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These are the user uploaded subtitles that are being translated: 1 00:00:02,000 --> 00:00:07,000 Downloaded from YTS.MX 2 00:00:08,000 --> 00:00:13,000 Official YIFY movies site: YTS.MX 3 00:00:17,640 --> 00:00:20,920 [ethereal music plays] 4 00:00:28,800 --> 00:00:30,640 [Randal Koene] There are all kinds of situations 5 00:00:30,720 --> 00:00:32,960 where we would love to have more control 6 00:00:33,040 --> 00:00:36,280 over what the brain can do, so that you have these choices 7 00:00:36,360 --> 00:00:39,600 of what exactly you are taking in, what you're learning, 8 00:00:39,680 --> 00:00:41,280 and where you're going with that. 9 00:00:42,120 --> 00:00:45,600 And there are also situations where we simply wish that we could experience more. 10 00:00:45,680 --> 00:00:50,200 Say, for example, that you would like to be able to perceive 11 00:00:50,280 --> 00:00:52,040 things that we currently can't perceive. 12 00:00:52,120 --> 00:00:54,200 You want to be able to see the ultraviolet, 13 00:00:54,280 --> 00:00:56,960 or you want to be able to hear ultrasound, 14 00:00:57,040 --> 00:01:00,160 or what if you wanted to be able to, 15 00:01:00,240 --> 00:01:02,880 uh, remember more things than you normally can remember. 16 00:01:03,560 --> 00:01:06,000 [computer beeping, computer processing] 17 00:01:07,640 --> 00:01:10,520 The most exciting part of the future to me 18 00:01:10,600 --> 00:01:14,000 is the potential to achieve humanistic intelligence. 19 00:01:14,080 --> 00:01:17,720 This idea that the late Marvin Minsky talked about, 20 00:01:17,800 --> 00:01:20,800 which is being able to create an environment 21 00:01:20,880 --> 00:01:25,280 where we have a symbiotic relationship with artificial intelligence, 22 00:01:25,360 --> 00:01:29,160 uh, and we will see a blurring of our physical, digital, 23 00:01:29,240 --> 00:01:33,120 and biological worlds, and not so much being separate parts, 24 00:01:33,200 --> 00:01:38,120 but as being seamless parts of one integrated human organism. 25 00:01:43,560 --> 00:01:46,440 It probably will be possible to read out 26 00:01:46,520 --> 00:01:49,240 what's inside a person's brain, to understand what's there, 27 00:01:49,320 --> 00:01:51,920 by translating it into something you can understand, 28 00:01:52,000 --> 00:01:55,280 and maybe even putting it back, giving it to someone, teaching. 29 00:01:57,720 --> 00:01:59,640 When we make a decision now, 30 00:01:59,720 --> 00:02:02,440 we are under the impression that we are the ones who are making the decision, 31 00:02:02,520 --> 00:02:04,680 and we make it because we want to make it, 32 00:02:04,760 --> 00:02:09,400 but if our brains are connected to the net, to a computer cloud, 33 00:02:09,479 --> 00:02:13,840 uh, and their algorithms that they are using are decision making, 34 00:02:13,920 --> 00:02:15,880 well, who is deciding? 35 00:02:21,320 --> 00:02:23,520 [theme music playing] 36 00:02:37,280 --> 00:02:38,920 [intense music playing] 37 00:03:03,120 --> 00:03:07,640 We are curious to understand who we are, and why we think the way we think, 38 00:03:07,720 --> 00:03:11,760 and what is the reason of our thoughts, 39 00:03:11,840 --> 00:03:14,440 our memories, our imagination, our feelings. 40 00:03:14,520 --> 00:03:16,120 [ethereal music playing] 41 00:03:27,400 --> 00:03:29,560 Understanding this incredibly complex organ, 42 00:03:29,640 --> 00:03:32,480 that gives rise to everything that makes us human. 43 00:03:32,560 --> 00:03:36,320 Everything we see, feel, hear, our sense of identity, 44 00:03:36,400 --> 00:03:40,920 and so, given the vast complexity of the brain, 45 00:03:41,000 --> 00:03:42,840 you know, a hundred billion neurons, 46 00:03:42,920 --> 00:03:45,600 you know, hundreds of trillions of connections, 47 00:03:45,680 --> 00:03:50,080 um, operating in a dynamic network that's constantly changing, 48 00:03:50,160 --> 00:03:55,080 it's just a really very, very complicated system 49 00:03:55,160 --> 00:03:57,000 for us to study with science. 50 00:03:57,080 --> 00:04:01,400 So it's a big challenge, but one that I really enjoy undertaking. 51 00:04:04,320 --> 00:04:06,520 In the human brain, you have about 52 00:04:06,600 --> 00:04:09,360 three million kilometers of fibers connecting it, 53 00:04:09,440 --> 00:04:13,720 so it's enough to go around the Moon a couple of times, just in one brain. 54 00:04:16,200 --> 00:04:18,000 [narrator] The place in the universe 55 00:04:18,079 --> 00:04:21,120 that is likely the most complex and mysterious… 56 00:04:21,959 --> 00:04:26,280 the place where emotions, thoughts and memories arise, 57 00:04:26,360 --> 00:04:31,360 that place in the universe that tries tirelessly to understand itself, 58 00:04:31,920 --> 00:04:34,400 an unsolved enigma. 59 00:04:35,280 --> 00:04:37,120 We don't know and we cannot build 60 00:04:37,200 --> 00:04:40,520 today anything that is even as closely 61 00:04:40,600 --> 00:04:44,120 connected to what we see in the human brain. 62 00:04:57,120 --> 00:04:58,480 There is one hypothesis 63 00:04:58,560 --> 00:05:01,880 that suggests that what brains are doing, 64 00:05:01,960 --> 00:05:06,720 what our brain is doing is generating a virtual reality, 65 00:05:06,800 --> 00:05:11,120 a model of the world that is running in our heads all the time. 66 00:05:11,200 --> 00:05:14,440 This has to do with ideas that have been floating around in philosophy 67 00:05:14,520 --> 00:05:15,960 for a few centuries, 68 00:05:16,040 --> 00:05:20,960 in particular, with the suggestion by Immanuel Kant, the German philosopher, 69 00:05:21,040 --> 00:05:24,880 that the reason why the world, on our minds, 70 00:05:24,960 --> 00:05:27,160 our views of the world agree… 71 00:05:28,160 --> 00:05:32,000 is not because our minds reflect the world. 72 00:05:32,080 --> 00:05:33,640 No, no, it's the opposite. 73 00:05:33,720 --> 00:05:36,320 Is that the world is created by our minds. 74 00:05:36,880 --> 00:05:42,000 In other words, that what we perceive is not out there. It's in here. 75 00:05:44,600 --> 00:05:47,280 [narrator] It weighs less than three pounds. 76 00:05:47,360 --> 00:05:51,400 It consumes scarcely 20 or 30 watts of power, 77 00:05:51,480 --> 00:05:54,840 and nevertheless, it's able to make calculations 78 00:05:54,920 --> 00:05:57,760 more complex than a supercomputer. 79 00:05:58,640 --> 00:06:05,200 There are a hundred to a thousand trillion synapses about the size of bacteria. 80 00:06:05,280 --> 00:06:08,240 They basically are chemical machines. 81 00:06:08,320 --> 00:06:12,360 They receive an electric pulse, and then they release chemicals. 82 00:06:12,440 --> 00:06:15,920 They hit receptors, a very complex machinery is triggered. 83 00:06:16,000 --> 00:06:19,960 These results in a change in the behavior of the neurons. 84 00:06:20,520 --> 00:06:24,720 It causes genes to express, new proteins to come in… 85 00:06:24,800 --> 00:06:29,400 The cascade of biochemical and biophysical processes 86 00:06:29,480 --> 00:06:31,480 is enormously complex. 87 00:06:40,480 --> 00:06:45,920 If you would try to describe how the networks of cells is working, 88 00:06:46,000 --> 00:06:50,160 I would say that imagine you are having 89 00:06:50,240 --> 00:06:53,920 phone calls for 10,000 people at one and the same time, 90 00:06:54,000 --> 00:06:56,000 and the same what you are doing, 91 00:06:56,080 --> 00:07:00,600 everybody is doing, who is living on our planet, on the Earth, 92 00:07:01,160 --> 00:07:03,200 about seven billion people. 93 00:07:03,280 --> 00:07:06,960 And when you then try to describe all this communication 94 00:07:07,040 --> 00:07:11,000 that is going on of all the seven billion people, 95 00:07:11,080 --> 00:07:15,960 and then you imagine that this is only one-tenth, perhaps, of the capacity, 96 00:07:16,040 --> 00:07:18,920 and everything is only within your skull, 97 00:07:19,000 --> 00:07:22,480 it is restricted to one and a half kilogram, 98 00:07:22,560 --> 00:07:24,480 and this is complexity in my view. 99 00:07:24,560 --> 00:07:26,280 [ethereal music continues] 100 00:07:32,840 --> 00:07:34,480 [dial rattling] 101 00:07:40,280 --> 00:07:44,400 In spite of a hundred years of neuroscience, 102 00:07:44,480 --> 00:07:46,600 we still don't understand how the brain works. 103 00:07:46,680 --> 00:07:51,360 We still don't have a general theory of the function of the brain. 104 00:07:55,760 --> 00:07:59,680 The first reason why I would argue is critical to understand 105 00:07:59,760 --> 00:08:04,280 how the brain works has to do with our own definition as human beings. 106 00:08:05,280 --> 00:08:08,920 We are a mental species. We are defined by our minds, 107 00:08:09,720 --> 00:08:14,320 not by our bodies, so we are a very special type of animal. 108 00:08:14,960 --> 00:08:18,440 We don't understand the organ that generates our minds, 109 00:08:19,040 --> 00:08:22,840 so when we understand how the brain works, 110 00:08:22,920 --> 00:08:28,200 we will be able to understand how our mind is from the inside, 111 00:08:28,280 --> 00:08:30,520 and we'll understand ourselves for the first time. 112 00:08:30,600 --> 00:08:31,960 [suspenseful music playing] 113 00:08:39,640 --> 00:08:43,200 The second reason has to do with the clinic, with patients. 114 00:08:43,280 --> 00:08:46,240 Humankind should understand how the brain works because we need… 115 00:08:46,320 --> 00:08:47,880 Uh, it's urgent 116 00:08:47,960 --> 00:08:50,680 that we help these patients that have mental and neurological diseases, 117 00:08:50,760 --> 00:08:53,520 and we have to understand the system in order to fix it. 118 00:09:03,720 --> 00:09:07,520 We estimate that, possibly, one person out of two 119 00:09:07,600 --> 00:09:10,800 to one person out of three in Europe 120 00:09:10,880 --> 00:09:15,080 have some kind of a disorder that is related to the brain. 121 00:09:15,160 --> 00:09:21,160 Altogether, it's maybe up to more than 200 million person in Europe 122 00:09:21,240 --> 00:09:23,120 who have one of these disorders. 123 00:09:23,760 --> 00:09:28,040 And it's also associated with a huge cost for the society. 124 00:09:28,120 --> 00:09:33,400 The cost of all disease affecting the brain is more than the cost 125 00:09:33,480 --> 00:09:39,360 of all cancer, plus all cardiovascular disease, plus diabetes. 126 00:09:42,680 --> 00:09:45,800 [Rafael Yuste] And then the third reason has to do with technology and the economy. 127 00:09:46,600 --> 00:09:48,360 And it is very likely that brains, 128 00:09:48,440 --> 00:09:51,120 not just of humans but brains of all animals, 129 00:09:51,200 --> 00:09:55,200 have discovered through hundreds of millions of years or evolution… 130 00:09:56,200 --> 00:10:00,600 ways to compute that could be much more efficient and powerful 131 00:10:00,680 --> 00:10:03,400 than what we're doing currently with our digital computers. 132 00:10:03,480 --> 00:10:05,720 So if this is the case, if we understood, 133 00:10:05,800 --> 00:10:11,560 if we were able to break this neural code and understand how the brain computes, 134 00:10:11,640 --> 00:10:14,000 and what are the algorithms that are present 135 00:10:14,080 --> 00:10:15,360 in our nervous systems, 136 00:10:15,440 --> 00:10:17,800 we will likely revolutionize, uh, 137 00:10:17,880 --> 00:10:19,200 computer science, 138 00:10:19,280 --> 00:10:20,360 computer technology, 139 00:10:20,440 --> 00:10:22,720 and I would say, the economy, at the same time. 140 00:10:26,680 --> 00:10:28,120 [monitor whirring] 141 00:10:29,800 --> 00:10:32,520 [Tan Le] The Holy Grail for this would be to create 142 00:10:32,600 --> 00:10:36,360 a much more symbiotic relationship with artificial intelligence. 143 00:10:36,440 --> 00:10:39,080 As we can see today, artificial intelligence 144 00:10:39,160 --> 00:10:41,120 is moving forward in leaps and bounds, 145 00:10:41,200 --> 00:10:44,920 offering us a myriad of new ways of being 146 00:10:45,000 --> 00:10:49,760 more productive and more efficient in how we conduct our businesses, 147 00:10:49,840 --> 00:10:52,160 and how we manage our daily lives. 148 00:10:52,240 --> 00:10:54,040 With the introduction 149 00:10:54,120 --> 00:10:57,240 of more and more devices that actually understand the human, 150 00:10:57,320 --> 00:11:00,240 and how humans optimize their own performance, 151 00:11:00,320 --> 00:11:03,480 we will have a way to create a much more… 152 00:11:03,560 --> 00:11:05,040 a different type of intelligence. 153 00:11:05,120 --> 00:11:07,440 What I would call humanistic intelligence. 154 00:11:07,520 --> 00:11:10,320 The distinction between the biological world, 155 00:11:10,400 --> 00:11:13,520 the physical world, and the digital world will just blur, 156 00:11:13,600 --> 00:11:17,640 and we will integrate seamlessly across all of these dimensions. 157 00:11:19,080 --> 00:11:21,120 [narrator] A deep understanding of the functioning 158 00:11:21,200 --> 00:11:26,440 of the human brain could bring answers to great philosophical questions 159 00:11:26,520 --> 00:11:29,920 such as what consciousness is and how it is built, 160 00:11:30,000 --> 00:11:31,880 or if there is free will. 161 00:11:32,440 --> 00:11:36,080 Concepts such as the inner self, guilt, 162 00:11:36,160 --> 00:11:38,720 or even reality could change forever. 163 00:11:40,320 --> 00:11:42,800 We are opening the door to a world 164 00:11:42,880 --> 00:11:47,160 where we will communicate directly with a computer through thought, 165 00:11:47,240 --> 00:11:50,520 a world where we will be able to share our thoughts 166 00:11:50,600 --> 00:11:52,720 and our emotions through the internet. 167 00:11:52,800 --> 00:11:56,680 We can envision a future in which we are able to read 168 00:11:56,760 --> 00:12:00,080 the thoughts of others and even to manipulate them. 169 00:12:05,920 --> 00:12:08,600 We are building technology to read the activity 170 00:12:08,680 --> 00:12:10,440 of all the neurons in these brains 171 00:12:10,520 --> 00:12:13,040 and to write activity to control 172 00:12:13,120 --> 00:12:15,480 and manipulate the activity of these neurons in the brain. 173 00:12:16,200 --> 00:12:20,800 And these technologies are necessary to be able to cure human patients. 174 00:12:25,000 --> 00:12:27,520 But the same technologies, technology is neutral, 175 00:12:27,600 --> 00:12:29,480 it could be used for good or for a bad. 176 00:12:29,560 --> 00:12:33,360 The same technologies to read and write activity into brains 177 00:12:33,440 --> 00:12:37,960 can be used to decipher what people are thinking, 178 00:12:38,040 --> 00:12:43,040 or to influence the activity of the minds of people. 179 00:12:43,120 --> 00:12:45,200 So you'll say, "Well, this is science fiction." 180 00:12:45,280 --> 00:12:46,880 Well, not really. 181 00:12:51,000 --> 00:12:52,720 [ethereal music playing] 182 00:12:55,560 --> 00:12:57,240 [narrator] In the middle of the '90s, 183 00:12:57,320 --> 00:13:00,960 the last decade of the 20th century and the second millennium, 184 00:13:01,040 --> 00:13:05,440 a whole revolution in the world of neuroscience occurred, 185 00:13:05,520 --> 00:13:08,240 the neuro-imaging techniques appeared. 186 00:13:10,240 --> 00:13:14,440 Neuro-imaging techniques are important for this revolution, 187 00:13:14,520 --> 00:13:17,800 out to learn and explore the brain 188 00:13:17,880 --> 00:13:22,640 because it's a nice non-invasive way to get inside the brain. 189 00:13:22,720 --> 00:13:24,640 [narrator] One of the imaging techniques 190 00:13:24,720 --> 00:13:29,040 that had the greatest impact was magnetic resonance imaging. 191 00:13:33,200 --> 00:13:37,680 For the first time ever, we could see the inner functioning of the brain 192 00:13:37,760 --> 00:13:41,000 while it experiences sensations and emotions. 193 00:13:42,080 --> 00:13:45,920 In fact, functional magnetic resonance imaging, 194 00:13:46,000 --> 00:13:49,160 able to detect the presence of oxygen in the blood in the brain, 195 00:13:49,240 --> 00:13:51,000 has allowed us to discover 196 00:13:51,080 --> 00:13:53,680 something unimaginable years ago, 197 00:13:54,240 --> 00:13:56,640 how different areas in the brain interact 198 00:13:56,720 --> 00:13:59,320 while the patient talks, sees an image, 199 00:13:59,400 --> 00:14:02,360 listens to a sound or simply thinks. 200 00:14:05,400 --> 00:14:08,840 But if you ask him to focus on one task, 201 00:14:08,920 --> 00:14:10,920 like listening to a sound, 202 00:14:11,000 --> 00:14:15,800 only the region from this specific task, the auditory cortex, for example, 203 00:14:15,880 --> 00:14:18,480 will have more conception of oxygen, 204 00:14:18,560 --> 00:14:20,680 and this region will pop out into contrast 205 00:14:20,760 --> 00:14:24,040 if you analyze the data, listening to sound 206 00:14:24,120 --> 00:14:25,720 against not listening to sound. 207 00:14:28,920 --> 00:14:31,360 The reason why we don't understand how the brain works 208 00:14:31,440 --> 00:14:33,360 is not because of its complexity, 209 00:14:33,440 --> 00:14:38,040 but because we've been lacking methods to study it at the right level. 210 00:14:38,600 --> 00:14:40,400 Now, if you think about it, trying to understand 211 00:14:40,480 --> 00:14:43,000 a system as complex as the brain, 212 00:14:43,080 --> 00:14:45,040 that has a hundred billion neurons, 213 00:14:45,120 --> 00:14:47,360 by recording from one neuron 214 00:14:47,440 --> 00:14:50,600 is a little bit like trying to watch a movie in a TV screen 215 00:14:51,280 --> 00:14:54,680 that has a million pixels by looking at a single pixel. 216 00:14:55,320 --> 00:14:58,360 So no matter for how long you study a single pixel, 217 00:14:58,440 --> 00:15:01,760 you study a single neuron, you will be missing the figures 218 00:15:01,840 --> 00:15:05,400 in the screen and the shapes of the images 219 00:15:05,480 --> 00:15:10,320 because they are an emergent property of the correlations in space 220 00:15:10,400 --> 00:15:12,680 and time between the individual pixels. 221 00:15:12,760 --> 00:15:14,680 [adventurous electronic music playing] 222 00:15:20,640 --> 00:15:22,880 We think that neuroscience should embark 223 00:15:22,960 --> 00:15:26,680 on this period of new technology, 224 00:15:26,760 --> 00:15:29,160 to develop the methods so that neuroscientists 225 00:15:29,240 --> 00:15:33,280 and clinicians will be able to see for the first time in the future 226 00:15:33,360 --> 00:15:36,000 the activity of complete neural circuits 227 00:15:36,080 --> 00:15:39,800 and be able to decipher the functional meaning of this pattern. 228 00:15:53,360 --> 00:15:56,000 How can one measure the activity 229 00:15:56,080 --> 00:16:00,800 of each and every one of the neurons in the brain at the same time? 230 00:16:00,880 --> 00:16:05,080 The methods that we and many other people are using are optical methods. 231 00:16:05,160 --> 00:16:09,960 We use light because light can penetrate the tissue in a non-invasive fashion. 232 00:16:10,040 --> 00:16:14,000 In particular, the method that I pioneered is called Calcium Imaging, 233 00:16:14,080 --> 00:16:18,560 and we used it for the first time to measure the activity of neural circuits. 234 00:16:18,640 --> 00:16:22,320 Every time a neuron fires, every time it's activated, 235 00:16:22,400 --> 00:16:24,080 calcium comes into the neuron, 236 00:16:24,760 --> 00:16:27,080 so that means if you have his little calcium indicators, 237 00:16:27,160 --> 00:16:30,160 these fluorescent molecules in all the neurons, 238 00:16:30,240 --> 00:16:33,480 you can directly see who is firing, 239 00:16:33,560 --> 00:16:36,240 who is being activated in the entire group at once, 240 00:16:36,320 --> 00:16:39,920 because you see these as changes in fluorescence 241 00:16:40,000 --> 00:16:42,720 that are happening in different neurons at different times. 242 00:16:44,520 --> 00:16:46,640 [narrator] Thanks to neuro-imaging techniques, 243 00:16:46,720 --> 00:16:48,640 we have learned more about the brain 244 00:16:48,720 --> 00:16:52,880 the last 15 years than in the whole history of humankind. 245 00:16:54,840 --> 00:16:59,080 The advances already made allow us to think that in the near future, 246 00:16:59,160 --> 00:17:02,080 we will be able to solve neurological damage, 247 00:17:02,160 --> 00:17:04,880 diseases like Parkinson's or Alzheimer's, 248 00:17:04,960 --> 00:17:07,119 depression or schizophrenia. 249 00:17:07,200 --> 00:17:10,319 Yeah, I think that the revolution we're experiencing now is, 250 00:17:10,400 --> 00:17:14,560 first, the birth and the success of human neuroscience. 251 00:17:14,640 --> 00:17:17,560 We now have fields like cognitive neuroscience, 252 00:17:17,640 --> 00:17:20,319 where we use functional brain imaging and non-invasive brain stimulation, 253 00:17:20,400 --> 00:17:23,640 to study the functioning human brain. 254 00:17:23,720 --> 00:17:26,000 And that was, I think, the first step. 255 00:17:26,079 --> 00:17:27,960 [adventurous electronic music playing] 256 00:17:35,760 --> 00:17:39,320 From my perspective, I've been doing neuroscience research for 30 years 257 00:17:39,400 --> 00:17:42,320 and this is the revolution now. 258 00:17:42,400 --> 00:17:44,160 But now, it's the time that neuroscience 259 00:17:44,240 --> 00:17:47,080 is starting to reach into people's lives directly. 260 00:17:47,160 --> 00:17:50,200 And to me, that's what we need to have a revolution. 261 00:17:50,280 --> 00:17:53,600 We need to advance from the lab into the real world. 262 00:18:04,640 --> 00:18:05,840 [Kim Old] This is a super application 263 00:18:05,920 --> 00:18:09,800 to be able to control the puzzle box orbit. 264 00:18:10,560 --> 00:18:14,440 I'll first connect it to the emotive NCIG headset. 265 00:18:14,520 --> 00:18:16,000 [app beeps] 266 00:18:16,080 --> 00:18:17,520 And it's now connected. 267 00:18:17,600 --> 00:18:20,480 What we have to do is train two patterns. 268 00:18:20,560 --> 00:18:22,840 Um, the first is a resting state, 269 00:18:22,920 --> 00:18:27,680 so that we understand when you want to control the orbit versus no. 270 00:18:28,240 --> 00:18:30,640 And then, the second pattern is to control 271 00:18:30,720 --> 00:18:33,320 what you want to apply for flying the orbit. 272 00:18:38,840 --> 00:18:40,160 [orbit whirring] 273 00:18:50,480 --> 00:18:52,280 -Woo-hoo! -[orbit clattering] 274 00:18:54,920 --> 00:18:57,560 -[indistinct chatter] -[laughter] 275 00:18:59,280 --> 00:19:01,880 [narrator] This leap from the lab to the real world, 276 00:19:01,960 --> 00:19:04,920 can already be seen in the form of the perfecting of what 277 00:19:05,000 --> 00:19:09,560 belonged to the realm of science fiction just a few years ago, 278 00:19:09,640 --> 00:19:11,960 brain-computer association. 279 00:19:12,920 --> 00:19:15,120 The so-called Brain-Machine Interfaces 280 00:19:15,200 --> 00:19:19,280 have solidified this revolution in the world of the neuroscience. 281 00:19:21,080 --> 00:19:24,480 BCI really just means Brain Computer Interface, 282 00:19:24,560 --> 00:19:28,080 so anything that makes a connection between processing going on 283 00:19:28,160 --> 00:19:31,760 inside your brain and a machine, or some other devices. 284 00:19:34,200 --> 00:19:37,600 Brain computer interfaces can be grouped as a group 285 00:19:37,680 --> 00:19:42,360 of technologies that can help both from a hardware and software perspective, 286 00:19:42,440 --> 00:19:47,160 able to both decode, process and activate 287 00:19:47,800 --> 00:19:50,480 the interface interactions between humans and machines, 288 00:19:50,560 --> 00:19:51,960 decoding the brain of course. 289 00:19:52,040 --> 00:19:55,640 But the typical definition would be a platform that can help us interact 290 00:19:55,720 --> 00:19:57,440 from the brain to the world. 291 00:19:57,520 --> 00:19:59,080 [ethereal music playing] 292 00:20:14,000 --> 00:20:17,320 [narrator] The Brain-Machine Interfaces are bringing great advances 293 00:20:17,400 --> 00:20:19,960 in various therapeutical applications. 294 00:20:20,040 --> 00:20:23,920 Up to now, one of the main practical applications 295 00:20:24,000 --> 00:20:28,200 is the treatment of different pathologies associated with paralysis. 296 00:20:28,920 --> 00:20:32,560 At the Federal Polytechnic School of Lausanne, Switzerland, 297 00:20:32,640 --> 00:20:36,480 Dr José Millán has been working for years on an ambitious project 298 00:20:36,560 --> 00:20:40,240 based on the development of a brain-machine interface 299 00:20:40,320 --> 00:20:44,720 that allows paralytics to control a robotic exoskeleton with their minds, 300 00:20:45,360 --> 00:20:48,280 thanks to which they can walk again or move a hand. 301 00:20:49,520 --> 00:20:51,600 The patients wear an electrode helmet 302 00:20:51,680 --> 00:20:54,640 that detects their cerebral electrical activity. 303 00:20:57,440 --> 00:20:59,840 What we ask people to do at the very beginning, 304 00:20:59,920 --> 00:21:01,720 because they need to go through a training 305 00:21:01,800 --> 00:21:07,440 in order to acquire the capability to modulate voluntarily their brain signals, 306 00:21:07,520 --> 00:21:12,280 is to imagine the movements that they want to accomplish, 307 00:21:12,360 --> 00:21:17,360 and this requires some time because it is not easy to do that. 308 00:21:17,440 --> 00:21:21,560 Our algorithms are capable to discover which are the areas, 309 00:21:21,640 --> 00:21:23,040 the specific areas 310 00:21:23,120 --> 00:21:26,280 that they are activating and de-activating, 311 00:21:26,360 --> 00:21:29,520 at which frequencies this is happening, 312 00:21:29,600 --> 00:21:33,120 and this is the input to our machine-learning algorithms 313 00:21:33,200 --> 00:21:36,680 that will build the model of the decoder 314 00:21:36,760 --> 00:21:40,120 that will differentiate an opening, 315 00:21:40,200 --> 00:21:42,560 a closing of the hand, a right step, 316 00:21:42,640 --> 00:21:45,360 a left step and so on and so forth. 317 00:21:45,440 --> 00:21:48,840 So during this training, people at the very beginning 318 00:21:48,920 --> 00:21:52,520 need to imagine the movement of their own body, 319 00:21:52,600 --> 00:21:56,560 and in many cases, people, after some training, 320 00:21:56,640 --> 00:22:00,960 and because of the fact that, as they imagine the movement of their body, 321 00:22:01,040 --> 00:22:04,280 this is executed via the exoskeleton, 322 00:22:04,360 --> 00:22:07,800 they don't need to think any longer about their own body. 323 00:22:07,880 --> 00:22:10,040 They think in terms of the exoskeleton 324 00:22:10,120 --> 00:22:13,200 because the exoskeleton has been integrated, somehow, 325 00:22:13,280 --> 00:22:18,080 in people's body scheme that we have in our brain. 326 00:22:19,480 --> 00:22:21,040 [amusing music playing] 327 00:22:22,600 --> 00:22:25,960 [narrator] The possibilities that this technique offers to these patients, 328 00:22:26,040 --> 00:22:28,360 have allowed to a quadriplegic patient 329 00:22:28,440 --> 00:22:32,440 to be able to drive a Formula One car just with his mind. 330 00:22:34,440 --> 00:22:39,520 In 2017, Rodrigo Hubner Mendes became the first person 331 00:22:39,600 --> 00:22:41,160 to reach such a milestone. 332 00:22:41,240 --> 00:22:44,520 [Tan Le] This opportunity to work with Rodrigo was incredible. 333 00:22:44,600 --> 00:22:48,320 Globo TV in Brazil created a vehicle, 334 00:22:48,400 --> 00:22:52,200 a Formula One vehicle that was completely controlled 335 00:22:52,280 --> 00:22:54,600 just using the power of thought. 336 00:22:54,680 --> 00:22:59,040 So, what they used was a 14-channel EPOC+ headset, 337 00:22:59,120 --> 00:23:03,040 uh, measuring electrical fluctuations from Rodrigo's brain. 338 00:23:03,120 --> 00:23:07,360 He spent a few months mapping and training the algorithms 339 00:23:07,440 --> 00:23:11,080 to understand how he associated specific thoughts 340 00:23:11,160 --> 00:23:15,760 whether it'd be drive forward, turn right, left, or stop, 341 00:23:15,840 --> 00:23:18,280 and then he was able to use those commands 342 00:23:18,360 --> 00:23:23,360 to drive this car completely just using his mind. 343 00:23:23,440 --> 00:23:28,880 So no steering wheel, no pedals, just him inside the vehicle. 344 00:23:35,120 --> 00:23:39,280 This was a very fortuitous moment when Lewis Hamilton, 345 00:23:39,360 --> 00:23:42,640 who is obviously world's reigning F1 champion, 346 00:23:42,720 --> 00:23:46,560 was in the same place as Rodrigo in the UAE. 347 00:23:46,640 --> 00:23:52,280 Rodrigo posted a very exciting challenge for Lewis, which is, 348 00:23:52,360 --> 00:23:54,080 "Would you like to race me?" 349 00:23:54,160 --> 00:23:57,600 Surprisingly, Lewis accepted the challenge, 350 00:23:57,680 --> 00:23:59,480 so I'm not sure when we are going to start 351 00:23:59,560 --> 00:24:01,480 seeing the two of them start practicing, 352 00:24:01,560 --> 00:24:05,400 but I know that Rodrigo is very excited about the ability 353 00:24:05,480 --> 00:24:09,120 and the opportunity to race with the reigning world champion 354 00:24:09,200 --> 00:24:11,200 just using his mind. 355 00:24:11,280 --> 00:24:12,760 [keyboard clacking] 356 00:24:15,920 --> 00:24:18,880 [narrator] Around the world, a wide variety of projects 357 00:24:18,960 --> 00:24:20,960 based on brain-machine interfaces 358 00:24:21,040 --> 00:24:22,840 are currently being developed. 359 00:24:24,160 --> 00:24:28,800 In Boston, the company Neuroelectrics has developed a technology 360 00:24:28,880 --> 00:24:31,760 based on the use of mind-controlled video games 361 00:24:31,840 --> 00:24:34,400 to learn to regulate brain activity. 362 00:24:36,440 --> 00:24:38,440 Okay. So, today, we are going to measure 363 00:24:38,520 --> 00:24:40,960 your brain waves with this device. 364 00:24:41,040 --> 00:24:43,360 Uh, this device physically uses dry electrodes 365 00:24:43,440 --> 00:24:45,280 to measure your brain waves like this. 366 00:24:45,360 --> 00:24:46,200 [man] Mm-hmm. 367 00:24:46,280 --> 00:24:49,880 And today, we are going to measure your, specifically, alpha brainwaves, 368 00:24:49,960 --> 00:24:51,920 and you're going to be able to control an object 369 00:24:52,000 --> 00:24:54,040 in these screen going up and down. 370 00:24:54,720 --> 00:24:56,800 So I'm gonna put you the cap. 371 00:25:01,800 --> 00:25:05,520 Then we are first going to measure your baseline, 372 00:25:05,600 --> 00:25:08,120 which is the baseline of your brain waves, 373 00:25:08,200 --> 00:25:11,080 the level in which your brain is right now. 374 00:25:11,160 --> 00:25:13,120 [techno music playing] 375 00:25:18,400 --> 00:25:21,280 So the way we have developed our brain-computer interface is, 376 00:25:21,360 --> 00:25:23,880 we are collecting brain signals, for example, 377 00:25:23,960 --> 00:25:27,480 alpha or beta or gamma, which are different frequencies, right? 378 00:25:27,560 --> 00:25:31,800 And we are capering your brain or power spectrum, your brain bands, 379 00:25:31,880 --> 00:25:35,440 to something in the screen, which is, in this case, a little avatar 380 00:25:35,520 --> 00:25:36,840 that goes up and down, 381 00:25:36,920 --> 00:25:39,920 according to if your brain waves are up or down. 382 00:25:41,840 --> 00:25:43,200 So this submarine here, 383 00:25:43,280 --> 00:25:45,680 this is going up and down according to your brainwaves 384 00:25:45,760 --> 00:25:47,240 and you're controlling it. 385 00:25:47,320 --> 00:25:49,680 So you need to focus on it and keep relaxed 386 00:25:49,760 --> 00:25:52,480 and try to control it, moving it up and down. 387 00:25:53,920 --> 00:25:55,440 [game ringing] 388 00:25:59,680 --> 00:26:01,640 [narrator] The mind-controlled video games 389 00:26:01,720 --> 00:26:04,560 are proving to be an efficient treatment for diseases 390 00:26:04,640 --> 00:26:08,000 like depression or hyperactivity disorder in children. 391 00:26:10,200 --> 00:26:13,440 At Neuroscape, a neuro-technological company 392 00:26:13,520 --> 00:26:15,040 based in San Francisco, 393 00:26:15,120 --> 00:26:18,400 they are using these video games controlled by the mind 394 00:26:18,480 --> 00:26:20,200 for therapeutic uses. 395 00:26:24,680 --> 00:26:26,160 All of our research right now 396 00:26:26,240 --> 00:26:30,600 relies on using the closed-loop video games that we've created, 397 00:26:30,680 --> 00:26:34,320 so far, just using the performance, not the cognitive brain computer interface. 398 00:26:34,400 --> 00:26:35,960 That's still very much a research, 399 00:26:36,040 --> 00:26:37,200 in the research phase. 400 00:26:37,280 --> 00:26:41,800 And then we apply these, uh, these closed-loop video game treatments 401 00:26:41,880 --> 00:26:44,360 to see if they can improve attention abilities 402 00:26:44,440 --> 00:26:46,520 in many different clinical populations, 403 00:26:46,600 --> 00:26:50,720 including ADHD, which is attention deficit hyperactivity disorder, 404 00:26:50,800 --> 00:26:53,480 but also post-traumatic stress disorder, 405 00:26:53,560 --> 00:26:56,200 traumatic brain injury, depression and autism. 406 00:26:56,280 --> 00:26:58,440 We developed this closed-loop video games 407 00:26:58,520 --> 00:27:02,320 that record your performance and use that data to challenge you 408 00:27:02,400 --> 00:27:04,200 in a very personalized manner. 409 00:27:04,280 --> 00:27:07,240 So if it's too hard, the game could back off. 410 00:27:07,320 --> 00:27:09,040 If it's too easy, it can make it more challenging. 411 00:27:09,120 --> 00:27:11,080 Just puts it right at that sweet spot. 412 00:27:11,160 --> 00:27:14,240 And then the game mechanics target different neural networks 413 00:27:14,320 --> 00:27:15,800 that we're trying to improve. 414 00:27:15,880 --> 00:27:17,800 So it could be a prescribable treatment, 415 00:27:17,880 --> 00:27:21,720 just like we currently use stimulants to help improve attention abilities 416 00:27:21,800 --> 00:27:24,040 in children that are suffering ADHD. 417 00:27:24,120 --> 00:27:25,560 [dreamy music playing] 418 00:27:31,840 --> 00:27:35,040 [narrator] In the last few years, there has been a progressive 419 00:27:35,120 --> 00:27:38,000 blossoming of neuro-tech start-ups that are revolutionizing 420 00:27:38,080 --> 00:27:41,080 the way to intervene in our mental processes. 421 00:27:42,440 --> 00:27:45,360 Nowadays, most of them are focused on helping patients 422 00:27:45,440 --> 00:27:49,720 with different types of damage or neurological disorders. 423 00:27:49,800 --> 00:27:52,840 However, in the not-so-distant future, 424 00:27:52,920 --> 00:27:54,800 these companies will end up transferring 425 00:27:54,880 --> 00:27:57,320 all these advances to our daily lives, 426 00:27:57,400 --> 00:27:59,840 radically modifying the way we interact 427 00:27:59,920 --> 00:28:03,960 with each other and even understand the world. 428 00:28:06,440 --> 00:28:09,560 Investing in novel neuro-technology today 429 00:28:09,640 --> 00:28:14,600 could be the best way to generate an economic revolution 430 00:28:14,680 --> 00:28:18,440 in the future by the development of this new technology, 431 00:28:19,320 --> 00:28:23,400 which instead of biotechnology, in the case of the Human Genome Project, 432 00:28:23,480 --> 00:28:25,840 now it would be neuro-technology. 433 00:28:25,920 --> 00:28:27,800 And this is something that is starting to happen. 434 00:28:27,880 --> 00:28:33,640 Last year, Elon Musk created a neuro-technology company, Neuralink. 435 00:28:33,720 --> 00:28:36,240 Brian Johnson, another billionaire, 436 00:28:36,320 --> 00:28:39,680 has created a similar company called Kernel, 437 00:28:39,760 --> 00:28:43,080 so we start to have some new companies 438 00:28:43,160 --> 00:28:46,920 that are based on the promise 439 00:28:47,000 --> 00:28:48,920 that these new neuro-technologies 440 00:28:49,000 --> 00:28:51,520 are going to be causing an economic revolution. 441 00:28:56,960 --> 00:28:59,160 Emotiv is a neuro-informatics company, 442 00:28:59,240 --> 00:29:03,000 so what we do is we are a platform that allows us 443 00:29:03,080 --> 00:29:06,400 to interface directly with the brain. 444 00:29:06,480 --> 00:29:09,680 Today, it's using non-invasive methods. 445 00:29:09,760 --> 00:29:12,280 So we start from the sensor input, 446 00:29:12,360 --> 00:29:15,120 so measuring the brain activity itself, 447 00:29:15,200 --> 00:29:17,160 through to the translation 448 00:29:17,240 --> 00:29:19,520 of the electrical signals from the brain 449 00:29:19,600 --> 00:29:22,200 and then we map those to control 450 00:29:22,280 --> 00:29:24,560 and influence the environment around us. 451 00:29:24,640 --> 00:29:27,560 -[Tan Le] Look at your brain, Kim. -[both laugh] 452 00:29:27,640 --> 00:29:30,720 So you're wearing a 14-channel EEG, 453 00:29:30,800 --> 00:29:34,200 and this is just picking up electrical fluctuations 454 00:29:34,280 --> 00:29:37,480 that resolve from neurons firing inside your brain. 455 00:29:37,560 --> 00:29:40,120 The brain is made up of billions of neurons 456 00:29:40,200 --> 00:29:42,400 and when they interact, the chemical reaction 457 00:29:42,480 --> 00:29:45,560 just emits an electrical impulse that we can pick up. 458 00:29:45,640 --> 00:29:48,440 You can see the different parts of your brain is lighting up 459 00:29:48,520 --> 00:29:50,720 depending on what you might be thinking 460 00:29:50,800 --> 00:29:53,720 or whether you're paying attention to what I'm saying. 461 00:29:53,800 --> 00:29:57,680 So, what we're doing here is we're mapping those electrical fluctuations 462 00:29:57,760 --> 00:30:01,600 into a 3D model of what your brain is doing, 463 00:30:01,680 --> 00:30:04,600 and each of the colors represent a different frequency band, 464 00:30:04,680 --> 00:30:08,280 which indicates how fast the information is traveling 465 00:30:08,360 --> 00:30:10,480 from one part of the brain to another. 466 00:30:12,600 --> 00:30:14,000 [ethereal music playing] 467 00:30:23,000 --> 00:30:26,120 [narrator] Located in Lausanne, Switzerland, in the centre of Europe, 468 00:30:26,200 --> 00:30:28,880 is the headquarters of MindMaze, 469 00:30:28,960 --> 00:30:32,120 one of the largest neuro-technological companies in the world. 470 00:30:32,720 --> 00:30:36,840 Our big goals are really to disrupt industries from health care, 471 00:30:36,920 --> 00:30:40,480 so really improving quality of life after a neurological injury, 472 00:30:40,560 --> 00:30:43,800 all the way to being able to help healthy individuals, 473 00:30:43,880 --> 00:30:46,560 you know, enable the ability of the brain to learn, 474 00:30:46,640 --> 00:30:49,440 to play, to interact, and entertain. 475 00:30:53,200 --> 00:30:55,040 [narrator] One of those technologies 476 00:30:55,120 --> 00:30:58,120 designed to help the rehabilitation of patients 477 00:30:58,200 --> 00:31:00,880 who have suffered stroke is MindMotion PRO. 478 00:31:02,120 --> 00:31:04,760 It's the first device a stroke or a brain, 479 00:31:04,840 --> 00:31:07,360 a brain injury patient sees after the injury. 480 00:31:07,440 --> 00:31:08,560 You know, the first two days 481 00:31:08,640 --> 00:31:10,720 when they come out and they need to recover. 482 00:31:10,800 --> 00:31:13,920 It's one of the first devices that's able to start training 483 00:31:14,000 --> 00:31:16,280 of both the brain and the body. 484 00:31:16,360 --> 00:31:19,440 So it's about neuro-plasticity, tricking the brain. 485 00:31:23,840 --> 00:31:25,680 So we're gonna put markers 486 00:31:26,640 --> 00:31:31,040 on you so that the camera can see your arms 487 00:31:31,120 --> 00:31:34,320 while we do some activity. 488 00:31:35,360 --> 00:31:36,440 So it's pretty intuitive. 489 00:31:36,520 --> 00:31:40,800 You just need to move your hand to the start button, 490 00:31:41,680 --> 00:31:44,200 and similarly, if you move it 491 00:31:44,280 --> 00:31:48,480 in the direction that isn't indicated, you'll see how to correct it. 492 00:31:49,200 --> 00:31:50,720 So let's say, someone who has a stroke 493 00:31:50,800 --> 00:31:52,720 cannot move the left hand, 494 00:31:52,800 --> 00:31:54,440 and he can move the right hand, 495 00:31:54,520 --> 00:31:58,000 the camera in the MindMotion PRO tracks the right hand 496 00:31:58,080 --> 00:32:01,000 and puts it on an avatar on the left side. 497 00:32:01,080 --> 00:32:02,840 And then the brain suddenly says, 498 00:32:02,920 --> 00:32:05,360 something's happening there, so I should try more, 499 00:32:05,440 --> 00:32:09,720 and it starts activating the pathways that used to control that hand, 500 00:32:09,800 --> 00:32:11,400 and slowly accelerates recovery. 501 00:32:11,480 --> 00:32:13,120 [upbeat electronic music playing] 502 00:32:14,920 --> 00:32:18,000 [narrator] The latest and most ambitious proposal of MindMaze, 503 00:32:18,080 --> 00:32:20,720 the CogniChip, goes one step further 504 00:32:20,800 --> 00:32:25,360 and merges neuro-technology with artificial intelligence. 505 00:32:33,600 --> 00:32:36,560 Some entrepreneurs are looking into augmenting our brains 506 00:32:36,640 --> 00:32:38,480 so that we can develop super-intelligence 507 00:32:38,560 --> 00:32:42,840 that allows us to collaborate with artificial intelligence. 508 00:32:42,920 --> 00:32:46,000 It would be a way to reduce the risk for human beings 509 00:32:46,080 --> 00:32:50,480 to become irrelevant due to the rise of artificial intelligence. 510 00:32:59,080 --> 00:33:02,360 It is the next frontier. Neuroscience and neuro-technology, 511 00:33:02,440 --> 00:33:04,680 brain technology, is definitely the next frontier. 512 00:33:04,760 --> 00:33:06,280 Now, we truly are at the frontier 513 00:33:06,360 --> 00:33:09,280 where we can do some impactful things with the brain. 514 00:33:09,360 --> 00:33:12,800 So, yeah, neuro-technology is now really going to kick off. 515 00:33:14,840 --> 00:33:17,560 [NASA operator] Ignition sequence starts. 516 00:33:17,640 --> 00:33:19,800 Six, five, 517 00:33:19,880 --> 00:33:22,320 four, three, two, 518 00:33:22,400 --> 00:33:24,480 one, zero. 519 00:33:24,560 --> 00:33:26,360 All engines running. 520 00:33:27,320 --> 00:33:28,960 [narrator] One of the greatest technological 521 00:33:29,040 --> 00:33:31,320 and scientific milestones in history 522 00:33:31,400 --> 00:33:34,280 was the arrival of man on the moon. 523 00:33:34,360 --> 00:33:35,840 [surreal music playing] 524 00:33:36,760 --> 00:33:39,600 The Kennedy era was one of the periods 525 00:33:39,680 --> 00:33:43,200 of the greatest scientific splendor the world has ever known. 526 00:33:43,280 --> 00:33:47,120 As a consequence, an important economy grew around it, 527 00:33:47,200 --> 00:33:49,520 which led in a very short time, 528 00:33:49,600 --> 00:33:53,000 to unprecedented technological development. 529 00:33:56,520 --> 00:33:58,160 [water splashes] 530 00:33:58,240 --> 00:34:00,800 Ideas are what power our economy. 531 00:34:00,880 --> 00:34:04,320 We do innovation better than anybody else. 532 00:34:05,720 --> 00:34:07,880 And that makes our economy stronger. 533 00:34:07,960 --> 00:34:09,920 We have had many interactions 534 00:34:10,000 --> 00:34:14,199 with the White House Office of Science and Technology Policy 535 00:34:14,280 --> 00:34:18,280 and they had explained to us that they were interested in grand challenges 536 00:34:18,360 --> 00:34:21,800 for the US government to pursue any different areas of science 537 00:34:21,880 --> 00:34:25,280 that they thought could really be of the same ilk 538 00:34:25,360 --> 00:34:27,960 as, for instance, the Apollo moon landings, 539 00:34:28,040 --> 00:34:32,880 a big project that really would allow the entire US community 540 00:34:32,960 --> 00:34:36,199 to get behind something that would make a huge impact in science. 541 00:34:36,280 --> 00:34:37,960 [upbeat synth-wave music playing] 542 00:34:38,840 --> 00:34:42,480 [narrator] They found that great science project in the BRAIN Initiative, 543 00:34:42,560 --> 00:34:46,840 a research megaproject that Obama announced in 2013, 544 00:34:46,920 --> 00:34:50,040 with the goal of unveiling the mysteries of the brain. 545 00:34:55,159 --> 00:34:57,080 It's a very exciting moment, uh, 546 00:34:57,160 --> 00:35:00,080 there are many groups around the world developing new methods, 547 00:35:00,600 --> 00:35:05,240 and this is now leading to reenergizing of neuroscience, 548 00:35:05,320 --> 00:35:07,920 and to the perception that we can really do it, 549 00:35:08,000 --> 00:35:10,440 that this is doable, that we can actually end up 550 00:35:10,520 --> 00:35:13,760 being able to record the activity of every neuron in a brain 551 00:35:13,840 --> 00:35:17,320 and decipher it, and this could really revolutionize neuroscience 552 00:35:17,400 --> 00:35:20,560 just like the Human Genome Project revolutionized genetics. 553 00:35:24,560 --> 00:35:27,840 [narrator] Very soon after the launching of the BRAIN Initiative, 554 00:35:27,920 --> 00:35:30,200 the European Union announced its own megaproject, 555 00:35:30,920 --> 00:35:32,320 the Human Brain Project. 556 00:35:33,880 --> 00:35:36,200 [Rafael Yuste] It turns out that similar initiatives 557 00:35:36,280 --> 00:35:38,480 have been created in different countries. 558 00:35:40,360 --> 00:35:43,720 So there is a brain initiative in Japan, 559 00:35:44,360 --> 00:35:50,920 in Canada, in China, in Australia, South Korea and Israel. 560 00:35:51,000 --> 00:35:52,480 [whooshing, crackling] 561 00:35:54,120 --> 00:35:56,320 [narrator] The development of all these projects 562 00:35:56,400 --> 00:35:59,200 could change the scenario of brain research 563 00:35:59,280 --> 00:36:03,160 and lead humanity to unprecedented advances. 564 00:36:03,240 --> 00:36:05,680 So this is very exciting. This is just happening, 565 00:36:05,760 --> 00:36:12,040 and I hope that this will provide the ability to generate, uh, knowledge 566 00:36:12,120 --> 00:36:15,800 and send this knowledge throughout the world, into different countries, 567 00:36:15,880 --> 00:36:18,760 uh, in a way in which no one is left behind, 568 00:36:18,840 --> 00:36:22,920 and we're all part of the same exciting moment in history. 569 00:36:23,000 --> 00:36:24,480 [surreal music playing] 570 00:36:27,520 --> 00:36:29,720 [narrator] We've started the path to a new world 571 00:36:29,800 --> 00:36:31,960 in which a deeper knowledge of the brain 572 00:36:32,040 --> 00:36:34,760 will radically transform our human condition. 573 00:36:44,040 --> 00:36:45,200 [powering up] 574 00:36:49,440 --> 00:36:50,880 [sweeping music playing] 575 00:36:51,920 --> 00:36:53,480 [whirring] 576 00:36:55,760 --> 00:36:57,320 [computer beeping] 577 00:36:59,520 --> 00:37:04,320 Brain-machine communication will grow progressively more efficient and precise, 578 00:37:04,400 --> 00:37:08,080 and will open up a vast range of possibilities for human beings 579 00:37:08,160 --> 00:37:12,960 to benefit from the potential offered to us by artificial intelligence. 580 00:37:13,040 --> 00:37:14,800 [sweeping music continues] 581 00:37:24,840 --> 00:37:28,600 With the introduction of more and more devices 582 00:37:28,680 --> 00:37:30,760 that actually understand the human 583 00:37:30,840 --> 00:37:33,600 and how humans optimize their own performance, 584 00:37:33,680 --> 00:37:36,800 we will have a way to create a much more… 585 00:37:36,880 --> 00:37:38,560 a different type of intelligence, 586 00:37:38,640 --> 00:37:41,040 what I would call, "Humanistic intelligence." 587 00:37:41,120 --> 00:37:46,360 The idea is that you can create a myriad of devices and sensors around us 588 00:37:46,440 --> 00:37:49,840 that interface and interplay with artificial intelligence 589 00:37:49,920 --> 00:37:55,240 in a way that makes humans much more symbiotic with their environment. 590 00:37:55,320 --> 00:37:58,960 So, you know, the distinction between the biological world, 591 00:37:59,040 --> 00:38:02,560 the physical world, and the digital worlds will just blur, 592 00:38:02,640 --> 00:38:06,600 and we will integrate seamlessly across all of these dimensions. 593 00:38:06,680 --> 00:38:10,000 And so, when you feel confused, 594 00:38:10,080 --> 00:38:13,480 your AI will recognize that and will prompt you with commands. 595 00:38:13,560 --> 00:38:15,680 If it recognizes your fatigue, 596 00:38:15,760 --> 00:38:17,680 it will send a command to brew the coffee pot, 597 00:38:17,760 --> 00:38:20,480 or a message to your phone reminding you to go out 598 00:38:20,560 --> 00:38:22,640 and take a short walk and stretch your legs. 599 00:38:22,720 --> 00:38:25,280 So you will become integrated with your environment, 600 00:38:25,360 --> 00:38:27,840 and your environment becomes an extension of your brain. 601 00:38:27,920 --> 00:38:30,080 And I think that's the type of humanistic intelligence 602 00:38:30,160 --> 00:38:32,640 is really what we are going to see the future go. 603 00:38:33,440 --> 00:38:35,280 [electronic whirring] 604 00:38:37,120 --> 00:38:38,840 [coffee dripping] 605 00:38:47,560 --> 00:38:49,520 [electronic whirring, beeps] 606 00:38:55,360 --> 00:38:59,600 [narrator] The cognitive capacities of human beings will be enhanced. 607 00:39:00,880 --> 00:39:02,880 There are experiments by colleagues, um, 608 00:39:02,960 --> 00:39:05,840 such as Roi Cohen Kadosh, that have shown 609 00:39:05,920 --> 00:39:10,000 that you can improve numerical abilities in children, 610 00:39:10,080 --> 00:39:13,200 um, that have dyscalculia, 611 00:39:13,280 --> 00:39:18,880 people who have difficulties in doing arithmetic and so on. 612 00:39:18,960 --> 00:39:24,600 I think enhancement via implants, um, and things like this 613 00:39:24,680 --> 00:39:26,160 is definitely gonna be possible. 614 00:39:26,240 --> 00:39:27,760 [beeping, electronic whirring] 615 00:39:33,960 --> 00:39:36,120 [Rafael Yuste] Technologies are going to enable humans 616 00:39:36,200 --> 00:39:38,280 to augment ourselves mentally. 617 00:39:38,360 --> 00:39:40,640 Just like holding an iPhone, 618 00:39:40,720 --> 00:39:43,200 we can have access to an enormous amount of information. 619 00:39:43,280 --> 00:39:45,400 If that comes directly piped into our brains, 620 00:39:45,480 --> 00:39:48,640 we are going to be able to operate at the cognitive level 621 00:39:48,720 --> 00:39:51,760 above what we operate at normally. 622 00:39:51,840 --> 00:39:54,120 So they're going to be augmented humans. 623 00:39:54,200 --> 00:39:59,400 So this could cause major difference in the society. 624 00:39:59,480 --> 00:40:01,280 Can accentuate the difference 625 00:40:01,360 --> 00:40:03,240 between different social groups and different countries. 626 00:40:03,320 --> 00:40:06,920 And we have to ensure that there is equal access to all of that. 627 00:40:07,000 --> 00:40:08,880 That there is a principle of fairness 628 00:40:08,960 --> 00:40:12,640 that runs across the application of these new neuro-technologies 629 00:40:12,720 --> 00:40:14,800 and artificial intelligence algorithms. 630 00:40:14,880 --> 00:40:17,840 -[surreal music playing] -[electronic whirring] 631 00:40:23,040 --> 00:40:26,680 It gets more interesting when you can think about neuro-prosthesis 632 00:40:26,760 --> 00:40:28,760 in the cognitive parts of the brain. 633 00:40:28,840 --> 00:40:31,960 So let's take for instance this hippocampus prosthesis. 634 00:40:32,840 --> 00:40:35,400 The patients who are going to be the first ones 635 00:40:35,480 --> 00:40:38,080 to use these devices are going to be the first people 636 00:40:38,160 --> 00:40:41,000 with some kind of superhuman memory ability. 637 00:40:41,760 --> 00:40:43,440 The very first type of memory ability 638 00:40:43,520 --> 00:40:45,400 is going to be that they can choose 639 00:40:45,480 --> 00:40:49,600 when they do remember something and when they don't. 640 00:40:49,680 --> 00:40:52,600 Because they can say, "Okay, the stuff that I… 641 00:40:52,680 --> 00:40:56,440 The experiences that were coming through at three o'clock yesterday… 642 00:40:57,320 --> 00:40:59,200 I want those to be enhanced." 643 00:40:59,280 --> 00:41:01,280 [surreal music continues] 644 00:41:04,040 --> 00:41:05,680 [electronic whirring, beeps] 645 00:41:18,520 --> 00:41:19,920 [piano music playing] 646 00:41:24,560 --> 00:41:27,360 [narrator] Brain-Computer communication will make way 647 00:41:27,440 --> 00:41:30,160 for Brain-Computer-Brain Interfaces. 648 00:41:32,000 --> 00:41:34,400 You take what this person has learnt, 649 00:41:34,480 --> 00:41:38,160 you run it through the translator, and you give it to someone else's brain. 650 00:41:38,960 --> 00:41:41,760 Or you just want to be able to communicate 651 00:41:41,840 --> 00:41:43,680 through something like telepathy. 652 00:41:43,760 --> 00:41:46,560 You can read out what a person is trying to say 653 00:41:46,640 --> 00:41:49,000 or what they're imaging, what they are imagining, 654 00:41:49,080 --> 00:41:51,280 and you can try to give those imaginings, 655 00:41:51,360 --> 00:41:54,000 or those sounds, to someone else. 656 00:41:54,080 --> 00:41:55,440 [dramatic music playing] 657 00:42:01,320 --> 00:42:04,040 Or you could try to detect what a person is feeling, 658 00:42:04,120 --> 00:42:07,320 and you can translate that in a way, and then give it to someone else. 659 00:42:07,400 --> 00:42:08,960 So you can imagine this as a… 660 00:42:09,040 --> 00:42:13,840 as a communication pathway that wouldn't just work for words, 661 00:42:13,920 --> 00:42:16,280 but it would work for images, it would work for feelings. 662 00:42:16,360 --> 00:42:19,320 It would work for anything that we share in a sense 663 00:42:19,400 --> 00:42:21,560 where you can say, because we are all humans, 664 00:42:21,640 --> 00:42:25,240 we all have feelings of happiness, and of sadness and of pain, 665 00:42:25,320 --> 00:42:28,360 and we have a smell, and we have vision. 666 00:42:28,440 --> 00:42:30,400 So you can transfer smells, 667 00:42:30,480 --> 00:42:33,840 you can transfer vision, you can transfer auditory, you can… 668 00:42:33,920 --> 00:42:35,480 eventually, with enough translation, 669 00:42:35,560 --> 00:42:37,960 even translate knowledge and memory. 670 00:42:39,600 --> 00:42:41,880 Connecting brains is gonna be done. 671 00:42:41,960 --> 00:42:43,520 Um, there are definitely hurdles, 672 00:42:43,600 --> 00:42:46,760 and it's gonna take very important technological breakthroughs. 673 00:42:47,560 --> 00:42:50,800 I think in the future, we will definitely have 674 00:42:51,480 --> 00:42:54,640 uh, very powerful synthetic telepathy technologies. 675 00:42:55,760 --> 00:42:57,600 [energy pulsating] 676 00:43:00,800 --> 00:43:02,800 [computer alarming] 677 00:43:02,880 --> 00:43:06,280 [narrator] It will be possible not only to read other's thoughts, 678 00:43:06,360 --> 00:43:08,560 but also to manipulate them. 679 00:43:10,480 --> 00:43:12,240 Let's think about it a little bit more, 680 00:43:12,320 --> 00:43:14,720 about the impact and repercussions 681 00:43:14,800 --> 00:43:18,440 of this new knowledge to society, to humanity. 682 00:43:19,160 --> 00:43:21,480 [electronic whirring] 683 00:43:21,560 --> 00:43:23,720 We can, uh, using mice. 684 00:43:23,800 --> 00:43:26,280 We cannot read the activity of every neuron in the brain from ours, 685 00:43:26,360 --> 00:43:28,280 but if you look at the visual cortex, 686 00:43:28,360 --> 00:43:31,400 you can actually read the activity of a few thousand neurons there. 687 00:43:32,280 --> 00:43:36,840 And we can decipher some of the patterns of activity, 688 00:43:36,920 --> 00:43:39,320 as they relate to what the animal is seeing, 689 00:43:39,400 --> 00:43:40,720 what the animal is looking at. 690 00:43:41,360 --> 00:43:45,120 And then we can go in with optical methods, with optogenetics, 691 00:43:45,200 --> 00:43:48,160 and selectively change the patterns of activity 692 00:43:48,240 --> 00:43:52,640 and fool the animal into thinking that he's seeing one thing or the other thing 693 00:43:53,400 --> 00:43:56,760 by essentially playing the piano with his neural circuits 694 00:43:56,840 --> 00:43:59,520 in the visual cortex of the brain. 695 00:43:59,600 --> 00:44:01,680 This is something we can do today. 696 00:44:01,760 --> 00:44:03,480 [circuits scrambling] 697 00:44:06,400 --> 00:44:11,160 People could do this with humans, not today. 698 00:44:11,240 --> 00:44:13,560 We don't have the methods to control, 699 00:44:13,640 --> 00:44:15,960 to read the activity of a… 700 00:44:16,040 --> 00:44:19,920 of many neurons in the brain of humans and to change that, 701 00:44:20,000 --> 00:44:21,960 but these methods are going to be developed 702 00:44:22,040 --> 00:44:24,040 because we need them for the patients. 703 00:44:24,120 --> 00:44:27,800 In fact, there is a project supported by DARPA, 704 00:44:27,880 --> 00:44:30,920 by the foundation of military research, 705 00:44:31,000 --> 00:44:33,120 to build an electronic chip 706 00:44:33,200 --> 00:44:36,120 to record the activity of one million neurons… 707 00:44:37,120 --> 00:44:38,880 in a human, in a human patient, 708 00:44:38,960 --> 00:44:42,800 and to stimulate 100,000 neurons at the same time. 709 00:44:43,480 --> 00:44:45,200 And this is not science fiction. 710 00:44:45,280 --> 00:44:47,840 This is something that is being built as we speak. 711 00:44:48,760 --> 00:44:50,160 In fact, we are helping to build them 712 00:44:50,240 --> 00:44:53,400 because they need to use this for patients. 713 00:44:53,480 --> 00:44:57,280 And this could be in the clinic in four years. 714 00:45:02,040 --> 00:45:04,320 [dramatic music playing] 715 00:45:04,400 --> 00:45:07,400 [narrator] A whole new world of opportunities is opening up 716 00:45:07,480 --> 00:45:08,760 before our eyes, 717 00:45:08,840 --> 00:45:11,240 a world where we will have the ability 718 00:45:11,320 --> 00:45:14,600 to co-evolve with the artificial intelligence. 719 00:45:14,680 --> 00:45:18,040 There is even a hypothesis that in the distant future, 720 00:45:18,120 --> 00:45:20,680 we won't need our biological structures. 721 00:45:20,760 --> 00:45:24,920 If all we are, are our thoughts, our memories, our emotions, 722 00:45:25,000 --> 00:45:28,600 our whole "self" can be transferred into a computer, 723 00:45:28,680 --> 00:45:32,240 our biological bodies will no longer be necessary. 724 00:45:33,080 --> 00:45:36,040 So now we are getting into the more far future 725 00:45:36,120 --> 00:45:39,000 science fiction aspect of this whole endeavor. 726 00:45:39,080 --> 00:45:41,960 There is a science fiction term called "mind uploading." 727 00:45:47,280 --> 00:45:50,600 What it means is that, mind, or who we are, 728 00:45:50,680 --> 00:45:53,640 is then no longer dependent on the biological brain as such. 729 00:45:54,200 --> 00:45:55,320 You still need a brain, of course, 730 00:45:55,400 --> 00:45:58,000 there is no such thing as no device 731 00:45:58,080 --> 00:46:02,200 running your mind, but it could be all sorts of devices. 732 00:46:02,280 --> 00:46:04,680 It could be a device that is better suited for, say, 733 00:46:04,760 --> 00:46:08,560 for example, living in space, or living on another planet, 734 00:46:08,640 --> 00:46:10,720 or living underwater, or something like that. 735 00:46:15,800 --> 00:46:19,960 So when you get to a far future where the technology of all brain emulation, 736 00:46:20,040 --> 00:46:22,080 which is, really, the more scientific concept, 737 00:46:22,160 --> 00:46:23,640 what is it you're actually doing here? 738 00:46:23,720 --> 00:46:26,520 You are trying to emulate what's going on in the circuitry. 739 00:46:26,600 --> 00:46:28,760 When you have that, then you can start thinking 740 00:46:28,840 --> 00:46:33,600 about the personal and social consequences of doing that, 741 00:46:33,680 --> 00:46:35,760 which is really what mind uploading means. 742 00:46:35,840 --> 00:46:38,480 It's a very philosophical term, in a sense. 743 00:46:38,560 --> 00:46:40,640 It's, like, what happens if you can take who I am, 744 00:46:40,720 --> 00:46:43,240 my mind and move me to something else. 745 00:46:43,320 --> 00:46:46,520 So many things are then, potentially, possible. 746 00:46:46,600 --> 00:46:48,320 You could make backups of your mind, 747 00:46:48,400 --> 00:46:52,640 so that if something happens, you can restore and it's not, uh… 748 00:46:52,720 --> 00:46:53,760 You know, it's not as devastating. 749 00:46:53,840 --> 00:46:55,000 [whooshing] 750 00:46:59,960 --> 00:47:01,760 [mellow music playing] 751 00:47:03,000 --> 00:47:04,920 [narrator] The knowledge we have acquired in recent years 752 00:47:05,000 --> 00:47:08,280 about the brain has given us possibilities 753 00:47:08,360 --> 00:47:10,880 until recently-considered science-fiction. 754 00:47:11,520 --> 00:47:14,320 We're advancing at very high speed. 755 00:47:14,400 --> 00:47:18,120 We can't know where a deeper knowledge of the brain will lead us, 756 00:47:18,200 --> 00:47:21,320 but it's in our hands to steer it in the right direction. 757 00:47:24,680 --> 00:47:29,600 It's critical to have guidelines, 758 00:47:30,240 --> 00:47:32,960 ethical guidelines, for the development of these technologies. 759 00:47:33,680 --> 00:47:39,080 We propose to add to the human universal declaration 760 00:47:39,160 --> 00:47:41,400 of human rights, new rights, 761 00:47:41,480 --> 00:47:45,200 to protect individuals from the abuse 762 00:47:45,280 --> 00:47:49,040 of neuro-technologies and artificial intelligence. 763 00:47:49,120 --> 00:47:52,520 So this is what we call the neuro rights. 764 00:47:52,600 --> 00:47:57,720 And they have to do with protecting the mental privacy of people, 765 00:47:57,800 --> 00:47:59,520 so this is our first one. 766 00:47:59,600 --> 00:48:03,000 Not just the data privacy of our phone. No, no, the mental privacy. 767 00:48:03,080 --> 00:48:07,480 Our thoughts, and even worse, our subconscious thoughts, 768 00:48:07,560 --> 00:48:11,080 things that we don't even know, we are not aware of knowing them. 769 00:48:11,160 --> 00:48:13,680 Those should be protected, should be… 770 00:48:13,760 --> 00:48:17,080 This is the ultimate human right, our mental privacy. 771 00:48:17,160 --> 00:48:19,040 [ethereal music playing] 772 00:48:21,960 --> 00:48:25,080 We should also have protection as we connect ourselves 773 00:48:25,720 --> 00:48:28,560 to computers through brain computer interfaces. 774 00:48:28,640 --> 00:48:31,920 Look at the effect that connecting us to the net through our iPhones 775 00:48:32,000 --> 00:48:33,280 has had in our culture. 776 00:48:33,360 --> 00:48:35,800 Well, imagine if that connection could be direct 777 00:48:35,880 --> 00:48:42,080 through some brain-computer interface that could be, maybe, wireless and, uh… 778 00:48:42,160 --> 00:48:46,480 and non-invasive. That could happen in the future. 779 00:48:46,560 --> 00:48:51,560 So this is going to affect our sense of identity, of who we are. 780 00:48:51,640 --> 00:48:56,600 We need to protect the sense of identity, the I, the self. 781 00:48:56,680 --> 00:49:00,000 This is something that humans never had to worry about in the past. [chuckles] 782 00:49:00,080 --> 00:49:02,000 No one ever had that problem before. 783 00:49:02,080 --> 00:49:03,800 [computer alarming] 784 00:49:07,680 --> 00:49:11,320 Related to this is also our sense of agency, our free will. 785 00:49:11,400 --> 00:49:15,480 There could be someone who wants to actually change the way you're operating. 786 00:49:15,560 --> 00:49:19,440 So that's another fundamental right that has to be protected. 787 00:49:25,760 --> 00:49:29,040 So these are the neuro rights and now we have to convince… 788 00:49:29,120 --> 00:49:32,000 um, the leaders of the world 789 00:49:32,080 --> 00:49:34,000 and the leaders of the society 790 00:49:34,080 --> 00:49:35,640 that this is a very important issue. 791 00:49:35,720 --> 00:49:40,280 Discussing the future of our society, the future of humankind, 792 00:49:40,360 --> 00:49:42,560 and that we have to make sure 793 00:49:42,640 --> 00:49:44,840 that these technologies, which are so powerful, 794 00:49:44,920 --> 00:49:47,880 and they could cause so much good, 795 00:49:48,640 --> 00:49:51,240 not just in patients but in among ourselves, 796 00:49:51,320 --> 00:49:53,280 we'll be able to finally understand who we are. 797 00:49:53,360 --> 00:49:55,800 It's like a new renaissance, 798 00:49:55,880 --> 00:49:58,760 that these technologies are not used against us. [chuckles] 799 00:49:58,840 --> 00:50:00,920 Um, we have to be vigilant 800 00:50:01,000 --> 00:50:04,720 and we have to put this ethical framework in place, 801 00:50:04,800 --> 00:50:06,520 so that doesn't happen. 802 00:50:11,720 --> 00:50:14,480 [Randal Koene] This understanding is just going to give us the tools 803 00:50:14,560 --> 00:50:17,400 to develop in many different directions, 804 00:50:17,480 --> 00:50:19,040 to explore in many directions, 805 00:50:19,120 --> 00:50:21,800 and also to be versatile and adaptable. 806 00:50:21,880 --> 00:50:25,320 So that maybe the human species has a really long-term future, 807 00:50:25,400 --> 00:50:27,400 not the kind of future where, you know, 808 00:50:27,480 --> 00:50:31,080 it works for a while and then we're not adapted well enough and that's it, 809 00:50:31,160 --> 00:50:33,040 but a really long-term future. 810 00:50:33,120 --> 00:50:35,440 That's what I'm hoping, that this could ultimately lead to. 811 00:50:35,520 --> 00:50:39,800 I hope it could provide us with the tools to have basically, uh… 812 00:50:39,880 --> 00:50:42,240 like, you might call it another Cambrian explosion 813 00:50:42,320 --> 00:50:47,000 where the new species develop in all kinds of directions, except it's us. 814 00:50:47,080 --> 00:50:49,320 It's the human species deciding 815 00:50:49,400 --> 00:50:51,640 that we want to try out this direction, 816 00:50:51,720 --> 00:50:53,800 try out that direction and so forth. 817 00:50:58,600 --> 00:51:00,440 [Rafael Yuste] Science can change the world. 818 00:51:00,520 --> 00:51:03,040 It can change society, it can change the course of history, 819 00:51:03,120 --> 00:51:04,840 and it can do that for good or for bad. 820 00:51:04,920 --> 00:51:09,040 It's up to us to make sure that it goes in the right direction. 821 00:51:14,240 --> 00:51:16,000 [narrator] We've entered a new age, 822 00:51:16,080 --> 00:51:18,520 the age of neuroscience, 823 00:51:18,600 --> 00:51:21,760 an age in which the way we experience and feel the world 824 00:51:21,840 --> 00:51:24,240 will radically change. 825 00:51:24,880 --> 00:51:27,760 Welcome to the world of tomorrow. 826 00:51:27,840 --> 00:51:29,840 [upbeat epic music playing] 827 00:52:52,400 --> 00:52:53,800 [music ends] 67757

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