All language subtitles for Through The Wormhole S02E08 Can We Live Forever 720p.HDTV.x264-DiVERGE

af Afrikaans
ak Akan
sq Albanian
am Amharic
ar Arabic Download
hy Armenian
az Azerbaijani
eu Basque
be Belarusian
bem Bemba
bn Bengali
bh Bihari
bs Bosnian
br Breton
bg Bulgarian
km Cambodian
ca Catalan
ceb Cebuano
chr Cherokee
ny Chichewa
zh-CN Chinese (Simplified)
zh-TW Chinese (Traditional)
co Corsican
hr Croatian
cs Czech
da Danish
nl Dutch
en English
eo Esperanto
et Estonian
ee Ewe
fo Faroese
tl Filipino
fi Finnish
fr French
fy Frisian
gaa Ga
gl Galician
ka Georgian
de German
el Greek
gn Guarani
gu Gujarati
ht Haitian Creole
ha Hausa
haw Hawaiian
iw Hebrew
hi Hindi
hmn Hmong
hu Hungarian
is Icelandic
ig Igbo
id Indonesian
ia Interlingua
ga Irish
it Italian
ja Japanese
jw Javanese
kn Kannada
kk Kazakh
rw Kinyarwanda
rn Kirundi
kg Kongo
ko Korean
kri Krio (Sierra Leone)
ku Kurdish
ckb Kurdish (Soranî)
ky Kyrgyz
lo Laothian
la Latin
lv Latvian
ln Lingala
lt Lithuanian
loz Lozi
lg Luganda
ach Luo
lb Luxembourgish
mk Macedonian
mg Malagasy
ms Malay
ml Malayalam
mt Maltese
mi Maori
mr Marathi
mfe Mauritian Creole
mo Moldavian
mn Mongolian
my Myanmar (Burmese)
sr-ME Montenegrin
ne Nepali
pcm Nigerian Pidgin
nso Northern Sotho
no Norwegian
nn Norwegian (Nynorsk)
oc Occitan
or Oriya
om Oromo
ps Pashto
fa Persian
pl Polish
pt-BR Portuguese (Brazil)
pt Portuguese (Portugal)
pa Punjabi
qu Quechua
ro Romanian
rm Romansh
nyn Runyakitara
ru Russian
sm Samoan
gd Scots Gaelic
sr Serbian
sh Serbo-Croatian
st Sesotho
tn Setswana
crs Seychellois Creole
sn Shona
sd Sindhi
si Sinhalese
sk Slovak
sl Slovenian
so Somali
es Spanish
es-419 Spanish (Latin American)
su Sundanese
sw Swahili
sv Swedish
tg Tajik
ta Tamil
tt Tatar
te Telugu
th Thai
ti Tigrinya
to Tonga
lua Tshiluba
tum Tumbuka
tr Turkish
tk Turkmen
tw Twi
ug Uighur
uk Ukrainian
ur Urdu
uz Uzbek
vi Vietnamese
cy Welsh
wo Wolof
xh Xhosa
yi Yiddish
yo Yoruba
zu Zulu
Would you like to inspect the original subtitles? These are the user uploaded subtitles that are being translated: 1 00:00:02,795 --> 00:00:04,829 Freeman: The end of life. 2 00:00:05,544 --> 00:00:11,333 It's a reality that terrifies us and motivates us. 3 00:00:11,334 --> 00:00:15,103 Now cutting-edge science embarks on a bold mission 4 00:00:15,105 --> 00:00:17,572 to extend human life. 5 00:00:17,574 --> 00:00:18,773 [ Engine revs ] 6 00:00:18,775 --> 00:00:21,442 Some think the answer lies in biology. 7 00:00:22,611 --> 00:00:26,581 Some believe it might be in our brains. 8 00:00:26,583 --> 00:00:28,950 And others claim that immortality would mean 9 00:00:28,952 --> 00:00:31,819 the end of humanity. 10 00:00:31,821 --> 00:00:36,157 Will death remain inevitable? 11 00:00:36,159 --> 00:00:38,660 Or can we live forever? 12 00:00:38,662 --> 00:00:39,861 [ Crying ] 13 00:00:43,532 --> 00:00:48,303 Freeman: Space, time, life itself. 14 00:00:50,406 --> 00:00:55,376 The secrets of the cosmos lie through the wormhole. 15 00:00:55,378 --> 00:00:59,378 ? Through the Wormhole 2x08 ? Can We Live Forever? Original Air Date on July 27, 2011 16 00:00:59,380 --> 00:01:03,380 == sync, corrected by elderman == 17 00:01:07,122 --> 00:01:11,025 The sands of time run swiftly, 18 00:01:11,027 --> 00:01:14,162 a reminder that life is fleeting; 19 00:01:14,164 --> 00:01:16,698 death is a humbling reality. 20 00:01:16,700 --> 00:01:21,569 But what if life had no end? 21 00:01:21,571 --> 00:01:24,706 In just the past 200 years, 22 00:01:24,708 --> 00:01:26,808 the average life-span has doubled 23 00:01:26,810 --> 00:01:30,078 from about 40 to almost 80 years. 24 00:01:30,080 --> 00:01:32,647 Breakthroughs in biology and physics 25 00:01:32,649 --> 00:01:36,117 could soon bring immortality within our grasp. 26 00:01:36,119 --> 00:01:40,121 For better or worse, many of you watching me right now 27 00:01:40,123 --> 00:01:41,589 may live to see the day 28 00:01:41,591 --> 00:01:47,395 when aging and death itself are relics of a distant past. 29 00:01:50,566 --> 00:01:53,935 I remember rummaging through my grandmother's trunk once, 30 00:01:53,937 --> 00:01:58,306 happening upon objects that had been stored away for years. 31 00:01:58,308 --> 00:02:04,612 Everything was faded, curled, rusted. 32 00:02:04,614 --> 00:02:06,481 I couldn't help but wonder, 33 00:02:06,483 --> 00:02:09,617 when would the same decay happen to me? 34 00:02:14,590 --> 00:02:16,624 Michio Kaku, 35 00:02:16,626 --> 00:02:19,660 a theoretical physicist at City College of New York, 36 00:02:19,662 --> 00:02:22,797 is fascinated with the big questions in science, 37 00:02:22,799 --> 00:02:25,133 like whether the laws of physics 38 00:02:25,135 --> 00:02:29,437 require that all living things die. 39 00:02:29,439 --> 00:02:31,272 One of the iron laws of physics 40 00:02:31,274 --> 00:02:33,574 is the second law of thermodynamics, 41 00:02:33,576 --> 00:02:35,009 which says that everything rusts, 42 00:02:35,011 --> 00:02:38,446 everything decays, falls apart. 43 00:02:38,448 --> 00:02:41,649 We're all made out of atoms, and these atoms, in turn, 44 00:02:41,651 --> 00:02:44,051 obey the second law of thermodynamics. 45 00:02:45,988 --> 00:02:49,223 Freeman: Anything and everything in the Universe 46 00:02:49,225 --> 00:02:53,561 has the tendency to go from order to disorder. 47 00:02:53,563 --> 00:02:56,164 And once the damage is done, 48 00:02:56,166 --> 00:03:01,536 it's extremely difficult to reverse things and un-mix them. 49 00:03:01,538 --> 00:03:04,372 It's a process known as entropy. 50 00:03:04,374 --> 00:03:06,741 If I mix coffee, 51 00:03:06,743 --> 00:03:12,747 I realize that when I put cream into coffee, I increase entropy. 52 00:03:12,749 --> 00:03:14,215 I increase disorder. 53 00:03:14,217 --> 00:03:18,953 In fact, to see this milk jump out and reform in this cup 54 00:03:18,955 --> 00:03:21,556 is such a preposterous event 55 00:03:21,558 --> 00:03:23,391 that you would have to wait longer 56 00:03:23,393 --> 00:03:26,994 than the lifetime of the Universe to see it happen. 57 00:03:26,996 --> 00:03:32,200 Freeman: The second law of thermodynamics is an unremitting force. 58 00:03:32,202 --> 00:03:36,971 Nothing is immune to the power of entropy, 59 00:03:36,973 --> 00:03:39,173 not even the cells in our body. 60 00:03:39,175 --> 00:03:41,309 Kaku: And that's why we age. 61 00:03:41,311 --> 00:03:44,645 In fact, that's why we die. 62 00:03:44,647 --> 00:03:49,550 But it turns out that there is a loophole to the law of entropy. 63 00:03:49,552 --> 00:03:54,422 There is a way to restore order from disorder. 64 00:03:54,424 --> 00:03:57,291 Kaku: Imagine that each one represents an atom. 65 00:03:57,293 --> 00:04:01,395 Now, if I apply the second law of thermodynamics, 66 00:04:01,397 --> 00:04:05,266 it means that entropy increases. It mixes. Chaos reigns. 67 00:04:05,268 --> 00:04:06,834 Watch this. 68 00:04:06,836 --> 00:04:11,205 Freeman: The candy on the tray starts off organized and color-coded. 69 00:04:11,207 --> 00:04:13,641 But if the tray begins to vibrate, 70 00:04:13,643 --> 00:04:16,010 the second law takes over. 71 00:04:16,012 --> 00:04:17,879 Kaku: Even though this is entropy in action, 72 00:04:17,881 --> 00:04:22,683 I can reverse entropy by adding energy from the outside. 73 00:04:23,619 --> 00:04:26,721 But the price is, I have to constantly be on alert, 74 00:04:26,723 --> 00:04:29,657 constantly add energy from the outside. 75 00:04:30,859 --> 00:04:34,161 I mean, this is hard work. 76 00:04:35,998 --> 00:04:38,199 Freeman: With energy and concentration, 77 00:04:38,201 --> 00:04:42,703 Michio can step in and stop the chaos. 78 00:04:42,705 --> 00:04:46,040 But reversing entropy in a tray of vibrating candy 79 00:04:46,042 --> 00:04:49,677 is far less complicated than reversing entropy in our bodies. 80 00:04:49,679 --> 00:04:52,513 Where would we even begin? 81 00:04:52,515 --> 00:04:53,714 [ Engine revving ] 82 00:04:56,919 --> 00:04:59,820 Valter Longo is searching for the answer. 83 00:04:59,822 --> 00:05:02,423 He is a Professor of Gerontology 84 00:05:02,425 --> 00:05:05,059 at the University of Southern California. 85 00:05:05,061 --> 00:05:10,665 He knows that many things live fast and die young, 86 00:05:10,667 --> 00:05:14,602 and he believes the road to reversing entropy in the body 87 00:05:14,604 --> 00:05:19,073 starts where things get the hottest -- in the engine. 88 00:05:19,075 --> 00:05:22,243 Longo: In the engine, the gasoline gets oxidized, 89 00:05:22,245 --> 00:05:23,744 and that's a combustion process, 90 00:05:23,746 --> 00:05:26,180 and this provides energy to the car. 91 00:05:26,182 --> 00:05:27,949 But because of the combustion, 92 00:05:27,951 --> 00:05:30,251 the engine itself can become damaged, 93 00:05:30,253 --> 00:05:33,020 and eventually, you have to rebuild the engine. 94 00:05:33,022 --> 00:05:35,856 Freeman: Every cell in our bodies 95 00:05:35,858 --> 00:05:41,462 have tiny engines called mitochondria. 96 00:05:41,464 --> 00:05:44,465 Mitochondria are double-membraned structures 97 00:05:44,467 --> 00:05:48,436 whose job is to provide energy. 98 00:05:48,438 --> 00:05:51,005 But when these powerhouses wear down, 99 00:05:51,007 --> 00:05:55,309 our body begins to decay and age. 100 00:05:55,311 --> 00:05:59,447 And so, you can imagine in the cells, instead, 101 00:05:59,449 --> 00:06:01,882 you have hundreds of these mitochondria, 102 00:06:01,884 --> 00:06:03,284 these little engines. 103 00:06:03,286 --> 00:06:06,387 And these hundreds of engines provide the energy locally 104 00:06:06,389 --> 00:06:08,656 to every single cell in our body. 105 00:06:08,658 --> 00:06:11,258 Freeman: But Valter has found a way 106 00:06:11,260 --> 00:06:13,961 to reverse this deterioration process 107 00:06:13,963 --> 00:06:18,666 and rejuvenate mitochondria in one tiny organism. 108 00:06:18,668 --> 00:06:21,535 He has extended the life of baker's yeast -- 109 00:06:21,537 --> 00:06:26,173 the kind you use to make bread and beer -- to 10 weeks. 110 00:06:26,175 --> 00:06:31,712 That's 10 times the yeast's normal life-span of 6 days. 111 00:06:31,714 --> 00:06:35,449 It may not sound like a long time, 112 00:06:35,451 --> 00:06:40,421 but it's equivalent to 800 human years. 113 00:06:40,423 --> 00:06:43,190 The yeast's longevity occurred 114 00:06:43,192 --> 00:06:48,529 when two genes, R.A.S.2 and S.C.H.9, 115 00:06:48,531 --> 00:06:50,731 were removed from its DNA. 116 00:06:50,733 --> 00:06:54,802 Longo: So these pathways that we've identified in yeast, 117 00:06:54,804 --> 00:06:59,240 in addition to promoting aging, they also promote DNA damage 118 00:06:59,242 --> 00:07:00,775 and the damage 119 00:07:00,777 --> 00:07:03,310 of a variety of different systems within the cells. 120 00:07:03,312 --> 00:07:06,147 Freeman: Valter wondered if this fountain of youth for yeast 121 00:07:06,149 --> 00:07:09,684 might apply to more complex life-forms. 122 00:07:09,686 --> 00:07:13,754 And so he began looking for the equivalent genes 123 00:07:13,756 --> 00:07:17,258 in a much larger organism -- 124 00:07:17,260 --> 00:07:19,226 mice. 125 00:07:19,228 --> 00:07:22,263 When he knocked out those two genes, 126 00:07:22,265 --> 00:07:26,133 these mice doubled their life expectancy. 127 00:07:26,135 --> 00:07:28,302 Longo: This is very encouraging 128 00:07:28,304 --> 00:07:30,871 because if you look at the similarities 129 00:07:30,873 --> 00:07:33,574 between a mouse and a human, 130 00:07:33,576 --> 00:07:36,777 we are over 90% identical in many ways. 131 00:07:36,779 --> 00:07:41,449 A mouse lives for 2 years, and people live for 100 years. 132 00:07:41,451 --> 00:07:42,783 So, you can see, 133 00:07:42,785 --> 00:07:45,720 with just a small modification of the genome, 134 00:07:45,722 --> 00:07:48,489 you can go from 2 years to 100 years. 135 00:07:48,491 --> 00:07:50,858 There's no law of physics 136 00:07:50,860 --> 00:07:54,228 that prevents us from finding the secret of longevity, 137 00:07:54,230 --> 00:07:57,865 the secret, perhaps, even of immortality. 138 00:07:57,867 --> 00:08:02,236 If you take, for example, the genome of millions of old people 139 00:08:02,238 --> 00:08:04,905 and the genome of millions of young people -- 140 00:08:04,907 --> 00:08:07,942 which we will do in the coming years -- and subtract, 141 00:08:07,944 --> 00:08:12,780 you will then find the genes where aging is concentrated. 142 00:08:12,782 --> 00:08:15,783 Already, we've identified over 60 genes 143 00:08:15,785 --> 00:08:17,952 involved in the aging process. 144 00:08:17,954 --> 00:08:19,453 Longo: Now, the question is, 145 00:08:19,455 --> 00:08:23,624 how do you reprogram a human that lives 100 years 146 00:08:23,626 --> 00:08:26,727 to be now a 2,000- or 3,000-year-old person? 147 00:08:26,729 --> 00:08:28,329 [ Engine revving ] 148 00:08:28,331 --> 00:08:31,232 Freeman: Valter's mission to keep our engines running forever 149 00:08:31,234 --> 00:08:35,402 has just begun, and he's in it for the long haul. 150 00:08:35,404 --> 00:08:37,104 Suppose we do find a way 151 00:08:37,106 --> 00:08:40,541 to keep our engines running for hundreds of years or more. 152 00:08:40,543 --> 00:08:45,012 We would all be very old for a very long time. 153 00:08:45,014 --> 00:08:46,981 But this scientist 154 00:08:46,983 --> 00:08:51,819 is digging for ways to keep us not just eternally alive... 155 00:08:51,821 --> 00:08:54,121 But eternally young. 156 00:08:58,184 --> 00:09:00,419 Take our current life-span 157 00:09:00,421 --> 00:09:05,024 and stretch it 5 or even 10 times longer. 158 00:09:05,026 --> 00:09:09,795 The joys of our youth would endure like an endless summer. 159 00:09:09,797 --> 00:09:14,933 But imagine suffering decade after decade with fragile bones, 160 00:09:14,935 --> 00:09:19,772 failing eyesight, and an ever-more-feeble mind. 161 00:09:19,774 --> 00:09:24,710 If we want to become immortal, we can't just extend life. 162 00:09:24,712 --> 00:09:30,749 We need to discover how to keep our bodies eternally youthful. 163 00:09:34,154 --> 00:09:39,425 Aubrey de Grey thinks of himself as a modern-day Methuselah. 164 00:09:39,427 --> 00:09:43,896 He has dedicated his career to fighting aging. 165 00:09:43,898 --> 00:09:47,232 Aubrey believes that many people who are born today 166 00:09:47,234 --> 00:09:49,735 could live to be 1,000 years old 167 00:09:49,737 --> 00:09:53,238 and remain physically young for most of that time. 168 00:09:53,240 --> 00:09:57,276 The key is a matter of good biological housekeeping -- 169 00:09:57,278 --> 00:10:00,346 taking the trash out of ourselves. 170 00:10:00,348 --> 00:10:02,014 So, what happens, indeed, 171 00:10:02,016 --> 00:10:05,017 is that certain types of material in the body 172 00:10:05,019 --> 00:10:07,152 just accumulate junk. 173 00:10:07,154 --> 00:10:11,557 Certain types of junk accumulate inside cells and between cells 174 00:10:11,559 --> 00:10:14,193 and stuff that we would not think of as junk, like DNA, 175 00:10:14,195 --> 00:10:18,597 accumulates randomness, which is a type of junk. 176 00:10:18,599 --> 00:10:20,632 Freeman: Cells have the important job 177 00:10:20,634 --> 00:10:23,001 of constantly breaking down waste, 178 00:10:23,003 --> 00:10:25,437 and they're mostly pretty good at it. 179 00:10:25,439 --> 00:10:26,572 But sometimes a cell 180 00:10:26,574 --> 00:10:29,274 comes across things that are so weird... 181 00:10:29,276 --> 00:10:32,711 None of this degradation machinery works on them. 182 00:10:32,713 --> 00:10:34,747 That's when the junk gets re-routed 183 00:10:34,749 --> 00:10:37,049 to what's called the lysosome, 184 00:10:37,051 --> 00:10:38,951 a vessel that houses 185 00:10:38,953 --> 00:10:42,421 the most powerful degradation machinery in the cell. 186 00:10:42,423 --> 00:10:45,023 And if the garbage can't be broken down, 187 00:10:45,025 --> 00:10:47,726 it stays there forever. 188 00:10:49,796 --> 00:10:53,399 Aubrey believes that the accumulation of garbage 189 00:10:53,401 --> 00:10:57,136 in the lysosomal storage unit is what causes aging. 190 00:10:57,138 --> 00:11:01,173 And he wants to free our bodies of these buildups. 191 00:11:01,175 --> 00:11:03,142 He realized the most logical way 192 00:11:03,144 --> 00:11:06,678 was to take a close look at waste itself. 193 00:11:06,680 --> 00:11:12,718 And he wondered, "In nature, what likes to eat junk?" 194 00:11:12,720 --> 00:11:14,853 Longo: We're working on an idea 195 00:11:14,855 --> 00:11:17,423 that we might be able to find other species, 196 00:11:17,425 --> 00:11:21,260 especially bacteria, that are able to break down 197 00:11:21,262 --> 00:11:24,730 the substances that accumulate in the human body. 198 00:11:24,732 --> 00:11:28,066 Freeman: Aubrey's hunt for the fountain of youth 199 00:11:28,068 --> 00:11:32,571 led him to a final resting place -- graveyards. 200 00:11:34,340 --> 00:11:36,008 Since graveyards are riddled 201 00:11:36,010 --> 00:11:39,011 with the waste of decomposing bodies, 202 00:11:39,013 --> 00:11:41,413 he suspected he might find microbes 203 00:11:41,415 --> 00:11:44,116 who live to feast on death. 204 00:11:44,118 --> 00:11:49,588 [De Grey] And if we can find the genes and enzymes that they are using 205 00:11:49,590 --> 00:11:51,590 to actually perform that function, 206 00:11:51,592 --> 00:11:54,726 then we might be able to put those genes and enzymes 207 00:11:54,728 --> 00:11:56,895 into our own cells 208 00:11:56,897 --> 00:11:58,897 so that our own cells can break stuff down 209 00:11:58,899 --> 00:12:00,833 that they could not naturally break down. 210 00:12:00,835 --> 00:12:04,336 Freeman: The secret to longevity might be 6 feet under. 211 00:12:04,338 --> 00:12:10,075 Aubrey and his team are still digging for the right microbe 212 00:12:10,077 --> 00:12:11,577 that will work in mammalian cells. 213 00:12:11,579 --> 00:12:13,445 And when they find it, 214 00:12:13,447 --> 00:12:19,351 he believes we will all live like 25-year-olds forever. 215 00:12:19,353 --> 00:12:23,155 [De Grey] I think that we have maybe a 50/50 chance 216 00:12:23,157 --> 00:12:25,858 in the next 25 years or so 217 00:12:25,860 --> 00:12:28,827 of developing what I think of as the first generation 218 00:12:28,829 --> 00:12:31,597 of bona fide rejuvenation biotechnology. 219 00:12:31,599 --> 00:12:32,898 In other words, 220 00:12:32,900 --> 00:12:35,534 technologies that are sufficiently comprehensive 221 00:12:35,536 --> 00:12:39,104 that we can give them to middle-aged people, 222 00:12:39,106 --> 00:12:42,941 people 60 or 70 or so, and fix them up well enough 223 00:12:42,943 --> 00:12:46,745 that they don't become biologically 60 or 70 again 224 00:12:46,747 --> 00:12:49,214 until 30 years later or something like that. 225 00:12:51,818 --> 00:12:55,621 Freeman: Aubrey is looking for the magic bullet that will fight aging, 226 00:12:55,623 --> 00:12:58,223 but synthetic biologist Chris Voigt 227 00:12:58,225 --> 00:13:01,493 is looking to build an entire army 228 00:13:01,495 --> 00:13:04,630 out of various parts from all over nature. 229 00:13:06,766 --> 00:13:10,402 Voigt: All right. Let's give this a shot. 230 00:13:14,741 --> 00:13:17,075 One of the things we're often trying to do 231 00:13:17,077 --> 00:13:19,444 in synthetic biology is create new functions 232 00:13:19,446 --> 00:13:23,048 out of parts that already exist in nature for other reason 233 00:13:23,050 --> 00:13:26,485 so we're often having to go out and grab those components 234 00:13:26,487 --> 00:13:29,388 from different organisms and put them together. 235 00:13:29,390 --> 00:13:32,357 Freeman: Chris searches for microorganisms 236 00:13:32,359 --> 00:13:36,194 throughout biology to find the right parts. 237 00:13:36,196 --> 00:13:38,664 And they end up at his lab 238 00:13:38,666 --> 00:13:41,800 at the University of California, San Francisco, 239 00:13:41,802 --> 00:13:45,103 where biology meets mechanics. 240 00:13:45,105 --> 00:13:47,940 Voigt: When you look at being able to fight disease, 241 00:13:47,942 --> 00:13:49,808 whether it's identifying malignant cells 242 00:13:49,810 --> 00:13:51,243 and killing them, 243 00:13:51,245 --> 00:13:53,512 we're trying to go through the garbage of all the functions 244 00:13:53,514 --> 00:13:55,013 that are out in the natural world 245 00:13:55,015 --> 00:13:58,550 and identify those that are useful to us 246 00:13:58,552 --> 00:14:00,686 in trying to be able to identify 247 00:14:00,688 --> 00:14:03,255 a correct disease state in the body. 248 00:14:03,257 --> 00:14:07,092 Freeman: To build a bio robot that can detect its surroundings, 249 00:14:07,094 --> 00:14:11,063 Chris and his team needed to find an organism with a sensor. 250 00:14:11,065 --> 00:14:15,300 And they found it... In pond scum... 251 00:14:15,302 --> 00:14:20,272 Where they discovered that algae are equipped with light sensors. 252 00:14:20,274 --> 00:14:23,508 Voigt: We took a bacterium that normally lives in your gut -- 253 00:14:23,510 --> 00:14:26,111 so it's not used to the Sun shining -- 254 00:14:26,113 --> 00:14:29,147 and we put in a light sensor out of an algae. 255 00:14:29,149 --> 00:14:32,951 Freeman: Inside Chris' bacterial darkroom, 256 00:14:32,953 --> 00:14:35,087 colonies of bacteria 257 00:14:35,089 --> 00:14:36,888 that are now implanted with algae light sensors 258 00:14:36,890 --> 00:14:40,258 are able to take photographs of slide-projected images. 259 00:14:42,495 --> 00:14:45,197 Freeman: It might look like bacterial art, 260 00:14:45,199 --> 00:14:47,332 but this is the first big step 261 00:14:47,334 --> 00:14:50,636 toward creating programmable biological robots 262 00:14:50,638 --> 00:14:53,305 that will keep our bodies healthy forever. 263 00:14:53,307 --> 00:14:56,842 Voigt: There are bacteria all throughout our bodies, 264 00:14:56,844 --> 00:14:59,945 and we can reprogram those bacteria 265 00:14:59,947 --> 00:15:03,148 in order to be able to implement therapeutic effects 266 00:15:03,150 --> 00:15:06,618 for just about any disease that you can imagine. 267 00:15:06,620 --> 00:15:10,555 The possibilities are limitless. 268 00:15:10,557 --> 00:15:13,258 Freeman: Chris' photographic bacteria 269 00:15:13,260 --> 00:15:15,494 are able to turn themselves on and off 270 00:15:15,496 --> 00:15:16,962 like the flip of a switch. 271 00:15:16,964 --> 00:15:18,530 But the question is, 272 00:15:18,532 --> 00:15:23,969 can Chris figure out how to program and control that switch? 273 00:15:23,971 --> 00:15:26,071 We'd like to see the programming of cells 274 00:15:26,073 --> 00:15:28,006 be the same as programming a computer 275 00:15:28,008 --> 00:15:29,541 or designing an electronic chip, 276 00:15:29,543 --> 00:15:32,210 where, as programmers, we would write out 277 00:15:32,212 --> 00:15:35,380 the exact function that we'd want the cells to do. 278 00:15:35,382 --> 00:15:38,283 And then that would be automatically compiled 279 00:15:38,285 --> 00:15:39,584 into a DNA sequence 280 00:15:39,586 --> 00:15:41,687 in the same way that a computer program 281 00:15:41,689 --> 00:15:45,123 gets compiled, ultimately, into ones and zeroes. 282 00:15:45,125 --> 00:15:46,458 That's the dream. 283 00:15:46,460 --> 00:15:48,994 [ Gulp! ] 284 00:15:48,996 --> 00:15:52,097 Freeman: Bio robots may one day roam our blood streams, 285 00:15:52,099 --> 00:15:56,635 police our organs, and respond to our internal 911 calls, 286 00:15:56,637 --> 00:16:00,672 keeping us free from the threat of disease. 287 00:16:02,341 --> 00:16:05,610 Chris Voigt's and Aubrey de Grey's research 288 00:16:05,612 --> 00:16:07,846 to keep our bodies healthy for eternity 289 00:16:07,848 --> 00:16:09,915 is still in the beginning stages. 290 00:16:09,917 --> 00:16:13,051 But what does this mean for us mere mortals 291 00:16:13,053 --> 00:16:15,620 who will never live to see the day 292 00:16:15,622 --> 00:16:18,056 when immortality is within reach? 293 00:16:18,058 --> 00:16:21,193 There is one chilling possibility 294 00:16:21,195 --> 00:16:27,699 that will give us all a chance to hang on, even after we die. 295 00:16:31,873 --> 00:16:34,675 We're all genetically programmed 296 00:16:34,677 --> 00:16:38,412 to lust for life and to flee from death. 297 00:16:38,414 --> 00:16:43,284 Eventually, we will discover the secret of immortality, 298 00:16:43,286 --> 00:16:45,586 but we're not there yet. 299 00:16:45,588 --> 00:16:50,691 To cheat death right now, we need to put aging on ice 300 00:16:50,693 --> 00:16:55,129 and be ready to grasp eternal life 301 00:16:55,131 --> 00:16:58,466 long after life abandons us. 302 00:17:01,636 --> 00:17:04,405 Greg Fahy is a cryobiologist. 303 00:17:04,407 --> 00:17:09,977 The goal of his team at biotech outfit 21st Century Medicine 304 00:17:09,979 --> 00:17:13,147 is to freeze human organs and tissues 305 00:17:13,149 --> 00:17:17,852 so that they can be revived, undamaged, centuries from now. 306 00:17:19,454 --> 00:17:22,022 Fahy: Cryopreservation is the preservation of living systems 307 00:17:22,024 --> 00:17:23,858 at very low temperatures. 308 00:17:23,860 --> 00:17:27,328 We usually are referring to temperatures that are low enough 309 00:17:27,330 --> 00:17:30,598 that you can store the system as long as you wish 310 00:17:30,600 --> 00:17:32,233 before you use it again. 311 00:17:32,235 --> 00:17:34,502 Cryopreservation is essential 312 00:17:34,504 --> 00:17:36,937 to get a cell or a tissue, an organ, 313 00:17:36,939 --> 00:17:39,940 from one place in time to another place in time 314 00:17:39,942 --> 00:17:43,844 without allowing that system to change in the process. 315 00:17:43,846 --> 00:17:46,113 Freeman: Scientists have been trying 316 00:17:46,115 --> 00:17:48,816 to preserve whole organs for decades. 317 00:17:48,818 --> 00:17:52,653 But it's a lot harder than throwing food in the freezer. 318 00:17:52,655 --> 00:17:58,526 When biological material freezes, ice crystals form, 319 00:17:58,528 --> 00:18:02,129 which push the cells out of their normal position. 320 00:18:02,131 --> 00:18:06,467 When you thaw the organ, it may look okay from the outside, 321 00:18:06,469 --> 00:18:10,871 but on the inside, it's damaged beyond repair. 322 00:18:12,941 --> 00:18:16,110 The biggest problem, we think, is really mechanical. 323 00:18:16,112 --> 00:18:18,679 It's the formation of ice between cells. 324 00:18:18,681 --> 00:18:21,849 If the cells are dislodged from their normal locations, 325 00:18:21,851 --> 00:18:23,083 then you can destroy 326 00:18:23,085 --> 00:18:25,753 the function of that structure as a whole 327 00:18:25,755 --> 00:18:27,421 even if the cells survive. 328 00:18:29,591 --> 00:18:32,626 Freeman: Greg and his team decided to focus their efforts 329 00:18:32,628 --> 00:18:34,528 on preventing bodily fluids from freezing 330 00:18:34,530 --> 00:18:36,630 and eventually developed a way 331 00:18:36,632 --> 00:18:41,502 to turn those fluids into a form of biological glass -- 332 00:18:41,504 --> 00:18:45,472 a technique he calls vitrification. 333 00:18:45,474 --> 00:18:48,709 Fahy: Vitrification is the formation of a glass. 334 00:18:48,711 --> 00:18:52,112 So if you take water and you mix it with various chemicals 335 00:18:52,114 --> 00:18:54,348 in high-enough concentrations of chemical 336 00:18:54,350 --> 00:18:56,850 and then cool it down to low temperatures, 337 00:18:56,852 --> 00:18:59,987 the system will never freeze no matter how low you go. 338 00:18:59,989 --> 00:19:01,455 Freeman: To test whether 339 00:19:01,457 --> 00:19:05,759 vitrification actually preserves the function of whole organs, 340 00:19:05,761 --> 00:19:09,897 Greg's team vitrified a rabbit kidney. 341 00:19:09,899 --> 00:19:13,233 Fahy: This is the kidney profusion lab. 342 00:19:13,235 --> 00:19:15,402 What John is doing in the background 343 00:19:15,404 --> 00:19:18,539 is delivering...through the vascular system of the kidney 344 00:19:18,541 --> 00:19:20,908 so the kidney becomes unfreezable. 345 00:19:20,910 --> 00:19:24,078 The kidney is sitting in a special chamber. 346 00:19:24,080 --> 00:19:25,546 The chamber is temperature-conditioned 347 00:19:25,548 --> 00:19:26,914 to minimize toxicity. 348 00:19:26,916 --> 00:19:28,749 And at the end of the process, 349 00:19:28,751 --> 00:19:30,851 the kidney's taken out and is transplanted. 350 00:19:30,853 --> 00:19:33,454 Freeman: This kidney, 351 00:19:33,456 --> 00:19:38,559 even though it has been stored at minus-22 degrees celsius, 352 00:19:38,561 --> 00:19:41,362 works just as well as a normal kidney. 353 00:19:41,364 --> 00:19:42,529 It's proof 354 00:19:42,531 --> 00:19:46,000 that Greg's vitrification technique actually works 355 00:19:46,002 --> 00:19:47,401 and might be the key 356 00:19:47,403 --> 00:19:52,539 to preserving human organs far into the future. 357 00:19:52,541 --> 00:19:56,410 So if you cool to below that glass-transition temperature, 358 00:19:56,412 --> 00:19:59,179 our calculations indicate you can store a system 359 00:19:59,181 --> 00:20:00,948 for tens of thousands of years. 360 00:20:00,950 --> 00:20:05,486 Freeman: Imagine being able to put your body on ice 361 00:20:05,488 --> 00:20:10,290 and then being revived 10,000 years from now. 362 00:20:10,292 --> 00:20:12,793 You could wake up and find yourself 363 00:20:12,795 --> 00:20:17,631 in an age when science has made immortality possible. 364 00:20:17,633 --> 00:20:20,000 Greg Fahy may be just a few years 365 00:20:20,002 --> 00:20:24,605 from giving a few select people a shot at eternal life. 366 00:20:24,607 --> 00:20:26,440 But that can only happen 367 00:20:26,442 --> 00:20:29,710 if cryopreservation works on an entire human body, 368 00:20:29,712 --> 00:20:33,080 not just simple organs like the kidney or the bladder, 369 00:20:33,082 --> 00:20:38,752 but on the most complex organ of all -- the brain. 370 00:20:38,754 --> 00:20:41,288 Fahy: This is the brain-slice vitrification lab. 371 00:20:41,290 --> 00:20:44,291 The setup shows a hippocampal slice -- 372 00:20:44,293 --> 00:20:47,728 the part of the brain that's associated with learning and memory -- 373 00:20:47,730 --> 00:20:50,597 in a little dish, essentially. 374 00:20:50,599 --> 00:20:53,600 On the right side, we have a stimulating electrode coming in, 375 00:20:53,602 --> 00:20:54,902 piercing the slice. 376 00:20:54,904 --> 00:20:57,938 On the left side, we have a recording electrode. 377 00:20:59,307 --> 00:21:03,077 Freeman: This brain slice has been vitrified. 378 00:21:03,079 --> 00:21:05,045 If it's still functional, 379 00:21:05,047 --> 00:21:08,515 when a pulse of electricity is fired into it, 380 00:21:08,517 --> 00:21:10,718 it should fire a signal back. 381 00:21:10,720 --> 00:21:14,488 To Greg and his team's surprise, it does. 382 00:21:14,490 --> 00:21:19,259 Electrical activity actually sparks up in this brain tissue. 383 00:21:19,261 --> 00:21:20,994 And the electrical response 384 00:21:20,996 --> 00:21:26,333 is every bit as strong as it was in its original state -- 385 00:21:26,335 --> 00:21:30,170 the recovery of the brain slice complete. 386 00:21:30,172 --> 00:21:33,407 Preserving a slice of the brain 387 00:21:33,409 --> 00:21:38,178 is a crucial first step toward preserving the whole thing. 388 00:21:38,180 --> 00:21:42,716 It's an ambitious project that Greg is already working on. 389 00:21:42,718 --> 00:21:47,354 We have found that it's fairly easy to vitrify the brain, 390 00:21:47,356 --> 00:21:51,158 that all of the structure seems to be preserved. 391 00:21:51,160 --> 00:21:53,260 But I have to say that so far, 392 00:21:53,262 --> 00:21:55,929 our techniques are not up to the level 393 00:21:55,931 --> 00:21:59,399 that we would like for that kind of speculative idea. 394 00:21:59,401 --> 00:22:02,035 But I couldn't say that you couldn't make up 395 00:22:02,037 --> 00:22:04,271 for whatever deficiencies 396 00:22:04,273 --> 00:22:07,141 that we have in our preservation technique today 397 00:22:07,143 --> 00:22:09,810 using some unknown future technology. 398 00:22:09,812 --> 00:22:12,412 I can't rule that out as a possibility. 399 00:22:16,017 --> 00:22:22,055 One day, centuries after we say goodbye to our loved ones, 400 00:22:22,057 --> 00:22:25,425 our frozen bodies could be reanimated, 401 00:22:25,427 --> 00:22:28,462 and we'll walk the earth again. 402 00:22:28,464 --> 00:22:31,598 But there could be a better route to immortality, 403 00:22:31,600 --> 00:22:33,267 one that would change 404 00:22:33,269 --> 00:22:36,937 the very nature of what it means to be human. 405 00:22:39,624 --> 00:22:42,459 Imagine if no one ever died. 406 00:22:42,461 --> 00:22:44,728 Where would we all live? 407 00:22:44,730 --> 00:22:47,497 Our planet is already crowded enough. 408 00:22:47,499 --> 00:22:50,434 But maybe there is a way to live forever 409 00:22:50,436 --> 00:22:54,204 without all this excess baggage. 410 00:22:54,206 --> 00:22:57,808 Poets say the essence of us is here, 411 00:22:57,810 --> 00:23:03,113 but I know what really makes me me is all up here. 412 00:23:03,115 --> 00:23:06,483 So if I want to endure for eternity, 413 00:23:06,485 --> 00:23:09,987 perhaps that's all I need to hang on to. 414 00:23:09,989 --> 00:23:14,324 What if we could find a way to upload our brains, 415 00:23:14,326 --> 00:23:17,928 to digitize the very essence of ourselves? 416 00:23:17,930 --> 00:23:22,566 Our minds could go on living long after our flesh has died. 417 00:23:22,568 --> 00:23:24,101 But to make that happen, 418 00:23:24,103 --> 00:23:27,037 we need to understand the brain's architecture 419 00:23:27,039 --> 00:23:31,108 and figure out what truly makes us who we are. 420 00:23:33,311 --> 00:23:38,482 Olaf Sporns is a neuroscientist at Indiana University. 421 00:23:38,484 --> 00:23:43,553 He is attempting to unscramble the brain's tangled web. 422 00:23:43,555 --> 00:23:45,188 Sporns: The brain is like a big city. 423 00:23:45,190 --> 00:23:48,125 Cities are examples of complex systems -- 424 00:23:48,127 --> 00:23:50,460 thousands of inhabitants and their social interactions, 425 00:23:50,462 --> 00:23:51,628 their flow of materials. 426 00:23:51,630 --> 00:23:54,931 The brain is like that -- millions of neurons, 427 00:23:54,933 --> 00:23:57,401 interactions between these neurons. 428 00:23:57,403 --> 00:24:00,704 In a sense, your brain is like a city of the mind. 429 00:24:00,706 --> 00:24:02,773 Freeman: The human brain 430 00:24:02,775 --> 00:24:06,310 is one of the most complex systems in the Universe. 431 00:24:06,312 --> 00:24:10,547 If you stretched out all of its electrical wiring, 432 00:24:10,549 --> 00:24:13,984 it would extend from the Earth to the Moon. 433 00:24:13,986 --> 00:24:17,487 Figuring out how we get from cells and wires 434 00:24:17,489 --> 00:24:19,990 to thoughts and memories 435 00:24:19,992 --> 00:24:24,494 is one of the greatest challenges known to science. 436 00:24:24,496 --> 00:24:26,797 Even though we've been studying the human brain, 437 00:24:26,799 --> 00:24:28,699 really, for decades, perhaps centuries, 438 00:24:28,701 --> 00:24:31,368 we still don't have a complete map of how it's connected. 439 00:24:31,370 --> 00:24:34,404 Freeman: But Olaf is taking on this challenge. 440 00:24:34,406 --> 00:24:39,209 His goal is to chart every single neuron and synapse 441 00:24:39,211 --> 00:24:43,447 and create a complete map of the brain, called the connectome. 442 00:24:43,449 --> 00:24:45,716 Sporns: It's a comprehensive set of connections 443 00:24:45,718 --> 00:24:47,651 that will allow us for the first time 444 00:24:47,653 --> 00:24:49,052 to understand in more detail 445 00:24:49,054 --> 00:24:51,388 how brain regions are connected to each other. 446 00:24:51,390 --> 00:24:53,924 Freeman: Olaf is creating the connectome 447 00:24:53,926 --> 00:24:58,028 using a leading-edge technique called diffusion imaging. 448 00:24:58,030 --> 00:25:00,864 It reveals the brain's long-distance connections 449 00:25:00,866 --> 00:25:04,067 by tracking water molecules along the neural highways. 450 00:25:04,069 --> 00:25:07,771 And what emerges is a detailed map 451 00:25:07,773 --> 00:25:11,208 of the central core of brain-cell connections. 452 00:25:11,210 --> 00:25:16,346 Olaf thinks this is the area where our personality resides. 453 00:25:16,348 --> 00:25:18,548 Sporns: As we've been discovering recently, 454 00:25:18,550 --> 00:25:21,051 some brain regions are more connected than others. 455 00:25:21,053 --> 00:25:23,053 Some are more essential, perhaps, 456 00:25:23,055 --> 00:25:25,021 for the functioning of the brain as a whole. 457 00:25:25,023 --> 00:25:28,325 Those regions, we call hubs. 458 00:25:28,327 --> 00:25:30,026 Freeman: If the brain is like a city... 459 00:25:30,028 --> 00:25:31,128 [ Tires screech ] 460 00:25:31,130 --> 00:25:33,397 ...Hubs are like major intersections 461 00:25:33,399 --> 00:25:36,099 where a constant flow of traffic passes through, 462 00:25:36,101 --> 00:25:38,568 getting people from one place to another. 463 00:25:38,570 --> 00:25:39,970 [ Bell clangs ] 464 00:25:39,972 --> 00:25:42,739 These intersections are so essential -- 465 00:25:42,741 --> 00:25:47,177 if they become disrupted in any way, the whole city shuts down. 466 00:25:47,179 --> 00:25:48,678 [ Sloop! ] 467 00:25:48,680 --> 00:25:53,016 By their nature, hubs are focal points of information traffic. 468 00:25:53,018 --> 00:25:55,452 Information converges on these regions, 469 00:25:55,454 --> 00:25:58,054 and it is that ebb and flow of information 470 00:25:58,056 --> 00:26:00,590 and the magnitude of the information flow 471 00:26:00,592 --> 00:26:02,492 that really sets these hubs apart 472 00:26:02,494 --> 00:26:04,327 from other regions of the brain. 473 00:26:04,329 --> 00:26:06,396 Freeman: Olaf is getting closer 474 00:26:06,398 --> 00:26:09,399 to figuring out where consciousness resides. 475 00:26:09,401 --> 00:26:12,302 Searching for the origins of consciousness 476 00:26:12,304 --> 00:26:15,005 is the holy grail of neuroscience. 477 00:26:15,007 --> 00:26:18,809 Only when this mystery is solved can we replicate the human brain 478 00:26:18,811 --> 00:26:21,611 and take consciousness from a person 479 00:26:21,613 --> 00:26:26,883 and transfer it to a machine as a way to live for eternity. 480 00:26:26,885 --> 00:26:31,087 And Olaf believes he has discovered a hub 481 00:26:31,089 --> 00:26:36,159 that might solve this mystery -- the medial parietal cortex. 482 00:26:36,161 --> 00:26:39,863 It's located between the brain's two hemispheres. 483 00:26:39,865 --> 00:26:45,368 Olaf suspects it might house the essence of who we are. 484 00:26:45,370 --> 00:26:48,538 Sporns: A lot of wires from the brain converge on that region. 485 00:26:48,540 --> 00:26:50,207 There are many lines of evidence 486 00:26:50,209 --> 00:26:52,375 that point to that part of the brain 487 00:26:52,377 --> 00:26:54,578 being really central and really important -- 488 00:26:54,580 --> 00:26:57,147 perhaps even for awareness and consciousness. 489 00:26:58,783 --> 00:27:00,050 Freeman: Olaf believes 490 00:27:00,052 --> 00:27:03,987 he may have solved the secrets of consciousness, 491 00:27:03,989 --> 00:27:08,124 but there is much more work to be done before he can be sure. 492 00:27:08,126 --> 00:27:11,495 Sporns: I think we're getting closer to answering this question. 493 00:27:11,497 --> 00:27:14,898 And as we identify which parts of the brain are critical 494 00:27:14,900 --> 00:27:17,901 in bringing about that particular functionality, 495 00:27:17,903 --> 00:27:20,270 that gets us closer to answering the question, 496 00:27:20,272 --> 00:27:21,605 "What is consciousness?" 497 00:27:21,607 --> 00:27:24,307 And also "Where are the critical components of the brain 498 00:27:24,309 --> 00:27:25,876 that contribute to it?" 499 00:27:25,878 --> 00:27:27,077 [ Electricity crackling ] 500 00:27:27,079 --> 00:27:29,713 Freeman: Neuroscience has taken enormous steps 501 00:27:29,715 --> 00:27:31,147 towards mapping the brain 502 00:27:31,149 --> 00:27:33,517 and solving the riddle of consciousness. 503 00:27:33,519 --> 00:27:36,186 But will we ever be able to capture 504 00:27:36,188 --> 00:27:39,589 the trillions of synapses, billions of neurons, 505 00:27:39,591 --> 00:27:43,827 and download ourselves onto a machine? 506 00:27:43,829 --> 00:27:46,730 Just imagine all the things that happen in the real world -- 507 00:27:46,732 --> 00:27:48,665 the conversation we are having now, 508 00:27:48,667 --> 00:27:50,867 me producing speech sounds and gestures, 509 00:27:50,869 --> 00:27:53,904 our brain's interacting in this embodied manner. 510 00:27:53,906 --> 00:27:56,273 That could not happen in a computer, 511 00:27:56,275 --> 00:27:57,407 and yet, it is somehow 512 00:27:57,409 --> 00:27:59,409 the essence of what life is all about. 513 00:27:59,411 --> 00:28:00,810 So I'm skeptical about that. 514 00:28:02,547 --> 00:28:06,850 Freeman: The brain might be far too complex to immortalize, 515 00:28:06,852 --> 00:28:11,555 but maybe there's a simpler path to eternal life -- 516 00:28:11,557 --> 00:28:13,023 not for you... 517 00:28:13,025 --> 00:28:18,028 But for immortal beings that we create from scratch. 518 00:28:21,245 --> 00:28:22,479 Life on this planet 519 00:28:22,481 --> 00:28:25,682 has had 4 billion years to evolve. 520 00:28:25,684 --> 00:28:30,120 We are the latest in a long line of species. 521 00:28:30,122 --> 00:28:32,522 We hope we're the last. 522 00:28:32,524 --> 00:28:37,694 But our quest for immortality could end in disaster 523 00:28:37,696 --> 00:28:42,999 because the first eternal beings may not be human. 524 00:28:43,001 --> 00:28:48,305 And they might just make us extinct. 525 00:28:51,242 --> 00:28:55,512 Complex life began from a few simple laws. 526 00:28:55,514 --> 00:29:00,217 The same might be true for artificial life. 527 00:29:00,219 --> 00:29:03,320 If humans discover those laws, there is a chance 528 00:29:03,322 --> 00:29:07,257 we could create living things that live forever. 529 00:29:07,259 --> 00:29:12,262 Oxford Physicist Vlatko Vedral is trying to understand 530 00:29:12,264 --> 00:29:15,765 how intelligence might emerge from a system 531 00:29:15,767 --> 00:29:19,503 that operates on just a few basic ground rules. 532 00:29:19,505 --> 00:29:21,638 Vedral: So, this is chess. 533 00:29:21,640 --> 00:29:23,440 It's a very complex game, 534 00:29:23,442 --> 00:29:27,477 and yet it's governed by a few very simple rules. 535 00:29:27,479 --> 00:29:31,114 You really have only 16 pieces on each side, 536 00:29:31,116 --> 00:29:33,583 and each piece can do one of two things. 537 00:29:33,585 --> 00:29:36,186 And you can say the same thing about life. 538 00:29:36,188 --> 00:29:37,787 Even though you are talking 539 00:29:37,789 --> 00:29:40,357 about one or two very simple rules, 540 00:29:40,359 --> 00:29:41,558 you still get this multitude 541 00:29:41,560 --> 00:29:44,294 of different possible behaviors in the Universe. 542 00:29:46,531 --> 00:29:50,534 Freeman: In 1970, a mathematician named John Conway 543 00:29:50,536 --> 00:29:52,369 ran with this idea 544 00:29:52,371 --> 00:29:55,205 and attempted to create artificial life-forms 545 00:29:55,207 --> 00:29:58,575 spontaneously using a computer program. 546 00:29:58,577 --> 00:30:01,011 He called it "The game of life." 547 00:30:01,013 --> 00:30:04,848 The game simulates the growth of artificial life, 548 00:30:04,850 --> 00:30:06,716 using a two-dimensional grid 549 00:30:06,718 --> 00:30:09,920 and simple cells that are either dead or alive. 550 00:30:09,922 --> 00:30:15,191 Whether the cells live or die is governed by a few basic rules. 551 00:30:15,193 --> 00:30:20,797 So, we have here in front of us a large cell block, 552 00:30:20,799 --> 00:30:24,467 and we can see this one central cell, which is on. 553 00:30:24,469 --> 00:30:29,906 And we can see that it has only one neighbor to its left. 554 00:30:29,908 --> 00:30:33,376 The cell just switches off, which means that it dies. 555 00:30:33,378 --> 00:30:35,045 And it dies of loneliness 556 00:30:35,047 --> 00:30:37,414 because it has too few neighbors. 557 00:30:37,416 --> 00:30:40,850 Well, now we've got a central cell, which is on, 558 00:30:40,852 --> 00:30:42,719 but it has five neighbors. 559 00:30:42,721 --> 00:30:45,722 It dies because of overcrowding, overpopulation. 560 00:30:45,724 --> 00:30:47,390 It doesn't like it, either. 561 00:30:47,392 --> 00:30:52,329 In the third example, a cell with only two neighbors -- 562 00:30:52,331 --> 00:30:54,297 the cell just keeps on living. 563 00:30:54,299 --> 00:30:57,267 It can even move around in this environment, 564 00:30:57,269 --> 00:30:58,735 and it can reproduce. 565 00:30:58,737 --> 00:31:02,238 So this is a good example where the population is just right 566 00:31:02,240 --> 00:31:04,808 for the cell to keep on living. 567 00:31:04,810 --> 00:31:08,144 Freeman: Given enough time, increasingly complex patterns 568 00:31:08,146 --> 00:31:11,014 emerge from this simple set of rules. 569 00:31:11,016 --> 00:31:15,418 Some even take on the appearance of living organisms. 570 00:31:15,420 --> 00:31:19,990 Vedral: John Conway tried to make the same point regarding life -- 571 00:31:19,992 --> 00:31:22,359 that it looks very complicated to us. 572 00:31:22,361 --> 00:31:24,661 And, indeed, it looks like a miracle 573 00:31:24,663 --> 00:31:26,396 that there is life around us, 574 00:31:26,398 --> 00:31:28,632 but, in fact, he constructed a game 575 00:31:28,634 --> 00:31:32,535 which consists of two or three, again, very simple rules, 576 00:31:32,537 --> 00:31:35,772 and it gives rise to some very complicated patterns. 577 00:31:35,774 --> 00:31:38,775 Freeman: How complex do these patterns need to be 578 00:31:38,777 --> 00:31:43,813 before they become something alive, intelligent, or immortal? 579 00:31:43,815 --> 00:31:47,617 Vlatko thinks the human brain is a good yardstick 580 00:31:47,619 --> 00:31:50,854 and has calculated its processing power. 581 00:31:50,856 --> 00:31:53,990 Vedral: The brain is currently still much more powerful 582 00:31:53,992 --> 00:31:55,625 than the existing computers. 583 00:31:55,627 --> 00:31:58,928 So the existing computers can do something like, you know, 584 00:31:58,930 --> 00:32:01,297 10 to the power of 12 beats per second, 585 00:32:01,299 --> 00:32:03,733 whereas our brain is still probably something 586 00:32:03,735 --> 00:32:06,136 like a million times faster than that. 587 00:32:06,138 --> 00:32:08,271 So you need 1 million laptops 588 00:32:08,273 --> 00:32:11,508 to simulate just a single human brain. 589 00:32:11,510 --> 00:32:14,844 Freeman: Today's computers are nowhere near powerful enough 590 00:32:14,846 --> 00:32:16,546 to house artificial intelligent life. 591 00:32:16,548 --> 00:32:19,149 Vlatko believes the answer might be to use 592 00:32:19,151 --> 00:32:21,317 a completely different type of computer -- 593 00:32:21,319 --> 00:32:23,853 the quantum computer. 594 00:32:23,855 --> 00:32:25,422 Quantum computer 595 00:32:25,424 --> 00:32:29,125 is basically the future technology of computation. 596 00:32:29,127 --> 00:32:32,662 It's a computer that's so fast, in principle, 597 00:32:32,664 --> 00:32:36,166 that no current computer can compete with it. 598 00:32:36,168 --> 00:32:38,635 Freeman: In place of transistors, 599 00:32:38,637 --> 00:32:41,971 quantum devices compute with individual atoms. 600 00:32:41,973 --> 00:32:45,375 And instead of sorting piles of ones and zeroes 601 00:32:45,377 --> 00:32:47,277 to give yes-and-no answers, 602 00:32:47,279 --> 00:32:49,345 the atoms in quantum computers 603 00:32:49,347 --> 00:32:52,682 can be ones, zeroes, and everything in between, 604 00:32:52,684 --> 00:32:56,886 existing as a computational maybe. 605 00:32:56,888 --> 00:32:59,355 The quantum computer really utilizes 606 00:32:59,357 --> 00:33:02,459 the quantum effect known as the super position, 607 00:33:02,461 --> 00:33:03,693 which means being 608 00:33:03,695 --> 00:33:06,496 in many different states at the same time. 609 00:33:06,498 --> 00:33:11,367 Freeman: This ability to handle a multiplicity of states 610 00:33:11,369 --> 00:33:13,369 allows quantum computers 611 00:33:13,371 --> 00:33:16,039 to juggle many overlapping problems at once, 612 00:33:16,041 --> 00:33:18,908 just the way our brains do. 613 00:33:20,211 --> 00:33:23,713 The analogy would be if I played a chord for you... 614 00:33:23,715 --> 00:33:26,416 [ Chord plays ] 615 00:33:26,418 --> 00:33:27,917 ...Then you would get 616 00:33:27,919 --> 00:33:31,521 many different modes played at the same time, 617 00:33:31,523 --> 00:33:33,089 which would really correspond 618 00:33:33,091 --> 00:33:36,126 to many states being out there simultaneously 619 00:33:36,128 --> 00:33:37,494 all in one location 620 00:33:37,496 --> 00:33:39,629 and the full power of quantum computation, 621 00:33:39,631 --> 00:33:41,798 which is actually unlimited, in some sense, 622 00:33:41,800 --> 00:33:42,999 if you start to store 623 00:33:43,001 --> 00:33:45,235 all the values in between the zero and the one. 624 00:33:45,237 --> 00:33:50,406 So then you really reach a stage where you can encode much more 625 00:33:50,408 --> 00:33:53,977 and the capacity really has no limits in that sense. 626 00:33:53,979 --> 00:33:55,445 Freeman: There might be a time 627 00:33:55,447 --> 00:33:58,848 when humans forego their own dream of immortality 628 00:33:58,850 --> 00:34:02,619 and create eternal artificial life. 629 00:34:02,621 --> 00:34:04,487 And if they do, 630 00:34:04,489 --> 00:34:07,524 how would artificial and biological life get along? 631 00:34:07,526 --> 00:34:10,660 Some people think that very soon 632 00:34:10,662 --> 00:34:14,164 computers will be smarter than us and they'll put us in zoos. 633 00:34:14,166 --> 00:34:17,834 They'll put us behind bars and throw peanuts at us 634 00:34:17,836 --> 00:34:19,969 and make us dance behind bars 635 00:34:19,971 --> 00:34:23,706 just like we make bears dance in zoos today. 636 00:34:23,708 --> 00:34:25,909 But at the present time, 637 00:34:25,911 --> 00:34:29,212 none of these technologies are ready for prime time. 638 00:34:29,214 --> 00:34:32,749 We simply don't have an operating quantum computer. 639 00:34:32,751 --> 00:34:37,587 The world's record for a quantum computer calculation is -- 640 00:34:37,589 --> 00:34:38,721 ta-da -- 641 00:34:38,723 --> 00:34:42,258 3 times 5 is 15. 642 00:34:42,260 --> 00:34:45,195 We sometimes forget that computers and robots, 643 00:34:45,197 --> 00:34:49,332 no matter how advanced they are, are adding machines. 644 00:34:49,334 --> 00:34:50,533 But that doesn't mean 645 00:34:50,535 --> 00:34:53,937 they have creativity, imagination, initiative. 646 00:34:53,939 --> 00:34:56,306 It doesn't mean they understand human values. 647 00:34:56,308 --> 00:34:59,442 It doesn't mean that they can make leaps of logic like we can. 648 00:34:59,444 --> 00:35:02,078 In other words, we have a long ways to go 649 00:35:02,080 --> 00:35:04,380 before we can begin to approximate 650 00:35:04,382 --> 00:35:08,017 the real thinking process that takes place in a human being. 651 00:35:08,019 --> 00:35:12,388 Freeman: We're safe from becoming slaves to quantum intelligence... 652 00:35:12,390 --> 00:35:13,923 For the time being. 653 00:35:13,925 --> 00:35:18,127 But this physicist envisions a different fate for mankind, 654 00:35:18,129 --> 00:35:22,565 one where the lines between artificial and biological life 655 00:35:22,567 --> 00:35:23,833 will blur 656 00:35:23,835 --> 00:35:27,403 and immortality will become reality, 657 00:35:27,405 --> 00:35:29,272 not just for the living... 658 00:35:29,274 --> 00:35:32,775 But also for the dead. 659 00:35:36,801 --> 00:35:38,768 We're taught to think of science and religion 660 00:35:38,770 --> 00:35:40,437 as separate truths. 661 00:35:40,439 --> 00:35:43,673 Albert Einstein didn't believe that. 662 00:35:43,675 --> 00:35:47,577 He said, "Science without religion is lame. 663 00:35:47,579 --> 00:35:50,847 Religion without science is blind." 664 00:35:50,849 --> 00:35:54,150 The secret to achieving immortality 665 00:35:54,152 --> 00:35:58,121 could require the fusion of humanity and God 666 00:35:58,123 --> 00:36:01,691 into an everlasting cosmic computer. 667 00:36:01,693 --> 00:36:05,695 Few people think further into the future than Frank Tipler, 668 00:36:05,697 --> 00:36:07,297 a mathematical physicist 669 00:36:07,299 --> 00:36:10,333 at Tulane university in New Orleans. 670 00:36:10,335 --> 00:36:13,803 Frank predicts that, at some point in our evolution, 671 00:36:13,805 --> 00:36:16,506 something truly remarkable will happen. 672 00:36:16,508 --> 00:36:22,779 Humanity, the Universe, and God will unite -- 673 00:36:22,781 --> 00:36:27,183 a moment he calls the omega point. 674 00:36:27,185 --> 00:36:31,955 Tipler: The omega point is the very end of the Universe. 675 00:36:31,957 --> 00:36:36,025 In the process, mankind, or, more precisely, our descendants, 676 00:36:36,027 --> 00:36:38,328 will expand out from this planet 677 00:36:38,330 --> 00:36:43,032 and ultimately engulf the entire Universe. 678 00:36:43,034 --> 00:36:47,303 As our descendants are moving into this final state, 679 00:36:47,305 --> 00:36:51,574 their knowledge and their power and their computer capacity 680 00:36:51,576 --> 00:36:55,245 is increasing without limit. 681 00:36:55,247 --> 00:36:56,646 The laws of physics 682 00:36:56,648 --> 00:36:59,682 allow a process that will convert matter -- 683 00:36:59,684 --> 00:37:05,555 stones of this graveyard, for instance -- into pure energy. 684 00:37:05,557 --> 00:37:08,324 That will be the ultimate energy source, 685 00:37:08,326 --> 00:37:11,861 which our descendants will use and gain control of it. 686 00:37:11,863 --> 00:37:14,964 Freeman: At the omega point, Frank argues, 687 00:37:14,966 --> 00:37:19,102 our descendants will be capable of doing anything. 688 00:37:19,104 --> 00:37:23,740 And with infinite power, they will create a cosmic computer 689 00:37:23,742 --> 00:37:25,642 and reconstruct in a simulation 690 00:37:25,644 --> 00:37:27,877 everything that has ever happened 691 00:37:27,879 --> 00:37:30,113 in the history of the Universe. 692 00:37:30,115 --> 00:37:33,950 Now, from the point of view of the beings in the far future, 693 00:37:33,952 --> 00:37:37,987 we will be their alternate ancestor as rational beings 694 00:37:37,989 --> 00:37:42,025 so they will be interested in what we were, what we were like. 695 00:37:42,027 --> 00:37:45,495 As a consequence, every man, woman, and child 696 00:37:45,497 --> 00:37:47,697 will be brought back into existence. 697 00:37:47,699 --> 00:37:50,900 It will be just like you are brought back with your body 698 00:37:50,902 --> 00:37:54,871 into a reconstructed earth just like we now live on. 699 00:37:54,873 --> 00:37:58,308 It will be different in one crucial respect. 700 00:37:58,310 --> 00:37:59,742 We will be resurrected, 701 00:37:59,744 --> 00:38:02,745 but we will never have to go through death again. 702 00:38:02,747 --> 00:38:05,348 Freeman: Frank claims the laws of physics 703 00:38:05,350 --> 00:38:08,651 not only permit this type of immortality -- 704 00:38:08,653 --> 00:38:11,421 they actually require it to happen. 705 00:38:11,423 --> 00:38:14,023 Tipler: Second law of thermodynamics says 706 00:38:14,025 --> 00:38:18,761 the complexity of the Universe at the most fundamental level 707 00:38:18,763 --> 00:38:21,030 is increasing without limit. 708 00:38:21,032 --> 00:38:22,932 I conclude 709 00:38:22,934 --> 00:38:25,869 that the validity of the second law of thermodynamics, 710 00:38:25,871 --> 00:38:28,471 throughout all of time, 711 00:38:28,473 --> 00:38:30,874 actually requires life 712 00:38:30,876 --> 00:38:35,311 to come into existence to gain control of the Universe. 713 00:38:35,313 --> 00:38:39,015 Freeman: Whether immortality comes in billions of years 714 00:38:39,017 --> 00:38:41,517 or whether it comes this century, 715 00:38:41,519 --> 00:38:46,022 the conquest of death will transform our civilization -- 716 00:38:46,024 --> 00:38:50,693 the way we live, the way we work, the way we love. 717 00:38:50,695 --> 00:38:53,997 Maybe the question is not "Can we live forever?" 718 00:38:53,999 --> 00:38:56,266 But "Should we?" 719 00:38:59,937 --> 00:39:01,537 Alexander Rose 720 00:39:01,539 --> 00:39:04,974 is the executive director of the Long Now Foundation, 721 00:39:04,976 --> 00:39:07,844 an organization whose main focus 722 00:39:07,846 --> 00:39:11,948 is the building of an unusual timepiece. 723 00:39:11,950 --> 00:39:16,419 It's called the clock of the long now, 724 00:39:16,421 --> 00:39:21,524 and it's designed to tick for 10,000 years. 725 00:39:21,526 --> 00:39:24,494 Rose: We built the 10,000-year clock 726 00:39:24,496 --> 00:39:27,597 to give people a different perspective 727 00:39:27,599 --> 00:39:29,499 of the really long term. 728 00:39:29,501 --> 00:39:31,901 If you believe that medical science or other things 729 00:39:31,903 --> 00:39:33,803 are going to increase human longevity, 730 00:39:33,805 --> 00:39:36,839 then the way that you would approach the world 731 00:39:36,841 --> 00:39:38,608 would be very, very differently -- 732 00:39:38,610 --> 00:39:41,477 just the same way that if we're designing a 10,000-year clock 733 00:39:41,479 --> 00:39:44,681 instead of a clock that just has to last for 10 years, 734 00:39:44,683 --> 00:39:47,750 we have approached this design problem very differently. 735 00:39:47,752 --> 00:39:50,887 And we have to be responsible over those next 10,000 years 736 00:39:50,889 --> 00:39:51,921 for our clock. 737 00:39:51,923 --> 00:39:54,090 Freeman: 10,000 years in the past, 738 00:39:54,092 --> 00:39:57,193 we were still living in the Stone Age. 739 00:39:57,195 --> 00:39:59,262 Flash forward the same period, 740 00:39:59,264 --> 00:40:01,898 and our civilization and technology 741 00:40:01,900 --> 00:40:04,701 will be unrecognizable. 742 00:40:04,703 --> 00:40:07,103 We realize in designing a 10,000-year clock 743 00:40:07,105 --> 00:40:10,974 that the most durable design is likely the simplest. 744 00:40:10,976 --> 00:40:15,211 Freeman: The clock of the long now will be all mechanical. 745 00:40:15,213 --> 00:40:18,314 Power in the clock will come from the force of gravity. 746 00:40:18,316 --> 00:40:23,386 A weight-driven system will turn a threaded bar. 747 00:40:23,388 --> 00:40:25,288 And the clock will keep time 748 00:40:25,290 --> 00:40:28,091 in both the short term, with the pendulum, 749 00:40:28,093 --> 00:40:30,827 and in the long term, through a solar synchronizer. 750 00:40:30,829 --> 00:40:35,331 This device may or may not last for 10 millennia, 751 00:40:35,333 --> 00:40:38,935 but that's not really Alexander's point. 752 00:40:38,937 --> 00:40:42,338 He wants to make us imagine what we will be like 753 00:40:42,340 --> 00:40:45,675 10,000 years from now. 754 00:40:45,677 --> 00:40:47,777 Rose: As soon as you see that 10,000-year clock 755 00:40:47,779 --> 00:40:50,313 and you visit it, the conversations that you have 756 00:40:50,315 --> 00:40:52,215 around whether or not humans will be there, 757 00:40:52,217 --> 00:40:54,684 the shapes of the hands of the people that might wind it -- 758 00:40:54,686 --> 00:40:56,352 "Are they gonna be the same as ours?" 759 00:40:56,354 --> 00:40:57,653 "Are they gonna be different?" 760 00:40:57,655 --> 00:41:00,423 Those kind of conversations immediately allow you 761 00:41:00,425 --> 00:41:03,292 to take responsibility for that kind of time span, 762 00:41:03,294 --> 00:41:05,495 and that's the hope with this clock. 763 00:41:05,497 --> 00:41:10,633 Freeman: 10,000 years from now, human beings may be immortal. 764 00:41:10,635 --> 00:41:12,068 Even if they're not, 765 00:41:12,070 --> 00:41:15,738 their life-spans will surely be vastly longer than ours. 766 00:41:15,740 --> 00:41:18,975 But it won't be just our bodies that will change. 767 00:41:18,977 --> 00:41:23,513 What it means to be human will be different. 768 00:41:23,515 --> 00:41:26,049 If you think about all the human values, 769 00:41:26,051 --> 00:41:27,550 quite a lot of them come 770 00:41:27,552 --> 00:41:30,453 from the fact that we know that life is finite. 771 00:41:30,455 --> 00:41:34,457 If you think, "How do I feel towards that person?" 772 00:41:34,459 --> 00:41:35,958 The fact that you know 773 00:41:35,960 --> 00:41:38,961 that the person is not gonna be there one day 774 00:41:38,963 --> 00:41:42,498 probably makes your emotions far stronger in some sense 775 00:41:42,500 --> 00:41:44,434 than other ways they would be. 776 00:41:44,436 --> 00:41:47,603 So this could all change, and maybe some of these things 777 00:41:47,605 --> 00:41:50,506 would even disappear from the human race 778 00:41:50,508 --> 00:41:52,909 if we simply knew we could live forever. 779 00:41:52,911 --> 00:41:55,878 Rose: What happens to marriage and relationships 780 00:41:55,880 --> 00:41:58,748 if our life-spans grow to 1,000 years or more? 781 00:41:58,750 --> 00:42:00,083 Right now, 782 00:42:00,085 --> 00:42:02,785 half of us get divorced just in our short lifetimes. 783 00:42:02,787 --> 00:42:04,787 But if we lived for 1,000 years, 784 00:42:04,789 --> 00:42:08,091 who knows how many times you might get married? 785 00:42:08,093 --> 00:42:10,660 I don't think that I would be able to live forever. 786 00:42:10,662 --> 00:42:12,595 I think my wife would kill me first. 787 00:42:12,597 --> 00:42:15,131 Freeman: Whether we like it or not, 788 00:42:15,133 --> 00:42:18,067 more and more scientists believe we will one day live 789 00:42:18,069 --> 00:42:22,338 in a world without age, disease, and death... 790 00:42:22,340 --> 00:42:26,476 That we'll revel in the joys and wonders of endless life 791 00:42:26,478 --> 00:42:30,480 and that we'll just have to learn to cope 792 00:42:30,482 --> 00:42:34,951 with the consequences of living forever. 793 00:42:34,953 --> 00:42:40,690 Mythology says that the Gods envy our mortality. 794 00:42:40,692 --> 00:42:42,325 Our mortality 795 00:42:42,327 --> 00:42:46,262 is what makes life precious and something to be savored. 796 00:42:46,264 --> 00:42:49,365 Driven by the pressure of time to achieve greatness, 797 00:42:49,367 --> 00:42:53,603 it may be our mortality that gives us our humanity. 798 00:42:53,605 --> 00:42:56,005 But as long as we are mortal, 799 00:42:56,007 --> 00:42:59,976 we'll never stop dreaming of life everlasting. 800 00:42:59,978 --> 00:43:04,180 That, too, is what makes us human. 801 00:43:04,254 --> 00:43:08,254 == sync, corrected by elderman ==65655

Can't find what you're looking for?
Get subtitles in any language from opensubtitles.com, and translate them here.