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Let's start by looking at the basics of male hormones
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So made hormones are hormones that are part of the steroid family
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Which is all the hormones
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Made from cholesterol
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As you can see your cholesterol transforms into multiple hormones
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Including
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That mineral cortic
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Like aldosterone
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Did you call karthika with like cortisol or the stress hormone
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As well as all our sexual hormones like testosterone
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By Hydro testosterone
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Or a fragile this is estrogen
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Now it is important to know
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That both men and women
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Have testosterone and estrogen
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But in very different r
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The top male sex hormone is obviously testosterone it is
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The one we hear most about
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And it acts on Androgen receptors in our cells
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To drive
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Male sexual maturation
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Sexual function
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Body function
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Psychological development
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Testosterone can transform into
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Dehydro testosterone or DHT
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Using the five Alpha reductase en
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This can happen in our skin for example
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Oriental Prost
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And this DHT is a more potent form of testosterone it will act on the Androgen receptors as well
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And it binds better to these receptors that's why it has
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Higher potency compared to the softer
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And now testosterone can also transform into
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Estradiol or estrogen
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Through the aromatized enzym
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This can happen in our fat cells our brain and our bones
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And this Estrella is going to act
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On estrogen receptors
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So this will be different from testosterone androgen recept
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Estrogel in the right amount
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In the right place is actually quite important for men
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Because it drives spermaturation
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It increases our bone health
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It is important for our libido and erectile function
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Another important concept is the difference between free and bound testost
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So in healthy men testosterone in the blood is going to be distributed between
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Free testosterone which should make between 2 and 4% of total testosterone
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And this is going to be the most bioactive form
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Meaning that it can
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Enter ourselves and activate them
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You should have around 40% albumin bound testosterone
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This is less bioactive than free testosterone because it is bound to album
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But because of this bond is weak
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You can actually easily dissociate
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And enter ourselves
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So this album in Bound testosterone
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Acts as a buffer for testoster
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Now the remaining amount is going to be
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Six hormone biting globulin bound
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Testost
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And this is the least bioactive form
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Because the bond between shbg and testosterone is very strong
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So it's very hard to dissoc
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This can still have an impact in our physiology because it can act on
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Sal's via the membrane receptors
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It doesn't have to get inside the cells
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To have an imp
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Now these two forms are what we call bioavailable testosterone
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With the free testosterone being the most important
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And these two forms are what we call
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Bound testost
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Now when you have too much shvg in your body
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You can start having issues because it will bind to too much of your free testosterone
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And actually lower this most bioactive form in your body
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However this does not mean that album in nshbg are bad
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Actually quite important because
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His hbg in albumin modulate the available testost
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And Optimal Health requires us to have
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Not only the
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Amount of horm
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Also the right ratios
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Ratios between testosterone estrogen DHT cortisol
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And SHP Gene I'll be mean are going to play an important role here
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Because they will control how much free testosterone we have in the body
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To keep these ratios right
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We also know that in balances of sex hormones
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Are often preceded by abnormalities
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In shb
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These proteins are also important to transport
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Testosterone to the right Tiss
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For example album
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Is required
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To get testosterone into our brain into our liver
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And other tissues
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And so the important to get testosterone everywhere in the body
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Now we also know that abnormal levels of
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Of shpg in Border in both directions
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To disease for example when you have
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Two little shpg it is associated with heart disease
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Type 2 diabetes high blood pressure
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At the same time when you have too much ssbg
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It can decrease your
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Bioactive testost
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Now let's look at how male hormones impact our cell
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The first approach is what we call the genomic response and this is where free testosterone
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Enters ourselves and binds to Androgen receptors
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It then activates them
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And these Androgen receptors activate specific genes in our DNA
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And drive Senator response
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Now the second approach is what we call the non-genomic response
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And this is where receptors
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On our cell membrane
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Can sense testosterone
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And then they drive Downstream changes
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Inside of the cell
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And this is for example how
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Shbg bound testosterone can have an impact on our sales
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Without testosterone actually entering the cell
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