Would you like to inspect the original subtitles? These are the user uploaded subtitles that are being translated:
1
00:00:03,525 --> 00:00:04,787
[WATER RUNNING]
2
00:00:10,184 --> 00:00:11,228
[SHOWER DOOR OPENS]
3
00:00:11,402 --> 00:00:12,012
Oh![GIGGLES]
4
00:00:18,279 --> 00:00:21,847
We can't both shower
at the same time, Lea.
5
00:00:22,022 --> 00:00:24,372
One of us would
block the steam
of water for the other.
6
00:00:24,546 --> 00:00:26,635
Oh, Shaun, this is not
for the purpose
of cleanliness.
7
00:00:26,809 --> 00:00:29,116
This is for the purpose
of having sex with you.
8
00:00:30,813 --> 00:00:32,510
Oh.
9
00:00:32,684 --> 00:00:34,643
N... No. No.
10
00:00:34,817 --> 00:00:36,862
It would be inconvenient,
possibly dangerous.
11
00:00:37,037 --> 00:00:39,169
Soap might get into
difficult places.
12
00:00:39,343 --> 00:00:40,736
If we leaned against
the shower handle,
13
00:00:40,910 --> 00:00:41,824
we could
scald ourselves.
14
00:00:41,998 --> 00:00:44,522
Bottles could
be disarranged.
15
00:00:44,696 --> 00:00:46,133
It was just a thought.
16
00:00:46,307 --> 00:00:48,265
It was a bad thought.
17
00:00:48,439 --> 00:00:49,440
I'm surprised.
18
00:00:49,614 --> 00:00:50,615
You're such an
intelligent person.
19
00:00:52,574 --> 00:00:54,880
I'll... Reset your alarm.
20
00:00:59,363 --> 00:01:01,583
DR LIM: It's
a three-day weekend
and a full moon.
21
00:01:01,757 --> 00:01:03,411
People are gonna do
stupid things.
22
00:01:03,585 --> 00:01:06,022
I'm asking everyone
to take an extra trauma call
in the ER.
23
00:01:06,196 --> 00:01:07,980
Make yourselves available
if you're needed.
24
00:01:08,155 --> 00:01:09,982
Questions?
25
00:01:10,157 --> 00:01:12,202
How'd you get
the bruise?
26
00:01:12,376 --> 00:01:13,464
First casualty
of the full moon.
27
00:01:13,638 --> 00:01:14,900
I smacked my head
on a cupboard door
28
00:01:15,075 --> 00:01:15,988
when I was reaching
for my coffee mug.
29
00:01:16,163 --> 00:01:17,642
Any other questions?
30
00:01:17,816 --> 00:01:20,297
Why is there a Subaru
in your parking space?
31
00:01:20,471 --> 00:01:21,907
Because it's my car.
32
00:01:22,082 --> 00:01:23,909
You have a car?
33
00:01:24,084 --> 00:01:25,085
You're gonna be seeing
a lot of it.
I sold the Ducati.
34
00:01:25,259 --> 00:01:26,173
What? No.
35
00:01:26,347 --> 00:01:27,565
It just
wasn't practical.
36
00:01:27,739 --> 00:01:28,653
Is it already gone?
Because...
37
00:01:28,827 --> 00:01:31,221
A guy from Craigslist
snatched it up.
38
00:01:31,395 --> 00:01:33,658
Any other questions...
Not dealing with the bike?
39
00:01:36,139 --> 00:01:37,662
It wasn't that much
of a bruise.
40
00:01:37,836 --> 00:01:39,229
[CELLPHONE CHIMES]
41
00:01:39,403 --> 00:01:41,405
But the doctor
at the ski resort told us
42
00:01:41,579 --> 00:01:43,407
I might develop
a hematoma?
43
00:01:43,581 --> 00:01:46,236
It's not unusual,
but it'll need to be drained.
44
00:01:46,410 --> 00:01:49,196
I see you were treated
for melanoma six years ago,
45
00:01:49,370 --> 00:01:51,023
and, more recently,
breast cancer.
46
00:01:51,198 --> 00:01:52,373
Hence the ski trip.
47
00:01:52,547 --> 00:01:55,115
A celebration.
48
00:01:55,289 --> 00:01:56,899
One year cancer-free.
Also five years cancer-free.
49
00:01:57,073 --> 00:01:59,771
[CELLPHONE CHIMES]
50
00:01:59,945 --> 00:02:03,993
I don't suppose a long needle
will be involved in this?
51
00:02:04,167 --> 00:02:05,951
Your hematoma extends
pretty deep,
52
00:02:06,126 --> 00:02:07,605
so the needle will
have to be long.
53
00:02:07,779 --> 00:02:09,520
But it's over quickly.
54
00:02:09,694 --> 00:02:11,218
Sorry, I have to intervene
before this deal goes south.
55
00:02:11,392 --> 00:02:14,873
You don't mind
if I step out?
56
00:02:15,047 --> 00:02:17,354
Would you like us to wait
for your husband to come back?
57
00:02:17,528 --> 00:02:19,356
No.
58
00:02:19,530 --> 00:02:20,183
Let's go ahead.
59
00:02:24,622 --> 00:02:26,146
DR REZNICK: How do you get
frostbite in San Jose?
60
00:02:26,320 --> 00:02:27,625
Cryotherapy accident.
61
00:02:27,799 --> 00:02:29,714
I stayed in the booth
a little too long.
62
00:02:29,888 --> 00:02:31,629
I was going to stand outside
for the full three minutes,
63
00:02:31,803 --> 00:02:33,283
but he said...I said, "No need."
64
00:02:33,457 --> 00:02:35,329
I'd set the stopwatch
on my phone,
65
00:02:35,503 --> 00:02:37,722
after which, my thoughts
immediately drifted, and...
66
00:02:37,896 --> 00:02:39,376
I came back to find him
frozen in carbonite.
67
00:02:39,550 --> 00:02:40,899
[CHUCKLES]
68
00:02:41,073 --> 00:02:43,337
You know, I'm more worried
about the fever.
69
00:02:43,511 --> 00:02:44,599
Was the cryotherapy
meant to treat something?
70
00:02:44,773 --> 00:02:46,557
No. Routine self-care.
71
00:02:46,731 --> 00:02:48,385
We've made life extension
part of our health regime...
72
00:02:48,559 --> 00:02:51,519
Supplements, meditation,
exercise.
73
00:02:51,693 --> 00:02:53,347
Three of my gaming apps
have gone viral.
74
00:02:53,521 --> 00:02:55,740
I'm lucky enough to afford
basically whatever I want,
75
00:02:55,914 --> 00:02:58,352
so I spend it
on my health.
76
00:02:58,526 --> 00:03:01,790
No, I figure fever,
must be an infection.
77
00:03:01,964 --> 00:03:04,880
Well, I know that frostbite
can make you vulnerable.
78
00:03:05,054 --> 00:03:09,667
It just... It didn't seem
severe enough to...
79
00:03:09,841 --> 00:03:12,017
Oh, sorry.
I feel a little queasy.
80
00:03:12,192 --> 00:03:13,236
Aah!
81
00:03:13,410 --> 00:03:14,063
Wyatt.
82
00:03:14,237 --> 00:03:15,238
Ow!
83
00:03:21,897 --> 00:03:23,725
[BEEPING]
84
00:03:23,899 --> 00:03:25,596
I need a medical
transport team, stat.
85
00:03:25,770 --> 00:03:27,685
Perforated bowel.
He needs immediate surgery.
86
00:03:27,859 --> 00:03:30,340
[THEME MUSIC PLAYING]
87
00:03:37,869 --> 00:03:40,045
No. No. Why do people hate
wind farms?
88
00:03:40,220 --> 00:03:42,091
Everyone thinks
they're noisy.
89
00:03:42,265 --> 00:03:43,745
This could make a turbine
sound as quiet
90
00:03:43,919 --> 00:03:45,050
as a page turning
in a library.
91
00:03:45,225 --> 00:03:46,704
That's not worth
our investing in?
92
00:03:46,878 --> 00:03:48,097
Did you even look...
Hold on.
93
00:03:48,271 --> 00:03:49,838
Anything I need to know?
94
00:03:50,012 --> 00:03:51,187
Hematoma's drained.
95
00:03:51,361 --> 00:03:52,971
We're sending a sample
to Pathology... Routine.
96
00:03:53,145 --> 00:03:54,451
Should have it back
sometime tomorrow.
97
00:03:54,625 --> 00:03:56,801
Thank you.
Mm-hmm.
98
00:03:56,975 --> 00:03:59,369
I couldn't help
overhearing a little.
99
00:03:59,543 --> 00:04:02,285
Are you
a venture capitalist?
100
00:04:02,459 --> 00:04:04,766
The only people who ask me
if I'm a VC
101
00:04:04,940 --> 00:04:06,811
are people who want a VC
to invest in their project.
102
00:04:09,161 --> 00:04:12,687
Maybe, after we get your wife
healthy again, we could talk?
103
00:04:12,861 --> 00:04:13,775
Call whenever
you're ready.
104
00:04:13,949 --> 00:04:15,864
My life is listening
to ideas.
105
00:04:16,038 --> 00:04:17,039
If it's good, I'll run it
by my two partners.
106
00:04:17,213 --> 00:04:18,954
If it's really good,
107
00:04:19,128 --> 00:04:20,347
we'll take
a 30% equity position
in your company.
108
00:04:22,697 --> 00:04:24,829
Yeah.
109
00:04:25,003 --> 00:04:26,440
Yeah, you're the one
who wanted us to
get into clean technology.
110
00:04:28,746 --> 00:04:30,357
I think I've been asked out
on a date.
111
00:04:32,315 --> 00:04:33,577
Nice.
112
00:04:33,751 --> 00:04:35,187
No, I work with him.
113
00:04:35,362 --> 00:04:36,754
Hasn't stopped you before.I supervise him.
114
00:04:36,928 --> 00:04:37,886
Schedules can be changed.
115
00:04:38,060 --> 00:04:39,801
He's polyamorous.
116
00:04:39,975 --> 00:04:42,847
Unless he also texted you
a ring, it's just a date.
117
00:04:43,021 --> 00:04:44,109
And you need to
get out more.
118
00:04:45,763 --> 00:04:46,634
So do I.
119
00:04:49,463 --> 00:04:50,115
[GLOVES SNAP]
120
00:04:53,075 --> 00:04:55,860
DR ANDREWS: You want to
take down
the splenocolic ligament.
121
00:04:56,034 --> 00:04:58,863
Just don't nick the
inferior mesenteric artery.
122
00:04:59,037 --> 00:05:02,650
ASHER: I feel the I.M.A.
under my finger.
123
00:05:02,824 --> 00:05:04,826
Placing the stapler.
124
00:05:05,000 --> 00:05:06,958
And cutting.
125
00:05:07,132 --> 00:05:08,525
I voted "approve."
126
00:05:11,920 --> 00:05:13,400
Disapprove.
127
00:05:13,574 --> 00:05:14,966
No opinion.
128
00:05:15,140 --> 00:05:16,098
There's a poll?
129
00:05:16,272 --> 00:05:18,840
Yes...
About shower sex.
130
00:05:19,014 --> 00:05:21,364
I know it's wrong
to discuss shower sex at work,
131
00:05:21,538 --> 00:05:23,061
so I did a poll instead.
132
00:05:23,235 --> 00:05:24,933
Much better.
133
00:05:25,107 --> 00:05:26,761
Dr. Murphy, do you really
want people knowing
the details
134
00:05:26,935 --> 00:05:28,458
of your personal life?
135
00:05:28,632 --> 00:05:32,157
You don't think they took it
as an abstract question?
136
00:05:32,332 --> 00:05:34,595
No. We all take it as
something that happened
between you and Lea.
137
00:05:34,769 --> 00:05:35,987
And that
there was a fight.
138
00:05:36,161 --> 00:05:37,728
DR PARK: Sometime before
8:00 a.m. today,
139
00:05:37,902 --> 00:05:39,513
which was when the poll
was sent out.
140
00:05:41,253 --> 00:05:43,168
You are very astute.
141
00:05:43,343 --> 00:05:46,041
I'm seeing diffuse dilation
of the large bowel here.
142
00:05:46,215 --> 00:05:48,435
Is that normal?
143
00:05:48,609 --> 00:05:51,568
Some calcified lesions.
144
00:05:51,742 --> 00:05:53,265
Wall's thin, too.
145
00:05:53,440 --> 00:05:54,919
Hirschsprung's.
146
00:05:55,093 --> 00:05:56,443
I thought Hirschsprung's
was a disease only babies
147
00:05:56,617 --> 00:05:57,357
and young children got.
148
00:05:57,531 --> 00:05:59,576
It is.
149
00:05:59,750 --> 00:06:00,403
But he has it.
150
00:06:09,281 --> 00:06:11,196
We treated the Hirschsprung's
151
00:06:11,371 --> 00:06:12,459
by removing the dilated part
of your colon.
152
00:06:12,633 --> 00:06:14,765
It won't impact your life,
153
00:06:14,939 --> 00:06:16,114
but we would like
an explanation.
154
00:06:16,288 --> 00:06:17,594
DR PARK:
Dr. Murphy doesn't mean
155
00:06:17,768 --> 00:06:18,813
we expect you
to be a diagnostician.
156
00:06:18,987 --> 00:06:20,423
It's just...
157
00:06:20,597 --> 00:06:22,251
This was
kind of singular.
158
00:06:22,425 --> 00:06:24,993
So, if you have
any thoughts...
159
00:06:25,167 --> 00:06:27,604
Did anyone in your family
suddenly develop
these symptoms?
160
00:06:31,956 --> 00:06:35,438
I did something singular to
myself about six months ago.
161
00:06:35,612 --> 00:06:38,267
I modified
my genetic code.
162
00:06:38,441 --> 00:06:40,748
I did a CRISPR procedure
under the guidance of
some researchers
163
00:06:40,922 --> 00:06:42,271
I know in China
through my work.
164
00:06:42,445 --> 00:06:44,142
They put together
a series of cocktails.
165
00:06:44,316 --> 00:06:48,320
They FedExed them to be, and
Sophie helped me inject them
166
00:06:48,495 --> 00:06:49,626
into my bone marrow.
167
00:06:49,800 --> 00:06:51,280
Why?
168
00:06:51,454 --> 00:06:52,803
If you know anything
about CRISPR,
169
00:06:52,977 --> 00:06:54,979
you know how risky it is
to tinker with your genome.
170
00:06:55,153 --> 00:06:57,634
You have no idea what problems
you might let loose.
171
00:06:57,808 --> 00:06:59,984
I needed to optimize
my telomerase activity.
172
00:07:00,158 --> 00:07:01,682
It's the enzyme responsible
for correcting
173
00:07:01,856 --> 00:07:02,900
cell replication errors,
174
00:07:03,074 --> 00:07:03,988
essentially,
the cause of aging.
175
00:07:04,162 --> 00:07:05,337
SHAWN: You can't stop aging
176
00:07:05,512 --> 00:07:07,557
through changing
your telomerase activity.
177
00:07:07,731 --> 00:07:10,908
You might extend your life
a little, but exercise...
178
00:07:11,082 --> 00:07:13,520
It does the same thing.
Much less risky.
179
00:07:13,694 --> 00:07:15,391
Your decision
makes no sense.
180
00:07:15,565 --> 00:07:18,699
Extending my life
by a few years
is only my short-term goal.
181
00:07:18,873 --> 00:07:20,831
Look, you know how fast
medicine is moving.
182
00:07:21,005 --> 00:07:22,964
The day isn't that far away
when cloning
183
00:07:23,138 --> 00:07:25,706
will make transplants as easy
as switching out
a light socket.
184
00:07:25,880 --> 00:07:27,577
AI will start
to make breakthroughs
185
00:07:27,751 --> 00:07:29,274
that we can't predict
or understand.
186
00:07:29,449 --> 00:07:32,582
Medical knowledge
will rise exponentially.
187
00:07:32,756 --> 00:07:34,758
There are babies born now
who could live to see it,
188
00:07:34,932 --> 00:07:36,847
could live to be
1,000 years old.
189
00:07:37,021 --> 00:07:38,501
Maybe more.
Maybe forever.
190
00:07:38,675 --> 00:07:41,373
Or at least,
as long as they want to.
191
00:07:41,548 --> 00:07:43,680
So, our plan is to give
my CRISPR a year
192
00:07:43,854 --> 00:07:45,769
to make sure the telomerase
change works,
193
00:07:45,943 --> 00:07:47,597
and then
we'll do her.
194
00:07:50,165 --> 00:07:52,297
We'll aspirate a sample
of your bone marrow.
195
00:07:52,472 --> 00:07:53,690
See if we can figure out
what the hell you did.
196
00:07:55,953 --> 00:07:57,041
[ELEVATOR BELL DINGS]
197
00:08:01,655 --> 00:08:02,873
Hey.
198
00:08:03,047 --> 00:08:07,051
Um... I don't think coffee's
a good idea.
199
00:08:07,225 --> 00:08:09,053
Entire civilizations
rely on it.
200
00:08:09,227 --> 00:08:10,968
But I don't think
you're referring to
the beverage itself.
201
00:08:11,142 --> 00:08:13,014
I don't think it's
a good idea for first-years
202
00:08:13,188 --> 00:08:14,450
and fourth-years
to go out.
203
00:08:14,624 --> 00:08:17,235
I am bound to supervise you
at some point in the future,
204
00:08:17,409 --> 00:08:20,325
and it'd get complicated
trying to change dates out,
205
00:08:20,500 --> 00:08:23,503
and the fact is...
206
00:08:23,677 --> 00:08:26,418
Seeing somebody you work with
rarely ends happily.
207
00:08:26,593 --> 00:08:28,246
So, I appreciate you
thinking of me, but I...
208
00:08:28,420 --> 00:08:31,728
Oh, you thought it was
a date.
209
00:08:31,902 --> 00:08:33,600
I'm still new here,
and I thought it was
210
00:08:33,774 --> 00:08:36,864
a good opportunity to get
to know each other.
211
00:08:37,038 --> 00:08:38,996
Coffee's perfect
because you're asking
212
00:08:39,170 --> 00:08:41,521
the least amount of commitment
from another human being.
213
00:08:41,695 --> 00:08:43,914
It's not even lunch.
214
00:08:44,088 --> 00:08:46,047
If it's still a "no,"
it's still a "no,"
215
00:08:46,221 --> 00:08:47,875
but I'll let you
re-think your answer.
216
00:09:01,932 --> 00:09:04,500
He only claimed
it wasn't a date
to save face.
217
00:09:04,674 --> 00:09:06,807
Or maybe I just assumed.
218
00:09:06,981 --> 00:09:08,417
But why did I assume?
219
00:09:08,591 --> 00:09:10,462
I don't think I'm
some kind of narcissist
220
00:09:10,637 --> 00:09:13,944
who thinks every man
wants to get close to me.
221
00:09:14,118 --> 00:09:17,034
Or we both assumed it's a date
because it's a date.
222
00:09:17,208 --> 00:09:19,080
This is fun.
I like being your bestie.
223
00:09:19,254 --> 00:09:20,168
Slumber party?
224
00:09:23,737 --> 00:09:26,870
[DOOR OPENS]
225
00:09:27,044 --> 00:09:29,220
I made a poll to test
the popularity of shower sex.
226
00:09:29,394 --> 00:09:30,874
I heard.
227
00:09:31,048 --> 00:09:33,094
I fielded some questions
about that.
228
00:09:33,268 --> 00:09:37,054
"Approve" has won,
but don't get too excited,
Lea.
229
00:09:37,228 --> 00:09:39,927
It's only 58-38,
230
00:09:40,101 --> 00:09:42,407
with several
complicated noncommittals,
231
00:09:42,582 --> 00:09:44,540
so clearly my attitude
is reasonable.
232
00:09:44,714 --> 00:09:47,064
We don't have room
for a...
233
00:09:47,238 --> 00:09:49,240
Skier exercise thing.
234
00:09:49,414 --> 00:09:51,765
I'm only putting it together
so I can take a picture
235
00:09:51,939 --> 00:09:53,723
and sell it online.
236
00:09:53,897 --> 00:09:55,464
Why do you have it
if you don't want it?
237
00:10:01,513 --> 00:10:05,169
My ex sent it.
238
00:10:05,343 --> 00:10:06,823
"Ex"?
239
00:10:06,997 --> 00:10:09,957
Husband.
240
00:10:10,131 --> 00:10:12,133
I left this thing
in the attic
241
00:10:12,307 --> 00:10:14,265
until I got settled somewhere
with enough space.
242
00:10:14,439 --> 00:10:15,876
And okay,
that was 10 years ago,
243
00:10:16,050 --> 00:10:17,268
but it's not like
it was in his way.
244
00:10:21,882 --> 00:10:25,668
We got married, not for long,
right out of high school.
245
00:10:25,842 --> 00:10:27,365
Literally
the boy next door.
246
00:10:27,539 --> 00:10:29,585
We grew up together.
People expected it.
247
00:10:29,759 --> 00:10:33,023
It... Was a big mistake.
248
00:10:33,197 --> 00:10:34,546
We both realized it
pretty quickly.
249
00:10:40,161 --> 00:10:41,945
ENRIQUE: Why would you even
want to live forever?
250
00:10:42,119 --> 00:10:42,642
You'd be bored
out of your mind.
251
00:10:42,816 --> 00:10:43,860
[CHUCKLES]
252
00:10:44,034 --> 00:10:45,601
The person I am now
253
00:10:45,775 --> 00:10:50,388
is miles away from the person
I was at 14.
254
00:10:50,562 --> 00:10:53,609
I only get more distant
every year.
255
00:10:53,783 --> 00:10:58,179
You learn to understand,
256
00:10:58,353 --> 00:11:01,704
love books that
you once hated,
257
00:11:01,878 --> 00:11:04,881
sometimes people
you once hated.
258
00:11:05,055 --> 00:11:09,407
Music that you didn't get
the point of becomes magical.
259
00:11:09,581 --> 00:11:11,540
And a thousand new doors
will open.
260
00:11:11,714 --> 00:11:14,021
I look forward
to the adventure.
261
00:11:14,195 --> 00:11:15,544
[NEEDLE SQUELCHES]Ow.
262
00:11:15,718 --> 00:11:17,764
Sorry. Adventure's not always
gonna be fun.
263
00:11:19,679 --> 00:11:22,943
I figure it takes
40 or 50 years
264
00:11:23,117 --> 00:11:25,728
just to get over
the things your parents did.
265
00:11:25,902 --> 00:11:27,512
If only we lived
long enough,
266
00:11:27,687 --> 00:11:30,864
the human race might finally
have a chance to grow up.
267
00:11:38,001 --> 00:11:39,960
What size shoes
do you wear?
268
00:11:40,134 --> 00:11:43,093
Seven and a half.
269
00:11:43,267 --> 00:11:45,356
"Dr. Allen's Walking On Clouds
Inserts."
270
00:11:45,530 --> 00:11:47,576
Putting "doctor" in the name
is always good
marketing strategy.
271
00:11:47,750 --> 00:11:50,231
They're designed
to reduce inflammation
272
00:11:50,405 --> 00:11:52,059
that could lead to
plantar fasciitis,
273
00:11:52,233 --> 00:11:55,192
calluses, arthritis,
and they feel damn good.
274
00:11:55,366 --> 00:11:56,933
Does this have anything
to do with our patient's
275
00:11:57,107 --> 00:11:58,021
venture capitalist
husband?
276
00:11:58,195 --> 00:11:59,719
I need testimonials.
277
00:11:59,893 --> 00:12:00,763
Labs and Path
for Hannah Palmer.
278
00:12:04,985 --> 00:12:07,639
Aren't we all busy enough
learning how to be surgeons?
279
00:12:07,814 --> 00:12:09,729
Do you really want to
divide your focus onto
something trivial?
280
00:12:15,560 --> 00:12:17,954
Because wanting to make money
taints the purity of medicine?
281
00:12:20,130 --> 00:12:21,871
I have five brothers.
282
00:12:22,045 --> 00:12:24,308
I've been
taking care of people
my whole life.
283
00:12:24,482 --> 00:12:27,790
Someone got hurt, they came
to me to patch them up.
284
00:12:27,964 --> 00:12:31,359
I became a doctor
so I could get paid for it,
285
00:12:31,533 --> 00:12:34,362
but also because I'm good
at taking care of people.
286
00:12:34,536 --> 00:12:36,146
It's possible to do something
for more than one reason.
287
00:12:48,071 --> 00:12:49,203
The news is bad.
288
00:12:58,821 --> 00:13:02,042
There's an abnormally
healthy population
289
00:13:02,216 --> 00:13:05,306
of hematopoietic progenitor
stem cells.
290
00:13:05,480 --> 00:13:07,656
He did it?It's significant.
291
00:13:07,830 --> 00:13:10,659
He's succeeded in optimizing
enough telomerase activity
292
00:13:10,833 --> 00:13:13,357
to potentially add 10 years
to his natural life.
293
00:13:13,531 --> 00:13:15,664
DR ANDREWS: Well, assuming it
doesn't subtract about 50.
294
00:13:15,838 --> 00:13:17,274
There's already
an autoimmune reaction
295
00:13:17,448 --> 00:13:18,362
that mimics
Hirschsprung's.
296
00:13:18,536 --> 00:13:20,321
Who knows what else
he did?
297
00:13:20,495 --> 00:13:22,497
What if this is the opposite
of an auto-immune condition?
298
00:13:22,671 --> 00:13:23,933
What if
he's done something
299
00:13:24,107 --> 00:13:25,326
that lowers his resistance
to infection?
300
00:13:25,500 --> 00:13:27,763
Then we'd be seeing
more opportunistic infections
301
00:13:27,937 --> 00:13:29,112
of the lungs and skin.
302
00:13:29,286 --> 00:13:31,332
If you lived
another 1,000 years,
303
00:13:31,506 --> 00:13:33,073
would you be with
the same person at the end
304
00:13:33,247 --> 00:13:34,552
as at the beginning?
305
00:13:34,726 --> 00:13:35,466
No.No.
306
00:13:37,077 --> 00:13:38,687
No, if you assume
monogamy.
307
00:13:38,861 --> 00:13:40,689
I mean, that puts too much
strain on a relationship.
308
00:13:40,863 --> 00:13:42,517
Is one person supposed to
be everything to another,
309
00:13:42,691 --> 00:13:44,475
all the time,
for 1,000 years?
310
00:13:44,649 --> 00:13:48,479
Apparently Jesus agrees.
On monogamy.
311
00:13:48,653 --> 00:13:50,742
He said that, in Heaven,
there'll be no more marriages.
312
00:13:50,917 --> 00:13:54,050
I guess humans can't sustain
a relationship that long.
313
00:13:54,224 --> 00:13:55,443
You read
the New Testament, too?
314
00:13:55,617 --> 00:13:58,185
And the Qur'an.
And other things.
315
00:13:58,359 --> 00:13:59,490
It's like
you're a stalker.
316
00:13:59,664 --> 00:14:01,971
It's like you and God had
an acrimonious divorce.
317
00:14:02,145 --> 00:14:05,757
What if he caused
neurofibromatosis?
318
00:14:05,932 --> 00:14:07,934
Microscopic tumors forming
on the nerve sheath?
319
00:14:08,108 --> 00:14:09,326
Mm. Possible,
but there'd have been
320
00:14:09,500 --> 00:14:10,414
some evidence
of Schwann cell growth
321
00:14:10,588 --> 00:14:12,199
around his colon.
322
00:14:12,373 --> 00:14:14,418
Would you still love your wife
in 1,000 years?
323
00:14:16,899 --> 00:14:18,945
You have three answers.
That should be enough.
324
00:14:19,119 --> 00:14:20,947
Park's marriage failed
in far less time,
325
00:14:21,121 --> 00:14:22,426
and Enrique
doesn't even try.
326
00:14:22,600 --> 00:14:24,080
Asher is an...
327
00:14:24,254 --> 00:14:25,690
Unknown quantity.
328
00:14:25,865 --> 00:14:27,170
You're committed.
329
00:14:27,344 --> 00:14:28,432
You've made promises.
330
00:14:31,305 --> 00:14:33,263
I've made promises
based on
331
00:14:33,437 --> 00:14:37,093
an understood
human life-span, Murphy.
332
00:14:37,267 --> 00:14:40,270
Most likely diagnosis is
autoimmune polyneuropathy.
333
00:14:40,444 --> 00:14:41,706
It damaged the enteral
ganglion nerve
334
00:14:41,881 --> 00:14:43,491
and led to
the perforations.
335
00:14:43,665 --> 00:14:45,797
Start him on steroids
and immunosuppressants.
336
00:14:45,972 --> 00:14:47,190
Dr. Andrews.
337
00:14:47,364 --> 00:14:49,410
So, you wouldn't
have gotten married
338
00:14:49,584 --> 00:14:51,281
if you thought
it would be forever.
339
00:14:51,455 --> 00:14:53,849
You expect all relationships
to fail over time.
340
00:14:54,023 --> 00:14:55,198
It's just a question
of how long?
341
00:14:57,287 --> 00:14:59,811
I love her now.
342
00:14:59,986 --> 00:15:04,207
I intend to love her
as long as I live.
343
00:15:04,381 --> 00:15:08,472
But, eventually,
everything breaks.
344
00:15:17,742 --> 00:15:18,961
I always go back
to comfort reading
345
00:15:19,135 --> 00:15:20,484
when I'm in
the hospital.
346
00:15:20,658 --> 00:15:22,269
Cozy mysteries
in little English villages,
347
00:15:22,443 --> 00:15:24,010
where nothing bad happens
to anyone we like.
348
00:15:26,490 --> 00:15:28,188
We've gotten
your results back.
349
00:15:28,362 --> 00:15:28,971
When will
your husband be...
350
00:15:29,145 --> 00:15:30,146
Is it cancer?
351
00:15:32,801 --> 00:15:33,758
Yes.
352
00:15:36,413 --> 00:15:38,938
Thyroid carcinoma.
353
00:15:39,112 --> 00:15:40,722
We're gonna do
a complete imaging series
354
00:15:40,896 --> 00:15:41,505
to pinpoint
just how advanced...
355
00:15:41,679 --> 00:15:44,247
Treatment?
356
00:15:44,421 --> 00:15:47,250
Surgery to remove some or all
of your thyroid
357
00:15:47,424 --> 00:15:49,687
is usually the first line
of defense.
358
00:15:49,861 --> 00:15:52,560
Sometimes, we can wait,
but given the hematoma
359
00:15:52,734 --> 00:15:56,520
was probably caused
by the tumor
invading nearby vasculatures,
360
00:15:56,694 --> 00:15:59,088
we should probably do it
in the next few days.[WHEEZES]
361
00:15:59,262 --> 00:16:02,004
Later, there'll be radioactive
iodine treatment...
362
00:16:02,178 --> 00:16:03,440
[WHEEZES]
363
00:16:03,614 --> 00:16:04,920
Panic attack?
364
00:16:05,094 --> 00:16:07,923
[WHEEZING]
365
00:16:11,231 --> 00:16:12,449
Her trachea's deviated
to the right.
366
00:16:12,623 --> 00:16:14,582
The tumor's compressing it.
We're doing surgery now.
367
00:16:14,756 --> 00:16:16,540
[GROANING]
368
00:16:20,805 --> 00:16:23,547
[MONITOR BEEPING]
369
00:16:27,464 --> 00:16:28,857
What happened?
The nurse just said "surgery."
370
00:16:29,031 --> 00:16:31,294
Was it the hematoma?
371
00:16:31,468 --> 00:16:32,556
It's more serious.
372
00:16:34,602 --> 00:16:36,778
I... It's not cancer...
373
00:16:36,952 --> 00:16:38,823
Again.
374
00:16:38,998 --> 00:16:41,739
Thyroid carcinoma.
375
00:16:41,913 --> 00:16:44,655
We've removed her thyroid.
She's doing well.
376
00:16:44,829 --> 00:16:46,266
We're looking into
potential causes...
377
00:16:46,440 --> 00:16:48,572
Genetic, environmental.
378
00:16:48,746 --> 00:16:51,662
There may be a deeper issue
that we can find and address.
379
00:17:02,456 --> 00:17:06,068
I can't do this.
380
00:17:06,242 --> 00:17:08,984
You've done it before.
381
00:17:09,158 --> 00:17:11,117
You'll do it
this time.
382
00:17:16,557 --> 00:17:19,386
Do you know
what it's like...
383
00:17:19,560 --> 00:17:20,648
To wake up every morning
and know your wife
384
00:17:20,822 --> 00:17:21,823
might not be here
next year?
385
00:17:24,217 --> 00:17:27,655
All those treatments...
386
00:17:27,829 --> 00:17:31,006
They all... They all have this
little tag attached to them
387
00:17:31,180 --> 00:17:34,140
that says,
"Because she might die."
388
00:17:34,314 --> 00:17:38,013
And you see them
put those gloves on
389
00:17:38,187 --> 00:17:39,145
before they hook up
the chemo.
390
00:17:39,319 --> 00:17:42,278
You know why
they do that.
391
00:17:42,452 --> 00:17:43,627
It's because
it's poison.
392
00:17:46,021 --> 00:17:49,503
And you sit there...
393
00:17:49,677 --> 00:17:52,593
And you watch them
shove poison
into the person you love.
394
00:17:52,767 --> 00:17:55,900
And why?
395
00:17:56,075 --> 00:17:57,859
Because she might die.
396
00:18:00,557 --> 00:18:02,951
We're killing her
because she might die.
397
00:18:07,999 --> 00:18:09,044
Go for a run.
398
00:18:09,218 --> 00:18:12,178
Go punch a wall.
399
00:18:12,352 --> 00:18:13,788
You need to release
some endorphins.
400
00:18:13,962 --> 00:18:15,398
My release is my job.
401
00:18:15,572 --> 00:18:17,183
That's why I love it.
402
00:18:17,357 --> 00:18:20,229
My work requires
total focus.
403
00:18:20,403 --> 00:18:21,578
And every minute
I'm working
404
00:18:21,752 --> 00:18:24,320
is a minute
I'm not thinking about...
405
00:18:24,494 --> 00:18:25,321
Losing her.
406
00:18:31,284 --> 00:18:32,241
I have to go.
407
00:18:38,639 --> 00:18:41,642
Your pain and weakness
are consistent with
polyneuropathy,
408
00:18:41,816 --> 00:18:44,471
treatable with steroids
and immunosuppressants.
409
00:18:44,645 --> 00:18:46,995
If you live 1,000 years,
will you still love Sophie?
410
00:18:49,867 --> 00:18:51,042
Yes.
411
00:18:51,217 --> 00:18:53,001
How can you be sure?
412
00:18:53,175 --> 00:18:55,656
People change.
You expect to change.
413
00:18:55,830 --> 00:18:59,007
Sophie and I
will change together.
414
00:18:59,181 --> 00:19:00,139
We'll go through
the same adventures
415
00:19:00,313 --> 00:19:01,357
and learn
the same lessons.
416
00:19:01,531 --> 00:19:04,099
What if you go through
the same adventures
417
00:19:04,273 --> 00:19:05,448
and learn
different lessons?
418
00:19:05,622 --> 00:19:08,625
Even if we did, whoever,
whatever we become,
419
00:19:08,799 --> 00:19:10,627
Sophie will always
be beautiful.
420
00:19:10,801 --> 00:19:13,500
I mean, she could turn into
a machine or a set of pixels
421
00:19:13,674 --> 00:19:16,329
or a giant purple flower,
and she'll still be beautiful,
422
00:19:16,503 --> 00:19:18,722
because it's part of
her essential nature.
423
00:19:22,639 --> 00:19:24,641
But if you don't know
how you'll change,
424
00:19:24,815 --> 00:19:26,252
you don't know
how you'll change.
425
00:19:26,426 --> 00:19:29,037
Shaun.
426
00:19:29,211 --> 00:19:30,473
We'll let you
get some rest.
427
00:19:30,647 --> 00:19:32,388
The steroids should make you
feel a lot better.
428
00:19:38,916 --> 00:19:44,008
Why didn't you ever mention
you had an ex-husband?
429
00:19:44,183 --> 00:19:48,056
Shaun, I've barely
thought about him in years.
430
00:19:48,230 --> 00:19:51,712
I didn't mention him
because he's not important.
431
00:19:51,886 --> 00:19:55,063
I know.
That's the problem.
432
00:19:55,237 --> 00:19:58,240
At one time, you felt he was
important enough to your life
433
00:19:58,414 --> 00:20:01,591
to marry him, and now
you barely think of him.
434
00:20:01,765 --> 00:20:05,204
You make long-term plans,
you have expectations,
435
00:20:05,378 --> 00:20:07,075
and then something
happens to you,
436
00:20:07,249 --> 00:20:11,514
and suddenly you're
a different person.
437
00:20:11,688 --> 00:20:16,737
I know you don't like change,
but it's not all bad.
438
00:20:16,911 --> 00:20:21,220
After all, you are working to
change yourself all the time.
439
00:20:21,394 --> 00:20:27,182
I'm working to be a better
surgeon, a better boyfriend,
440
00:20:27,356 --> 00:20:29,228
better at the things
I've chosen,
441
00:20:29,402 --> 00:20:31,360
but this...
442
00:20:31,534 --> 00:20:32,492
Other change...
It's unpredictable.
443
00:20:32,666 --> 00:20:33,667
You don't choose it.
444
00:20:33,841 --> 00:20:36,104
It just comes at you.
445
00:20:36,278 --> 00:20:38,889
Oh, it's like hurricanes
before 1873,
446
00:20:39,063 --> 00:20:41,065
when the Army Signal Corps
first put up flags
447
00:20:41,240 --> 00:20:42,545
to warn people
storms were coming.
448
00:20:42,719 --> 00:20:45,592
Before that, houses were
flattened, lives destroyed,
449
00:20:45,766 --> 00:20:47,202
and there was no way to see
it was heading for you.
450
00:20:47,376 --> 00:20:50,031
Shaun.
451
00:20:50,205 --> 00:20:53,252
Our relationship will not end
in natural disaster.
452
00:20:53,426 --> 00:20:54,818
It did begin in one.
453
00:20:57,517 --> 00:21:00,302
I'm going to look in
on my patient.
454
00:21:00,476 --> 00:21:02,043
Okay.
455
00:21:09,746 --> 00:21:13,010
Blood and saliva will tell us
if there's a genetic cause,
456
00:21:13,184 --> 00:21:14,969
and the samples
we take from your house
457
00:21:15,143 --> 00:21:16,449
will tell us if there's
something environmental.
458
00:21:18,712 --> 00:21:22,281
I know it's s... Stupid.
459
00:21:22,455 --> 00:21:25,109
I've almost felt guilty
for my cancer,
460
00:21:25,284 --> 00:21:28,852
like I arbitrarily decided
to be sick and burdensome.
461
00:21:31,725 --> 00:21:33,248
Do the people
you're close to
462
00:21:33,422 --> 00:21:35,859
ever act like
you're a burden to them?
463
00:21:36,033 --> 00:21:36,860
You mean Alan.
464
00:21:39,298 --> 00:21:41,648
He's scared.
465
00:21:41,822 --> 00:21:45,695
He takes the exit he's got
and he turns to his work.
466
00:21:45,869 --> 00:21:47,088
You're okay with that?
467
00:21:55,183 --> 00:21:57,141
I accept this compromise.
468
00:21:57,316 --> 00:21:58,317
That's not the hard part.
469
00:21:58,491 --> 00:22:00,536
The hard part is...
470
00:22:00,710 --> 00:22:03,974
Not knowing.
471
00:22:04,148 --> 00:22:08,327
Each new thing that happens,
I worry, "Is this it?
472
00:22:08,501 --> 00:22:11,808
"Is this where
I lose him?
473
00:22:11,982 --> 00:22:13,244
"Is this where
he breaks?"
474
00:22:20,904 --> 00:22:23,211
CLAIRE: So, this is
boiled coffee.
475
00:22:23,385 --> 00:22:25,082
Some people call it
"Turkish coffee,"
476
00:22:25,256 --> 00:22:28,129
or "Greek coffee,"
or "Egyptian coffee"...
477
00:22:28,303 --> 00:22:29,435
Because we need to
take ownership
478
00:22:29,609 --> 00:22:30,610
and put things
in categories.
479
00:22:30,784 --> 00:22:32,394
Yeah.
480
00:22:32,568 --> 00:22:34,222
You actually live
in this thing,
481
00:22:34,396 --> 00:22:36,311
in the hospital
parking garage?
482
00:22:36,485 --> 00:22:37,399
Why not?
483
00:22:37,573 --> 00:22:38,922
Convenient for work.
484
00:22:39,096 --> 00:22:41,577
When I want to spend
a few days off
the beaten track,
485
00:22:41,751 --> 00:22:43,666
it's convenient
for that, too.
486
00:22:43,840 --> 00:22:46,626
Ooh. I'm gonna get
three sips in this.
487
00:22:46,800 --> 00:22:48,018
But three
really great sips.
488
00:22:50,456 --> 00:22:52,240
That's how I try
to live my life...
489
00:22:52,414 --> 00:22:55,939
Try to appreciate, savor,
not pass by.
490
00:22:59,682 --> 00:23:02,859
Is that what
the polyamory is about?
491
00:23:03,033 --> 00:23:05,427
Does it really work,
or is it one of those
theories about life
492
00:23:05,601 --> 00:23:07,124
that people
regret later?
493
00:23:07,298 --> 00:23:08,517
No regrets so far.
494
00:23:08,691 --> 00:23:10,301
Mm-hmm.
No, I guess not.
495
00:23:10,476 --> 00:23:13,392
Not while you're young
and having fun.
496
00:23:13,566 --> 00:23:14,654
It is fun,
497
00:23:14,828 --> 00:23:16,220
but not for the reasons
that you're thinking.
498
00:23:16,395 --> 00:23:18,788
It isn't about sex.
499
00:23:18,962 --> 00:23:21,661
It's about commitment,
emotional connection.
500
00:23:21,835 --> 00:23:23,924
The joy I'm sure you get
out of a relationship,
501
00:23:24,098 --> 00:23:25,099
I get a little more.
502
00:23:25,273 --> 00:23:27,362
Also, I have to give
a little more.
503
00:23:27,536 --> 00:23:29,625
But that's meaningful,
too.
504
00:23:29,799 --> 00:23:32,498
Hmm.
505
00:23:32,672 --> 00:23:34,282
Do you mind if I
ask you something,
506
00:23:34,456 --> 00:23:35,544
since we're
getting personal?
507
00:23:39,635 --> 00:23:41,507
Sure.
508
00:23:41,681 --> 00:23:43,465
What's your favorite
misheard song lyric?
509
00:23:45,641 --> 00:23:47,991
[LAUGHS]
510
00:23:52,256 --> 00:23:53,301
This is nice.
511
00:23:55,695 --> 00:23:58,088
I'm glad it's
not a date.
512
00:23:58,262 --> 00:23:59,742
Me, too.
513
00:23:59,916 --> 00:24:01,048
I don't believe
in those categories.
514
00:24:06,662 --> 00:24:08,447
[MACHINE BEEPING]He reported widespread
bilateral pain,
515
00:24:08,621 --> 00:24:09,535
then he keeled over.
516
00:24:09,709 --> 00:24:10,971
B.P. dropped to 80
over palp.
517
00:24:11,145 --> 00:24:12,233
I'll order a vasopressor.
518
00:24:12,407 --> 00:24:14,061
Already did.Good.
519
00:24:14,235 --> 00:24:17,891
We need an EKG, CBC, and chest
images, and a new diagnosis.
520
00:24:18,065 --> 00:24:20,589
Whatever he caused
with CRISPR,
it's not just neuropathy.
521
00:24:20,763 --> 00:24:22,025
Something else
is killing him.
522
00:24:30,556 --> 00:24:32,253
What if he's caused something
that mimics
523
00:24:32,427 --> 00:24:33,559
carcinomatous
autonomic neuropathy?
524
00:24:33,733 --> 00:24:35,996
It explains the B.P.
and bowel issue.
525
00:24:36,170 --> 00:24:38,346
That doesn't explain
the sensory issue
that led to the frostbite.
526
00:24:42,045 --> 00:24:43,830
A connective
tissue disorder?
527
00:24:44,004 --> 00:24:44,961
That would have shown up
on the scans.
528
00:24:45,135 --> 00:24:45,614
His chest looks normal.
529
00:24:51,925 --> 00:24:52,708
Maybe we can't think
of the answer
530
00:24:52,882 --> 00:24:54,318
because there is
no answer.
531
00:24:54,493 --> 00:24:56,190
We keep trying to jam it
into these categories we know,
532
00:24:56,364 --> 00:24:57,452
the diseases
that we know.
533
00:24:57,626 --> 00:25:00,237
But this never
existed before.
534
00:25:00,411 --> 00:25:02,152
He created a new combination
of genetic code.
535
00:25:02,326 --> 00:25:04,328
That means a new combination
of symptoms.
536
00:25:04,503 --> 00:25:06,548
DR ANDREWS:
So, we shouldn't be looking at
what fits the picture,
537
00:25:06,722 --> 00:25:07,897
but at what's closest to
the picture,
538
00:25:08,071 --> 00:25:09,899
so we can at least
figure out a treatment.
539
00:25:10,073 --> 00:25:13,773
And what it's closest to
is amyloidosis.
540
00:25:13,947 --> 00:25:16,515
This isn't
an autoimmune neuropathy,
541
00:25:16,689 --> 00:25:19,039
so the nerves must be under
attack by something else.
542
00:25:19,213 --> 00:25:21,171
Something like amyloid disease
could leave deposits
543
00:25:21,345 --> 00:25:23,652
along the nerves,
causing the symptoms
we've seen.
544
00:25:23,826 --> 00:25:25,262
Where do we look
for those deposits?
545
00:25:25,436 --> 00:25:27,090
The spleen.
546
00:25:33,967 --> 00:25:35,229
Drink all 8 ounces.
547
00:25:35,403 --> 00:25:38,362
We talked.
We had a few laughs.
548
00:25:38,537 --> 00:25:40,016
Well,
sounds date-y to me.
549
00:25:40,190 --> 00:25:41,452
[GROANS]
550
00:25:41,627 --> 00:25:43,019
I don't think Enrique's
a player.
551
00:25:43,193 --> 00:25:44,804
No, he's kind of the opposite
of a player.
552
00:25:44,978 --> 00:25:47,067
With him, emotional connection
is the point.
553
00:25:47,241 --> 00:25:49,417
He's trying to live
some idealistic fantasy
554
00:25:49,591 --> 00:25:51,027
where everyone is nice
and no one is jealous.
555
00:25:51,201 --> 00:25:52,855
I am so staying away.
556
00:25:53,029 --> 00:25:54,291
Well, of course.
557
00:25:54,465 --> 00:25:55,075
Once I heard
"emotional connection,"
558
00:25:55,249 --> 00:25:56,859
I knew the game was over.
559
00:25:57,033 --> 00:25:58,252
What does that mean?
560
00:25:58,426 --> 00:26:00,341
I'm against emotion?
561
00:26:00,515 --> 00:26:02,038
[CHUCKLES] I'm not the one
with "cold-hearted bitch"
562
00:26:02,212 --> 00:26:04,127
as my social media hashtag.
563
00:26:04,301 --> 00:26:05,302
She's an
excellent doctor.
564
00:26:05,476 --> 00:26:06,913
Every time
you've loved somebody,
565
00:26:07,087 --> 00:26:08,567
it's ended in disappointment
or death...
566
00:26:08,741 --> 00:26:09,785
Sometimes both.
567
00:26:09,959 --> 00:26:11,308
It's like a reflex now.
568
00:26:11,482 --> 00:26:14,224
You just expect that
everything ends badly,
so why start?
569
00:26:14,398 --> 00:26:17,793
So, despite the many
practical reasons
not to go out
570
00:26:17,967 --> 00:26:19,490
with a first-year,
this is all about me?
571
00:26:19,665 --> 00:26:23,059
Is that a diamond ring?
572
00:26:23,233 --> 00:26:24,452
I mean, it's pretty.
573
00:26:24,626 --> 00:26:26,062
Our patient caught
her fiance cheating.
574
00:26:26,236 --> 00:26:27,890
Big fight.
He demanded the ring back.
575
00:26:28,064 --> 00:26:29,413
She swallowed it.
576
00:26:29,588 --> 00:26:31,154
I did.
577
00:26:31,328 --> 00:26:31,938
You don't even know
if this is "going out,"
578
00:26:32,112 --> 00:26:33,679
and that's the point.
579
00:26:33,853 --> 00:26:35,594
It doesn't matter
what Enrique's offering.
580
00:26:35,768 --> 00:26:37,683
Whether it's friendship or
romance, you're not investing.
581
00:26:37,857 --> 00:26:39,380
You're risk-averse.
582
00:26:39,554 --> 00:26:42,252
Your portfolio right now
is entirely in T-Bills
and money market.
583
00:26:42,426 --> 00:26:43,776
I have no idea
what that means.
584
00:26:43,950 --> 00:26:45,212
And it's too bad,
because a guy
that can make you laugh
585
00:26:45,386 --> 00:26:47,127
might be just what you need
right now.
586
00:26:47,301 --> 00:26:49,608
It's progressed to
your large intestine.
587
00:26:49,782 --> 00:26:52,436
Here's a plastic bag.
Put it over the toilet seat.
588
00:26:52,611 --> 00:26:53,612
You'll have every opportunity
to recover your property.
589
00:26:58,529 --> 00:27:01,445
Don't run away
from a chance at love.
590
00:27:01,620 --> 00:27:04,666
It's a date...
591
00:27:04,840 --> 00:27:05,841
Maybe.
592
00:27:06,015 --> 00:27:06,625
I don't know.
593
00:27:06,799 --> 00:27:07,626
Oh.
594
00:27:09,889 --> 00:27:11,586
OLIVIA: Her house
is full of T.C.E.,
595
00:27:11,760 --> 00:27:12,718
a side effect
from chip-making
596
00:27:12,892 --> 00:27:14,894
back in Silicon Valley's
early days.
597
00:27:15,068 --> 00:27:16,765
So, they move away
from their toxic home,
598
00:27:16,939 --> 00:27:18,027
and hopefully
things get a little better.
599
00:27:18,201 --> 00:27:19,638
Probably not much.
600
00:27:19,812 --> 00:27:21,335
She also has a genetic
predisposition.
601
00:27:21,509 --> 00:27:23,293
It's both?
602
00:27:23,467 --> 00:27:24,773
She shouldn't go outside
in a rainstorm.
603
00:27:26,862 --> 00:27:28,559
How do you tell a woman
that her third cancer
604
00:27:28,734 --> 00:27:29,648
likely won't be close
to her last?
605
00:27:33,564 --> 00:27:35,697
Unfortunately,
this is a teaching moment.
606
00:27:38,961 --> 00:27:41,311
Dr. Allen,
after 12 hours on duty,
607
00:27:41,485 --> 00:27:44,140
I can report that
your inserts came through.
608
00:27:44,314 --> 00:27:46,142
Check your e-mail.
You'll find my testimonial.
609
00:27:46,316 --> 00:27:47,274
[EXHALES SHARPLY]
610
00:27:47,448 --> 00:27:48,101
Claire. Olivia.
611
00:27:55,064 --> 00:27:56,413
[EXHALES SHARPLY]
612
00:27:56,587 --> 00:27:59,503
And if you're right,
what will you do?
613
00:27:59,678 --> 00:28:02,289
We'll treat the symptoms
with targeted drug therapies.
614
00:28:02,463 --> 00:28:04,508
There really isn't a disease,
as such, that we can address.
615
00:28:04,683 --> 00:28:05,771
Ow.
616
00:28:12,081 --> 00:28:12,995
The pain shifted?
617
00:28:13,169 --> 00:28:15,606
Yeah.
Oh.
618
00:28:15,781 --> 00:28:17,652
Never mind about
the ultrasound.
619
00:28:17,826 --> 00:28:19,175
It'll be easier to check
for deposits after
the organ's been removed.
620
00:28:19,349 --> 00:28:20,829
After it's...Yeah.
621
00:28:21,003 --> 00:28:21,961
His spleen's about to rupture.
Call a transport team.
622
00:28:24,180 --> 00:28:26,574
[ALARM BEEPING]
623
00:28:26,748 --> 00:28:27,836
[GRUNTS]
624
00:28:35,191 --> 00:28:37,977
It's called
Li-Fraumeni Syndrome... LFS.
625
00:28:38,151 --> 00:28:39,805
An inherited
predisposition
626
00:28:39,979 --> 00:28:42,895
to developing a wide range
of cancers.
627
00:28:43,069 --> 00:28:44,548
Yes, there was a toxin
in your environment
628
00:28:44,723 --> 00:28:46,202
that likely played a role
in this,
629
00:28:46,376 --> 00:28:48,335
but there will be other
triggers in the future.
630
00:28:48,509 --> 00:28:51,077
Your body
is super sensitive
631
00:28:51,251 --> 00:28:52,861
and will respond with tumors
for the rest of your life.
632
00:29:00,869 --> 00:29:03,480
I know that's a shock,
633
00:29:03,654 --> 00:29:06,309
but here's what
you should know...
634
00:29:06,483 --> 00:29:09,312
Most cancers are treatable
if found early enough.
635
00:29:13,316 --> 00:29:15,754
We know the most common
associated with LFS,
636
00:29:15,928 --> 00:29:18,147
and we can
do surveillance,
637
00:29:18,321 --> 00:29:23,413
nip anything in the bud
before it becomes a problem.
638
00:29:23,587 --> 00:29:27,287
It may not seem this way now,
but this is good.
639
00:29:27,461 --> 00:29:29,332
We know what
we're dealing with.
640
00:29:29,506 --> 00:29:31,857
We're warned,
and we'll be ready.
641
00:29:40,343 --> 00:29:41,823
He won't be able
to handle this.
642
00:29:47,568 --> 00:29:49,788
DR ANDREWS: Liver, pancreas,
other organs look normal.
643
00:29:49,962 --> 00:29:51,398
Ah.
644
00:29:51,572 --> 00:29:54,575
But there are
calcified lesions
along these nerves.
645
00:29:54,749 --> 00:29:56,490
He's gonna be
in pain like this
for the rest of his life.
646
00:29:56,664 --> 00:29:57,883
SHAUN: No.
647
00:29:58,057 --> 00:29:59,798
There's a reasonable chance
it'll get worse
648
00:29:59,972 --> 00:30:01,147
as time goes on.
649
00:30:01,321 --> 00:30:03,627
I need my sharp-blunt
curved scissors.
650
00:30:03,802 --> 00:30:05,368
ENRIQUE: What if we
used CRISPR
to reverse CRISPR?
651
00:30:07,544 --> 00:30:10,156
Researchers have identified
a protein in certain bacteria
652
00:30:10,330 --> 00:30:12,419
that inhibits CRISPR.
653
00:30:12,593 --> 00:30:14,551
What if we insert the DNA
that makes that protein
654
00:30:14,725 --> 00:30:15,901
into our
patient's genome?
655
00:30:16,075 --> 00:30:17,685
That would deactivate
the CRISPR gene.
656
00:30:17,859 --> 00:30:19,121
ASHER: So, CRISPR messed
him up permanently,
657
00:30:19,295 --> 00:30:20,906
and you think we should
do more of it?
658
00:30:21,080 --> 00:30:22,516
I don't know.
Our patient is a risk-taker.
659
00:30:22,690 --> 00:30:24,431
We'd need
a delivery mechanism.
660
00:30:24,605 --> 00:30:26,737
The code would have to be
introduced through a virus...
661
00:30:26,912 --> 00:30:29,262
A virus that specifically
targets nerves.
662
00:30:31,481 --> 00:30:33,092
Polio targets nerves.
663
00:30:33,266 --> 00:30:35,050
Because this isn't
risky enough.
664
00:30:35,224 --> 00:30:36,791
Polio is such
a dangerous virus
665
00:30:36,965 --> 00:30:38,488
because it's so good
at penetrating
the nervous system.
666
00:30:56,855 --> 00:30:57,725
Dr. Murphy?
667
00:31:02,295 --> 00:31:07,343
She's going to be
this way... Forever.
668
00:31:07,517 --> 00:31:10,346
She'll have good periods
and bad periods.
669
00:31:10,520 --> 00:31:14,437
But she will always
have to be on her guard.
670
00:31:14,611 --> 00:31:18,311
Is she always gonna have to be
on guard against you, too?
671
00:31:18,485 --> 00:31:20,052
What does that mean?
672
00:31:20,226 --> 00:31:22,402
Chronic illness puts strain
on relationships.
673
00:31:22,576 --> 00:31:25,622
Statistically,
it is more often
the man who can't handle it.
674
00:31:25,796 --> 00:31:27,929
Our marriage is none
of your business.
675
00:31:28,103 --> 00:31:29,844
Her health
is my business.
676
00:31:30,018 --> 00:31:31,454
And your behavior
adds to her stress.
677
00:31:34,675 --> 00:31:38,113
You look at her,
and you imagine she's gone,
and that is hard.
678
00:31:38,287 --> 00:31:39,027
I get it.
679
00:31:41,900 --> 00:31:45,425
She thinks the same thing
when she looks at you.
680
00:31:45,599 --> 00:31:48,297
I never complain to her.
I know it's nobody's fault.
681
00:31:48,471 --> 00:31:50,996
You don't think she knows you
have trouble with all this?
682
00:31:51,170 --> 00:31:53,215
Every time
something new happens,
683
00:31:53,389 --> 00:31:56,305
she wonders,
is this the straw
684
00:31:56,479 --> 00:31:59,787
that is gonna break
your marriage?
685
00:31:59,961 --> 00:32:02,572
You've got her living in a
constant state of uncertainty.
686
00:32:02,746 --> 00:32:06,228
That is practically
the definition of stress.
687
00:32:06,402 --> 00:32:09,971
So, this is the "straighten up
and fly right" lecture.
688
00:32:10,145 --> 00:32:11,146
No.
689
00:32:12,974 --> 00:32:16,456
I am...
690
00:32:16,630 --> 00:32:22,853
I'm telling you to consider
how best to time your divorce.
691
00:32:23,028 --> 00:32:25,421
There are gonna be
a lot of new issues
dropping on Hannah,
692
00:32:25,595 --> 00:32:27,206
and if you're gonna end up
leaving anyway,
693
00:32:27,380 --> 00:32:28,555
you should start
planning now.
694
00:32:28,729 --> 00:32:29,860
I don't want to leave
my wife.
695
00:32:30,035 --> 00:32:32,733
My best advice?
696
00:32:32,907 --> 00:32:36,650
Help her through
this next round of treatment
as best you can,
697
00:32:36,824 --> 00:32:39,870
and then get out.
698
00:32:40,045 --> 00:32:43,526
It's hard living with someone
who needs so much.
699
00:32:43,700 --> 00:32:47,226
I know you feel
there is a point
where you have nothing left,
700
00:32:47,400 --> 00:32:50,185
where you're ready
to break.
701
00:32:50,359 --> 00:32:55,016
Just... Don't break
when she needs you most.
702
00:32:57,018 --> 00:32:58,541
Get out
before that happens.
703
00:33:20,433 --> 00:33:22,783
Reading an article
that's five years old?
704
00:33:22,957 --> 00:33:25,481
Dr. Glassman was once involved
in an experimental attempt
705
00:33:25,655 --> 00:33:28,049
to treat Parkinson's
with CRISPR technology.
706
00:33:28,223 --> 00:33:29,616
It failed.
707
00:33:29,790 --> 00:33:31,618
So, it's both old
and it didn't work?
708
00:33:31,792 --> 00:33:33,968
Dr. Glassman
likes his failures
to be informative.
709
00:33:34,142 --> 00:33:36,014
That's why his articles
are longer.
710
00:33:36,188 --> 00:33:37,624
Do you worry about losing
the people you love?
711
00:33:44,718 --> 00:33:47,068
Because we can't stop
ourselves from changing,
712
00:33:47,242 --> 00:33:49,375
which means we might
stop loving someone,
713
00:33:49,549 --> 00:33:50,767
or they might stop
loving us.
714
00:33:50,941 --> 00:33:53,074
It is a very bad thing.
715
00:33:53,248 --> 00:33:54,597
It is.
716
00:33:58,166 --> 00:34:02,649
So, no one can
ever feel... Safe.
717
00:34:02,823 --> 00:34:06,218
How can you keep going
if you never feel safe?
718
00:34:11,049 --> 00:34:13,138
Well, sometimes, not changing
is just as dangerous.
719
00:34:16,750 --> 00:34:20,493
So, how do you know
when to do what?
720
00:34:20,667 --> 00:34:22,886
[CHUCKLES]
721
00:34:23,061 --> 00:34:24,497
If you find
the answer to that,
let me know.
722
00:34:31,156 --> 00:34:32,940
I have it.You do?
723
00:34:33,114 --> 00:34:36,161
Dr. Glassman used
varicella zoster virus
724
00:34:36,335 --> 00:34:38,902
as the delivery mechanism,
which didn't work.
725
00:34:39,077 --> 00:34:40,687
His first choice
was herpes simplex,
726
00:34:40,861 --> 00:34:42,732
but the technology
was not up
727
00:34:42,906 --> 00:34:44,343
to putting their DNA package
into it.
728
00:34:44,517 --> 00:34:46,693
The technology
has improved.
729
00:34:46,867 --> 00:34:47,650
It can be done.
730
00:34:52,264 --> 00:34:54,353
[GRUNTS]
731
00:34:54,527 --> 00:34:55,963
Using conventional
treatments,
732
00:34:56,137 --> 00:34:58,008
there's nothing more
we can do for you.
733
00:34:58,183 --> 00:35:00,228
The pain will be permanent,
and it could get worse.
734
00:35:02,274 --> 00:35:07,148
Well, I've not been one to be
limited by the conventional.
735
00:35:07,322 --> 00:35:09,498
We think we can reverse
the CRISPR.
736
00:35:09,672 --> 00:35:11,805
You want to
reverse what I did?
My telomerase change?
737
00:35:11,979 --> 00:35:13,328
They want to
stop your pain.
738
00:35:13,502 --> 00:35:15,504
Soph, it's temporary.
739
00:35:15,678 --> 00:35:17,289
What is it, 40 years?
740
00:35:17,463 --> 00:35:19,943
That's nothing.
Our real lives are
ahead of us.
741
00:35:20,118 --> 00:35:22,555
Hey, look, as long as this
doesn't kill me,
742
00:35:22,729 --> 00:35:25,166
I've made the right choice,
no matter how bad things get.
743
00:35:25,340 --> 00:35:26,341
No.
744
00:35:28,082 --> 00:35:33,000
I was willing to exercise
for hours and fast,
745
00:35:33,174 --> 00:35:35,698
to give up all sugar
and alcohol
746
00:35:35,872 --> 00:35:38,048
and do all the other things
that we needed to do
747
00:35:38,223 --> 00:35:43,271
to get to a future that I knew
might never come.
748
00:35:43,445 --> 00:35:47,188
But now, you're asking me
to watch you suffer
749
00:35:47,362 --> 00:35:48,711
for the rest
of your life.
750
00:35:58,068 --> 00:36:02,377
You're the one
who embraces change.
751
00:36:02,551 --> 00:36:07,948
So, change to the person
who can be happy with me...
752
00:36:08,122 --> 00:36:09,341
Here and now.
753
00:36:18,872 --> 00:36:20,743
Doctors, would you mind
waiting outside?
754
00:36:27,707 --> 00:36:30,927
Why did she want us
to leave?
755
00:36:31,101 --> 00:36:32,842
I think she's delivering
an ultimatum.
756
00:36:33,016 --> 00:36:34,757
[MATT BERNINGER'S
ONE MORE SECONDPLAYS]
757
00:36:43,984 --> 00:36:45,812
♪♪ The last time...
758
00:36:45,986 --> 00:36:47,727
Are you sure
about this?
759
00:36:47,901 --> 00:36:50,164
It seems there's always
something else
760
00:36:50,338 --> 00:36:51,557
that I have to give up.
761
00:36:54,429 --> 00:36:57,432
But this isn't like sugar
or cigarettes.
762
00:36:57,606 --> 00:36:59,782
You won't get over this
in a hurry.
763
00:36:59,956 --> 00:37:01,915
No.
764
00:37:02,089 --> 00:37:03,612
Not in 1,000 years.
765
00:37:06,702 --> 00:37:13,535
♪♪ And the way we talked
Last night
766
00:37:13,709 --> 00:37:15,842
Are you gonna
be okay?
767
00:37:16,016 --> 00:37:17,322
I'm fine.
768
00:37:17,496 --> 00:37:20,107
Alan's at work, but there
should be a taxi waiting.
769
00:37:20,281 --> 00:37:23,328
I won't say goodbye,
Dr. Browne,
770
00:37:23,502 --> 00:37:26,548
'cause I'll probably be
seeing you again pretty soon.
771
00:37:26,722 --> 00:37:29,029
♪♪ Baby, don't lie to me
772
00:37:29,203 --> 00:37:32,032
I sent your cab away.
773
00:37:32,206 --> 00:37:35,035
I'm sorry
I wasn't here sooner.
774
00:37:35,209 --> 00:37:38,647
I had to present a proposal
to my partners.
775
00:37:38,821 --> 00:37:42,172
♪♪ Just give me
A little more time
776
00:37:42,347 --> 00:37:44,914
♪♪ Give me a little bit
Of warning
777
00:37:45,088 --> 00:37:46,089
♪♪ Baby, I'm gonna be fine
778
00:37:46,264 --> 00:37:48,004
I'm selling them my share
of the business.
779
00:37:48,178 --> 00:37:51,747
♪♪ When I figure out
Where I'm going
780
00:37:51,921 --> 00:37:54,184
Is... Is there something else
you want to do?
781
00:37:54,359 --> 00:37:55,795
♪♪ Why can't
You just tell me
782
00:37:55,969 --> 00:37:56,970
Yes.
783
00:37:57,144 --> 00:37:59,364
♪♪ What you're doing here?
784
00:37:59,538 --> 00:38:00,669
I want to be
your husband.
785
00:38:04,107 --> 00:38:08,590
♪♪ Don't be cruel,
If you're leaving me
786
00:38:08,764 --> 00:38:12,594
I realized I was so...
787
00:38:12,768 --> 00:38:17,904
Afraid of losing you
in the future...
788
00:38:18,078 --> 00:38:19,035
I was losing you now.
789
00:38:19,209 --> 00:38:21,429
[SNIFFLES]
790
00:38:21,603 --> 00:38:24,606
♪♪ Give me one more second
To dry my eyes
791
00:38:24,780 --> 00:38:27,348
♪♪ Give me one more day
To realize
792
00:38:27,522 --> 00:38:30,656
♪♪ Smoke's in our eyes
Or in the distance
793
00:38:30,830 --> 00:38:33,311
♪♪ Either way,
We're gonna miss it
794
00:38:33,485 --> 00:38:35,878
♪♪ Give me one more year
To get back on track
795
00:38:36,052 --> 00:38:38,925
♪♪ Give me one more life
To win you back
796
00:38:39,099 --> 00:38:42,232
♪♪ Smoke's in our eyes
Or in the distance
797
00:38:42,407 --> 00:38:46,759
♪♪ Either way,
We're gonna miss it
798
00:38:46,933 --> 00:38:49,109
Sorry.
799
00:38:49,283 --> 00:38:50,980
I hear your VC contact
decided to quit the business.
800
00:38:54,244 --> 00:38:55,376
He did the right thing.
801
00:38:59,989 --> 00:39:02,470
♪♪ Baby, don't lie to me
802
00:39:02,644 --> 00:39:05,560
You know...
803
00:39:05,734 --> 00:39:08,433
My feet
are killing me.
804
00:39:08,607 --> 00:39:11,871
♪♪ If it ain't me, come on
805
00:39:12,045 --> 00:39:15,396
♪♪ Just give me
A little more time
806
00:39:15,570 --> 00:39:17,833
♪♪ Give me a little bit
Of warning
807
00:39:18,007 --> 00:39:20,619
♪♪ Baby, I'm gonna be fine
808
00:39:20,793 --> 00:39:22,272
♪♪ When I figure out where
809
00:39:22,447 --> 00:39:25,406
♪♪ Give me one more second
To dry my eyes
810
00:39:25,580 --> 00:39:28,017
♪♪ Give me one more day
To realize
811
00:39:28,191 --> 00:39:31,020
♪♪ Smoke's in our eyes
Or in the distance
812
00:39:31,194 --> 00:39:33,675
I'm open.
To being friends.
813
00:39:33,849 --> 00:39:35,155
That's great.
814
00:39:35,329 --> 00:39:38,419
I'm open, too,
to wherever this goes.
815
00:39:38,593 --> 00:39:41,117
It's going
to friendship.
816
00:39:41,291 --> 00:39:42,945
Understood.
817
00:39:43,119 --> 00:39:44,556
But life is
about change,
818
00:39:44,730 --> 00:39:46,253
which means, one day,
you might change your mind.
819
00:39:46,427 --> 00:39:48,211
And if you did,
I'd be open to that, too.
820
00:39:48,386 --> 00:39:49,735
It's not gonna happen.
821
00:39:53,086 --> 00:39:53,826
Okay.
822
00:39:58,308 --> 00:39:59,745
[SIGHS]
823
00:40:15,108 --> 00:40:17,197
First, there should be
no soap involved.
824
00:40:17,371 --> 00:40:19,329
Also, we need to stay
at one end of the shower,
825
00:40:19,504 --> 00:40:22,028
so we don't accidentally knock
into the temperature control.
826
00:40:22,202 --> 00:40:25,248
What changed
your mind?
827
00:40:25,423 --> 00:40:28,295
I've been thinking about
change over time.
828
00:40:28,469 --> 00:40:30,079
I spoke with people
and also graphed
829
00:40:30,253 --> 00:40:31,559
several possibilities
for us,
830
00:40:31,733 --> 00:40:33,213
using time as
the horizontal axis
831
00:40:33,387 --> 00:40:34,780
and change as
the vertical.
832
00:40:34,954 --> 00:40:38,044
I realized that the problem
isn't really change.
833
00:40:38,218 --> 00:40:42,091
It's whether two people change
in the same direction.
834
00:40:42,265 --> 00:40:43,919
We want to keep
our coordinates
close to each other
835
00:40:44,093 --> 00:40:47,009
for the rest
of our lives.
836
00:40:47,183 --> 00:40:50,099
We certainly do.
837
00:40:50,273 --> 00:40:52,972
But people sometimes
do drift apart.
838
00:40:53,146 --> 00:40:54,626
Yes.
839
00:40:54,800 --> 00:40:56,454
You need a warning
when you and your partner
840
00:40:56,628 --> 00:40:58,325
might be starting
to veer off,
841
00:40:58,499 --> 00:41:00,109
so you can both
change course a little.
842
00:41:00,283 --> 00:41:01,937
You don't want
a surprise realization
when it's too late.
843
00:41:02,111 --> 00:41:03,765
Surprises are awful.
844
00:41:03,939 --> 00:41:06,507
The U.S. Army Signal Corps
used flags to warn
of hurricanes.
845
00:41:06,681 --> 00:41:08,509
I brought us this.
846
00:41:08,683 --> 00:41:11,599
[CHUCKLES]
A cowbell?
847
00:41:11,773 --> 00:41:14,689
If you see us heading
in different directions,
848
00:41:14,863 --> 00:41:16,212
you ring it.
849
00:41:16,386 --> 00:41:18,301
Do we really need a bell?
Can't I just tell you?
850
00:41:18,476 --> 00:41:19,999
[BELL CLANGS]
851
00:41:20,173 --> 00:41:21,914
Oh! When you ring it,
I'll pay attention.
852
00:41:22,088 --> 00:41:23,263
I really hate
the sound.
853
00:41:23,437 --> 00:41:27,223
Only in emergencies.
854
00:41:27,397 --> 00:41:31,445
I've already moved
the shampoo bottles.
855
00:41:31,619 --> 00:41:33,316
What?
856
00:41:33,491 --> 00:41:34,970
♪♪ Give me one more second
to dry my eyes
857
00:41:35,144 --> 00:41:36,189
Oh.
858
00:41:36,363 --> 00:41:38,365
You mean now?
859
00:41:38,539 --> 00:41:41,847
♪♪ Smoke's in our eyes
Or in the distance
860
00:41:42,021 --> 00:41:43,762
Don't worry about putting
the bottles back.
861
00:41:43,936 --> 00:41:44,937
I'll do it later.
862
00:41:45,111 --> 00:41:46,025
[LAUGHS]
863
00:41:46,199 --> 00:41:48,288
I love you.
864
00:41:48,462 --> 00:41:51,117
It's no trouble.
I remember where they all go.
865
00:41:51,291 --> 00:41:53,380
♪♪ Smoke's in our eyes
Or in the distance
866
00:41:53,554 --> 00:41:55,817
♪♪ Either way,
We're gonna miss it
867
00:41:58,211 --> 00:41:59,647
[CAR ALARM BEEPS]
868
00:41:59,821 --> 00:42:01,388
♪♪ Give me one more second
To dry my eyes
869
00:42:01,562 --> 00:42:04,391
♪♪ Give me one more day
To realize
870
00:42:04,565 --> 00:42:07,655
♪♪ Smoke's in our eyes
Or in the distance
871
00:42:07,829 --> 00:42:10,528
♪♪ Either way,
We're gonna miss it
872
00:42:10,702 --> 00:42:13,269
♪♪ Give me one more year
To get back on track
873
00:42:13,443 --> 00:42:16,316
♪♪ Give me one more life
To win you back
874
00:42:16,490 --> 00:42:19,537
♪♪ Smoke's in our eyes
Or in the distance
875
00:42:19,711 --> 00:42:21,713
♪♪ Either way,
We're gonna miss it
876
00:42:27,196 --> 00:42:28,371
♪♪ When it's gone ♪♪
65192
Can't find what you're looking for?
Get subtitles in any language from opensubtitles.com, and translate them here.