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a few years ago i broke into my own
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house uh i had just driven home it was
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around midnight in the dead of montreal
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winter i'd been visiting my friend jeff
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across town
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and
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the thermometer on the front porch read
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minus 40 degrees
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and don't bother asking if that celsius
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or fahrenheit minus 40 is where the two
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scales meet
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it was very cold and as i stood on the
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front porch fumbling in my pockets
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i found i didn't have my keys
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in fact i could see them through the
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window lying on the dining room table
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where i'd left them
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so i quickly ran around and tried all
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the other doors and windows and they
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were locked tight
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i thought about calling a locksmith at
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least i had my cell phone but at
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midnight it could take a while for a
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locksmith to show up and it was cold
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i couldn't go back to my friend jeff's
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house for the night because i had an
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early flight to europe the next morning
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and i needed to get my passport in my
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suitcase
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so desperate and freezing cold i found a
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large rock and i broke through the
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basement window cleared out the shards
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of glass i crawled through i found a
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piece of cardboard and taped it up over
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the whole opening figuring that in the
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morning on the way to the airport i
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could call my contractor and ask him to
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to fix it this was going to be expensive
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but probably no more expensive than the
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middle of the night locksmith so i
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figured under the circumstances i was
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coming out even
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now i'm a neuroscientist by training and
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i know a little bit about how the brain
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performs under stress
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it releases cortisol that raises your
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heart rate
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it modulates adrenaline levels and it
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clouds your thinking
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so the next morning
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when i woke up i'm too little sleep
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worrying about the hole in the window
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and the mental note that i had to call
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my contractor and the freezing
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temperatures and the meetings i had
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upcoming in europe and
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you know with all the cortisol in my
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brain my thinking was cloudy but i
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didn't know it was cloudy because my
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thinking was cloudy and
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it wasn't until i got to the airport
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check encounter
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that i realized i didn't have my
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passport
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so i raced home in the snow and ice 40
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minutes got my passport raced back to
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the airport i made it just in time but
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they had given away my seat to someone
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else so i got stuck in the back of the
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plane next to the bathrooms in a seat
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that wouldn't recline on an eight-hour
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flight
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well i had a lot of time to think during
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those eight hours of no sleep
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and i started wondering are there things
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that i can do systems that i can put
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into place
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that'll prevent bad things from
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happening
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or at least if bad things happen will
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minimize the likelihood of it being a
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total catastrophe
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so i started thinking about that but my
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thoughts didn't crystallize until about
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a month later i was having dinner with
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my colleague danny kahneman the nobel
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prize winner and i somewhat
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embarrassedly told him about having
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broken my window and
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you know forgot my passport and danny
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shared with me that he'd been practicing
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something called
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prospective hindsight
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it's something that he had gotten from
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the psychologist gary klein who had
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written about it a few years before also
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called the pre-mortem now you all know
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what the post-mortem is whenever there's
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a disaster you know team of experts come
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in and they try to figure out what went
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wrong right well in the pre-mortem danny
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explained you look ahead and you try to
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figure out all the things that could go
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wrong
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and then you
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try to figure out what you can do to
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prevent those things from happening or
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to minimize the damage so what i want to
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talk to you about today are some of the
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things we can do in the form of a
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pre-mortem some of them are obvious
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some of them are not so obvious i'll
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start with the obvious ones around the
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home
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designate a place for things that are
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easily lost
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now this sounds like common sense and it
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is but there's a lot of science to back
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this up based on the way our spatial
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memory works there's a structure in the
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brain called the hippocampus that
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evolved over tens of thousands of years
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to keep track of the locations of
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important things
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uh where the well is where fish can be
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found that stand of fruit trees
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where the friendly and enemy tribes live
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the hippocampus is the part of the brain
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that in london taxi cab drivers becomes
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enlarged it's the part of the brain that
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allows squirrels to find their nuts and
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if you're wondering somebody actually
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did the experiment while they cut off
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the olfactory scents of the squirrels
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and they could still find their nuts
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they weren't using smell they were using
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the hippocampus this exquisitely evolved
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mechanism in the brain for finding
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things
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but it's really good for things that
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don't move around much not so good for
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things that move around so this is why
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we lose car keys and reading glasses and
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passports so in the home designate a
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spot for your keys a hook by the door
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maybe a decorative bowl for your
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passport a particular drawer for your
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reading glasses a particular table if
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you designate a spot and you're
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scrupulous about it your things will
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always be there when you look for them
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what about travel take a cell phone
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picture of your credit cards your
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driver's license your passport
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mail it to yourself so it's in the cloud
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if these things are lost or stolen you
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can facilitate replacement
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now these are some rather obvious things
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remember when you're under stress the
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brain releases cortisol cortisol is
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toxic and it causes cloudy thinking so
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part of the practice of the premortem is
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to recognize that under stress you're
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not going to be at your best and you
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should put systems in place
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and there's perhaps no more stressful a
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situation than when you're confronted
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with a medical decision to make and at
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some point all of us are going to be in
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that position where we have to make a
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very important decision about the future
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of our medical care or that of a loved
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one to help them with the decision and
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so i want to talk about that and i'm
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going to talk about a very particular
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medical condition
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but this stands as a proxy for all kinds
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of medical decision making and indeed
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for financial decision making and social
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decision making any kind of decision you
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have to make that would benefit from a
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rational assessment of the facts
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so suppose you go to your doctor and the
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doctor says i just got your lab work
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back
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your cholesterol is a little high
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now you all know that cholesterol is
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high cholesterol is associated with an
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increased risk of cardiovascular disease
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heart attack stroke and so you're
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thinking having high cholesterol isn't
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the best thing and so the doctor says
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you know i'd like to give you a drug
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that'll help you lower your cholesterol
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a statin
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and you've probably heard of statins you
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know that they're among the most widely
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prescribed drugs in the world today you
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probably even know people who take them
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and so you're thinking yeah give me the
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statin
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but there's a question you should ask at
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this point a statistic you should ask
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for that most doctors don't like talking
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about and pharmaceutical companies like
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talking about even less
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uh it's for the number needed to treat
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now what is this the nnt
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it's the number of people that need to
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take a drug or undergo a surgery or any
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medical procedure before one person is
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helped
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you're thinking what kind of crazy
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statistic is that right the number
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should be one my doctor wouldn't
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prescribe something to me if it's not
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going to help
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but actually medical practice doesn't
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work that way and it's not the doctor's
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fault if if anybody's fault it's the
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fault of scientists like me we haven't
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figured out the underlying mechanisms
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well enough but galaxo smith klein
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estimates that ninety percent of the
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drugs work in only thirty to fifty
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percent of the people
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so the number needed to treat for the
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most widely prescribed statin
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what do you suppose it is
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how many people have to take it before
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one person's helped 300.
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this is according to research by
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research practitioners jerome groupen
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and pamela hartsband independently
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confirmed by bloomberg.com i ran through
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the numbers myself
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300 people have to take the drug for a
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year before one heart attack stroke or
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other adverse event is prevented now
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you're probably thinking well okay uh
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one in 300 chance of lowering my
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cholesterol why not doc give me the
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prescription anyway but you should ask
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at this point for another statistic and
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that is tell me about the side effects
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right so for this particular drug the
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side effects occur in five percent of
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the patients and they include terrible
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things debilitating muscle and joint
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pain
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gastrointestinal distress but now you're
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thinking well five percent not very
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likely it's going to happen to me i'll
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still take the drug but wait a minute
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remember under stress we're not thinking
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clearly so think about how you're going
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to work through this ahead of time so
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you don't have to manufacture the chain
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of reasoning on the spot 300 people take
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the drug right one person's helped five
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percent of those 300 have side effects
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that's 15 people
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you're 15 times more likely to be harmed
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by the drug
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than you are to be helped by the drug
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now i'm not saying whether you should
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take the statin or not i'm just saying
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you should have this conversation with
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your doctor medical ethics requires it
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it's part of the principle of informed
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consent you have the right to have
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access to this kind of information to
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begin the conversation about whether you
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want to take the risks or not now you
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might be thinking i've pulled this
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number out of the air for shock value
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but in fact it's rather typical this
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number needed to treat for the most
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widely performed surgery on men over the
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age of 50 removal of the prostate for
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cancer the number needed to treat is 49
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that's right 49 surgeries are done for
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every one person who's helped and the
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side effects in that case
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occur in 50 percent of the patients they
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include impotence erectile dysfunction
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urinary incontinence rectal tearing
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fecal incontinence and if you're lucky
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and you're one of the 50 percent who has
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these they'll only last for a year or
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two
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so
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the idea of the pre-mortem is to think
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ahead of time to the questions that you
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might be able to ask that will push the
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conversation forward you don't want to
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have to manufacture all of this on the
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spot and you also want to think about
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things like quality of life because you
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have a choice oftentimes do i want a
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shorter life that's
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or a longer life that might have a great
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deal of pain towards the end these are
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things to talk about and think about now
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with your family and your loved ones you
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might change your mind in the heat of
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the moment but at least you're practiced
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with this kind of thinking
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remember our brain uh under stress
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releases cortisol and one of the things
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that happens at that moment is a whole
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bunch of systems shut down there's an
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evolutionary reason for this face to
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face with a predator you don't need your
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digestive system or your libido or your
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immune system because if your body is
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expending metabolism on those things and
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you don't react quickly you might become
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the lion's lunch and then none of those
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things matter
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what uh unfortunately one of the things
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that goes out the window during those
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time to stress is rational logical
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thinking as danny kahneman and his
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colleagues have shown
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so we need to train ourselves to think
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ahead to these kinds of situations
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i think the important point here
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is recognizing that all of us are flawed
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we all are going to fail now and then
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the idea is to think ahead to what those
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failures might be to put systems in
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place that will help minimize the damage
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or to prevent the bad things from
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happening in the first place
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getting back to that snowy night in
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montreal when i got back from my trip i
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had my contractor install a combination
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lock next to the door
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with a key to the front door in it an
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easy to remember combination and i have
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to admit i still have piles of mail that
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haven't
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been sorted and piles of emails that i
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haven't gone through so i'm not
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completely organized but i see
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organization as a gradual process and
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i'm getting there thank you very much
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[Music]
25533
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