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That is yuck, right?
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What's yuck'?
5
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-Blood.
-Yeah. It is what it is.
6
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Okay, push hard.
7
00:00:26,548 --> 00:00:28,289
-Oh!
-You see it's here!
8
00:00:28,332 --> 00:00:31,031
I know and then
I have to squeeze it.
9
00:00:32,597 --> 00:00:35,078
-Is it out?
-Look at how much blood there is
10
00:00:41,650 --> 00:00:45,784
Mmm, what does that say? Do it?
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-No? OK. Two, ni--, go ahead.
-...Two, nine, four.
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Mmm, yeah.
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Sucks, . Weird!
14
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I don't know, Jack
15
00:01:01,148 --> 00:01:02,932
Yeah, I know.
This is just not good.
16
00:01:02,975 --> 00:01:04,455
I don't know why it's going up.
17
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I have to talk to my doctor.
18
00:01:09,069 --> 00:01:13,073
The average person has three
traumatic events in their life.
19
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Waking up in the
ICU was one of mine.
20
00:01:19,557 --> 00:01:22,038
Maybe we can test
daddy's blood sugar
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-Let's see what daddy's is.
-Mhmm.
22
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-There it is.
-There.
23
00:01:33,049 --> 00:01:35,878
-Hey, look!
-Yeah. Okay.
24
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-Nine, six.
-Wow!
25
00:01:43,538 --> 00:01:48,064
I've spent the last 30 years
trying to outrun my disease,
26
00:01:48,543 --> 00:01:50,284
but it's not working.
27
00:01:52,373 --> 00:01:56,594
The irony is,
I look healthy but I'm not.
28
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I always feel like I'm going to
29
00:02:01,121 --> 00:02:03,558
the principal's office for
these calls.
30
00:02:04,515 --> 00:02:06,735
I hate doing these calls.
31
00:02:09,955 --> 00:02:12,654
My little stress ball, pancreas.
32
00:02:13,829 --> 00:02:17,963
-Hi, Mary Rose.
-Hi Lisa.
33
00:02:18,007 --> 00:02:20,227
You know, there's one
thing I want to say.
34
00:02:20,270 --> 00:02:22,142
I wanted to tell you that
35
00:02:22,185 --> 00:02:25,754
I have a little tingling in
my heel, in my left heel.
36
00:02:25,797 --> 00:02:28,235
And it's only like
when I'm in the shower
37
00:02:28,278 --> 00:02:29,845
and I'm shaving my leg
or whatever,
38
00:02:29,888 --> 00:02:32,195
but I've been feeling
a bit of tingling and that's,
39
00:02:32,239 --> 00:02:33,675
I'll be honest, it's kind of
freaking me out
40
00:02:33,718 --> 00:02:35,938
but I don't know.
Like...
41
00:02:35,981 --> 00:02:39,985
Well, it can. The diabetes can
be starting to affect
42
00:02:40,029 --> 00:02:41,465
your nervous system.
43
00:02:41,509 --> 00:02:43,467
This could be
the beginning of neuropathy.
44
00:02:43,815 --> 00:02:46,209
So, the best thing to do
45
00:02:46,253 --> 00:02:48,124
is get your blood
sugars under control.
46
00:02:48,168 --> 00:02:51,475
I mean, you know, I've had
Type 1 now 31 years.
47
00:02:51,519 --> 00:02:54,391
And I wasn't always in
really tight control.
48
00:02:54,826 --> 00:02:56,437
Yeah. Oh my God.
49
00:02:58,178 --> 00:02:59,962
-Okay.
-Well...
50
00:03:00,005 --> 00:03:03,313
-I, yeah.
-I know, it's hard.
51
00:03:08,753 --> 00:03:10,712
-Yeah.
-Well...
52
00:03:10,755 --> 00:03:14,063
We've got today and we can
move forward from here.
53
00:03:14,281 --> 00:03:19,373
You know, it's best to face this
before it gets real bad, Lisa.
54
00:03:20,983 --> 00:03:24,029
I could never judge you for not
being perfect with this, honey
55
00:03:24,073 --> 00:03:26,162
'cause I couldn't do it myself
56
00:03:27,816 --> 00:03:31,123
and I don't, that's why I think
you should come see me more
57
00:03:31,167 --> 00:03:33,909
because you can't do it
yourself either.
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00:03:33,952 --> 00:03:35,302
Yeah.
59
00:03:35,780 --> 00:03:38,653
-Bye.
-Bye. Thank you.
60
00:03:45,442 --> 00:03:46,704
Hmm.
61
00:03:49,490 --> 00:03:53,363
It's just something
I hope that goes away,
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00:03:53,407 --> 00:03:55,147
if I take better care of myself.
63
00:04:05,723 --> 00:04:07,638
It's become a joke
in the community
64
00:04:07,682 --> 00:04:11,251
that the cure is
always five years away.
65
00:04:12,252 --> 00:04:15,516
Stay strong, the cure
is on the horizon.
66
00:04:18,606 --> 00:04:22,871
But each year more than 5
million people die from diabetes
67
00:04:22,914 --> 00:04:24,525
waiting for that cure.
68
00:04:25,395 --> 00:04:29,486
If it's so close,
why it's taking so long?
69
00:04:31,619 --> 00:04:34,361
We started looking
for a biotech company
70
00:04:34,404 --> 00:04:36,145
that was doing
something different,
71
00:04:36,537 --> 00:04:38,190
something radical.
72
00:04:39,104 --> 00:04:43,718
Then in 2014, my husband Guy
and I heard about a company
73
00:04:44,240 --> 00:04:47,156
that was rethinking
how to cure diabetes.
74
00:04:48,897 --> 00:04:52,988
They had engineered stem
cells to implant into humans.
75
00:04:54,163 --> 00:04:57,514
We were skeptical but intrigued.
76
00:05:03,433 --> 00:05:06,349
The first patient got
his insulin in 1922.
77
00:05:08,743 --> 00:05:13,008
We cannot be a strong nation
unless we are a healthy nation.
78
00:05:13,051 --> 00:05:16,707
And so we must recruit not
only men and materials,
79
00:05:17,273 --> 00:05:20,450
but also knowledge and science.
80
00:05:22,278 --> 00:05:24,324
Scientist Cutter in a new
medical age
81
00:05:24,367 --> 00:05:25,977
with the monumental reports
82
00:05:26,021 --> 00:05:28,328
that prove the Salk vaccine
against crippling polio
83
00:05:28,371 --> 00:05:30,765
to be a sensational success.
84
00:05:32,288 --> 00:05:35,204
Dr. Salk's own child was 1
of the 2 million children
85
00:05:35,247 --> 00:05:36,640
involved in tests
of his vaccine.
86
00:05:37,206 --> 00:05:38,816
Tests which have ended
for all time,
87
00:05:38,860 --> 00:05:41,428
the threat of one of the
world's most vicious diseases.
88
00:05:41,471 --> 00:05:44,648
Measles vaccines have
been successfully tested
89
00:05:44,692 --> 00:05:47,216
by thousands of parents who
have permitted their children
90
00:05:47,259 --> 00:05:49,131
to participate
in the field trial.
91
00:05:50,132 --> 00:05:52,134
Behind it all are
tests and research
92
00:05:52,177 --> 00:05:53,875
and years of
development and hope.
93
00:05:55,224 --> 00:05:57,748
Do you think that
you'll live to see a cure?
94
00:05:57,792 --> 00:05:59,228
No.
95
00:05:59,446 --> 00:06:02,362
Science moves in a way
that's not linear.
96
00:06:03,406 --> 00:06:07,367
It can be incremental,
punctuated by breakthroughs,
97
00:06:07,410 --> 00:06:08,846
back to incremental.
98
00:06:09,412 --> 00:06:12,763
Is there any guarantee
this will actually work?
99
00:06:12,807 --> 00:06:16,506
There is never a guarantee when
you're doing a clinical trial.
100
00:06:16,550 --> 00:06:20,118
If there was a guarantee, you
wouldn't have to do the trial.
101
00:06:50,497 --> 00:06:56,067
We just submitted our first IND
to the FDA in the United States.
102
00:06:57,591 --> 00:07:00,245
And that's an investigative
new drug application.
103
00:07:01,769 --> 00:07:05,207
And altogether it's
over 8,500 pages.
104
00:07:07,557 --> 00:07:09,951
I'm just going to
clear off some space
105
00:07:09,994 --> 00:07:11,561
so that it doesn't
look so awful.
106
00:07:11,605 --> 00:07:13,041
Why? No.
107
00:07:16,653 --> 00:07:17,828
Perfect.
108
00:07:17,872 --> 00:07:19,264
For me, it's only
the culmination
109
00:07:19,308 --> 00:07:21,049
of a little over
three years of work.
110
00:07:21,092 --> 00:07:23,747
But for some of my colleagues,
they've been involved in
111
00:07:23,791 --> 00:07:25,314
ViaCyte for over a decade.
112
00:07:25,357 --> 00:07:27,664
and their heart and soul
professionally
113
00:07:27,708 --> 00:07:31,799
has gone into this
company and our product.
114
00:07:33,061 --> 00:07:34,932
So, this is a mock up
115
00:07:34,976 --> 00:07:37,326
and it doesn't contain
an actual device but
116
00:07:37,935 --> 00:07:40,372
Actually let me just take
a look, maybe I'm lying to you.
117
00:07:40,416 --> 00:07:42,244
it's easier if I take
it out of this package.
118
00:07:43,985 --> 00:07:45,421
Oh, I lied.
119
00:07:45,943 --> 00:07:47,858
So, you can see the
implant right in there.
120
00:07:48,293 --> 00:07:49,860
And it contains cells.
121
00:07:50,426 --> 00:07:51,949
That one contains cells
right now?
122
00:07:51,993 --> 00:07:53,821
Yeah.
123
00:07:53,864 --> 00:07:56,954
What we're developing
is a bio artificial pancreas
124
00:07:56,998 --> 00:07:58,347
that uses stem cells
125
00:07:58,390 --> 00:08:02,046
to potentially cure
Type 1 diabetes.
126
00:08:04,353 --> 00:08:08,270
It sounds groundbreaking,
but diabetes is complicated.
127
00:08:08,531 --> 00:08:09,489
Alright.
128
00:08:11,316 --> 00:08:13,231
It all started with the
pancreas,
129
00:08:13,275 --> 00:08:15,886
the ugliest organ in the body.
130
00:08:17,497 --> 00:08:20,717
In Type 1 diabetes,
the body attacks itself
131
00:08:20,761 --> 00:08:23,503
and destroys the cells
that produce insulin.
132
00:08:25,505 --> 00:08:27,332
And when you don't have insulin,
133
00:08:27,376 --> 00:08:31,032
sugar builds up in the blood
and it can't get into the cells.
134
00:08:31,511 --> 00:08:34,426
It's as vital to
the body as oxygen.
135
00:08:35,863 --> 00:08:37,995
While people
with Type 2 diabetes
136
00:08:38,256 --> 00:08:40,476
have trouble absorbing insulin,
137
00:08:40,520 --> 00:08:44,306
Type 1's don't produce
any insulin at all.
138
00:08:45,307 --> 00:08:49,137
Either way, too much sugar
in your blood is toxic.
139
00:08:51,008 --> 00:08:54,838
High blood sugars can lead
to blindness, kidney failure,
140
00:08:55,230 --> 00:08:57,537
strokes and amputation.
141
00:08:58,755 --> 00:09:02,803
Low blood sugars, and you risk
unconsciousness and death.
142
00:09:04,152 --> 00:09:06,458
So, I'm constantly
injecting insulin
143
00:09:06,502 --> 00:09:08,939
to control the amount
of sugar in my blood.
144
00:09:10,027 --> 00:09:13,074
Normal blood sugars are
flat with the odd spike.
145
00:09:14,249 --> 00:09:16,947
My blood sugars look
like the Himalayas.
146
00:09:23,650 --> 00:09:24,912
Perfect.
147
00:09:27,392 --> 00:09:30,178
ViaCyte wants to fix
this toxic rollercoaster,
148
00:09:31,309 --> 00:09:33,660
program stem cells
to make insulin,
149
00:09:34,008 --> 00:09:35,836
put them in a high tech teabag,
150
00:09:36,271 --> 00:09:39,622
implant them into humans
and over time,
151
00:09:39,666 --> 00:09:41,755
they'll replace
the damaged cells in the body.
152
00:09:41,798 --> 00:09:43,278
Okay Jay, ready?
153
00:09:46,107 --> 00:09:47,456
Seal.
154
00:09:47,499 --> 00:09:50,415
We can do as much testing
on the bench
155
00:09:50,459 --> 00:09:52,809
and in animals as we want.
156
00:09:52,853 --> 00:09:56,639
And we still don't know
how it'll work in people.
157
00:09:56,987 --> 00:09:58,510
And that's why we're all here
158
00:09:58,728 --> 00:10:00,295
to make it work in people.
159
00:10:03,820 --> 00:10:09,043
Okay, so today was our
30-day clock on the IND.
160
00:10:09,086 --> 00:10:11,567
I was hoping to make this
a very suspenseful meeting,
161
00:10:11,611 --> 00:10:14,265
but somehow having
bowels of champagne.
162
00:10:14,309 --> 00:10:16,137
And I guess if
the answer was bad,
163
00:10:16,180 --> 00:10:17,181
it would've been hard liquor.
164
00:10:20,054 --> 00:10:21,664
There are no hold issues
165
00:10:21,708 --> 00:10:23,535
and the clinical trial
may proceed.
166
00:10:32,893 --> 00:10:34,764
The third or fourth
emotion I had,
167
00:10:34,808 --> 00:10:37,158
It was like, "Oh yeah. Now,
I can be excited about this."
168
00:10:38,855 --> 00:10:40,770
Been here 12 years.
169
00:10:41,684 --> 00:10:43,207
This is my life's work
170
00:10:43,555 --> 00:10:47,211
to see it come this far and
officially go into a patient.
171
00:10:48,691 --> 00:10:49,997
It's amazing.
172
00:10:51,651 --> 00:10:53,870
This is a new frontier.
173
00:10:54,654 --> 00:10:56,960
The FDA is understandably
concerned
174
00:10:57,004 --> 00:10:58,527
about the safety risks
175
00:10:58,570 --> 00:11:00,790
associated with any kind
of cell therapy,
176
00:11:00,834 --> 00:11:04,664
but they recognize that
patients need better treatments.
177
00:11:06,578 --> 00:11:10,365
It takes 10 to 20 years
to develop a new drug,
178
00:11:10,844 --> 00:11:14,064
but those are usually drugs
that are not that novel.
179
00:11:14,108 --> 00:11:16,501
It's a pill, you eat it.
Everyone knows how to do that.
180
00:11:17,851 --> 00:11:19,461
This is extremely novel.
181
00:11:19,504 --> 00:11:20,680
Nightie Night.
182
00:11:28,122 --> 00:11:29,776
I don't think anyone knew
183
00:11:29,819 --> 00:11:32,082
how long this trial
was going to take.
184
00:11:33,170 --> 00:11:34,737
We were still in Phase 1,
185
00:11:34,781 --> 00:11:37,653
where scientists test
if their product is safe
186
00:11:37,697 --> 00:11:39,742
and tolerated by humans.
187
00:11:39,786 --> 00:11:42,658
I am sure you were hoping we
would have definitive answers
188
00:11:42,702 --> 00:11:44,181
for you to film by now.
189
00:11:44,225 --> 00:11:45,705
Welcome to the exciting,
190
00:11:45,748 --> 00:11:48,620
but often frustrating
world of biotechnology.
191
00:11:51,275 --> 00:11:53,016
It's a critical stage,
192
00:11:53,060 --> 00:11:55,453
but it doesn't show if
the product is working.
193
00:11:59,631 --> 00:12:02,504
Clinical studies like this
are set up in phases
194
00:12:02,547 --> 00:12:03,853
for very good reason.
195
00:12:04,593 --> 00:12:07,335
The first phase is
designed to determine
196
00:12:07,378 --> 00:12:09,816
basic safety tolerance
197
00:12:09,859 --> 00:12:11,643
and not put a whole
bunch of patients at risk
198
00:12:11,687 --> 00:12:13,733
without understanding
that it's safe first.
199
00:12:15,691 --> 00:12:17,824
The second phase is
the most exciting,
200
00:12:17,867 --> 00:12:19,913
because that's where
you get the data.
201
00:12:19,956 --> 00:12:21,001
The proof of concept.
202
00:12:22,306 --> 00:12:23,655
Two, three.
203
00:12:24,656 --> 00:12:27,355
Then the moment
we'd all been waiting for.
204
00:12:27,398 --> 00:12:30,140
The FDA gave them
the green light
205
00:12:30,184 --> 00:12:32,142
to move to Phase 2 of the trial.
206
00:12:33,013 --> 00:12:35,232
It was finally time to see
207
00:12:35,276 --> 00:12:37,408
if the cells could
work in people.
208
00:12:42,152 --> 00:12:43,501
How much is riding on this?
209
00:12:44,459 --> 00:12:45,765
Everything.
210
00:12:47,767 --> 00:12:49,507
Everything, sorry.
211
00:13:01,519 --> 00:13:05,219
ViaCyte opened 7 trial sites
in the US and Canada.
212
00:13:07,134 --> 00:13:09,658
Including one at the
University of Minnesota.
213
00:13:12,487 --> 00:13:14,489
And that's where
we met patient one,
214
00:13:14,881 --> 00:13:16,186
Maren.
215
00:13:42,865 --> 00:13:44,301
Want to come downstairs?
216
00:13:45,215 --> 00:13:46,477
Come on.
217
00:13:54,094 --> 00:13:56,444
When did you give me insulin?
218
00:13:56,487 --> 00:13:59,621
3:30, more or less.
219
00:14:04,452 --> 00:14:05,888
From the time I was very little,
220
00:14:05,932 --> 00:14:08,456
I said that I would
always be first in line.
221
00:14:08,848 --> 00:14:12,503
If something came up or there
was the opportunity for a cure.
222
00:14:15,463 --> 00:14:16,943
Nervous?
223
00:14:18,205 --> 00:14:19,728
There's a lot of unknowns
224
00:14:19,771 --> 00:14:22,035
and I think it's the unknowns,
that are terrifying.
225
00:14:27,997 --> 00:14:30,260
I'd like to think I'm a pioneer.
226
00:14:31,261 --> 00:14:33,916
When you read in
textbooks 50 years later,
227
00:14:33,960 --> 00:14:35,178
she was the first.
228
00:14:36,310 --> 00:14:39,530
She was the first one
to try it and it worked.
229
00:14:46,929 --> 00:14:48,191
This is you.
230
00:14:48,844 --> 00:14:50,063
It's a huge deal.
231
00:14:51,542 --> 00:14:54,632
This can impact
millions of diabetics.
232
00:14:55,590 --> 00:14:58,419
And it's me, it's me on
that operating table.
233
00:14:58,462 --> 00:14:59,986
This way.
234
00:15:00,029 --> 00:15:01,770
We're the first door
on the left here.
235
00:15:03,032 --> 00:15:06,079
Hi Maren, welcome.
236
00:15:25,098 --> 00:15:27,535
-So, it's done.
-It's done.
237
00:15:27,578 --> 00:15:29,232
It's great.
It went really, really well.
238
00:15:29,276 --> 00:15:31,495
She's in the main
O.R. waking up area
239
00:15:31,539 --> 00:15:33,106
where they really watch
airway and everything.
240
00:15:33,149 --> 00:15:34,585
And then once they
deem her to be safe,
241
00:15:34,629 --> 00:15:36,239
then she'll come here for
a little bit more time
242
00:15:36,283 --> 00:15:37,675
and they'll be
checking her sugars
243
00:15:37,719 --> 00:15:39,286
and doing all
those other things.
244
00:15:39,329 --> 00:15:40,461
And then you guys
can be with her here.
245
00:15:40,504 --> 00:15:42,115
-Perfect.
-Alright, thank you.
246
00:15:44,030 --> 00:15:45,727
Take a deep breath. Huh?
247
00:15:47,381 --> 00:15:51,037
32 years in the waiting.
It's been a long time.
248
00:15:52,516 --> 00:15:54,562
Hoped and prayed for
this for a long time.
249
00:16:01,569 --> 00:16:03,179
Oh yeah. These ones look great.
250
00:16:03,223 --> 00:16:04,572
-They don't even hurt at all.
-Yeah.
251
00:16:04,615 --> 00:16:06,530
They're barely even
bruised around there.
252
00:16:06,574 --> 00:16:08,141
-Those don't hurt at all.
-Yeah.
253
00:16:08,184 --> 00:16:10,578
Other than that, it's sore
down here.
254
00:16:10,621 --> 00:16:12,406
-Yeah.
-Right in this area.
255
00:16:12,449 --> 00:16:16,149
-You have such art on your arm.
-Still right now.
256
00:16:18,020 --> 00:16:20,980
10 pods were implanted
into Maren's body.
257
00:16:21,502 --> 00:16:24,418
Six in her arm
and four in her side.
258
00:16:24,461 --> 00:16:25,810
Great.
259
00:16:26,637 --> 00:16:29,901
Every few weeks,
one of her pods will be removed
260
00:16:29,945 --> 00:16:33,383
to see if the cells are
surviving and producing insulin.
261
00:16:33,427 --> 00:16:35,037
Yeah, I think sometimes
the hardest part
262
00:16:35,081 --> 00:16:36,473
is getting used to
the medications.
263
00:16:36,734 --> 00:16:38,432
I really do.
264
00:16:38,475 --> 00:16:40,042
It's sore but the
pain isn't that bad.
265
00:16:40,086 --> 00:16:41,826
It's sore but it's not the pain.
266
00:16:42,523 --> 00:16:46,048
We'll be continuing
to monitor blood tests
267
00:16:46,092 --> 00:16:48,007
for evidence of
insulin production.
268
00:16:48,529 --> 00:16:52,185
And I'm sure Cathy
will text you or call you
269
00:16:52,228 --> 00:16:55,536
to make sure that it got done.
So, yeah.
270
00:16:56,102 --> 00:16:57,755
-All right. Good.
-Thank you.
271
00:16:57,799 --> 00:17:00,149
All right, I'll let you go
do the hard work here, Cathy.
272
00:17:00,193 --> 00:17:03,022
-Yeah.
-And I'll see you next week.
273
00:17:03,065 --> 00:17:05,372
Alright, sounds good.
Thank you. Bye.
274
00:17:08,984 --> 00:17:11,421
I was diagnosed with
diabetes at the age of two.
275
00:17:11,943 --> 00:17:13,771
I don't know any other way.
276
00:17:13,815 --> 00:17:17,036
Living a normal life to me
is living life as a diabetic.
277
00:17:19,560 --> 00:17:22,998
I have some extreme lows which
caused me to have seizures.
278
00:17:24,739 --> 00:17:28,482
You're so terrified that
you're going to go so low
279
00:17:28,525 --> 00:17:30,310
or you're going to pass out
280
00:17:30,353 --> 00:17:32,007
and your kids are going to find
you seizing on the floor.
281
00:17:32,660 --> 00:17:34,053
Just the sweat,
282
00:17:34,096 --> 00:17:35,576
just the dripping and the sweat
283
00:17:35,619 --> 00:17:38,927
and the tremors
and the shaking and the fear.
284
00:17:38,970 --> 00:17:40,581
I mean just the fear,
285
00:17:40,624 --> 00:17:43,279
the fear of
the low blood sugars.
286
00:17:44,019 --> 00:17:46,282
You can feel your
body shutting down
287
00:17:46,326 --> 00:17:47,936
and you've got to stop it.
288
00:17:56,205 --> 00:17:59,687
T, Z, Y, something, something L.
289
00:18:00,166 --> 00:18:01,819
And then blink a couple times.
290
00:18:01,863 --> 00:18:03,517
Can you pick out
anything below that?
291
00:18:03,865 --> 00:18:08,478
T, Z V, E, C, L.
292
00:18:08,522 --> 00:18:10,132
Go ahead and take
your glasses off.
293
00:18:10,176 --> 00:18:11,046
I want you to look
straight ahead towards
294
00:18:11,090 --> 00:18:12,526
the end of the room.
295
00:18:13,483 --> 00:18:15,137
And if a light gets
bright, you can look up.
296
00:18:15,181 --> 00:18:16,399
Okay.
297
00:18:18,097 --> 00:18:22,013
When I was younger, my family
with all their good intentions
298
00:18:22,057 --> 00:18:23,363
they'd tell me things like,
299
00:18:23,406 --> 00:18:24,581
"If you don't check your
blood sugar
300
00:18:24,625 --> 00:18:27,018
you're going to loose your foot"
301
00:18:27,062 --> 00:18:28,498
And you know, I'm just like,
302
00:18:28,542 --> 00:18:30,239
"Okay, I'm going to lose
my feet."
303
00:18:32,154 --> 00:18:36,245
And that would cause
depression, fear,
304
00:18:38,334 --> 00:18:40,162
and a lot of the times,
305
00:18:40,206 --> 00:18:42,164
it made me feel like
I just want to give up.
306
00:18:42,208 --> 00:18:43,731
And I have,
307
00:18:43,774 --> 00:18:46,386
I've spent years not
taking care of my disease.
308
00:18:46,864 --> 00:18:48,127
Just like,
309
00:18:49,780 --> 00:18:51,042
"Fuck it."
310
00:18:57,005 --> 00:18:58,920
My dad and me are
the only two people,
311
00:18:58,963 --> 00:19:00,617
with diabetes that I ever knew.
312
00:19:02,271 --> 00:19:04,969
He was legally blind
by the time he was 30.
313
00:19:08,886 --> 00:19:10,453
I'm going blind.
314
00:19:24,119 --> 00:19:25,251
It's an apple orchard.
315
00:19:25,294 --> 00:19:26,687
Apple orchard.
316
00:19:27,905 --> 00:19:30,299
What? Oh.
317
00:19:32,867 --> 00:19:34,912
Come on ladies,
let's go find a pumpkin.
318
00:19:38,133 --> 00:19:39,743
We're talking
about my life here.
319
00:19:39,787 --> 00:19:42,355
And I'm not afraid of death,
but I'm here.
320
00:19:42,398 --> 00:19:44,226
I need to be here
for my daughter.
321
00:19:45,227 --> 00:19:46,837
That's what this is about.
322
00:19:47,273 --> 00:19:49,449
Well, come here.
Let's see pumpkin.
323
00:19:49,492 --> 00:19:51,015
Quick, quick, there.
324
00:19:51,059 --> 00:19:52,495
And it's not just because
325
00:19:52,539 --> 00:19:54,280
she's going to be
in this world alone.
326
00:19:54,323 --> 00:19:56,325
I want to see her
fucking grow up.
327
00:19:57,239 --> 00:20:00,373
I don't want to abandon her.
328
00:20:01,156 --> 00:20:03,071
That's the worst feeling
on earth.
329
00:20:14,822 --> 00:20:18,826
So, then this talks about
the number of participants here.
330
00:20:18,869 --> 00:20:20,610
And so there's a site in Canada,
331
00:20:20,654 --> 00:20:23,134
and right now there's two sites
in the United States.
332
00:20:23,178 --> 00:20:24,353
And there'll probably
be a few more
333
00:20:24,397 --> 00:20:26,355
that are added over time.
334
00:20:26,399 --> 00:20:28,270
This part talks about the cells
335
00:20:28,314 --> 00:20:29,793
that are actually being tested
336
00:20:29,837 --> 00:20:32,883
and what the cells are,
is they're human cells.
337
00:20:32,927 --> 00:20:34,320
So, they're actually derived
338
00:20:34,363 --> 00:20:36,278
from an embryonic
stem cell source.
339
00:20:36,322 --> 00:20:38,498
So it's a embryo
that was going to be
340
00:20:38,541 --> 00:20:40,326
disposed of from
in-vitro fertilization.
341
00:20:40,369 --> 00:20:41,762
Okay.
342
00:20:41,805 --> 00:20:45,461
We don't expect them in
that first month or two
343
00:20:45,505 --> 00:20:47,811
to actually do anything
functionally yet,
344
00:20:47,855 --> 00:20:50,423
because we do know that
they need time to mature
345
00:20:50,466 --> 00:20:51,815
to make insulin.
346
00:20:51,859 --> 00:20:53,208
-Sure.
-Okay?
347
00:20:54,340 --> 00:20:56,298
Remind me, when
were you diagnosed?
348
00:20:56,342 --> 00:20:57,647
-I was 11 years old.
-11 Years old?
349
00:20:57,691 --> 00:20:58,953
-Yeah.
-Okay.
350
00:20:58,996 --> 00:21:00,911
About how many times
in the past year
351
00:21:00,955 --> 00:21:03,436
do you think you've been so out
of it, mentally or physically
352
00:21:03,479 --> 00:21:05,220
that you wouldn't have been
able to treat yourself,
353
00:21:05,264 --> 00:21:06,700
you need someone
to help treat you?
354
00:21:06,743 --> 00:21:10,530
Gosh, I'd say at probably
about 10, at least.
355
00:21:10,573 --> 00:21:12,532
-About 10 in the past years.
-At least, yeah.
356
00:21:12,575 --> 00:21:15,883
I get like confusion.
I don't know what to do.
357
00:21:15,926 --> 00:21:18,538
I get panicky and
then I'll over-treat.
358
00:21:18,581 --> 00:21:21,454
So, then I have
to deal with that.
359
00:21:21,497 --> 00:21:24,283
Well, and then when
he gets sick,
360
00:21:24,326 --> 00:21:26,937
he ends up so much worse
361
00:21:26,981 --> 00:21:30,376
because the cold
or the flu he has
362
00:21:30,419 --> 00:21:32,943
is making his blood
sugar all over the place.
363
00:21:33,727 --> 00:21:36,120
Yeah, he spent four
days in the hospital
364
00:21:36,164 --> 00:21:37,557
and with DKA and pneumonia
365
00:21:37,600 --> 00:21:38,775
-And pneumonia.
-Yeah.
366
00:21:38,819 --> 00:21:43,084
I mean, I resent my disease.
367
00:21:44,303 --> 00:21:45,565
I really want...
368
00:21:47,088 --> 00:21:48,568
This to work.
369
00:21:50,526 --> 00:21:52,572
I completely get that. Yep.
370
00:21:54,443 --> 00:21:56,053
Do you want a minute?
or do you want to-
371
00:21:56,097 --> 00:21:57,533
-No.
-Go through this still?
372
00:21:57,577 --> 00:21:59,318
All right. You sure? Okay.
373
00:22:05,367 --> 00:22:06,629
How you doing?
374
00:22:10,938 --> 00:22:12,287
It's a lot.
375
00:22:15,551 --> 00:22:16,726
Okay.
376
00:22:17,292 --> 00:22:18,598
You okay?
377
00:22:38,269 --> 00:22:40,837
Let me take a look at your
temperature under your tongue.
378
00:22:47,061 --> 00:22:48,410
I think you're good.
379
00:22:50,107 --> 00:22:51,544
Okay, you can step away.
380
00:22:57,376 --> 00:22:59,421
Okay, you're going to
feel a little poke.
381
00:23:09,475 --> 00:23:11,085
Hi, this is Maren.
382
00:23:11,128 --> 00:23:12,608
-I'm Greg.
-Hi, nice to meet you.
383
00:23:12,652 --> 00:23:14,218
-Maren?
-Maren, yep.
384
00:23:14,262 --> 00:23:15,916
-Nice to meet you.
-I'm Greg.
385
00:23:15,959 --> 00:23:17,396
Are you overwhelmed?
386
00:23:17,439 --> 00:23:19,310
-A little bit.
-A little bit.
387
00:23:19,659 --> 00:23:21,138
Well, they're awesome here.
388
00:23:21,182 --> 00:23:22,531
They will take good
care of you, I promise.
389
00:23:22,575 --> 00:23:25,969
So, you probably have
a ton of questions.
390
00:23:26,013 --> 00:23:28,102
I had a ton of questions
and I was first.
391
00:23:28,145 --> 00:23:31,105
-Yeah.
-So, ask away.
392
00:23:31,497 --> 00:23:35,762
Well, so,
where did they put all that?
393
00:23:36,632 --> 00:23:38,504
And those are the scars
that you got?
394
00:23:38,547 --> 00:23:41,376
Yep, you can feel them,
you can feel them inside.
395
00:23:41,420 --> 00:23:43,160
-Do you mind?
-Yeah, go for it.
396
00:23:44,248 --> 00:23:46,860
-Oh. Okay!
-Interesting.
397
00:23:46,903 --> 00:23:49,906
So there's one, two,
three, four, five, six,
398
00:23:50,516 --> 00:23:53,693
and then I have four
more right here.
399
00:23:54,084 --> 00:23:55,695
Hmm. Okay.
400
00:23:56,260 --> 00:23:58,567
It's a very surreal feeling
401
00:23:58,611 --> 00:24:01,135
that you can't describe
unless, you know.
402
00:24:01,178 --> 00:24:03,920
This whole thing's been
a surreal ride for me.
403
00:24:04,181 --> 00:24:05,792
I'm still just, ah.
404
00:24:05,835 --> 00:24:08,229
And even the day of,
405
00:24:08,534 --> 00:24:10,057
they're wheeling me
back to the O.R.,
406
00:24:10,100 --> 00:24:11,450
I was laying there
and I'm going,
407
00:24:11,493 --> 00:24:12,712
"Oh my God, I don't
know if I can do this,
408
00:24:12,755 --> 00:24:14,148
I don't know if I can do this."
409
00:24:14,191 --> 00:24:15,279
'Cause they haven't done it.
410
00:24:16,672 --> 00:24:19,675
And I'm thinking to myself
going, "Can I do this?"
411
00:24:19,719 --> 00:24:21,068
Wow.
412
00:24:22,417 --> 00:24:23,897
Is it affecting you?
413
00:24:23,940 --> 00:24:27,422
-You know, technically, no.
-Yeah.
414
00:24:27,466 --> 00:24:29,772
But I think there's
definitely some changes
415
00:24:29,816 --> 00:24:31,078
going on in my body.
416
00:24:31,121 --> 00:24:32,906
I can't exactly
tell what they are.
417
00:24:33,472 --> 00:24:34,951
And then at the
end of the study,
418
00:24:34,995 --> 00:24:36,475
they take them out, it's like,
419
00:24:36,910 --> 00:24:38,738
you know what I mean?
420
00:24:38,781 --> 00:24:40,435
I don't know what that's going
to do to me psychologically.
421
00:24:40,479 --> 00:24:42,132
Well, it is.
It'll mess with you.
422
00:24:42,176 --> 00:24:43,960
I guarantee it'll mess with you.
423
00:24:44,004 --> 00:24:47,442
And they're taking one out in
a week and a half already.
424
00:24:47,486 --> 00:24:50,576
And I don't want them to.
425
00:24:50,619 --> 00:24:52,229
- Right.
-You know what I mean?
426
00:24:52,273 --> 00:24:54,014
'Cause I want to see
if it's going to work,
427
00:24:54,057 --> 00:24:55,842
but yet part of science
428
00:24:55,885 --> 00:24:58,497
and I'm trying to come
to grips with on my own is,
429
00:24:59,062 --> 00:25:00,673
is it even working?
430
00:25:00,716 --> 00:25:03,066
I've told people it's
like winning the lottery.
431
00:25:03,110 --> 00:25:05,982
Because if it works, it's
like winning the lottery.
432
00:25:06,026 --> 00:25:07,462
Exactly.
433
00:25:07,506 --> 00:25:09,856
I'd rather have this
than win the lottery.
434
00:26:16,009 --> 00:26:19,142
There are two worlds
in a clinical trial.
435
00:26:20,709 --> 00:26:23,233
Inside the lives of the patients
436
00:26:23,277 --> 00:26:26,149
who are putting themselves
on the line to be first
437
00:26:29,370 --> 00:26:31,677
and inside the labs
of the researchers,
438
00:26:32,155 --> 00:26:36,159
who want to transform
patient hope into reality.
439
00:26:42,035 --> 00:26:44,820
The two worlds create
a dynamic universe
440
00:26:45,386 --> 00:26:47,170
yet they aren't allowed to meet.
441
00:26:50,478 --> 00:26:53,916
There's a firewall between
the patients and researchers
442
00:26:54,177 --> 00:26:56,397
to ensure the study
remains objective.
443
00:26:58,486 --> 00:27:01,620
We became the bridge
between these two worlds.
444
00:27:05,406 --> 00:27:08,322
We learned that whatever
was revealed to us,
445
00:27:08,365 --> 00:27:10,193
could never be
revealed to the other,
446
00:27:12,718 --> 00:27:15,285
including the question
on everyone's minds.
447
00:27:16,504 --> 00:27:17,897
Is it working?
448
00:27:29,256 --> 00:27:31,040
Was that Tamara? Hi Tamara.
449
00:27:31,084 --> 00:27:32,651
-Hi Lisa.
-How are you?
450
00:27:37,003 --> 00:27:38,787
-Okay guys.
451
00:27:46,099 --> 00:27:48,754
We get email all the time.
452
00:27:48,797 --> 00:27:50,756
These come from all
around the world.
453
00:27:51,234 --> 00:27:53,846
"Hi, I have diabetes type 1
454
00:27:53,889 --> 00:27:55,674
and I would like to know
if there's any chance
455
00:27:55,717 --> 00:27:58,198
to participate as a volunteer
living here in Brazil.
456
00:27:58,241 --> 00:28:00,113
Thanks from Paolo."
457
00:28:01,114 --> 00:28:02,637
Here's another one.
458
00:28:02,681 --> 00:28:05,640
"Hi, our 15-year old son
was diagnosed with
459
00:28:05,684 --> 00:28:07,555
type 1 diabetes this week."
460
00:28:07,947 --> 00:28:09,383
Wow.
461
00:28:09,775 --> 00:28:12,778
This is an email from Mexico.
462
00:28:13,300 --> 00:28:15,868
"Hello, yesterday, my
six-years old Paulina
463
00:28:15,911 --> 00:28:18,871
was diagnostic diabetes type 1,
insulin independent.
464
00:28:19,480 --> 00:28:21,743
She had a perfect
health till yesterday
465
00:28:21,787 --> 00:28:23,963
that my little girl was rushed
into the emergency room
466
00:28:24,006 --> 00:28:25,660
with a 480 glucose level.
467
00:28:26,574 --> 00:28:29,751
She's so cheerful and all day,
every day is singing
468
00:28:29,795 --> 00:28:31,710
every song she hears and
469
00:28:32,493 --> 00:28:34,843
know she is attached
to a machine
470
00:28:34,887 --> 00:28:38,020
that has to introduce insulin to
her little hand and her body."
471
00:28:38,717 --> 00:28:41,720
Capital letters, "I don't want
that life for her."
472
00:28:43,983 --> 00:28:47,116
Yes, so these keep
473
00:28:49,989 --> 00:28:51,381
keep things in perspective.
474
00:28:53,601 --> 00:28:54,994
Just goes on and on.
475
00:29:31,291 --> 00:29:33,032
I have two biological children
476
00:29:33,075 --> 00:29:35,686
and four adopted children.
477
00:29:36,731 --> 00:29:38,646
Is your phone working
after you spilled on it?
478
00:29:38,689 --> 00:29:40,343
Yeah.
479
00:29:40,387 --> 00:29:42,519
I'll try calling you quick
and see if it makes the noise.
480
00:29:42,563 --> 00:29:44,739
-My phone's over here.
-No, don't answer.
481
00:29:44,783 --> 00:29:47,524
When I gave birth to
Katelyn, I had a seizure.
482
00:29:47,568 --> 00:29:49,048
That was the first
seizure I had had.
483
00:29:50,440 --> 00:29:52,051
-Yeah, it worked.
-Okay.
484
00:29:52,660 --> 00:29:54,270
Okay. Bye Kate.
485
00:29:54,314 --> 00:29:55,924
-Bye.
-See ya.
486
00:29:55,968 --> 00:29:57,578
We'll see you at church, okay?
487
00:29:57,621 --> 00:29:59,014
Bye. Katelyn. Love you.
488
00:29:59,493 --> 00:30:00,799
I almost died.
489
00:30:01,538 --> 00:30:04,759
I almost left my
daughter without a mom
490
00:30:05,281 --> 00:30:06,805
and my husband without a wife.
491
00:30:08,589 --> 00:30:11,374
The second seizure I had was
after the birth of Andrew,
492
00:30:11,418 --> 00:30:13,246
which was actually
in the hospital.
493
00:30:15,291 --> 00:30:16,815
So, we made
the determination that
494
00:30:16,858 --> 00:30:19,034
we were done having biological
children at that point.
495
00:30:19,600 --> 00:30:20,644
Go pack lunch.
496
00:30:21,297 --> 00:30:22,951
Cold lunch, you mean?
497
00:30:22,995 --> 00:30:24,083
Yep. Cold lunch.
498
00:30:24,953 --> 00:30:26,825
Get your shoes on.
You got backpack?
499
00:30:27,260 --> 00:30:28,827
I want to go.
500
00:30:33,614 --> 00:30:36,573
I think living with a disease,
501
00:30:36,617 --> 00:30:39,925
it creates who you are
and it makes you more accepting
502
00:30:39,968 --> 00:30:42,101
of other people in
their unique situations.
503
00:30:44,103 --> 00:30:46,192
I don't know why
her tales moping.
504
00:30:50,283 --> 00:30:51,850
Guess what's for dinner?
505
00:30:52,720 --> 00:30:54,113
Pizza night.
506
00:30:54,156 --> 00:30:55,592
Mom, are you going to come?
507
00:30:55,636 --> 00:30:56,811
-To church?
-Yeah.
508
00:30:57,246 --> 00:30:59,509
-I'll help Merlie again.
-Okay.
509
00:30:59,814 --> 00:31:01,424
I do the arithmetic in my head.
510
00:31:02,208 --> 00:31:04,993
I want to see them graduate.
I want to see them get married.
511
00:31:06,734 --> 00:31:09,911
I set personal goals for myself.
What I want to see them reach.
512
00:31:31,672 --> 00:31:33,804
I thought they were
going to get an IV in,
513
00:31:33,848 --> 00:31:35,371
but I don't know.
514
00:31:35,415 --> 00:31:38,070
I don't think so.
We're doing a blood draw today.
515
00:31:45,599 --> 00:31:48,907
-Yeah, we got it.
-First try too.
516
00:31:50,430 --> 00:31:51,953
Are you showing
them your sugars?
517
00:31:51,997 --> 00:31:55,696
No,
I have no explanation.
518
00:31:55,739 --> 00:31:57,393
I know.
519
00:31:57,437 --> 00:32:01,484
The average glucose
dropped from 164 to 140
520
00:32:01,528 --> 00:32:05,532
-164 to 140 was your average.
-To 140.
521
00:32:05,575 --> 00:32:07,403
That's really good.
522
00:32:07,969 --> 00:32:09,579
-Here was your surgery day.
-Yeah.
523
00:32:09,623 --> 00:32:11,930
And I wasn't feeling real
great those couple days
524
00:32:11,973 --> 00:32:15,150
-That is not a surprise, there.
-But--
525
00:32:15,194 --> 00:32:17,587
But it really hasn't gone
much up since then
526
00:32:17,631 --> 00:32:20,199
and it's actually gone down.
527
00:32:20,808 --> 00:32:21,983
That's interesting.
528
00:32:24,725 --> 00:32:26,074
Let's see if the doctor--
529
00:32:26,118 --> 00:32:27,902
Okay, so here we go.
530
00:32:27,946 --> 00:32:29,599
Look what happened on its own?
531
00:32:30,339 --> 00:32:33,081
My blood sugars went up
and now it's plateauing.
532
00:32:33,473 --> 00:32:36,128
That's, I think
probably 200 points less
533
00:32:36,171 --> 00:32:37,781
than what it got to last time.
534
00:32:38,565 --> 00:32:40,741
Well, I'm anxious to
get the results now
535
00:32:40,784 --> 00:32:42,395
'cause I'm curious,
I'm very curious.
536
00:32:42,438 --> 00:32:43,918
I think everybody is.
537
00:32:43,962 --> 00:32:46,877
It's not really good
to speculate that much,
538
00:32:46,921 --> 00:32:50,446
but it should be too early
for yourselves to be working.
539
00:32:50,490 --> 00:32:52,622
I know it is.
That's what they said.
540
00:32:53,145 --> 00:32:55,321
Whatever it is,
something's working.
541
00:33:06,375 --> 00:33:09,291
No, no. 'Cause it had only
went up to like 260
542
00:33:09,335 --> 00:33:10,901
and then it went
down on its own.
543
00:33:11,467 --> 00:33:13,339
It's on its way
down right now.
544
00:33:13,382 --> 00:33:15,558
I didn't dose.
545
00:33:20,041 --> 00:33:23,566
Yeah. I mean, you can't really
argue it at this point.
546
00:33:23,610 --> 00:33:25,916
I mean, it doesn't do that
on its own.
547
00:33:25,960 --> 00:33:27,657
You know what I
mean? For a diabetic?
548
00:33:30,878 --> 00:33:32,140
Right, so.
549
00:33:36,188 --> 00:33:39,843
Right. Not fully.
Three weeks today.
550
00:33:40,192 --> 00:33:41,845
Three weeks today. Yup.
551
00:33:43,108 --> 00:33:44,544
You guys want to bite of this?
552
00:33:44,587 --> 00:33:46,241
Andrew, you want to
share it with me?
553
00:33:46,285 --> 00:33:48,374
-What is it?
-I don't like the texture.
554
00:33:50,071 --> 00:33:51,551
I think I'm blind.
555
00:33:51,594 --> 00:33:54,467
-Does it work?
-Yep.
556
00:33:54,728 --> 00:33:55,990
Okay.
557
00:33:57,861 --> 00:33:59,037
That's good.
558
00:34:10,700 --> 00:34:12,398
Six weeks into the trial,
559
00:34:12,441 --> 00:34:14,661
Maren was telling me
how good she felt
560
00:34:14,704 --> 00:34:17,490
and that her blood sugars
had never looked better.
561
00:34:20,145 --> 00:34:22,538
But, the researchers were
telling me something different.
562
00:34:23,800 --> 00:34:26,499
That it was too early for
her cells to be working.
563
00:34:28,675 --> 00:34:30,068
Gotta get them on the phone now.
564
00:34:30,111 --> 00:34:31,417
I don't know your sign in.
565
00:34:31,460 --> 00:34:33,723
I was now straddling
the firewall
566
00:34:33,767 --> 00:34:36,291
that separated the patients
from the researchers.
567
00:34:38,163 --> 00:34:39,729
So I called Howard Foyt,
568
00:34:39,773 --> 00:34:42,645
who's in charge of
clinical trials at ViaCyte.
569
00:34:43,777 --> 00:34:45,518
Hi Howard, it's Lisa.
570
00:34:45,561 --> 00:34:48,738
He became my bridge to what
was happening in the lab.
571
00:34:48,782 --> 00:34:52,916
So, can I ask you
as a patient with type 1, me?
572
00:34:52,960 --> 00:34:55,876
If I was doing all the work
573
00:34:55,919 --> 00:34:59,793
testing my sugars, uploading,
going in three times a week
574
00:34:59,836 --> 00:35:03,013
to my uni to get tested,
all that jazz
575
00:35:03,057 --> 00:35:05,103
and I was seeing
some good results,
576
00:35:06,016 --> 00:35:08,584
do you think and
you weren't told anything,
577
00:35:08,628 --> 00:35:11,283
do you think that emotionally
that would be hard?
578
00:35:11,718 --> 00:35:14,199
Because they're seeking answers.
579
00:35:14,242 --> 00:35:19,508
The patients are so desperate
to know what's happening.
580
00:35:19,552 --> 00:35:22,163
I see way what you
are challenging.
581
00:35:23,033 --> 00:35:25,993
because they have a lot
of hopes and aspirations
582
00:35:26,036 --> 00:35:28,648
that this therapy is
going to help them.
583
00:35:28,691 --> 00:35:30,345
And so,
584
00:35:30,389 --> 00:35:33,566
yes, I can see where it
would be frustrating,
585
00:35:33,609 --> 00:35:35,263
but at the same time,
586
00:35:35,307 --> 00:35:38,223
they understand that this
is clinical research.
587
00:35:38,745 --> 00:35:40,747
It's a convoluted protocol.
588
00:35:40,790 --> 00:35:43,402
I mean, it's one of
the most complicated studies
589
00:35:43,445 --> 00:35:45,404
I have ever been involved with.
590
00:35:45,665 --> 00:35:47,710
I'm the first one to admit that.
591
00:35:48,494 --> 00:35:50,496
Have you seen any
C-peptide levels yet?
592
00:35:50,974 --> 00:35:53,760
I cannot comment on that
and you know that.
593
00:35:56,850 --> 00:35:58,156
Oh, perfect timing.
594
00:35:58,199 --> 00:36:00,810
-Bye.
595
00:36:04,640 --> 00:36:08,514
C-peptide levels are
the holy grail of this study.
596
00:36:09,123 --> 00:36:12,909
They mean the cells are
producing insulin in patients.
597
00:36:24,747 --> 00:36:26,445
Greg, is it going to bother
you too much
598
00:36:26,488 --> 00:36:27,924
if I turn lights on here?
599
00:36:27,968 --> 00:36:29,056
-No.
-Okay.
600
00:36:30,927 --> 00:36:32,190
There we go.
601
00:36:33,843 --> 00:36:35,410
So, it sounds a lot worse today
than you feel over the weekend.
602
00:36:38,457 --> 00:36:41,286
So like Saturday it was mostly
like sore throat, right?
603
00:36:44,332 --> 00:36:48,858
Okay. So, one of those
infections that
604
00:36:49,772 --> 00:36:52,514
could be something that
you would've gotten anyway
605
00:36:52,558 --> 00:36:55,169
if you weren't on the drugs,
so it's tough.
606
00:36:57,302 --> 00:36:58,781
Okay, that's fine.
607
00:36:58,825 --> 00:37:00,870
What we're going to,
for just a couple days,
608
00:37:00,914 --> 00:37:04,222
we're going to cut the dose of
the CellCept in half. Okay?
609
00:37:12,708 --> 00:37:15,102
But you've had a headache,
in particular this morning.
610
00:37:15,145 --> 00:37:16,799
-It was splitting.
-Yeah.
611
00:37:23,980 --> 00:37:26,461
Hopefully by tomorrow,
it's already a better for you.
612
00:37:27,636 --> 00:37:30,117
That would be wonderful. Yeah.
613
00:38:42,711 --> 00:38:44,234
Oink. Oink.
614
00:38:45,801 --> 00:38:47,586
Ooh, those got
chocolate ones too.
615
00:38:47,629 --> 00:38:49,631
Those are my favorite
when I was a kid.
616
00:38:49,675 --> 00:38:51,241
Will you put one in my hand?
617
00:38:52,895 --> 00:38:54,332
Oh thank you.
618
00:38:55,594 --> 00:38:57,378
Yeah, that's my favorite.
619
00:38:58,161 --> 00:38:59,641
A lot of mail to go through.
620
00:39:00,033 --> 00:39:03,906
The disease is expensive.
It's very expensive.
621
00:39:03,950 --> 00:39:05,212
Thousands of dollars
622
00:39:05,473 --> 00:39:08,128
just from the last couple years.
623
00:39:08,737 --> 00:39:10,086
This is July.
624
00:39:17,050 --> 00:39:19,444
I'm getting 125 bucks.
625
00:39:21,315 --> 00:39:23,143
Then there's this bill.
626
00:39:25,275 --> 00:39:27,495
What is this?
Oh, that's for you.
627
00:39:28,583 --> 00:39:30,977
That doesn't even
have my name on it.
628
00:39:32,195 --> 00:39:36,635
Diabetes supplies include
sensors for the Dexcom,
629
00:39:36,678 --> 00:39:39,333
the CGM, the constant
glucose monitoring,
630
00:39:39,377 --> 00:39:40,682
my insulin pump,
631
00:39:41,596 --> 00:39:45,687
the insulin itself,
and all that stuff adds up.
632
00:39:48,473 --> 00:39:51,563
I mean, I lived for years
working in restaurants,
633
00:39:52,128 --> 00:39:54,348
so, I didn't have
insurance and stuff
634
00:39:54,914 --> 00:39:57,003
and I didn't have the $100
635
00:39:57,046 --> 00:39:59,092
to pay for the vials
that you get.
636
00:40:00,441 --> 00:40:02,878
I'd get sick and
end up in the ER
637
00:40:02,922 --> 00:40:07,883
for like eight hours getting
bags and bags of fluids.
638
00:40:07,927 --> 00:40:09,624
And then they'd
eventually let me leave
639
00:40:09,668 --> 00:40:11,060
with a bottle of insulin.
640
00:40:11,670 --> 00:40:15,325
which is enough to last
me maybe about a month.
641
00:40:15,369 --> 00:40:16,718
Oh, a card.
642
00:40:17,502 --> 00:40:21,288
They're envelopes.
But cards do come in envelopes.
643
00:40:21,331 --> 00:40:23,856
I wish they were cards.
Like all birthday cards.
644
00:40:26,989 --> 00:40:28,556
Come on, pup.
645
00:40:28,600 --> 00:40:30,819
Insulin is like one of
the most expensive liquids
646
00:40:30,863 --> 00:40:32,125
on earth.
647
00:40:32,473 --> 00:40:34,170
They're making a
boatload of money
648
00:40:34,214 --> 00:40:36,172
from selling us all this crap.
649
00:40:36,216 --> 00:40:38,479
So I mean, why would they
want to get rid of that?
650
00:40:42,918 --> 00:40:44,920
I hate insulin needles.
651
00:40:44,964 --> 00:40:47,227
I hate the smell of insulin.
652
00:40:50,099 --> 00:40:52,493
I just want this
disease to go away.
653
00:41:15,342 --> 00:41:17,736
This is the most important
room in our house.
654
00:41:17,779 --> 00:41:21,740
This is where the world
changed on October 31st, 1920.
655
00:41:21,783 --> 00:41:23,829
It was here at 2:00 AM,
after a night restless sleep.
656
00:41:23,872 --> 00:41:25,744
Dr. Banting came
up with this idea,
657
00:41:25,787 --> 00:41:27,833
which led to the
discovery of insulin.
658
00:41:27,876 --> 00:41:32,141
Diabetes was a death sentence
before the discovery of insulin.
659
00:41:33,926 --> 00:41:38,060
A hundred years ago,
insulin wasn't a business.
660
00:41:38,670 --> 00:41:42,500
It was a medical breakthrough
that saved millions of lives.
661
00:41:43,979 --> 00:41:46,765
When Frederick Banting
accepted the Nobel Prize
662
00:41:46,808 --> 00:41:49,245
for Medicine,
he famously said,
663
00:41:49,768 --> 00:41:53,989
"Insulin doesn't belong to me,
it belongs to the world."
664
00:41:55,208 --> 00:41:57,427
He and his team,
sold their patents
665
00:41:57,471 --> 00:42:01,649
to the University of Toronto
for a dollar, each.
666
00:42:03,912 --> 00:42:09,570
Now our illness fuels
a $245 billion industry
667
00:42:09,614 --> 00:42:12,181
designed to manage our disease.
668
00:42:15,620 --> 00:42:17,012
Here, I'll show you this.
669
00:42:18,274 --> 00:42:20,146
So, before they
discovered insulin,
670
00:42:20,189 --> 00:42:22,452
the only way you could treat
a person who has diabetes,
671
00:42:22,496 --> 00:42:25,455
like your mom, was to put him
on a really horrible diet.
672
00:42:25,499 --> 00:42:30,330
And so this child is 3 years old
and weighs 15 pounds.
673
00:42:31,113 --> 00:42:32,550
Do you think you
weigh more than him?
674
00:42:32,593 --> 00:42:34,508
-No.
-Oh you do.
675
00:42:34,552 --> 00:42:36,466
- You weigh a lot more.
- You weigh 50 pounds.
676
00:42:36,510 --> 00:42:37,903
50 pounds.
677
00:42:41,080 --> 00:42:42,734
But there's a catch 22.
678
00:42:43,343 --> 00:42:47,303
Biotech needs big pharma's
profits to fund clinical trials.
679
00:42:48,087 --> 00:42:49,915
That without its support,
680
00:42:50,393 --> 00:42:52,482
the researchers wouldn't
have gotten this far.
681
00:42:55,268 --> 00:42:59,098
Like most relationships,
it's complicated.
682
00:43:06,192 --> 00:43:09,369
It's the Flame of Hope,
it was lit 30 years ago
683
00:43:09,412 --> 00:43:11,937
and it stays lit until a
cure for diabetes is found.
684
00:43:12,851 --> 00:43:17,116
So, it burns for everyone around
the world who has diabetes.
685
00:43:17,159 --> 00:43:18,639
Jack, you know what this means?
686
00:43:18,683 --> 00:43:20,510
If the light goes
out for your mom?
687
00:43:21,163 --> 00:43:24,906
It means you don't have
to get insulin no more.
688
00:43:25,646 --> 00:43:28,606
-No more scary nights.
-Yeah.
689
00:43:44,317 --> 00:43:46,449
-Hi. How are you? I'm Mike.
-I'm Michelle.
690
00:43:46,493 --> 00:43:48,451
Michelle, good to meet
you in person.
691
00:43:48,887 --> 00:43:50,192
Sure.
692
00:43:50,236 --> 00:43:51,977
As a biotech startup company,
693
00:43:52,020 --> 00:43:54,806
there are a lot of expectations
around what are we going
694
00:43:54,849 --> 00:43:57,547
to achieve and how quickly
are we going to achieve it.
695
00:43:57,591 --> 00:43:59,114
Good to meet you, Mike Scott.
696
00:44:00,376 --> 00:44:02,422
There's something that's
called the valley of death.
697
00:44:04,163 --> 00:44:07,079
When a startup company
gets through
698
00:44:07,122 --> 00:44:08,776
an initially successful period
699
00:44:09,168 --> 00:44:10,735
and then gets to the point
700
00:44:10,778 --> 00:44:13,563
where some of the initial
excitement has died,
701
00:44:13,607 --> 00:44:15,696
we're faced with
trying to raise money
702
00:44:15,740 --> 00:44:19,091
without convincing
clinical data yet.
703
00:44:19,569 --> 00:44:21,180
We're still making progress,
704
00:44:21,223 --> 00:44:23,704
but not to that critical
juncture where you have that
705
00:44:23,748 --> 00:44:25,880
data that's going to get
people over the hump of saying,
706
00:44:25,924 --> 00:44:27,360
"Yes, we're going
to write a check."
707
00:44:27,403 --> 00:44:29,318
The other really key part is,
708
00:44:29,362 --> 00:44:31,538
is vascularization
around the outside.
709
00:44:31,886 --> 00:44:34,454
You can see that at one end,
there's a piece of tubing.
710
00:44:34,497 --> 00:44:36,848
And it's not that there
isn't a lot of interest.
711
00:44:36,891 --> 00:44:39,546
It's just that the nature
of investors at this stage
712
00:44:39,589 --> 00:44:42,288
is that, "Well, just show
me a little nibble,
713
00:44:42,331 --> 00:44:44,638
give me a taste of
the success there,
714
00:44:44,682 --> 00:44:46,858
and then I'll dump a
whole ton of money in."
715
00:44:46,901 --> 00:44:49,164
And from our perspective it's,
716
00:44:49,208 --> 00:44:51,689
"Well, that's what we need
the investment for,
717
00:44:52,080 --> 00:44:53,560
to collect that data.
718
00:44:53,603 --> 00:44:55,867
So, we can prove to you
that this works."
719
00:44:55,910 --> 00:44:56,998
It's not going to work.
720
00:44:57,042 --> 00:44:59,174
That's the challenge right now.
721
00:44:59,609 --> 00:45:01,655
So what tugs at my
heartstrings too is, I mean...
722
00:45:07,095 --> 00:45:09,097
First thing to keep in mind is,
723
00:45:09,141 --> 00:45:13,623
we're down to about $13 million
and change at this point,
724
00:45:13,667 --> 00:45:15,190
including the $10 million loan.
725
00:45:15,234 --> 00:45:18,280
So, we're getting down
to the nitty gritty here.
726
00:45:19,064 --> 00:45:22,894
We also have the CIRM
and JDRF fundings,
727
00:45:23,242 --> 00:45:26,419
but we still need to
raise some equity capital.
728
00:45:26,724 --> 00:45:31,380
Yeah, we have 180 days of cash.
729
00:45:32,425 --> 00:45:35,733
Till that, $40 million
round is closed.
730
00:45:35,776 --> 00:45:39,040
We are on life support.
731
00:45:40,650 --> 00:45:42,304
In this company,
732
00:45:43,044 --> 00:45:46,526
that discontinuous
development might be terminal.
733
00:45:46,569 --> 00:45:49,790
If we have to cut back
on some of that core,
734
00:45:49,834 --> 00:45:54,012
the thought leaders,
you lose those folks.
735
00:45:54,055 --> 00:45:56,101
There's no guarantee you're
going to get them back.
736
00:45:56,144 --> 00:45:57,755
So, what you're talking about
737
00:45:57,798 --> 00:46:00,975
is not just a delay in
getting back rolling again.
738
00:46:01,019 --> 00:46:04,674
You may not be able to rebuild,
as effective a team.
739
00:46:15,685 --> 00:46:19,385
The cost of developing
a drug is staggering.
740
00:46:19,646 --> 00:46:23,432
On average, $3 billion.
741
00:46:24,129 --> 00:46:27,045
That's a lot to raise
from bike rides and walks.
742
00:46:29,830 --> 00:46:33,616
And while government and
nonprofit funding is critical,
743
00:46:33,660 --> 00:46:36,924
it alone can't cover
the cost of a clinical trial.
744
00:46:39,013 --> 00:46:41,450
So, we followed Paul,
following the money.
745
00:46:43,191 --> 00:46:44,976
And that took us to Riyadh.
746
00:46:54,899 --> 00:46:56,988
It turns out that Saudi Arabia
747
00:46:57,031 --> 00:47:01,819
has one of the highest rates of
type 1 diabetes in the world.
748
00:47:10,392 --> 00:47:13,482
One thing about running
a biotech company is,
749
00:47:13,526 --> 00:47:15,920
you never stop raising money.
750
00:47:15,963 --> 00:47:18,226
You have to turn
over a lot of rocks.
751
00:47:18,270 --> 00:47:23,057
And you don't know where
the investment might come from.
752
00:47:23,101 --> 00:47:26,234
This really represents
potentially a functional cure.
753
00:47:26,278 --> 00:47:28,323
If this works as
well in humans,
754
00:47:28,367 --> 00:47:30,804
as it has in the
animal models we study,
755
00:47:30,848 --> 00:47:32,893
it would essentially
take it to a disease
756
00:47:32,937 --> 00:47:36,375
where patients no longer have
to think about it any further.
757
00:47:37,245 --> 00:47:39,160
Does the American
public understand
758
00:47:39,204 --> 00:47:41,336
the cost of developing a cure?
759
00:47:42,337 --> 00:47:44,426
I don't think they really
have much of a clue
760
00:47:44,470 --> 00:47:48,126
as to what goes into
getting that funding
761
00:47:48,169 --> 00:47:50,084
and how much you have to raise.
762
00:47:50,128 --> 00:47:52,870
-Hi, Paul Laikind.
-Hi, nice to meet you.
763
00:47:56,525 --> 00:47:59,093
We've raised about $70 million
764
00:47:59,137 --> 00:48:00,486
in venture financing.
765
00:48:00,529 --> 00:48:03,271
In total, it's about
$150 million
766
00:48:03,315 --> 00:48:05,143
that's been invested
in a company to date
767
00:48:05,186 --> 00:48:06,971
to get us to where we are.
768
00:48:09,756 --> 00:48:13,238
That's the billion
dollar question.
769
00:48:15,588 --> 00:48:17,590
What happens if you
don't raise the money?
770
00:48:18,373 --> 00:48:19,897
Shut the doors.
771
00:48:49,274 --> 00:48:52,625
We're going to meet with
a large pharmaceutical firm.
772
00:48:52,668 --> 00:48:55,280
It's been doing due
diligence on ViaCyte.
773
00:48:57,151 --> 00:48:58,718
So, what we're looking for
774
00:48:58,761 --> 00:49:00,285
is that they would
be able to take
775
00:49:00,328 --> 00:49:01,764
a position in the company,
776
00:49:01,808 --> 00:49:03,375
invest in the company
to the tune
777
00:49:03,418 --> 00:49:05,159
of about $15 million or so.
778
00:49:08,423 --> 00:49:13,341
All right, so tomorrow
we start at 9:00 AM.
779
00:49:15,039 --> 00:49:16,736
ViaCyte is a small fish.
780
00:49:17,258 --> 00:49:18,956
We're good at inventing.
781
00:49:18,999 --> 00:49:20,435
We're good at innovating,
782
00:49:20,479 --> 00:49:22,263
but we don't have deep pockets.
783
00:49:22,785 --> 00:49:25,788
And that's where big pharma
can play a critical role
784
00:49:25,832 --> 00:49:27,747
in taking this new technology
785
00:49:27,790 --> 00:49:30,184
to the many, many
patients who need it.
786
00:49:33,535 --> 00:49:35,973
-Exactly.
787
00:49:38,888 --> 00:49:41,717
It's not that big pharma
companies don't take risks,
788
00:49:41,979 --> 00:49:43,632
they take a wait
and see attitude
789
00:49:44,155 --> 00:49:46,635
until it's proven that
the benefit outweighs the risk.
790
00:49:53,468 --> 00:49:56,994
This is a byproduct
of our profit driven society,
791
00:49:57,037 --> 00:49:58,647
where we have to
answer to shareholders.
792
00:50:02,434 --> 00:50:06,873
That's the reality of national
and international business.
793
00:50:20,626 --> 00:50:24,760
Ladies and gentlemen,
welcome to the Shinkansen.
794
00:50:25,283 --> 00:50:28,199
This is the Hikari
Super Express.
795
00:50:30,592 --> 00:50:35,771
We will be stopping at
796
00:50:43,518 --> 00:50:45,477
Start running and
then jump on it.
797
00:50:46,043 --> 00:50:49,089
I'm serious. Run, run, run.
798
00:50:55,095 --> 00:50:56,879
What you go over there for?
799
00:51:06,715 --> 00:51:09,718
Someone will be taken
out before the end of this.
800
00:51:10,719 --> 00:51:12,373
I just hope it's not me.
801
00:51:21,904 --> 00:51:24,690
It's fun. It's exciting.
802
00:51:24,733 --> 00:51:28,085
It's scary but I can't
explain what is happening.
803
00:51:29,347 --> 00:51:31,218
I've had two explants.
804
00:51:31,262 --> 00:51:33,960
I had two taken out of my side
and one taken out of my arm.
805
00:51:34,265 --> 00:51:36,310
One in October and
one in December.
806
00:51:38,399 --> 00:51:41,533
It's exhausting.
I'm tired.
807
00:51:42,186 --> 00:51:43,622
It's a lot physically.
808
00:51:43,665 --> 00:51:44,840
It's a lot mentally,
it's a lot emotionally.
809
00:51:46,146 --> 00:51:48,888
It has been more
than I ever expected.
810
00:51:48,931 --> 00:51:52,674
Okay. So now Amber, don't squish
them but shake it.
811
00:51:53,240 --> 00:51:54,633
Shake it.
812
00:51:59,812 --> 00:52:03,294
That's the last 24 hours.
813
00:52:04,817 --> 00:52:06,819
My insulin dose is about half,
814
00:52:06,862 --> 00:52:09,038
but 50% overall.
815
00:52:10,605 --> 00:52:13,173
I feel good, down
about 20 pounds
816
00:52:13,217 --> 00:52:14,740
without even trying.
817
00:52:15,654 --> 00:52:19,397
I haven't had any extreme lows.
Have I Case?
818
00:52:19,832 --> 00:52:22,182
No extreme lows,
but you've had lows.
819
00:52:22,226 --> 00:52:25,403
Lows, but not extreme lows.
No extreme highs.
820
00:52:25,881 --> 00:52:27,927
So, I think it's definitely
narrowed the gap.
821
00:52:28,536 --> 00:52:30,886
Sounds like the cells
are working.
822
00:52:32,323 --> 00:52:33,889
Something's working.
823
00:52:34,194 --> 00:52:36,022
I don't know what's working,
something's working.
824
00:52:37,937 --> 00:52:39,765
What does Dr. Bellin say?
825
00:52:39,808 --> 00:52:41,810
She said something
826
00:52:41,854 --> 00:52:43,812
that have pointed me
in the direction that,
827
00:52:44,161 --> 00:52:45,597
"Oh, they know something,
828
00:52:45,640 --> 00:52:47,338
but they're not filling
me in on everything,
829
00:52:47,381 --> 00:52:49,209
'cause I think they're
cautiously optimistic as well."
830
00:52:50,776 --> 00:52:53,692
I never had super high
expectations to begin with,
831
00:52:53,735 --> 00:52:55,302
but this is better
than I ever expected.
832
00:52:55,346 --> 00:52:56,651
Even where I'm at right now.
833
00:52:56,695 --> 00:52:59,567
So, would you agree
with that Case?
834
00:52:59,611 --> 00:53:01,221
- I wasn't listening.
-Okay.
835
00:53:09,273 --> 00:53:10,926
Hi Howard.
836
00:53:41,218 --> 00:53:43,698
I don't believe it, necessarily.
837
00:53:46,266 --> 00:53:47,789
Why not? You've been telling us
838
00:53:47,833 --> 00:53:49,487
that the C-peptide is
the gold standard test.
839
00:53:49,530 --> 00:53:51,010
It's the gold standard.
840
00:53:51,053 --> 00:53:54,405
I'm not convinced given
that level of C-peptide,
841
00:53:54,448 --> 00:53:56,755
given that it's a solitary
measurement.
842
00:53:56,798 --> 00:53:59,584
And given that it's
a single patient.
843
00:53:59,627 --> 00:54:00,759
I don't get it.
844
00:54:00,802 --> 00:54:03,631
You guys would
get desensitized
845
00:54:03,675 --> 00:54:05,633
if you were following
each and every patient
846
00:54:05,677 --> 00:54:07,548
of the 11 we're doing right now,
847
00:54:07,592 --> 00:54:09,898
but you're focusing
in on two patients,
848
00:54:09,942 --> 00:54:12,074
the two patients at
the Minnesota site.
849
00:54:13,728 --> 00:54:15,339
Everybody's hopeful.
850
00:54:15,382 --> 00:54:17,254
-Yeah, well.
-Even the PI.
851
00:54:17,297 --> 00:54:18,559
Yeah, I know.
852
00:54:18,603 --> 00:54:21,214
That's why they pay me
to be skeptical.
853
00:54:30,963 --> 00:54:32,486
Deep breath.
854
00:54:34,575 --> 00:54:37,274
Good. Did you check your
wristband to make sure
855
00:54:37,317 --> 00:54:38,666
that everything's
right on there?
856
00:54:38,710 --> 00:54:40,189
-Sure.
-What's your birthday?
857
00:54:40,233 --> 00:54:42,366
-Today.
-It's your birthday today?
858
00:54:42,409 --> 00:54:45,325
-Yes. Happy birthday.
-Yeah.
859
00:56:34,216 --> 00:56:36,828
I would say this cell
survival is moderate.
860
00:56:37,785 --> 00:56:40,266
It just looks like, to me,
they might be fewer
861
00:56:40,309 --> 00:56:42,486
than we would hope for at...
862
00:56:42,921 --> 00:56:44,575
12 weeks.
863
00:56:44,618 --> 00:56:46,838
...Which is a pretty
definitive time point.
864
00:56:47,447 --> 00:56:49,667
It can keep going up after that,
865
00:56:49,928 --> 00:56:51,669
but I wish it were
more right now.
866
00:56:51,712 --> 00:56:54,193
Or you would
expect it to continue
867
00:56:54,236 --> 00:56:55,890
to increase after 12 weeks.
868
00:56:55,934 --> 00:56:57,152
Yes.
869
00:57:13,038 --> 00:57:15,910
It's been 12 weeks since
Maren got her implant
870
00:57:15,954 --> 00:57:19,827
and still no C-peptide levels
have shown up in her blood.
871
00:57:24,397 --> 00:57:27,356
The researchers think her cells
should have matured by now.
872
00:57:28,314 --> 00:57:30,011
They should be
producing insulin.
873
00:57:36,278 --> 00:57:37,976
Do you think it's fair to say
874
00:57:38,019 --> 00:57:40,979
that the patient shouldn't
give up hope just yet,
875
00:57:41,545 --> 00:57:43,329
because as you always
tell me, Howard.
876
00:57:43,372 --> 00:57:44,591
Rats are not humans
877
00:57:44,635 --> 00:57:46,767
and this is an
experimental study.
878
00:57:47,420 --> 00:57:48,943
Sure. Absolutely.
879
00:57:48,987 --> 00:57:52,599
I mean, you have to
consider the outcome.
880
00:57:52,643 --> 00:57:55,907
In rodent, the earliest
that we would anticipate
881
00:57:55,950 --> 00:57:59,563
seeing C-peptide is on the
order of two to three months,
882
00:58:00,128 --> 00:58:03,784
again though, that is depending
upon the assumption
883
00:58:03,828 --> 00:58:07,788
that the time course in man,
is the same as that in rodent.
884
00:58:07,832 --> 00:58:09,747
And we do not know
that for sure.
885
00:58:09,790 --> 00:58:12,053
So, we're still in the
game with these two patients?
886
00:58:12,358 --> 00:58:14,229
We're still in the game
with these two patients
887
00:58:14,273 --> 00:58:15,796
and we haven't ruled them out.
888
00:58:16,449 --> 00:58:17,798
Just want to know,
889
00:58:17,842 --> 00:58:19,278
we've been working
together for a long time
890
00:58:19,321 --> 00:58:20,975
and want to know like,
891
00:58:21,019 --> 00:58:23,935
"Hey, I should still have
hope, me.
892
00:58:23,978 --> 00:58:28,026
Not the filmmaker, but
me Lisa, the patient."
893
00:58:28,505 --> 00:58:30,463
I mean, everything
is getting better.
894
00:58:30,724 --> 00:58:32,073
You just have to be patient.
895
00:58:32,683 --> 00:58:34,859
All right, Howard.
Thanks for your time.
896
00:58:35,599 --> 00:58:36,904
Okay. Bye-bye.
897
00:58:43,868 --> 00:58:46,435
Hi, I'm just going to
complain the whole time.
898
00:58:46,479 --> 00:58:48,568
I'm a mess of a wreck.
899
00:58:50,962 --> 00:58:53,268
I don't know if I can
keep doing this anymore.
900
00:58:56,097 --> 00:59:00,058
I might have to go
back in today again,
901
00:59:00,101 --> 00:59:02,147
which would be
surgery number five
902
00:59:02,190 --> 00:59:08,545
in four months, and so tired.
903
00:59:09,850 --> 00:59:11,635
Tired doing this and
904
00:59:12,636 --> 00:59:15,769
so much physically
and emotionally on me.
905
00:59:19,294 --> 00:59:22,341
All this in hopes of the cure.
906
00:59:37,269 --> 00:59:40,838
I can't compare this experience
to anything in my life, ever.
907
00:59:41,186 --> 00:59:44,537
It has been an
emotional rollercoaster,
908
00:59:44,581 --> 00:59:45,930
is the only way to explain it.
909
00:59:47,018 --> 00:59:48,628
I would give anything.
910
00:59:48,672 --> 00:59:51,936
If I could sit down with
the people doing the study
911
00:59:51,979 --> 00:59:53,677
out in San Diego and say,
912
00:59:53,720 --> 00:59:55,330
"This is what it's
like on our end.
913
00:59:55,374 --> 00:59:56,767
You can go ahead
and see my labs.
914
00:59:56,810 --> 00:59:57,855
You can go ahead
and see the blood work.
915
00:59:58,682 --> 01:00:00,597
But, talk to Greg and me.
916
01:00:00,640 --> 01:00:02,381
Talk to us about
how we're doing."
917
01:00:02,424 --> 01:00:03,774
Nice and close.
918
01:00:04,165 --> 01:00:06,167
But I'm going to
have to stick it out
919
01:00:06,211 --> 01:00:09,518
until someone tells me to stop.
920
01:00:11,346 --> 01:00:12,739
I don't know what else to do.
921
01:00:12,783 --> 01:00:14,785
I mean, I'm knee
deep in horse shit.
922
01:00:14,828 --> 01:00:16,351
So, I don't know
923
01:00:16,395 --> 01:00:17,831
what I'm supposed to do.
924
01:00:17,875 --> 01:00:19,616
I mean, I've already
got eight incisions
925
01:00:19,659 --> 01:00:22,270
all over my body
and been a lab rat.
926
01:00:22,314 --> 01:00:24,185
I'm this far into it.
I might as well keep going.
927
01:00:39,940 --> 01:00:42,900
Me and the other patients
are experiencing
928
01:00:42,943 --> 01:00:44,945
better glucose numbers.
929
01:00:45,511 --> 01:00:47,469
And I think that
could be attributed
930
01:00:47,513 --> 01:00:50,298
to a placebo effect because
we're under a microscope.
931
01:00:52,518 --> 01:00:54,259
Humans are self-conscious.
932
01:00:55,913 --> 01:00:58,089
And they wanna leave
a good impression
933
01:01:00,526 --> 01:01:03,311
So, looking at this
at the broad overview,
934
01:01:03,355 --> 01:01:05,966
I'd say you're doing
reasonably well.
935
01:01:06,010 --> 01:01:07,707
I mean, you're in
target 70% of the time.
936
01:01:07,751 --> 01:01:09,491
Yeah.
937
01:01:09,535 --> 01:01:10,797
You obviously have some
highs, but we expect that.
938
01:01:10,841 --> 01:01:12,407
You have some lows,
but they seem like
939
01:01:12,451 --> 01:01:14,627
they're pretty brief in nature.
940
01:01:14,671 --> 01:01:17,674
You have a little more
highs maybe after lunchtime,
941
01:01:17,717 --> 01:01:19,632
but nothing that I'm concerned
about for you.
942
01:01:20,807 --> 01:01:22,243
Do you think it's working?
943
01:01:22,766 --> 01:01:25,943
I do.
I think it's doing something
944
01:01:25,986 --> 01:01:30,817
because my disease
seems easier to manage,
945
01:01:30,861 --> 01:01:33,211
but it could just be me.
946
01:01:33,254 --> 01:01:35,648
Oh, I like the socks today.
947
01:01:35,692 --> 01:01:36,954
Yeah. Striped.
948
01:01:58,584 --> 01:02:01,456
Used to play a lot of
craps on the streets.
949
01:02:01,500 --> 01:02:04,938
I should probably paint some
dots on this thing.
950
01:02:04,982 --> 01:02:06,070
Make him feel at home.
951
01:02:10,074 --> 01:02:13,077
-What is that, Greg?
- This is my father.
952
01:02:15,383 --> 01:02:19,605
He passed away about a year ago
from complications
953
01:02:19,648 --> 01:02:22,869
of Pneumonia and diabetes.
954
01:02:24,001 --> 01:02:26,307
-Is there an urn in it?
-This is an urn.
955
01:02:26,351 --> 01:02:27,613
-Oh, that's the urn.
-Yeah.
956
01:02:28,440 --> 01:02:31,051
For a Mexican family,
this is it, man.
957
01:02:31,312 --> 01:02:32,618
This is what we got.
958
01:02:32,879 --> 01:02:34,054
Yeah,
959
01:02:35,839 --> 01:02:37,101
this is him.
960
01:02:39,190 --> 01:02:41,366
He was in a nursing home
961
01:02:41,409 --> 01:02:43,760
due to a hypoglycemic episode
962
01:02:43,803 --> 01:02:47,154
that left him
mentally handicapped.
963
01:02:47,764 --> 01:02:50,418
He couldn't live on his own.
He couldn't function.
964
01:02:51,071 --> 01:02:52,769
He had to relearn how to talk
965
01:02:52,812 --> 01:02:55,423
and he... but he
relearned, barely.
966
01:02:56,511 --> 01:03:00,907
So yeah, this is:
Gregory Romero Senior.
967
01:03:11,091 --> 01:03:13,615
Gracious God, we thank you
for Maren.
968
01:03:13,659 --> 01:03:15,574
And for the love that she has,
969
01:03:15,617 --> 01:03:17,881
that has been poured
out into so many lives.
970
01:03:17,924 --> 01:03:21,406
And especially of all her kids,
who are gathered around her now.
971
01:03:21,841 --> 01:03:23,625
Heavenly father,
we pray for Maren
972
01:03:23,669 --> 01:03:26,498
and for the doctors who
will be looking after her,
973
01:03:26,541 --> 01:03:30,067
we ask that your presence
will be with Maren
974
01:03:30,110 --> 01:03:32,069
and be with the
rest of her family.
975
01:03:32,112 --> 01:03:33,810
Lord, we lift her up to you
976
01:03:33,853 --> 01:03:37,857
and know that she is in your
careful and loving arms.
977
01:03:37,901 --> 01:03:39,467
In Jesus' name, we pray.
978
01:03:39,511 --> 01:03:41,034
-Amen.
-Amen.
979
01:03:44,037 --> 01:03:45,822
Katelyn, can stand up.
980
01:03:59,009 --> 01:04:00,967
So, you're getting
some results today?
981
01:04:01,750 --> 01:04:03,274
Hopefully I find something out,
982
01:04:03,317 --> 01:04:04,797
either yes or no.
983
01:04:05,493 --> 01:04:08,105
Are the cell's dead
or are they alive?
984
01:04:17,984 --> 01:04:20,247
Okay, so they did
the explants, right?
985
01:04:20,291 --> 01:04:22,162
Yep. So this is the January one.
986
01:04:22,206 --> 01:04:24,599
-This is the most recent one.
-Okay. A couple weeks ago.
987
01:04:24,643 --> 01:04:27,124
Remember they were looking
at the T cells before
988
01:04:27,167 --> 01:04:29,082
that cause rejection.
989
01:04:29,126 --> 01:04:30,692
So, they still see those cells.
990
01:04:30,736 --> 01:04:33,652
Around the implant
and inside of it.
991
01:04:33,695 --> 01:04:38,091
They see very, very few
from what they told me,
992
01:04:38,135 --> 01:04:39,876
actual donor cells anymore.
993
01:04:39,919 --> 01:04:41,573
Interesting, okay. Yep.
994
01:04:42,574 --> 01:04:44,663
They don't think
that there's any chance
995
01:04:44,706 --> 01:04:46,926
that the remaining ones
are going to make insulin.
996
01:04:47,622 --> 01:04:50,016
Is this happening with everyone?
Do you know?
997
01:04:50,321 --> 01:04:52,758
So, you are the only person
998
01:04:52,801 --> 01:04:57,023
in the study so far that has
had this type of rejection.
999
01:04:57,067 --> 01:04:58,677
Interesting.
1000
01:04:58,720 --> 01:05:01,506
So from our standpoint,
if they're not going to work,
1001
01:05:01,854 --> 01:05:03,638
then we're putting medicine
that you don't need,
1002
01:05:03,682 --> 01:05:05,727
leaving them in when
you don't need it.
1003
01:05:28,359 --> 01:05:30,665
Truly, truly I'm relieved.
1004
01:05:31,101 --> 01:05:34,017
I feel like I can breathe.
1005
01:05:36,019 --> 01:05:37,803
It's been a long five months.
1006
01:05:37,846 --> 01:05:39,892
It's been a really
long five months.
1007
01:05:40,371 --> 01:05:42,503
Six months almost
since the start of it.
1008
01:05:44,114 --> 01:05:46,507
I feel like I can maybe go
back to normal for a bit,
1009
01:05:49,597 --> 01:05:52,339
My normal, whatever
my normal is.
1010
01:06:25,459 --> 01:06:28,636
Do you feel guilty that the cure
is always 5 years away?
1011
01:06:28,680 --> 01:06:31,726
I don't feel guilty.
I feel hopeful.
1012
01:06:32,684 --> 01:06:35,382
I feel really hopeful.
I'm not kidding.
1013
01:06:35,426 --> 01:06:37,384
-You do?
-Yes.
1014
01:06:37,428 --> 01:06:38,864
-Really, for real?
-That's so nice of you.
1015
01:06:38,907 --> 01:06:41,998
I'm working here.
I can see what's going on.
1016
01:06:45,262 --> 01:06:46,611
It's going to be good for you.
1017
01:06:46,654 --> 01:06:48,787
I know it's been
really hard as heck.
1018
01:06:54,662 --> 01:06:56,273
Thanks.
1019
01:06:56,316 --> 01:06:57,709
I'm not kidding.
1020
01:06:58,231 --> 01:06:59,580
It's true.
1021
01:07:00,103 --> 01:07:03,758
I mean, there's nobody,
no person with a Dexcom
1022
01:07:03,802 --> 01:07:07,849
or a pump or anything
works as well as the cells.
1023
01:07:09,112 --> 01:07:12,289
The cells have evolved
over millions of years.
1024
01:07:12,593 --> 01:07:15,553
They're the best glucose
sensors, the best insulin
1025
01:07:16,293 --> 01:07:18,947
pumps in the world.
1026
01:07:18,991 --> 01:07:20,340
That's what biology's all about.
1027
01:07:20,384 --> 01:07:23,996
And that's why
we're doing it this way.
1028
01:07:24,040 --> 01:07:26,259
It takes a ton of work
and a ton of money,
1029
01:07:26,303 --> 01:07:27,956
but it's worth it.
1030
01:07:38,141 --> 01:07:39,490
That's good.
1031
01:07:39,533 --> 01:07:41,970
We want them to
get blood vessels.
1032
01:07:42,014 --> 01:07:43,276
Oh, that's great.
1033
01:07:45,148 --> 01:07:48,368
The loading port, right?
1034
01:07:48,412 --> 01:07:51,371
-Do you see it, Greg?
-It's the top one.
1035
01:07:51,632 --> 01:07:54,331
And for the other
one, there it is.
1036
01:07:54,374 --> 01:07:56,289
And then the port, port, port.
1037
01:07:57,247 --> 01:07:59,684
So if I come up this way.
1038
01:08:17,093 --> 01:08:18,659
I used to have great vision.
1039
01:08:20,139 --> 01:08:21,967
I remember as a child,
1040
01:08:22,010 --> 01:08:24,796
my dad being diabetic would
ask me to look down the street
1041
01:08:24,839 --> 01:08:26,754
and see what bus is coming
1042
01:08:27,190 --> 01:08:28,452
and I'd have to tell him.
1043
01:08:29,061 --> 01:08:31,281
And I'm like,
"How do you not see that?"
1044
01:08:36,024 --> 01:08:37,591
Now I understand.
1045
01:08:40,638 --> 01:08:42,161
Mr. Romero.
1046
01:08:42,205 --> 01:08:43,554
-Hi.
-How are you doing?
1047
01:08:43,597 --> 01:08:45,556
-Good, how are you?
-Good, good.
1048
01:08:45,599 --> 01:08:47,340
Your left eye vision
seems a lot more blurry
1049
01:08:47,384 --> 01:08:49,037
than it was last time I saw you.
1050
01:08:49,081 --> 01:08:50,300
It is a little bit.
1051
01:08:50,343 --> 01:08:52,084
Let me take a look real quick.
1052
01:08:52,519 --> 01:08:54,478
I looked at your pictures
1053
01:08:54,521 --> 01:08:57,829
and I have a suspicion
as to what's going on.
1054
01:08:59,831 --> 01:09:01,224
Look up.
1055
01:09:01,963 --> 01:09:03,443
Up and left.
1056
01:09:05,532 --> 01:09:07,143
and down,
1057
01:09:07,882 --> 01:09:09,449
down and right.
1058
01:09:11,669 --> 01:09:12,670
And right.
1059
01:09:17,414 --> 01:09:18,806
And left.
1060
01:09:26,814 --> 01:09:30,992
So, it seems that
you've had some bleeding
1061
01:09:31,036 --> 01:09:34,257
inside your left eye
from the diabetes.
1062
01:09:34,300 --> 01:09:39,697
Yeah, I see a floater or
it looks like a drop of blood.
1063
01:09:39,740 --> 01:09:41,438
Yeah.
1064
01:09:41,481 --> 01:09:43,353
So, that's probably at
the bottom of my eye somewhere.
1065
01:09:43,396 --> 01:09:44,919
Yeah, there's quite a bit of
blood in there
1066
01:09:44,963 --> 01:09:46,834
that is blocking your vision.
1067
01:09:46,878 --> 01:09:49,141
And it's definitely worse than
it was last time we saw you.
1068
01:09:49,185 --> 01:09:51,317
If it fails to clear, we might
have to do surgery,
1069
01:09:51,361 --> 01:09:53,189
-but I'm hoping to avoid that.
-Okay.
1070
01:09:53,711 --> 01:09:55,800
-Thank you very much.
-Oh, sure.
1071
01:09:56,453 --> 01:09:59,456
Yeah, whatever.
1072
01:10:01,371 --> 01:10:03,721
It's all part of the experience,
I guess.
1073
01:10:09,030 --> 01:10:11,294
I can't fucking see.
1074
01:10:22,479 --> 01:10:25,264
The study is the positive
thing for me right now.
1075
01:10:25,308 --> 01:10:26,831
We're just waiting.
1076
01:10:26,874 --> 01:10:28,920
We're all waiting
to see if these things work.
1077
01:10:28,963 --> 01:10:30,269
If they don't,
1078
01:10:31,009 --> 01:10:33,098
we'll cross that bridge
when we get to it.
1079
01:10:35,405 --> 01:10:40,018
I have neuropathy, retinopathy
1080
01:10:41,846 --> 01:10:43,500
and other
1081
01:10:45,284 --> 01:10:47,852
complications due to
the high blood sugars
1082
01:10:47,895 --> 01:10:49,027
throughout the years.
1083
01:10:49,070 --> 01:10:52,117
A lot of nerve damage I have.
1084
01:10:54,641 --> 01:10:56,252
I'm sorry.
1085
01:10:59,167 --> 01:11:01,300
I'm not going to say what
I was just going to say.
1086
01:11:01,344 --> 01:11:02,736
But yeah.
1087
01:11:04,085 --> 01:11:06,262
You suffer from
the disease as well.
1088
01:11:06,305 --> 01:11:08,307
So, I'm sorry too.
1089
01:11:10,614 --> 01:11:12,790
It's something that
we're all going to have
1090
01:11:12,833 --> 01:11:15,619
to encounter and deal with,
every one of us.
1091
01:11:21,886 --> 01:11:23,279
Sorry.
1092
01:11:27,848 --> 01:11:29,676
But if these cells work,
1093
01:11:38,511 --> 01:11:40,121
I'll cry for a week,
1094
01:11:41,862 --> 01:11:43,603
like, out loud
1095
01:11:45,910 --> 01:11:48,695
and I'm not the type of
person to do that very much.
1096
01:11:56,964 --> 01:11:58,183
I'm tired.
1097
01:12:37,918 --> 01:12:40,704
You had the ViaCyte?
1098
01:12:40,747 --> 01:12:42,401
-Yeah.
-Are they all gone now?
1099
01:12:42,445 --> 01:12:43,837
-They're gone.
-Okay.
1100
01:12:43,881 --> 01:12:45,535
I assume they're gone.
1101
01:12:45,926 --> 01:12:47,319
I got a phone call
1102
01:12:47,363 --> 01:12:50,017
and there's
a pancreas available.
1103
01:12:50,453 --> 01:12:53,499
I thought about it for years,
for years.
1104
01:12:53,543 --> 01:12:56,633
And the trial gave me
1105
01:12:57,024 --> 01:12:58,896
the opportunity to
try the medicine
1106
01:12:58,939 --> 01:13:00,201
and see how I handled it.
1107
01:13:00,245 --> 01:13:02,769
And I handled it just fine.
1108
01:13:02,813 --> 01:13:04,641
Recent changes in your
vision or your hearing?
1109
01:13:04,684 --> 01:13:05,946
No.
1110
01:13:05,990 --> 01:13:07,426
So, it opened the door for me
1111
01:13:07,992 --> 01:13:10,821
to think more about
doing this transplant.
1112
01:13:10,864 --> 01:13:12,039
-Sore throat?
-No.
1113
01:13:12,083 --> 01:13:13,954
I would do the trial over again.
1114
01:13:13,998 --> 01:13:15,956
I would do everything
all over again.
1115
01:13:16,000 --> 01:13:17,393
'Cause, it got me to this point.
1116
01:13:18,132 --> 01:13:20,091
I have zero regrets.
1117
01:13:21,658 --> 01:13:22,920
Zero.
1118
01:13:29,317 --> 01:13:31,407
-Hi.
-Hi, come here.
1119
01:13:34,410 --> 01:13:36,629
-How are you?
-Good, how are you?
1120
01:13:36,673 --> 01:13:37,891
Okay.
1121
01:13:45,943 --> 01:13:48,032
I'm going to sneak
a hug in there.
1122
01:13:48,075 --> 01:13:49,990
See you. Wish me luck.
1123
01:13:50,034 --> 01:13:51,557
I'm going to see you next time.
1124
01:13:52,515 --> 01:13:53,907
We'll go out for cheesecake.
1125
01:13:54,691 --> 01:13:57,737
-Cheesecake Factory
1126
01:13:58,477 --> 01:14:01,480
-with sugar.
1127
01:14:01,524 --> 01:14:03,700
Okay. Take care.
1128
01:14:03,743 --> 01:14:06,137
Come visit me. Okay?
1129
01:14:10,054 --> 01:14:11,708
All right. We'll see you, Greg.
1130
01:14:20,673 --> 01:14:22,153
One, two, three.
1131
01:14:26,549 --> 01:14:29,377
A friend of mine that
had a pancreas transplant
1132
01:14:29,421 --> 01:14:31,815
a year and a half ago,
text me this afternoon.
1133
01:14:31,858 --> 01:14:35,253
She goes, "You'll wake up
tomorrow with a new life."
1134
01:14:36,950 --> 01:14:38,778
So, it was pretty cool.
1135
01:14:39,953 --> 01:14:42,782
So, fingers crossed.
1136
01:14:57,536 --> 01:15:00,757
I've been going with Paul
to meetings
1137
01:15:00,800 --> 01:15:05,196
with potential investors
for the last two years.
1138
01:15:05,588 --> 01:15:07,546
Every time you're like,
"Oh, this is it."
1139
01:15:07,590 --> 01:15:10,723
These guys get it.
They're excited about it.
1140
01:15:10,767 --> 01:15:12,116
And then
1141
01:15:13,291 --> 01:15:16,424
they just don't call you back.
1142
01:15:16,468 --> 01:15:19,819
Don't reply the email. Or
1143
01:15:20,559 --> 01:15:22,996
It just falls apart
one way or the other.
1144
01:15:23,040 --> 01:15:27,087
So, that's been really hard.
1145
01:15:28,088 --> 01:15:30,526
The pouch is
designed to fully contain
1146
01:15:30,569 --> 01:15:32,092
the implant itself,
1147
01:15:32,136 --> 01:15:34,225
but still allow vital
nutrients and proteins
1148
01:15:34,268 --> 01:15:36,575
such as oxygen,
glucose, insulin,
1149
01:15:36,619 --> 01:15:39,578
and other hormones to
travel between the cells.
1150
01:15:39,622 --> 01:15:41,362
Well, it's nice. It's a good
description of the product.
1151
01:15:41,406 --> 01:15:42,755
Well, it's nice.
Good to see you.
1152
01:15:42,799 --> 01:15:44,627
All right.
1153
01:15:50,850 --> 01:15:54,201
I'm really pleased to announce
that as of this morning,
1154
01:15:54,245 --> 01:15:55,768
the checks rolled in
1155
01:15:55,812 --> 01:16:00,077
and we completed an $80 million
financing for ViaCyte.
1156
01:16:04,647 --> 01:16:07,911
That's $105 million over
the last three months.
1157
01:16:08,215 --> 01:16:10,130
It's really exciting,
1158
01:16:10,174 --> 01:16:12,219
but boy, we're going to be
under pressure to perform.
1159
01:16:12,263 --> 01:16:15,919
I believe that everybody in here
will redouble their efforts
1160
01:16:15,962 --> 01:16:18,704
to really show this new group
of investors
1161
01:16:18,748 --> 01:16:20,314
that they made a great decision.
1162
01:16:24,928 --> 01:16:28,758
All right, let's do a toast
to the success of this team,
1163
01:16:28,801 --> 01:16:32,936
the success of this program and
to curing type 1 diabetes.
1164
01:16:37,680 --> 01:16:40,944
I feel like Paul has mastered
the game of selling risk.
1165
01:16:43,424 --> 01:16:47,603
He convinces venture capitalists
to embrace the long game,
1166
01:16:47,646 --> 01:16:50,997
that science takes time
and progress is incremental.
1167
01:16:51,041 --> 01:16:53,783
You got to be optimistic
and stress resistant.
1168
01:16:55,480 --> 01:16:56,916
Two criteria.
1169
01:16:56,960 --> 01:16:59,049
If it doesn't work in
patient two,
1170
01:16:59,092 --> 01:17:01,834
it's going to work in 22.
1171
01:17:04,445 --> 01:17:07,492
But what if Paul's
strategy hadn't worked?
1172
01:17:09,102 --> 01:17:10,582
I can't help but think
1173
01:17:10,626 --> 01:17:13,237
this promising trial
would've been cut short,
1174
01:17:13,280 --> 01:17:15,543
only to languish on a shelf
1175
01:17:15,587 --> 01:17:18,111
next to the thousands
of other patents
1176
01:17:18,155 --> 01:17:19,896
collecting dust.
1177
01:17:19,939 --> 01:17:22,028
ViaCyte believes it
has the key elements needed
1178
01:17:22,072 --> 01:17:25,858
to produce transformative
therapies to treat diabetes.
1179
01:17:34,214 --> 01:17:35,955
Hello? I'm Greg.
1180
01:17:36,739 --> 01:17:38,262
Good. How are you?
1181
01:17:43,615 --> 01:17:45,791
We're going to talk
about your results.
1182
01:17:45,835 --> 01:17:47,837
-Yeah.
-And when you had your surgery
1183
01:17:47,880 --> 01:17:50,448
to remove one of the
small cell pouches.
1184
01:17:52,319 --> 01:17:53,756
So, I had a really
good conversation
1185
01:17:53,799 --> 01:17:55,627
with a sponsor yesterday.
1186
01:17:56,062 --> 01:17:58,848
And so there are some
donor cells there,
1187
01:17:58,891 --> 01:18:00,501
but there are not many of them
1188
01:18:00,545 --> 01:18:02,808
and they don't expect them
to get any better
1189
01:18:02,852 --> 01:18:04,114
from this point on.
1190
01:18:05,419 --> 01:18:07,813
So, we look for
C-peptide as a marker
1191
01:18:07,857 --> 01:18:10,033
of the cells actually making
insulin in your bloodstream
1192
01:18:10,076 --> 01:18:12,296
and that's always been negative.
1193
01:18:12,992 --> 01:18:17,823
So, I don't know if we're not
going to get any more benefit
1194
01:18:17,867 --> 01:18:20,696
from you, that it's
worthwhile for you
1195
01:18:20,739 --> 01:18:23,263
to have to continue to
take these medications
1196
01:18:23,307 --> 01:18:24,874
and have potential side effects
1197
01:18:24,917 --> 01:18:26,353
-and risk from the medications.
-Yeah.
1198
01:18:26,397 --> 01:18:28,094
And I, had to...
1199
01:18:29,487 --> 01:18:32,446
-Yes, I feel the--
-You feel the same way.
1200
01:18:32,490 --> 01:18:35,798
Well, you've done a great job
of taking care of yourself
1201
01:18:35,841 --> 01:18:38,583
and staying on top of things
through this whole process.
1202
01:18:39,627 --> 01:18:42,587
So, well then that would
lead me to this question,
1203
01:18:42,630 --> 01:18:45,677
which is, so you guys
have a Eureka moment
1204
01:18:45,721 --> 01:18:47,461
and this is something
that's going to work
1205
01:18:47,505 --> 01:18:49,507
for a large majority
of the population.
1206
01:18:49,550 --> 01:18:52,205
How long would
it take for your guys,
1207
01:18:52,510 --> 01:18:55,556
the cure, the solution
that you found
1208
01:18:55,600 --> 01:18:58,429
to hit clinics where
I'd be able to actually go
1209
01:18:58,472 --> 01:18:59,996
and get the dang thing?
1210
01:19:00,039 --> 01:19:02,650
Yeah, right. Good question.
1211
01:19:03,956 --> 01:19:06,306
That probably is at least,
1212
01:19:06,350 --> 01:19:08,787
from the time they're starting
these phase one studies,
1213
01:19:08,831 --> 01:19:11,224
I'd say it's probably at least
a five to seven year process.
1214
01:19:11,268 --> 01:19:12,748
Okay.
1215
01:19:14,401 --> 01:19:15,663
All right.
1216
01:19:19,058 --> 01:19:20,756
Other questions you have?
1217
01:19:24,237 --> 01:19:25,543
I don't know.
1218
01:19:28,067 --> 01:19:29,982
The more silent I get outside,
1219
01:19:30,026 --> 01:19:32,332
the more loud it
gets inside my head.
1220
01:20:03,886 --> 01:20:07,541
So, even if the patients
we've been following, Howard
1221
01:20:07,585 --> 01:20:10,153
don't seem to be
producing C-peptides
1222
01:20:10,196 --> 01:20:12,416
or essentially
their own insulin,
1223
01:20:12,459 --> 01:20:14,026
that's not a failure?
1224
01:20:14,418 --> 01:20:17,029
It depends upon how
you define failure.
1225
01:20:17,073 --> 01:20:21,120
It's obviously a setback
for these patients
1226
01:20:21,164 --> 01:20:24,123
who have volunteered
their time and effort
1227
01:20:24,167 --> 01:20:27,126
to participate in
these clinical trials.
1228
01:20:28,606 --> 01:20:30,738
But we've learned
a lot from them
1229
01:20:30,782 --> 01:20:34,046
and we continue to tweak
the implantation procedure,
1230
01:20:34,090 --> 01:20:37,180
trying to improve the
engraftment process.
1231
01:20:37,223 --> 01:20:39,443
And we continue
to make gains there.
1232
01:20:39,965 --> 01:20:43,142
What's the mood like
at ViaCyte right now?
1233
01:20:43,186 --> 01:20:44,404
I think the mood is upbeat.
1234
01:20:44,448 --> 01:20:46,145
Everybody is excited.
1235
01:20:46,189 --> 01:20:48,495
I mean, everybody
here at ViaCyte
1236
01:20:48,539 --> 01:20:51,759
is convinced our cells
do a great job,
1237
01:20:51,803 --> 01:20:53,109
they work the way
they're supposed to
1238
01:20:53,152 --> 01:20:55,502
and behave very physiologically.
1239
01:20:55,546 --> 01:20:58,810
They will cure type 1 diabetes.
1240
01:20:59,028 --> 01:21:01,769
There is one thing that
you would like to know.
1241
01:21:02,205 --> 01:21:03,554
Yeah.
1242
01:21:03,597 --> 01:21:05,425
Remember the first
patient from Minnesota.
1243
01:21:06,035 --> 01:21:07,340
Yeah.
1244
01:21:08,254 --> 01:21:11,040
We early terminated that patient
1245
01:21:11,083 --> 01:21:14,913
because of lack of C-peptide,
1246
01:21:14,957 --> 01:21:17,916
lack of potential
efficacy and the like,
1247
01:21:17,960 --> 01:21:21,659
so we explained all of
the remaining units.
1248
01:21:21,702 --> 01:21:24,357
Would you like to know
what the histology showed?
1249
01:21:24,401 --> 01:21:25,663
Yes.
1250
01:21:26,098 --> 01:21:29,188
That were viable clumps
of viable cells there.
1251
01:21:30,189 --> 01:21:33,105
So Howard, what does that mean?
What's the takeaway?
1252
01:21:33,149 --> 01:21:35,499
What's my takeaway
as a layperson.
1253
01:21:35,542 --> 01:21:39,633
The takeaway is
that cells can survive
1254
01:21:39,677 --> 01:21:44,638
for long periods of time in
this encapsulated environment.
1255
01:21:44,900 --> 01:21:46,727
And that's important.
1256
01:21:46,771 --> 01:21:48,033
That's really good news.
1257
01:21:48,904 --> 01:21:50,383
It's great news.
1258
01:21:50,818 --> 01:21:53,821
Would've been even better
if we'd been seeing C-peptides,
1259
01:21:53,865 --> 01:21:56,824
but you know, you don't always
get exactly what you want.
1260
01:21:56,868 --> 01:22:00,089
If you actually could
talk to these patients,
1261
01:22:00,132 --> 01:22:02,178
the ones we've
gotten to know well,
1262
01:22:02,961 --> 01:22:08,401
is there anything that you would
tell them as a message?
1263
01:22:10,360 --> 01:22:13,972
We owe all of these subjects,
a tremendous debt of gratitude.
1264
01:22:14,016 --> 01:22:17,149
Thus far, we have been
able to give them a lot
1265
01:22:17,193 --> 01:22:20,892
in terms of effectively
treating their own disease.
1266
01:22:20,936 --> 01:22:24,330
But we have gained a
tremendous amount of knowledge,
1267
01:22:24,374 --> 01:22:28,552
which hopefully will help us
get across the finish line
1268
01:22:28,595 --> 01:22:30,946
in terms of future iterations.
1269
01:22:34,210 --> 01:22:35,820
What are you thinking?
1270
01:22:36,125 --> 01:22:38,823
If it hadn't been
for Greg and Maren,
1271
01:22:38,866 --> 01:22:41,782
for the other patients who
participated in this trial
1272
01:22:41,826 --> 01:22:43,262
and they're up to patient 19,
1273
01:22:43,306 --> 01:22:45,395
they wouldn't be
where they are today.
1274
01:22:45,438 --> 01:22:48,920
And it's been a huge
sacrifice for these patients.
1275
01:23:12,944 --> 01:23:14,467
It's just been
really hard on them.
1276
01:23:14,511 --> 01:23:15,816
And I wish it had
worked for them,
1277
01:23:15,860 --> 01:23:19,603
but they're paving
the way for others, so,
1278
01:23:22,258 --> 01:23:23,563
that's it.
1279
01:23:37,838 --> 01:23:40,450
I was trying to come
to terms with the fact,
1280
01:23:40,493 --> 01:23:42,060
this may not work.
1281
01:23:44,236 --> 01:23:48,806
The trial wasn't over but
it was for Greg and Maren.
1282
01:24:33,590 --> 01:24:36,071
Any of the negative crap
you hear coming from me,
1283
01:24:36,114 --> 01:24:38,856
that's subjective crap.
That's Greg.
1284
01:24:52,565 --> 01:24:55,438
I know that I've been part
of something very important
1285
01:24:55,481 --> 01:25:00,399
and very beneficial to us.
All of us with diabetes.
1286
01:25:32,605 --> 01:25:34,346
Officially, as of today,
1287
01:25:34,390 --> 01:25:36,914
I'm considered a failed
transplant patient.
1288
01:25:40,700 --> 01:25:44,661
I have an appointment at my
1-year mark, late July
1289
01:25:44,704 --> 01:25:46,141
to get relisted.
1290
01:25:47,577 --> 01:25:50,536
I'm young, I'm healthy.
So therefore I'm a priority.
1291
01:25:51,058 --> 01:25:54,453
I'm not ready physically or
emotionally yet to do it again.
1292
01:25:54,497 --> 01:25:56,368
In time, maybe I will.
1293
01:26:01,634 --> 01:26:05,856
I have shared only this
with a few people.
1294
01:26:06,291 --> 01:26:08,511
I will cross that
bridge if people ask,
1295
01:26:08,946 --> 01:26:10,513
but it's a tremendous loss,
1296
01:26:11,253 --> 01:26:14,169
a loss I thought I was
ready for, but I was not.
1297
01:26:15,953 --> 01:26:17,476
Thank you for listening.
1298
01:26:56,298 --> 01:26:59,649
-Hey,
-Good to see you.
1299
01:26:59,692 --> 01:27:01,216
-Good to see you.
-Yeah.
1300
01:27:03,305 --> 01:27:07,439
We have the data that
shows that the product
1301
01:27:07,483 --> 01:27:10,790
is producing insulin in the
patients for the first time.
1302
01:27:12,662 --> 01:27:16,622
It's the first patients ever
in the history of
1303
01:27:17,362 --> 01:27:19,973
diabetes cure research.
1304
01:27:20,017 --> 01:27:22,280
So, this is a big deal.
1305
01:27:25,240 --> 01:27:28,939
I mean, we know now
that the cells work,
1306
01:27:29,374 --> 01:27:32,290
we didn't know that
five years ago.
1307
01:27:35,467 --> 01:27:37,034
All the pieces are there.
1308
01:27:37,077 --> 01:27:40,559
It's just a matter now
of completing the puzzle.
1309
01:27:49,612 --> 01:27:52,919
We all want stories
with a beginning,
1310
01:27:52,963 --> 01:27:54,747
middle and end.
1311
01:27:55,835 --> 01:27:58,490
One where all the loose
ends fit together.
1312
01:28:00,884 --> 01:28:04,409
But clinical research
is messy and hard.
1313
01:28:06,019 --> 01:28:08,370
It doesn't fit into
a tidy headline,
1314
01:28:08,979 --> 01:28:10,763
no matter how much
you want it to.
1315
01:28:14,637 --> 01:28:17,988
The cells may not have
worked for Greg and Maren,
1316
01:28:19,163 --> 01:28:23,036
but they're producing
insulin in nine patients.
1317
01:28:23,907 --> 01:28:26,605
Nine patients.
1318
01:28:27,867 --> 01:28:29,086
Because of them,
1319
01:28:29,391 --> 01:28:32,394
we are one step
closer to a cure.
1320
01:28:36,528 --> 01:28:39,357
But science alone isn't enough.
1321
01:28:40,271 --> 01:28:43,187
It needs a spotlight,
a champion
1322
01:28:44,667 --> 01:28:46,016
and money.
1323
01:28:48,453 --> 01:28:51,456
If we rethink how
we cure disease,
1324
01:28:51,848 --> 01:28:53,458
then the breakthroughs
1325
01:28:53,502 --> 01:28:56,069
that we so desperately
need and want
1326
01:28:56,809 --> 01:28:58,202
will come.
1327
01:29:01,118 --> 01:29:03,686
Will we get there in five years?
1328
01:29:05,252 --> 01:29:06,906
I think we can.
1329
01:29:34,020 --> 01:29:36,327
♪ I met two angels
1330
01:29:36,371 --> 01:29:39,939
♪ But they were in disguise
1331
01:29:40,200 --> 01:29:44,683
♪ Took one look to realize
1332
01:29:45,467 --> 01:29:47,599
♪ Tell them anything
1333
01:29:47,643 --> 01:29:50,123
♪ And they will sympathize
1334
01:29:52,038 --> 01:29:56,391
♪ These arms hold me tight
1335
01:29:56,913 --> 01:29:58,654
♪ Old fears
1336
01:30:06,879 --> 01:30:08,315
♪ Why me
1337
01:30:08,359 --> 01:30:13,146
♪ How'd I get this hallelujah
1338
01:30:14,800 --> 01:30:19,326
♪ Hallelujah
1339
01:30:27,073 --> 01:30:31,469
♪ Been that way since '95
1340
01:30:38,737 --> 01:30:42,828
♪ Three roads, one light
1341
01:30:53,578 --> 01:30:55,101
♪ Why me
1342
01:30:55,145 --> 01:30:59,628
♪ How'd I get this hallelujah
1343
01:31:01,499 --> 01:31:06,591
♪ Hallelujah
1344
01:31:06,635 --> 01:31:11,553
♪ Hallelujah
1345
01:31:11,596 --> 01:31:13,076
♪ Why me
1346
01:31:13,119 --> 01:31:19,735
♪ How'd I get this hallelujah
1347
01:31:26,306 --> 01:31:31,050
♪ One I wish I could see now
1348
01:31:38,057 --> 01:31:42,932
♪ These arms reach out
1349
01:32:02,255 --> 01:32:03,561
♪ Why me
1350
01:32:03,605 --> 01:32:06,912
♪ How'd I get this hallelujah
1351
01:32:07,434 --> 01:32:09,088
♪ Why me
1352
01:32:09,132 --> 01:32:12,352
♪ How'd I get this hallelujah
1353
01:32:12,396 --> 01:32:14,180
♪ Why me
1354
01:32:14,224 --> 01:32:19,316
♪ How'd I get this hallelujah
1355
01:32:20,360 --> 01:32:24,234
♪ Hallelujah
95439
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