 00:20:26,440
But that can only happen
367
00:20:26,442 --> 00:20:29,710
if cryopreservation works
on an entire human body,
368
00:20:29,712 --> 00:20:33,080
not just simple organs
like the kidney or the bladder,
369
00:20:33,082 --> 00:20:38,752
but on the most complex organ
of all -- the brain.
370
00:20:38,754 --> 00:20:41,288
Fahy: This is the brain-slice
vitrification lab.
371
00:20:41,290 --> 00:20:44,291
The setup shows
a hippocampal slice --
372
00:20:44,293 --> 00:20:47,728
the part of the brain that's associated
with learning and memory --
373
00:20:47,730 --> 00:20:50,597
in a little dish, essentially.
374
00:20:50,599 --> 00:20:53,600
On the right side, we have a
stimulating electrode coming in,
375
00:20:53,602 --> 00:20:54,902
piercing the slice.
376
00:20:54,904 --> 00:20:57,938
On the left side,
we have a recording electrode.
377
00:20:59,307 --> 00:21:03,077
Freeman: This brain slice
has been vitrified.
378
00:21:03,079 --> 00:21:05,045
If it's still functional,
379
00:21:05,047 --> 00:21:08,515
when a pulse of electricity
is fired into it,
380
00:21:08,517 --> 00:21:10,718
it should fire a signal back.
381
00:21:10,720 --> 00:21:14,488
To Greg and his team's surprise,
it does.
382
00:21:14,490 --> 00:21:19,259
Electrical activity actually
sparks up in this brain tissue.
383
00:21:19,261 --> 00:21:20,994
And the electrical response
384
00:21:20,996 --> 00:21:26,333
is every bit as strong as it was
in its original state --
385
00:21:26,335 --> 00:21:30,170
the recovery of the brain slice
complete.
386
00:21:30,172 --> 00:21:33,407
Preserving a slice of the brain
387
00:21:33,409 --> 00:21:38,178
is a crucial first step toward
preserving the whole thing.
388
00:21:38,180 --> 00:21:42,716
It's an ambitious project
that Greg is already working on.
389
00:21:42,718 --> 00:21:47,354
We have found that it's fairly
easy to vitrify the brain,
390
00:21:47,356 --> 00:21:51,158
that all of the structure
seems to be preserved.
391
00:21:51,160 --> 00:21:53,260
But I have to say that so far,
392
00:21:53,262 --> 00:21:55,929
our techniques
are not up to the level
393
00:21:55,931 --> 00:21:59,399
that we would like for that
kind of speculative idea.
394
00:21:59,401 --> 00:22:02,035
But I couldn't say
that you couldn't make up
395
00:22:02,037 --> 00:22:04,271
for whatever deficiencies
396
00:22:04,273 --> 00:22:07,141
that we have in our
preservation technique today
397
00:22:07,143 --> 00:22:09,810
using some
unknown future technology.
398
00:22:09,812 --> 00:22:12,412
I can't rule that out
as a possibility.
399
00:22:16,017 --> 00:22:22,055
One day, centuries after we say
goodbye to our loved ones,
400
00:22:22,057 --> 00:22:25,425
our frozen bodies
could be reanimated,
401
00:22:25,427 --> 00:22:28,462
and we'll walk the earth again.
402
00:22:28,464 --> 00:22:31,598
But there could be
a better route to immortality,
403
00:22:31,600 --> 00:22:33,267
one that would change
404
00:22:33,269 --> 00:22:36,937
the very nature
of what it means to be human.
405
00:22:39,624 --> 00:22:42,459
Imagine if no one ever died.
406
00:22:42,461 --> 00:22:44,728
Where would we all live?
407
00:22:44,730 --> 00:22:47,497
Our planet
is already crowded enough.
408
00:22:47,499 --> 00:22:50,434
But maybe there
is a way to live forever
409
00:22:50,436 --> 00:22:54,204
without all this excess baggage.
410
00:22:54,206 --> 00:22:57,808
Poets say the essence of us
is here,
411
00:22:57,810 --> 00:23:03,113
but I know what really makes me
me is all up here.
412
00:23:03,115 --> 00:23:06,483
So if I want to endure
for eternity,
413
00:23:06,485 --> 00:23:09,987
perhaps that's
all I need to hang on to.
414
00:23:09,989 --> 00:23:14,324
What if we could find a way
to upload our brains,
415
00:23:14,326 --> 00:23:17,928
to digitize
the very essence of ourselves?
416
00:23:17,930 --> 00:23:22,566
Our minds could go on living
long after our flesh has died.
417
00:23:22,568 --> 00:23:24,101
But to make that happen,
418
00:23:24,103 --> 00:23:27,037
we need to understand
the brain's architecture
419
00:23:27,039 --> 00:23:31,108
and figure out
what truly makes us who we are.
420
00:23:33,311 --> 00:23:38,482
Olaf Sporns is a neuroscientist
at Indiana University.
421
00:23:38,484 --> 00:23:43,553
He is attempting to unscramble
the brain's tangled web.
422
00:23:43,555 --> 00:23:45,188
Sporns:
The brain is like a big city.
423
00:23:45,190 --> 00:23:48,125
Cities are examples
of complex systems --
424
00:23:48,127 --> 00:23:50,460
thousands of inhabitants
and their social interactions,
425
00:23:50,462 --> 00:23:51,628
their flow of materials.
426
00:23:51,630 --> 00:23:54,931
The brain is like that --
millions of neurons,
427
00:23:54,933 --> 00:23:57,401
interactions
between these neurons.
428
00:23:57,403 --> 00:24:00,704
In a sense, your brain
is like a city of the mind.
429
00:24:00,706 --> 00:24:02,773
Freeman:
The human brain
430
00:24:02,775 --> 00:24:06,310
is one of the most complex
systems in the Universe.
431
00:24:06,312 --> 00:24:10,547
If you stretched out
all of its electrical wiring,
432
00:24:10,549 --> 00:24:13,984
it would extend
from the Earth to the Moon.
433
00:24:13,986 --> 00:24:17,487
Figuring out how we get
from cells and wires
434
00:24:17,489 --> 00:24:19,990
to thoughts and memories
435
00:24:19,992 --> 00:24:24,494
is one of the greatest
challenges known to science.
436
00:24:24,496 --> 00:24:26,797
Even though we've been studying
the human brain,
437
00:24:26,799 --> 00:24:28,699
really, for decades,
perhaps centuries,
438
00:24:28,701 --> 00:24:31,368
we still don't have a complete
map of how it's connected.
439
00:24:31,370 --> 00:24:34,404
Freeman: But Olaf
is taking on this challenge.
440
00:24:34,406 --> 00:24:39,209
His goal is to chart every
single neuron and synapse
441
00:24:39,211 --> 00:24:43,447
and create a complete map of the
brain, called the connectome.
442
00:24:43,449 --> 00:24:45,716
Sporns: It's a comprehensive set
of connections
443
00:24:45,718 --> 00:24:47,651
that will allow us
for the first time
444
00:24:47,653 --> 00:24:49,052
to understand in more detail
445
00:24:49,054 --> 00:24:51,388
how brain regions are connected
to each other.
446
00:24:51,390 --> 00:24:53,924
Freeman:
Olaf is creating the connectome
447
00:24:53,926 --> 00:24:58,028
using a leading-edge technique
called diffusion imaging.
448
00:24:58,030 --> 00:25:00,864
It reveals the brain's
long-distance connections
449
00:25:00,866 --> 00:25:04,067
by tracking water molecules
along the neural highways.
450
00:25:04,069 --> 00:25:07,771
And what emerges
is a detailed map
451
00:25:07,773 --> 00:25:11,208
of the central core
of brain-cell connections.
452
00:25:11,210 --> 00:25:16,346
Olaf thinks this is the area
where our personality resides.
453
00:25:16,348 --> 00:25:18,548
Sporns: As we've been
discovering recently,
454
00:25:18,550 --> 00:25:21,051
some brain regions
are more connected than others.
455
00:25:21,053 --> 00:25:23,053
Some are more essential,
perhaps,
456
00:25:23,055 --> 00:25:25,021
for the functioning of the brain
as a whole.
457
00:25:25,023 --> 00:25:28,325
Those regions, we call hubs.
458
00:25:28,327 --> 00:25:30,026
Freeman:
If the brain is like a city...
459
00:25:30,028 --> 00:25:31,128
[ Tires screech ]
460
00:25:31,130 --> 00:25:33,397
...Hubs are like
major intersections
461
00:25:33,399 --> 00:25:36,099
where a constant flow of traffic
passes through,
462
00:25:36,101 --> 00:25:38,568
getting people
from one place to another.
463
00:25:38,570 --> 00:25:39,970
[ Bell clangs ]
464
00:25:39,972 --> 00:25:42,739
These intersections
are so essential --
465
00:25:42,741 --> 00:25:47,177
if they become disrupted in any
way, the whole city shuts down.
466
00:25:47,179 --> 00:25:48,678
[ Sloop! ]
467
00:25:48,680 --> 00:25:53,016
By their nature, hubs are focal
points of information traffic.
468
00:25:53,018 --> 00:25:55,452
Information converges
on these regions,
469
00:25:55,454 --> 00:25:58,054
and it is that ebb and flow
of information
470
00:25:58,056 --> 00:26:00,590
and the magnitude
of the information flow
471
00:26:00,592 --> 00:26:02,492
that really sets
these hubs apart
472
00:26:02,494 --> 00:26:04,327
from other regions
of the brain.
473
00:26:04,329 --> 00:26:06,396
Freeman:
Olaf is getting closer
474
00:26:06,398 --> 00:26:09,399
to figuring out
where consciousness resides.
475
00:26:09,401 --> 00:26:12,302
Searching for the origins
of consciousness
476
00:26:12,304 --> 00:26:15,005
is the holy grail
of neuroscience.
477
00:26:15,007 --> 00:26:18,809
Only when this mystery is solved
can we replicate the human brain
478
00:26:18,811 --> 00:26:21,611
and take consciousness
from a person
479
00:26:21,613 --> 00:26:26,883
and transfer it to a machine
as a way to live for eternity.
480
00:26:26,885 --> 00:26:31,087
And Olaf believes
he has discovered a hub
481
00:26:31,089 --> 00:26:36,159
that might solve this mystery --
the medial parietal cortex.
482
00:26:36,161 --> 00:26:39,863
It's located between
the brain's two hemispheres.
483
00:26:39,865 --> 00:26:45,368
Olaf suspects it might house
the essence of who we are.
484
00:26:45,370 --> 00:26:48,538
Sporns: A lot of wires from the
brain converge on that region.
485
00:26:48,540 --> 00:26:50,207
There are many lines of evidence
486
00:26:50,209 --> 00:26:52,375
that point
to that part of the brain
487
00:26:52,377 --> 00:26:54,578
being really central
and really important --
488
00:26:54,580 --> 00:26:57,147
perhaps even for awareness
and consciousness.
489
00:26:58,783 --> 00:27:00,050
Freeman: Olaf believes
490
00:27:00,052 --> 00:27:03,987
he may have solved
the secrets of consciousness,
491
00:27:03,989 --> 00:27:08,124
but there is much more work to
be done before he can be sure.
492
00:27:08,126 --> 00:27:11,495
Sporns: I think we're getting closer
to answering this question.
493
00:27:11,497 --> 00:27:14,898
And as we identify which parts
of the brain are critical
494
00:27:14,900 --> 00:27:17,901
in bringing about
that particular functionality,
495
00:27:17,903 --> 00:27:20,270
that gets us closer
to answering the question,
496
00:27:20,272 --> 00:27:21,605
"What is consciousness?"
497
00:27:21,607 --> 00:27:24,307
And also "Where are the critical
components of the brain
498
00:27:24,309 --> 00:27:25,876
that contribute to it?"
499
00:27:25,878 --> 00:27:27,077
[ Electricity crackling ]
500
00:27:27,079 --> 00:27:29,713
Freeman: Neuroscience
has taken enormous steps
501
00:27:29,715 --> 00:27:31,147
towards mapping the brain
502
00:27:31,149 --> 00:27:33,517
and solving
the riddle of consciousness.
503
00:27:33,519 --> 00:27:36,186
But will we ever be able
to capture
504
00:27:36,188 --> 00:27:39,589
the trillions of synapses,
billions of neurons,
505
00:27:39,591 --> 00:27:43,827
and download ourselves
onto a machine?
506
00:27:43,829 --> 00:27:46,730
Just imagine all the things
that happen in the real world --
507
00:27:46,732 --> 00:27:48,665
the conversation
we are having now,
508
00:27:48,667 --> 00:27:50,867
me producing speech sounds
and gestures,
509
00:27:50,869 --> 00:27:53,904
our brain's interacting
in this embodied manner.
510
00:27:53,906 --> 00:27:56,273
That could not happen
in a computer,
511
00:27:56,275 --> 00:27:57,407
and yet, it is somehow
512
00:27:57,409 --> 00:27:59,409
the essence
of what life is all about.
513
00:27:59,411 --> 00:28:00,810
So I'm skeptical about that.
514
00:28:02,547 --> 00:28:06,850
Freeman: The brain might be
far too complex to immortalize,
515
00:28:06,852 --> 00:28:11,555
but maybe there's a simpler path
to eternal life --
516
00:28:11,557 --> 00:28:13,023
not for you...
517
00:28:13,025 --> 00:28:18,028
But for immortal beings
that we create from scratch.
518
00:28:21,245 --> 00:28:22,479
Life on this planet
519
00:28:22,481 --> 00:28:25,682
has had 4 billion years
to evolve.
520
00:28:25,684 --> 00:28:30,120
We are the latest
in a long line of species.
521
00:28:30,122 --> 00:28:32,522
We hope we're the last.
522
00:28:32,524 --> 00:28:37,694
But our quest for immortality
could end in disaster
523
00:28:37,696 --> 00:28:42,999
because the first eternal beings
may not be human.
524
00:28:43,001 --> 00:28:48,305
And they might
just make us extinct.
525
00:28:51,242 --> 00:28:55,512
Complex life began
from a few simple laws.
526
00:28:55,514 --> 00:29:00,217
The same might be true
for artificial life.
527
00:29:00,219 --> 00:29:03,320
If humans discover those laws,
there is a chance
528
00:29:03,322 --> 00:29:07,257
we could create living things
that live forever.
529
00:29:07,259 --> 00:29:12,262
Oxford Physicist Vlatko Vedral
is trying to understand
530
00:29:12,264 --> 00:29:15,765
how intelligence might emerge
from a system
531
00:29:15,767 --> 00:29:19,503
that operates on just
a few basic ground rules.
532
00:29:19,505 --> 00:29:21,638
Vedral:
So, this is chess.
533
00:29:21,640 --> 00:29:23,440
It's a very complex game,
534
00:29:23,442 --> 00:29:27,477
and yet it's governed
by a few very simple rules.
535
00:29:27,479 --> 00:29:31,114
You really have only 16 pieces
on each side,
536
00:29:31,116 --> 00:29:33,583
and each piece
can do one of two things.
537
00:29:33,585 --> 00:29:36,186
And you can say the same thing
about life.
538
00:29:36,188 --> 00:29:37,787
Even though you are talking
539
00:29:37,789 --> 00:29:40,357
about one or two
very simple rules,
540
00:29:40,359 --> 00:29:41,558
you still get this multitude
541
00:29:41,560 --> 00:29:44,294
of different possible behaviors
in the Universe.
542
00:29:46,531 --> 00:29:50,534
Freeman: In 1970, a
mathematician named John Conway
543
00:29:50,536 --> 00:29:52,369
ran with this idea
544
00:29:52,371 --> 00:29:55,205
and attempted to create
artificial life-forms
545
00:29:55,207 --> 00:29:58,575
spontaneously
using a computer program.
546
00:29:58,577 --> 00:30:01,011
He called it "The game of life."
547
00:30:01,013 --> 00:30:04,848
The game simulates
the growth of artificial life,
548
00:30:04,850 --> 00:30:06,716
using a two-dimensional grid
549
00:30:06,718 --> 00:30:09,920
and simple cells
that are either dead or alive.
550
00:30:09,922 --> 00:30:15,191
Whether the cells live or die is
governed by a few basic rules.
551
00:30:15,193 --> 00:30:20,797
So, we have here in front of us
a large cell block,
552
00:30:20,799 --> 00:30:24,467
and we can see this
one central cell, which is on.
553
00:30:24,469 --> 00:30:29,906
And we can see that it has
only one neighbor to its left.
554
00:30:29,908 --> 00:30:33,376
The cell just switches off,
which means that it dies.
555
00:30:33,378 --> 00:30:35,045
And it dies of loneliness
556
00:30:35,047 --> 00:30:37,414
because it has
too few neighbors.
557
00:30:37,416 --> 00:30:40,850
Well, now we've got
a central cell, which is on,
558
00:30:40,852 --> 00:30:42,719
but it has five neighbors.
559
00:30:42,721 --> 00:30:45,722
It dies because
of overcrowding, overpopulation.
560
00:30:45,724 --> 00:30:47,390
It doesn't like it, either.
561
00:30:47,392 --> 00:30:52,329
In the third example, a cell
with only two neighbors --
562
00:30:52,331 --> 00:30:54,297
the cell just keeps on living.
563
00:30:54,299 --> 00:30:57,267
It can even move around
in this environment,
564
00:30:57,269 --> 00:30:58,735
and it can reproduce.
565
00:30:58,737 --> 00:31:02,238
So this is a good example where
the population is just right
566
00:31:02,240 --> 00:31:04,808
for the cell to keep on living.
567
00:31:04,810 --> 00:31:08,144
Freeman: Given enough time,
increasingly complex patterns
568
00:31:08,146 --> 00:31:11,014
emerge
from this simple set of rules.
569
00:31:11,016 --> 00:31:15,418
Some even take on the appearance
of living organisms.
570
00:31:15,420 --> 00:31:19,990
Vedral: John Conway tried to make
the same point regarding life --
571
00:31:19,992 --> 00:31:22,359
that it looks very complicated
to us.
572
00:31:22,361 --> 00:31:24,661
And, indeed,
it looks like a miracle
573
00:31:24,663 --> 00:31:26,396
that there is life around us,
574
00:31:26,398 --> 00:31:28,632
but, in fact,
he constructed a game
575
00:31:28,634 --> 00:31:32,535
which consists of two or three,
again, very simple rules,
576
00:31:32,537 --> 00:31:35,772
and it gives rise to some
very complicated patterns.
577
00:31:35,774 --> 00:31:38,775
Freeman: How complex
do these patterns need to be
578
00:31:38,777 --> 00:31:43,813
before they become something
alive, intelligent, or immortal?
579
00:31:43,815 --> 00:31:47,617
Vlatko thinks the human brain
is a good yardstick
580
00:31:47,619 --> 00:31:50,854
and has calculated
its processing power.
581
00:31:50,856 --> 00:31:53,990
Vedral: The brain is currently
still much more powerful
582
00:31:53,992 --> 00:31:55,625
than the existing computers.
583
00:31:55,627 --> 00:31:58,928
So the existing computers
can do something like, you know,
584
00:31:58,930 --> 00:32:01,297
10 to the power of 12 beats
per second,
585
00:32:01,299 --> 00:32:03,733
whereas our brain
is still probably something
586
00:32:03,735 --> 00:32:06,136
like a million times
faster than that.
587
00:32:06,138 --> 00:32:08,271
So you need 1 million laptops
588
00:32:08,273 --> 00:32:11,508
to simulate
just a single human brain.
589
00:32:11,510 --> 00:32:14,844
Freeman: Today's computers
are nowhere near powerful enough
590
00:32:14,846 --> 00:32:16,546
to house
artificial intelligent life.
591
00:32:16,548 --> 00:32:19,149
Vlatko believes the answer
might be to use
592
00:32:19,151 --> 00:32:21,317
a completely different type
of computer --
593
00:32:21,319 --> 00:32:23,853
the quantum computer.
594
00:32:23,855 --> 00:32:25,422
Quantum computer
595
00:32:25,424 --> 00:32:29,125
is basically the future
technology of computation.
596
00:32:29,127 --> 00:32:32,662
It's a computer that's so fast,
in principle,
597
00:32:32,664 --> 00:32:36,166
that no current computer
can compete with it.
598
00:32:36,168 --> 00:32:38,635
Freeman:
In place of transistors,
599
00:32:38,637 --> 00:32:41,971
quantum devices compute
with individual atoms.
600
00:32:41,973 --> 00:32:45,375
And instead of sorting piles
of ones and zeroes
601
00:32:45,377 --> 00:32:47,277
to give yes-and-no answers,
602
00:32:47,279 --> 00:32:49,345
the atoms in quantum computers
603
00:32:49,347 --> 00:32:52,682
can be ones, zeroes,
and everything in between,
604
00:32:52,684 --> 00:32:56,886
existing
as a computational maybe.
605
00:32:56,888 --> 00:32:59,355
The quantum computer
really utilizes
606
00:32:59,357 --> 00:33:02,459
the quantum effect
known as the super position,
607
00:33:02,461 --> 00:33:03,693
which means being
608
00:33:03,695 --> 00:33:06,496
in many different states
at the same time.
609
00:33:06,498 --> 00:33:11,367
Freeman: This ability to handle
a multiplicity of states
610
00:33:11,369 --> 00:33:13,369
allows quantum computers
611
00:33:13,371 --> 00:33:16,039
to juggle many overlapping
problems at once,
612
00:33:16,041 --> 00:33:18,908
just the way our brains do.
613
00:33:20,211 --> 00:33:23,713
The analogy would be
if I played a chord for you...
614
00:33:23,715 --> 00:33:26,416
[ Chord plays ]
615
00:33:26,418 --> 00:33:27,917
...Then you would get
616
00:33:27,919 --> 00:33:31,521
many different modes
played at the same time,
617
00:33:31,523 --> 00:33:33,089
which would really correspond
618
00:33:33,091 --> 00:33:36,126
to many states
being out there simultaneously
619
00:33:36,128 --> 00:33:37,494
all in one location
620
00:33:37,496 --> 00:33:39,629
and the full power
of quantum computation,
621
00:33:39,631 --> 00:33:41,798
which is actually unlimited,
in some sense,
622
00:33:41,800 --> 00:33:42,999
if you start to store
623
00:33:43,001 --> 00:33:45,235
all the values in between
the zero and the one.
624
00:33:45,237 --> 00:33:50,406
So then you really reach a stage
where you can encode much more
625
00:33:50,408 --> 00:33:53,977
and the capacity really has
no limits in that sense.
626
00:33:53,979 --> 00:33:55,445
Freeman:
There might be a time
627
00:33:55,447 --> 00:33:58,848
when humans forego
their own dream of immortality
628
00:33:58,850 --> 00:34:02,619
and create
eternal artificial life.
629
00:34:02,621 --> 00:34:04,487
And if they do,
630
00:34:04,489 --> 00:34:07,524
how would artificial and
biological life get along?
631
00:34:07,526 --> 00:34:10,660
Some people think that very soon
632
00:34:10,662 --> 00:34:14,164
computers will be smarter than
us and they'll put us in zoos.
633
00:34:14,166 --> 00:34:17,834
They'll put us behind bars
and throw peanuts at us
634
00:34:17,836 --> 00:34:19,969
and make us dance behind bars
635
00:34:19,971 --> 00:34:23,706
just like we make bears dance
in zoos today.
636
00:34:23,708 --> 00:34:25,909
But at the present time,
637
00:34:25,911 --> 00:34:29,212
none of these technologies
are ready for prime time.
638
00:34:29,214 --> 00:34:32,749
We simply don't have
an operating quantum computer.
639
00:34:32,751 --> 00:34:37,587
The world's record for a quantum
computer calculation is --
640
00:34:37,589 --> 00:34:38,721
ta-da --
641
00:34:38,723 --> 00:34:42,258
3 times 5 is 15.
642
00:34:42,260 --> 00:34:45,195
We sometimes forget
that computers and robots,
643
00:34:45,197 --> 00:34:49,332
no matter how advanced they are,
are adding machines.
644
00:34:49,334 --> 00:34:50,533
But that doesn't mean
645
00:34:50,535 --> 00:34:53,937
they have creativity,
imagination, initiative.
646
00:34:53,939 --> 00:34:56,306
It doesn't mean
they understand human values.
647
00:34:56,308 --> 00:34:59,442
It doesn't mean that they can
make leaps of logic like we can.
648
00:34:59,444 --> 00:35:02,078
In other words,
we have a long ways to go
649
00:35:02,080 --> 00:35:04,380
before we can begin
to approximate
650
00:35:04,382 --> 00:35:08,017
the real thinking process that
takes place in a human being.
651
00:35:08,019 --> 00:35:12,388
Freeman: We're safe from becoming slaves
to quantum intelligence...
652
00:35:12,390 --> 00:35:13,923
For the time being.
653
00:35:13,925 --> 00:35:18,127
But this physicist envisions
a different fate for mankind,
654
00:35:18,129 --> 00:35:22,565
one where the lines between
artificial and biological life
655
00:35:22,567 --> 00:35:23,833
will blur
656
00:35:23,835 --> 00:35:27,403
and immortality
will become reality,
657
00:35:27,405 --> 00:35:29,272
not just for the living...
658
00:35:29,274 --> 00:35:32,775
But also for the dead.
659
00:35:36,801 --> 00:35:38,768
We're taught to think
of science and religion
660
00:35:38,770 --> 00:35:40,437
as separate truths.
661
00:35:40,439 --> 00:35:43,673
Albert Einstein
didn't believe that.
662
00:35:43,675 --> 00:35:47,577
He said, "Science
without religion is lame.
663
00:35:47,579 --> 00:35:50,847
Religion without science
is blind."
664
00:35:50,849 --> 00:35:54,150
The secret
to achieving immortality
665
00:35:54,152 --> 00:35:58,121
could require the fusion
of humanity and God
666
00:35:58,123 --> 00:36:01,691
into an everlasting
cosmic computer.
667
00:36:01,693 --> 00:36:05,695
Few people think further into
the future than Frank Tipler,
668
00:36:05,697 --> 00:36:07,297
a mathematical physicist
669
00:36:07,299 --> 00:36:10,333
at Tulane university
in New Orleans.
670
00:36:10,335 --> 00:36:13,803
Frank predicts that,
at some point in our evolution,
671
00:36:13,805 --> 00:36:16,506
something truly remarkable
will happen.
672
00:36:16,508 --> 00:36:22,779
Humanity, the Universe,
and God will unite --
673
00:36:22,781 --> 00:36:27,183
a moment he calls
the omega point.
674
00:36:27,185 --> 00:36:31,955
Tipler: The omega point
is the very end of the Universe.
675
00:36:31,957 --> 00:36:36,025
In the process, mankind, or,
more precisely, our descendants,
676
00:36:36,027 --> 00:36:38,328
will expand out from this planet
677
00:36:38,330 --> 00:36:43,032
and ultimately engulf
the entire Universe.
678
00:36:43,034 --> 00:36:47,303
As our descendants are moving
into this final state,
679
00:36:47,305 --> 00:36:51,574
their knowledge and their power
and their computer capacity
680
00:36:51,576 --> 00:36:55,245
is increasing without limit.
681
00:36:55,247 --> 00:36:56,646
The laws of physics
682
00:36:56,648 --> 00:36:59,682
allow a process
that will convert matter --
683
00:36:59,684 --> 00:37:05,555
stones of this graveyard, for
instance -- into pure energy.
684
00:37:05,557 --> 00:37:08,324
That will be
the ultimate energy source,
685
00:37:08,326 --> 00:37:11,861
which our descendants will use
and gain control of it.
686
00:37:11,863 --> 00:37:14,964
Freeman: At the omega point,
Frank argues,
687
00:37:14,966 --> 00:37:19,102
our descendants will be capable
of doing anything.
688
00:37:19,104 --> 00:37:23,740
And with infinite power, they
will create a cosmic computer
689
00:37:23,742 --> 00:37:25,642
and reconstruct in a simulation
690
00:37:25,644 --> 00:37:27,877
everything
that has ever happened
691
00:37:27,879 --> 00:37:30,113
in the history of the Universe.
692
00:37:30,115 --> 00:37:33,950
Now, from the point of view
of the beings in the far future,
693
00:37:33,952 --> 00:37:37,987
we will be their alternate
ancestor as rational beings
694
00:37:37,989 --> 00:37:42,025
so they will be interested in
what we were, what we were like.
695
00:37:42,027 --> 00:37:45,495
As a consequence,
every man, woman, and child
696
00:37:45,497 --> 00:37:47,697
will be brought back
into existence.
697
00:37:47,699 --> 00:37:50,900
It will be just like you are
brought back with your body
698
00:37:50,902 --> 00:37:54,871
into a reconstructed earth
just like we now live on.
699
00:37:54,873 --> 00:37:58,308
It will be different
in one crucial respect.
700
00:37:58,310 --> 00:37:59,742
We will be resurrected,
701
00:37:59,744 --> 00:38:02,745
but we will never have to go
through death again.
702
00:38:02,747 --> 00:38:05,348
Freeman:
Frank claims the laws of physics
703
00:38:05,350 --> 00:38:08,651
not only permit
this type of immortality --
704
00:38:08,653 --> 00:38:11,421
they actually require it
to happen.
705
00:38:11,423 --> 00:38:14,023
Tipler: Second law
of thermodynamics says
706
00:38:14,025 --> 00:38:18,761
the complexity of the Universe
at the most fundamental level
707
00:38:18,763 --> 00:38:21,030
is increasing without limit.
708
00:38:21,032 --> 00:38:22,932
I conclude
709
00:38:22,934 --> 00:38:25,869
that the validity of the second
law of thermodynamics,
710
00:38:25,871 --> 00:38:28,471
throughout all of time,
711
00:38:28,473 --> 00:38:30,874
actually requires life
712
00:38:30,876 --> 00:38:35,311
to come into existence
to gain control of the Universe.
713
00:38:35,313 --> 00:38:39,015
Freeman: Whether immortality
comes in billions of years
714
00:38:39,017 --> 00:38:41,517
or whether it comes
this century,
715
00:38:41,519 --> 00:38:46,022
the conquest of death will
transform our civilization --
716
00:38:46,024 --> 00:38:50,693
the way we live, the way
we work, the way we love.
717
00:38:50,695 --> 00:38:53,997
Maybe the question is not
"Can we live forever?"
718
00:38:53,999 --> 00:38:56,266
But "Should we?"
719
00:38:59,937 --> 00:39:01,537
Alexander Rose
720
00:39:01,539 --> 00:39:04,974
is the executive director
of the Long Now Foundation,
721
00:39:04,976 --> 00:39:07,844
an organization whose main focus
722
00:39:07,846 --> 00:39:11,948
is the building
of an unusual timepiece.
723
00:39:11,950 --> 00:39:16,419
It's called
the clock of the long now,
724
00:39:16,421 --> 00:39:21,524
and it's designed to tick
for 10,000 years.
725
00:39:21,526 --> 00:39:24,494
Rose:
We built the 10,000-year clock
726
00:39:24,496 --> 00:39:27,597
to give people
a different perspective
727
00:39:27,599 --> 00:39:29,499
of the really long term.
728
00:39:29,501 --> 00:39:31,901
If you believe that
medical science or other things
729
00:39:31,903 --> 00:39:33,803
are going to increase
human longevity,
730
00:39:33,805 --> 00:39:36,839
then the way that you
would approach the world
731
00:39:36,841 --> 00:39:38,608
would be
very, very differently --
732
00:39:38,610 --> 00:39:41,477
just the same way that if we're
designing a 10,000-year clock
733
00:39:41,479 --> 00:39:44,681
instead of a clock that just
has to last for 10 years,
734
00:39:44,683 --> 00:39:47,750
we have approached this
design problem very differently.
735
00:39:47,752 --> 00:39:50,887
And we have to be responsible
over those next 10,000 years
736
00:39:50,889 --> 00:39:51,921
for our clock.
737
00:39:51,923 --> 00:39:54,090
Freeman:
10,000 years in the past,
738
00:39:54,092 --> 00:39:57,193
we were still living
in the Stone Age.
739
00:39:57,195 --> 00:39:59,262
Flash forward the same period,
740
00:39:59,264 --> 00:40:01,898
and our civilization
and technology
741
00:40:01,900 --> 00:40:04,701
will be unrecognizable.
742
00:40:04,703 --> 00:40:07,103
We realize in designing
a 10,000-year clock
743
00:40:07,105 --> 00:40:10,974
that the most durable design
is likely the simplest.
744
00:40:10,976 --> 00:40:15,211
Freeman: The clock of the
long now will be all mechanical.
745
00:40:15,213 --> 00:40:18,314
Power in the clock will come
from the force of gravity.
746
00:40:18,316 --> 00:40:23,386
A weight-driven system
will turn a threaded bar.
747
00:40:23,388 --> 00:40:25,288
And the clock will keep time
748
00:40:25,290 --> 00:40:28,091
in both the short term,
with the pendulum,
749
00:40:28,093 --> 00:40:30,827
and in the long term,
through a solar synchronizer.
750
00:40:30,829 --> 00:40:35,331
This device may or may not last
for 10 millennia,
751
00:40:35,333 --> 00:40:38,935
but that's not really
Alexander's point.
752
00:40:38,937 --> 00:40:42,338
He wants to make us imagine
what we will be like
753
00:40:42,340 --> 00:40:45,675
10,000 years from now.
754
00:40:45,677 --> 00:40:47,777
Rose: As soon as you see
that 10,000-year clock
755
00:40:47,779 --> 00:40:50,313
and you visit it, the
conversations that you have
756
00:40:50,315 --> 00:40:52,215
around whether or not
humans will be there,
757
00:40:52,217 --> 00:40:54,684
the shapes of the hands of
the people that might wind it --
758
00:40:54,686 --> 00:40:56,352
"Are they gonna be
the same as ours?"
759
00:40:56,354 --> 00:40:57,653
"Are they gonna be different?"
760
00:40:57,655 --> 00:41:00,423
Those kind of conversations
immediately allow you
761
00:41:00,425 --> 00:41:03,292
to take responsibility
for that kind of time span,
762
00:41:03,294 --> 00:41:05,495
and that's the hope
with this clock.
763
00:41:05,497 --> 00:41:10,633
Freeman: 10,000 years from now,
human beings may be immortal.
764
00:41:10,635 --> 00:41:12,068
Even if they're not,
765
00:41:12,070 --> 00:41:15,738
their life-spans will surely be
vastly longer than ours.
766
00:41:15,740 --> 00:41:18,975
But it won't be just our bodies
that will change.
767
00:41:18,977 --> 00:41:23,513
What it means to be human
will be different.
768
00:41:23,515 --> 00:41:26,049
If you think
about all the human values,
769
00:41:26,051 --> 00:41:27,550
quite a lot of them come
770
00:41:27,552 --> 00:41:30,453
from the fact that we know
that life is finite.
771
00:41:30,455 --> 00:41:34,457
If you think, "How do I feel
towards that person?"
772
00:41:34,459 --> 00:41:35,958
The fact that you know
773
00:41:35,960 --> 00:41:38,961
that the person is not gonna be
there one day
774
00:41:38,963 --> 00:41:42,498
probably makes your emotions
far stronger in some sense
775
00:41:42,500 --> 00:41:44,434
than other ways they would be.
776
00:41:44,436 --> 00:41:47,603
So this could all change,
and maybe some of these things
777
00:41:47,605 --> 00:41:50,506
would even disappear
from the human race
778
00:41:50,508 --> 00:41:52,909
if we simply knew
we could live forever.
779
00:41:52,911 --> 00:41:55,878
Rose: What happens
to marriage and relationships
780
00:41:55,880 --> 00:41:58,748
if our life-spans grow
to 1,000 years or more?
781
00:41:58,750 --> 00:42:00,083
Right now,
782
00:42:00,085 --> 00:42:02,785
half of us get divorced
just in our short lifetimes.
783
00:42:02,787 --> 00:42:04,787
But if we lived for 1,000 years,
784
00:42:04,789 --> 00:42:08,091
who knows how many times
you might get married?
785
00:42:08,093 --> 00:42:10,660
I don't think that I
would be able to live forever.
786
00:42:10,662 --> 00:42:12,595
I think
my wife would kill me first.
787
00:42:12,597 --> 00:42:15,131
Freeman:
Whether we like it or not,
788
00:42:15,133 --> 00:42:18,067
more and more scientists believe
we will one day live
789
00:42:18,069 --> 00:42:22,338
in a world without age,
disease, and death...
790
00:42:22,340 --> 00:42:26,476
That we'll revel in the joys
and wonders of endless life
791
00:42:26,478 --> 00:42:30,480
and that we'll
just have to learn to cope
792
00:42:30,482 --> 00:42:34,951
with the consequences
of living forever.
793
00:42:34,953 --> 00:42:40,690
Mythology says that
the Gods envy our mortality.
794
00:42:40,692 --> 00:42:42,325
Our mortality
795
00:42:42,327 --> 00:42:46,262
is what makes life precious
and something to be savored.
796
00:42:46,264 --> 00:42:49,365
Driven by the pressure of time
to achieve greatness,
797
00:42:49,367 --> 00:42:53,603
it may be our mortality
that gives us our humanity.
798
00:42:53,605 --> 00:42:56,005
But as long as we are mortal,
799
00:42:56,007 --> 00:42:59,976
we'll never stop dreaming
of life everlasting.
800
00:42:59,978 --> 00:43:04,180
That, too,
is what makes us human.
801
00:43:04,254 --> 00:43:08,254
== sync, corrected by elderman ==65655
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