Original subtitles

Let's start by looking at the basics of male hormones

So made hormones are hormones that are part of the steroid family

Which is all the hormones

Made from cholesterol

As you can see your cholesterol transforms into multiple hormones

Including

That mineral cortic

Like aldosterone

Did you call karthika with like cortisol or the stress hormone

As well as all our sexual hormones like testosterone

By Hydro testosterone

Or a fragile this is estrogen

Now it is important to know

That both men and women

Have testosterone and estrogen

But in very different r

The top male sex hormone is obviously testosterone it is

The one we hear most about

And it acts on Androgen receptors in our cells

To drive

Male sexual maturation

Sexual function

Body function

Psychological development

Testosterone can transform into

Dehydro testosterone or DHT

Using the five Alpha reductase en

This can happen in our skin for example

Oriental Prost

And this DHT is a more potent form of testosterone it will act on the Androgen receptors as well

And it binds better to these receptors that's why it has

Higher potency compared to the softer

And now testosterone can also transform into

Estradiol or estrogen

Through the aromatized enzym

This can happen in our fat cells our brain and our bones

And this Estrella is going to act

On estrogen receptors

So this will be different from testosterone androgen recept

Estrogel in the right amount

In the right place is actually quite important for men

Because it drives spermaturation

It increases our bone health

It is important for our libido and erectile function

Another important concept is the difference between free and bound testost

So in healthy men testosterone in the blood is going to be distributed between

Free testosterone which should make between 2 and 4% of total testosterone

And this is going to be the most bioactive form

Meaning that it can

Enter ourselves and activate them

You should have around 40% albumin bound testosterone

This is less bioactive than free testosterone because it is bound to album

But because of this bond is weak

You can actually easily dissociate

And enter ourselves

So this album in Bound testosterone

Acts as a buffer for testoster

Now the remaining amount is going to be

Six hormone biting globulin bound

Testost

And this is the least bioactive form

Because the bond between shbg and testosterone is very strong

So it's very hard to dissoc

This can still have an impact in our physiology because it can act on

Sal's via the membrane receptors

It doesn't have to get inside the cells

To have an imp

Now these two forms are what we call bioavailable testosterone

With the free testosterone being the most important

And these two forms are what we call

Bound testost

Now when you have too much shvg in your body

You can start having issues because it will bind to too much of your free testosterone

And actually lower this most bioactive form in your body

However this does not mean that album in nshbg are bad

Actually quite important because

His hbg in albumin modulate the available testost

And Optimal Health requires us to have

Not only the

Amount of horm

Also the right ratios

Ratios between testosterone estrogen DHT cortisol

And SHP Gene I'll be mean are going to play an important role here

Because they will control how much free testosterone we have in the body

To keep these ratios right

We also know that in balances of sex hormones

Are often preceded by abnormalities

In shb

These proteins are also important to transport

Testosterone to the right Tiss

For example album

Is required

To get testosterone into our brain into our liver

And other tissues

And so the important to get testosterone everywhere in the body

Now we also know that abnormal levels of

Of shpg in Border in both directions

To disease for example when you have

Two little shpg it is associated with heart disease

Type 2 diabetes high blood pressure

At the same time when you have too much ssbg

It can decrease your

Bioactive testost

Now let's look at how male hormones impact our cell

The first approach is what we call the genomic response and this is where free testosterone

Enters ourselves and binds to Androgen receptors

It then activates them

And these Androgen receptors activate specific genes in our DNA

And drive Senator response

Now the second approach is what we call the non-genomic response

And this is where receptors

On our cell membrane

Can sense testosterone

And then they drive Downstream changes

Inside of the cell

And this is for example how

Shbg bound testosterone can have an impact on our sales

Without testosterone actually entering the cell