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1
00:00:03,546 --> 00:00:04,808
[WATER RUNNING]
2
00:00:10,205 --> 00:00:11,249
[SHOWER DOOR OPENS]
3
00:00:11,423 --> 00:00:12,033
Oh![GIGGLES]
4
00:00:18,300 --> 00:00:21,868
We can't both shower
at the same time, Lea.
5
00:00:22,043 --> 00:00:24,393
One of us would
block the steam
of water for the other.
6
00:00:24,567 --> 00:00:26,656
Oh, Shaun, this is not
for the purpose
of cleanliness.
7
00:00:26,830 --> 00:00:29,137
This is for the purpose
of having sex with you.
8
00:00:30,834 --> 00:00:32,531
Oh.
9
00:00:32,705 --> 00:00:34,664
N... No. No.
10
00:00:34,838 --> 00:00:36,883
It would be inconvenient,
possibly dangerous.
11
00:00:37,058 --> 00:00:39,190
Soap might get into
difficult places.
12
00:00:39,364 --> 00:00:40,757
If we leaned against
the shower handle,
13
00:00:40,931 --> 00:00:41,845
we could
scald ourselves.
14
00:00:42,019 --> 00:00:44,543
Bottles could
be disarranged.
15
00:00:44,717 --> 00:00:46,154
It was just a thought.
16
00:00:46,328 --> 00:00:48,286
It was a bad thought.
17
00:00:48,460 --> 00:00:49,461
I'm surprised.
18
00:00:49,635 --> 00:00:50,636
You're such an
intelligent person.
19
00:00:52,595 --> 00:00:54,901
I'll... Reset your alarm.
20
00:00:59,384 --> 00:01:01,604
DR LIM: It's
a three-day weekend
and a full moon.
21
00:01:01,778 --> 00:01:03,432
People are gonna do
stupid things.
22
00:01:03,606 --> 00:01:06,043
I'm asking everyone
to take an extra trauma call
in the ER.
23
00:01:06,217 --> 00:01:08,001
Make yourselves available
if you're needed.
24
00:01:08,176 --> 00:01:10,003
Questions?
25
00:01:10,178 --> 00:01:12,223
How'd you get
the bruise?
26
00:01:12,397 --> 00:01:13,485
First casualty
of the full moon.
27
00:01:13,659 --> 00:01:14,921
I smacked my head
on a cupboard door
28
00:01:15,096 --> 00:01:16,009
when I was reaching
for my coffee mug.
29
00:01:16,184 --> 00:01:17,663
Any other questions?
30
00:01:17,837 --> 00:01:20,318
Why is there a Subaru
in your parking space?
31
00:01:20,492 --> 00:01:21,928
Because it's my car.
32
00:01:22,103 --> 00:01:23,930
You have a car?
33
00:01:24,105 --> 00:01:25,106
You're gonna be seeing
a lot of it.
I sold the Ducati.
34
00:01:25,280 --> 00:01:26,194
What? No.
35
00:01:26,368 --> 00:01:27,586
It just
wasn't practical.
36
00:01:27,760 --> 00:01:28,674
Is it already gone?
Because...
37
00:01:28,848 --> 00:01:31,242
A guy from Craigslist
snatched it up.
38
00:01:31,416 --> 00:01:33,679
Any other questions...
Not dealing with the bike?
39
00:01:36,160 --> 00:01:37,683
It wasn't that much
of a bruise.
40
00:01:37,857 --> 00:01:39,250
[CELLPHONE CHIMES]
41
00:01:39,424 --> 00:01:41,426
But the doctor
at the ski resort told us
42
00:01:41,600 --> 00:01:43,428
I might develop
a hematoma?
43
00:01:43,602 --> 00:01:46,257
It's not unusual,
but it'll need to be drained.
44
00:01:46,431 --> 00:01:49,217
I see you were treated
for melanoma six years ago,
45
00:01:49,391 --> 00:01:51,044
and, more recently,
breast cancer.
46
00:01:51,219 --> 00:01:52,394
Hence the ski trip.
47
00:01:52,568 --> 00:01:55,136
A celebration.
48
00:01:55,310 --> 00:01:56,920
One year cancer-free.
Also five years cancer-free.
49
00:01:57,094 --> 00:01:59,792
[CELLPHONE CHIMES]
50
00:01:59,966 --> 00:02:04,014
I don't suppose a long needle
will be involved in this?
51
00:02:04,188 --> 00:02:05,972
Your hematoma extends
pretty deep,
52
00:02:06,147 --> 00:02:07,626
so the needle will
have to be long.
53
00:02:07,800 --> 00:02:09,541
But it's over quickly.
54
00:02:09,715 --> 00:02:11,239
Sorry, I have to intervene
before this deal goes south.
55
00:02:11,413 --> 00:02:14,894
You don't mind
if I step out?
56
00:02:15,068 --> 00:02:17,375
Would you like us to wait
for your husband to come back?
57
00:02:17,549 --> 00:02:19,377
No.
58
00:02:19,551 --> 00:02:20,204
Let's go ahead.
59
00:02:24,643 --> 00:02:26,167
DR REZNICK: How do you get
frostbite in San Jose?
60
00:02:26,341 --> 00:02:27,646
Cryotherapy accident.
61
00:02:27,820 --> 00:02:29,735
I stayed in the booth
a little too long.
62
00:02:29,909 --> 00:02:31,650
I was going to stand outside
for the full three minutes,
63
00:02:31,824 --> 00:02:33,304
but he said...I said, "No need."
64
00:02:33,478 --> 00:02:35,350
I'd set the stopwatch
on my phone,
65
00:02:35,524 --> 00:02:37,743
after which, my thoughts
immediately drifted, and...
66
00:02:37,917 --> 00:02:39,397
I came back to find him
frozen in carbonite.
67
00:02:39,571 --> 00:02:40,920
[CHUCKLES]
68
00:02:41,094 --> 00:02:43,358
You know, I'm more worried
about the fever.
69
00:02:43,532 --> 00:02:44,620
Was the cryotherapy
meant to treat something?
70
00:02:44,794 --> 00:02:46,578
No. Routine self-care.
71
00:02:46,752 --> 00:02:48,406
We've made life extension
part of our health regime...
72
00:02:48,580 --> 00:02:51,540
Supplements, meditation,
exercise.
73
00:02:51,714 --> 00:02:53,368
Three of my gaming apps
have gone viral.
74
00:02:53,542 --> 00:02:55,761
I'm lucky enough to afford
basically whatever I want,
75
00:02:55,935 --> 00:02:58,373
so I spend it
on my health.
76
00:02:58,547 --> 00:03:01,811
No, I figure fever,
must be an infection.
77
00:03:01,985 --> 00:03:04,901
Well, I know that frostbite
can make you vulnerable.
78
00:03:05,075 --> 00:03:09,688
It just... It didn't seem
severe enough to...
79
00:03:09,862 --> 00:03:12,038
Oh, sorry.
I feel a little queasy.
80
00:03:12,213 --> 00:03:13,257
Aah!
81
00:03:13,431 --> 00:03:14,084
Wyatt.
82
00:03:14,258 --> 00:03:15,259
Ow!
83
00:03:21,918 --> 00:03:23,746
[BEEPING]
84
00:03:23,920 --> 00:03:25,617
I need a medical
transport team, stat.
85
00:03:25,791 --> 00:03:27,706
Perforated bowel.
He needs immediate surgery.
86
00:03:27,880 --> 00:03:30,361
[THEME MUSIC PLAYING]
87
00:03:37,890 --> 00:03:40,066
No. No. Why do people hate
wind farms?
88
00:03:40,241 --> 00:03:42,112
Everyone thinks
they're noisy.
89
00:03:42,286 --> 00:03:43,766
This could make a turbine
sound as quiet
90
00:03:43,940 --> 00:03:45,071
as a page turning
in a library.
91
00:03:45,246 --> 00:03:46,725
That's not worth
our investing in?
92
00:03:46,899 --> 00:03:48,118
Did you even look...
Hold on.
93
00:03:48,292 --> 00:03:49,859
Anything I need to know?
94
00:03:50,033 --> 00:03:51,208
Hematoma's drained.
95
00:03:51,382 --> 00:03:52,992
We're sending a sample
to Pathology... Routine.
96
00:03:53,166 --> 00:03:54,472
Should have it back
sometime tomorrow.
97
00:03:54,646 --> 00:03:56,822
Thank you.
Mm-hmm.
98
00:03:56,996 --> 00:03:59,390
I couldn't help
overhearing a little.
99
00:03:59,564 --> 00:04:02,306
Are you
a venture capitalist?
100
00:04:02,480 --> 00:04:04,787
The only people who ask me
if I'm a VC
101
00:04:04,961 --> 00:04:06,832
are people who want a VC
to invest in their project.
102
00:04:09,182 --> 00:04:12,708
Maybe, after we get your wife
healthy again, we could talk?
103
00:04:12,882 --> 00:04:13,796
Call whenever
you're ready.
104
00:04:13,970 --> 00:04:15,885
My life is listening
to ideas.
105
00:04:16,059 --> 00:04:17,060
If it's good, I'll run it
by my two partners.
106
00:04:17,234 --> 00:04:18,975
If it's really good,
107
00:04:19,149 --> 00:04:20,368
we'll take
a 30% equity position
in your company.
108
00:04:22,718 --> 00:04:24,850
Yeah.
109
00:04:25,024 --> 00:04:26,461
Yeah, you're the one
who wanted us to
get into clean technology.
110
00:04:28,767 --> 00:04:30,378
I think I've been asked out
on a date.
111
00:04:32,336 --> 00:04:33,598
Nice.
112
00:04:33,772 --> 00:04:35,208
No, I work with him.
113
00:04:35,383 --> 00:04:36,775
Hasn't stopped you before.I supervise him.
114
00:04:36,949 --> 00:04:37,907
Schedules can be changed.
115
00:04:38,081 --> 00:04:39,822
He's polyamorous.
116
00:04:39,996 --> 00:04:42,868
Unless he also texted you
a ring, it's just a date.
117
00:04:43,042 --> 00:04:44,130
And you need to
get out more.
118
00:04:45,784 --> 00:04:46,655
So do I.
119
00:04:49,484 --> 00:04:50,136
[GLOVES SNAP]
120
00:04:53,096 --> 00:04:55,881
DR ANDREWS: You want to
take down
the splenocolic ligament.
121
00:04:56,055 --> 00:04:58,884
Just don't nick the
inferior mesenteric artery.
122
00:04:59,058 --> 00:05:02,671
ASHER: I feel the I.M.A.
under my finger.
123
00:05:02,845 --> 00:05:04,847
Placing the stapler.
124
00:05:05,021 --> 00:05:06,979
And cutting.
125
00:05:07,153 --> 00:05:08,546
I voted "approve."
126
00:05:11,941 --> 00:05:13,421
Disapprove.
127
00:05:13,595 --> 00:05:14,987
No opinion.
128
00:05:15,161 --> 00:05:16,119
There's a poll?
129
00:05:16,293 --> 00:05:18,861
Yes...
About shower sex.
130
00:05:19,035 --> 00:05:21,385
I know it's wrong
to discuss shower sex at work,
131
00:05:21,559 --> 00:05:23,082
so I did a poll instead.
132
00:05:23,256 --> 00:05:24,954
Much better.
133
00:05:25,128 --> 00:05:26,782
Dr. Murphy, do you really
want people knowing
the details
134
00:05:26,956 --> 00:05:28,479
of your personal life?
135
00:05:28,653 --> 00:05:32,178
You don't think they took it
as an abstract question?
136
00:05:32,353 --> 00:05:34,616
No. We all take it as
something that happened
between you and Lea.
137
00:05:34,790 --> 00:05:36,008
And that
there was a fight.
138
00:05:36,182 --> 00:05:37,749
DR PARK: Sometime before
8:00 a.m. today,
139
00:05:37,923 --> 00:05:39,534
which was when the poll
was sent out.
140
00:05:41,274 --> 00:05:43,189
You are very astute.
141
00:05:43,364 --> 00:05:46,062
I'm seeing diffuse dilation
of the large bowel here.
142
00:05:46,236 --> 00:05:48,456
Is that normal?
143
00:05:48,630 --> 00:05:51,589
Some calcified lesions.
144
00:05:51,763 --> 00:05:53,286
Wall's thin, too.
145
00:05:53,461 --> 00:05:54,940
Hirschsprung's.
146
00:05:55,114 --> 00:05:56,464
I thought Hirschsprung's
was a disease only babies
147
00:05:56,638 --> 00:05:57,378
and young children got.
148
00:05:57,552 --> 00:05:59,597
It is.
149
00:05:59,771 --> 00:06:00,424
But he has it.
150
00:06:09,302 --> 00:06:11,217
We treated the Hirschsprung's
151
00:06:11,392 --> 00:06:12,480
by removing the dilated part
of your colon.
152
00:06:12,654 --> 00:06:14,786
It won't impact your life,
153
00:06:14,960 --> 00:06:16,135
but we would like
an explanation.
154
00:06:16,309 --> 00:06:17,615
DR PARK:
Dr. Murphy doesn't mean
155
00:06:17,789 --> 00:06:18,834
we expect you
to be a diagnostician.
156
00:06:19,008 --> 00:06:20,444
It's just...
157
00:06:20,618 --> 00:06:22,272
This was
kind of singular.
158
00:06:22,446 --> 00:06:25,014
So, if you have
any thoughts...
159
00:06:25,188 --> 00:06:27,625
Did anyone in your family
suddenly develop
these symptoms?
160
00:06:31,977 --> 00:06:35,459
I did something singular to
myself about six months ago.
161
00:06:35,633 --> 00:06:38,288
I modified
my genetic code.
162
00:06:38,462 --> 00:06:40,769
I did a CRISPR procedure
under the guidance of
some researchers
163
00:06:40,943 --> 00:06:42,292
I know in China
through my work.
164
00:06:42,466 --> 00:06:44,163
They put together
a series of cocktails.
165
00:06:44,337 --> 00:06:48,341
They FedExed them to be, and
Sophie helped me inject them
166
00:06:48,516 --> 00:06:49,647
into my bone marrow.
167
00:06:49,821 --> 00:06:51,301
Why?
168
00:06:51,475 --> 00:06:52,824
If you know anything
about CRISPR,
169
00:06:52,998 --> 00:06:55,000
you know how risky it is
to tinker with your genome.
170
00:06:55,174 --> 00:06:57,655
You have no idea what problems
you might let loose.
171
00:06:57,829 --> 00:07:00,005
I needed to optimize
my telomerase activity.
172
00:07:00,179 --> 00:07:01,703
It's the enzyme responsible
for correcting
173
00:07:01,877 --> 00:07:02,921
cell replication errors,
174
00:07:03,095 --> 00:07:04,009
essentially,
the cause of aging.
175
00:07:04,183 --> 00:07:05,358
SHAWN: You can't stop aging
176
00:07:05,533 --> 00:07:07,578
through changing
your telomerase activity.
177
00:07:07,752 --> 00:07:10,929
You might extend your life
a little, but exercise...
178
00:07:11,103 --> 00:07:13,541
It does the same thing.
Much less risky.
179
00:07:13,715 --> 00:07:15,412
Your decision
makes no sense.
180
00:07:15,586 --> 00:07:18,720
Extending my life
by a few years
is only my short-term goal.
181
00:07:18,894 --> 00:07:20,852
Look, you know how fast
medicine is moving.
182
00:07:21,026 --> 00:07:22,985
The day isn't that far away
when cloning
183
00:07:23,159 --> 00:07:25,727
will make transplants as easy
as switching out
a light socket.
184
00:07:25,901 --> 00:07:27,598
AI will start
to make breakthroughs
185
00:07:27,772 --> 00:07:29,295
that we can't predict
or understand.
186
00:07:29,470 --> 00:07:32,603
Medical knowledge
will rise exponentially.
187
00:07:32,777 --> 00:07:34,779
There are babies born now
who could live to see it,
188
00:07:34,953 --> 00:07:36,868
could live to be
1,000 years old.
189
00:07:37,042 --> 00:07:38,522
Maybe more.
Maybe forever.
190
00:07:38,696 --> 00:07:41,394
Or at least,
as long as they want to.
191
00:07:41,569 --> 00:07:43,701
So, our plan is to give
my CRISPR a year
192
00:07:43,875 --> 00:07:45,790
to make sure the telomerase
change works,
193
00:07:45,964 --> 00:07:47,618
and then
we'll do her.
194
00:07:50,186 --> 00:07:52,318
We'll aspirate a sample
of your bone marrow.
195
00:07:52,493 --> 00:07:53,711
See if we can figure out
what the hell you did.
196
00:07:55,974 --> 00:07:57,062
[ELEVATOR BELL DINGS]
197
00:08:01,676 --> 00:08:02,894
Hey.
198
00:08:03,068 --> 00:08:07,072
Um... I don't think coffee's
a good idea.
199
00:08:07,246 --> 00:08:09,074
Entire civilizations
rely on it.
200
00:08:09,248 --> 00:08:10,989
But I don't think
you're referring to
the beverage itself.
201
00:08:11,163 --> 00:08:13,035
I don't think it's
a good idea for first-years
202
00:08:13,209 --> 00:08:14,471
and fourth-years
to go out.
203
00:08:14,645 --> 00:08:17,256
I am bound to supervise you
at some point in the future,
204
00:08:17,430 --> 00:08:20,346
and it'd get complicated
trying to change dates out,
205
00:08:20,521 --> 00:08:23,524
and the fact is...
206
00:08:23,698 --> 00:08:26,439
Seeing somebody you work with
rarely ends happily.
207
00:08:26,614 --> 00:08:28,267
So, I appreciate you
thinking of me, but I...
208
00:08:28,441 --> 00:08:31,749
Oh, you thought it was
a date.
209
00:08:31,923 --> 00:08:33,621
I'm still new here,
and I thought it was
210
00:08:33,795 --> 00:08:36,885
a good opportunity to get
to know each other.
211
00:08:37,059 --> 00:08:39,017
Coffee's perfect
because you're asking
212
00:08:39,191 --> 00:08:41,542
the least amount of commitment
from another human being.
213
00:08:41,716 --> 00:08:43,935
It's not even lunch.
214
00:08:44,109 --> 00:08:46,068
If it's still a "no,"
it's still a "no,"
215
00:08:46,242 --> 00:08:47,896
but I'll let you
re-think your answer.
216
00:09:01,953 --> 00:09:04,521
He only claimed
it wasn't a date
to save face.
217
00:09:04,695 --> 00:09:06,828
Or maybe I just assumed.
218
00:09:07,002 --> 00:09:08,438
But why did I assume?
219
00:09:08,612 --> 00:09:10,483
I don't think I'm
some kind of narcissist
220
00:09:10,658 --> 00:09:13,965
who thinks every man
wants to get close to me.
221
00:09:14,139 --> 00:09:17,055
Or we both assumed it's a date
because it's a date.
222
00:09:17,229 --> 00:09:19,101
This is fun.
I like being your bestie.
223
00:09:19,275 --> 00:09:20,189
Slumber party?
224
00:09:23,758 --> 00:09:26,891
[DOOR OPENS]
225
00:09:27,065 --> 00:09:29,241
I made a poll to test
the popularity of shower sex.
226
00:09:29,415 --> 00:09:30,895
I heard.
227
00:09:31,069 --> 00:09:33,115
I fielded some questions
about that.
228
00:09:33,289 --> 00:09:37,075
"Approve" has won,
but don't get too excited,
Lea.
229
00:09:37,249 --> 00:09:39,948
It's only 58-38,
230
00:09:40,122 --> 00:09:42,428
with several
complicated noncommittals,
231
00:09:42,603 --> 00:09:44,561
so clearly my attitude
is reasonable.
232
00:09:44,735 --> 00:09:47,085
We don't have room
for a...
233
00:09:47,259 --> 00:09:49,261
Skier exercise thing.
234
00:09:49,435 --> 00:09:51,786
I'm only putting it together
so I can take a picture
235
00:09:51,960 --> 00:09:53,744
and sell it online.
236
00:09:53,918 --> 00:09:55,485
Why do you have it
if you don't want it?
237
00:10:01,534 --> 00:10:05,190
My ex sent it.
238
00:10:05,364 --> 00:10:06,844
"Ex"?
239
00:10:07,018 --> 00:10:09,978
Husband.
240
00:10:10,152 --> 00:10:12,154
I left this thing
in the attic
241
00:10:12,328 --> 00:10:14,286
until I got settled somewhere
with enough space.
242
00:10:14,460 --> 00:10:15,897
And okay,
that was 10 years ago,
243
00:10:16,071 --> 00:10:17,289
but it's not like
it was in his way.
244
00:10:21,903 --> 00:10:25,689
We got married, not for long,
right out of high school.
245
00:10:25,863 --> 00:10:27,386
Literally
the boy next door.
246
00:10:27,560 --> 00:10:29,606
We grew up together.
People expected it.
247
00:10:29,780 --> 00:10:33,044
It... Was a big mistake.
248
00:10:33,218 --> 00:10:34,567
We both realized it
pretty quickly.
249
00:10:40,182 --> 00:10:41,966
ENRIQUE: Why would you even
want to live forever?
250
00:10:42,140 --> 00:10:42,663
You'd be bored
out of your mind.
251
00:10:42,837 --> 00:10:43,881
[CHUCKLES]
252
00:10:44,055 --> 00:10:45,622
The person I am now
253
00:10:45,796 --> 00:10:50,409
is miles away from the person
I was at 14.
254
00:10:50,583 --> 00:10:53,630
I only get more distant
every year.
255
00:10:53,804 --> 00:10:58,200
You learn to understand,
256
00:10:58,374 --> 00:11:01,725
love books that
you once hated,
257
00:11:01,899 --> 00:11:04,902
sometimes people
you once hated.
258
00:11:05,076 --> 00:11:09,428
Music that you didn't get
the point of becomes magical.
259
00:11:09,602 --> 00:11:11,561
And a thousand new doors
will open.
260
00:11:11,735 --> 00:11:14,042
I look forward
to the adventure.
261
00:11:14,216 --> 00:11:15,565
[NEEDLE SQUELCHES]Ow.
262
00:11:15,739 --> 00:11:17,785
Sorry. Adventure's not always
gonna be fun.
263
00:11:19,700 --> 00:11:22,964
I figure it takes
40 or 50 years
264
00:11:23,138 --> 00:11:25,749
just to get over
the things your parents did.
265
00:11:25,923 --> 00:11:27,533
If only we lived
long enough,
266
00:11:27,708 --> 00:11:30,885
the human race might finally
have a chance to grow up.
267
00:11:38,022 --> 00:11:39,981
What size shoes
do you wear?
268
00:11:40,155 --> 00:11:43,114
Seven and a half.
269
00:11:43,288 --> 00:11:45,377
"Dr. Allen's Walking On Clouds
Inserts."
270
00:11:45,551 --> 00:11:47,597
Putting "doctor" in the name
is always good
marketing strategy.
271
00:11:47,771 --> 00:11:50,252
They're designed
to reduce inflammation
272
00:11:50,426 --> 00:11:52,080
that could lead to
plantar fasciitis,
273
00:11:52,254 --> 00:11:55,213
calluses, arthritis,
and they feel damn good.
274
00:11:55,387 --> 00:11:56,954
Does this have anything
to do with our patient's
275
00:11:57,128 --> 00:11:58,042
venture capitalist
husband?
276
00:11:58,216 --> 00:11:59,740
I need testimonials.
277
00:11:59,914 --> 00:12:00,784
Labs and Path
for Hannah Palmer.
278
00:12:05,006 --> 00:12:07,660
Aren't we all busy enough
learning how to be surgeons?
279
00:12:07,835 --> 00:12:09,750
Do you really want to
divide your focus onto
something trivial?
280
00:12:15,581 --> 00:12:17,975
Because wanting to make money
taints the purity of medicine?
281
00:12:20,151 --> 00:12:21,892
I have five brothers.
282
00:12:22,066 --> 00:12:24,329
I've been
taking care of people
my whole life.
283
00:12:24,503 --> 00:12:27,811
Someone got hurt, they came
to me to patch them up.
284
00:12:27,985 --> 00:12:31,380
I became a doctor
so I could get paid for it,
285
00:12:31,554 --> 00:12:34,383
but also because I'm good
at taking care of people.
286
00:12:34,557 --> 00:12:36,167
It's possible to do something
for more than one reason.
287
00:12:48,092 --> 00:12:49,224
The news is bad.
288
00:12:58,842 --> 00:13:02,063
There's an abnormally
healthy population
289
00:13:02,237 --> 00:13:05,327
of hematopoietic progenitor
stem cells.
290
00:13:05,501 --> 00:13:07,677
He did it?It's significant.
291
00:13:07,851 --> 00:13:10,680
He's succeeded in optimizing
enough telomerase activity
292
00:13:10,854 --> 00:13:13,378
to potentially add 10 years
to his natural life.
293
00:13:13,552 --> 00:13:15,685
DR ANDREWS: Well, assuming it
doesn't subtract about 50.
294
00:13:15,859 --> 00:13:17,295
There's already
an autoimmune reaction
295
00:13:17,469 --> 00:13:18,383
that mimics
Hirschsprung's.
296
00:13:18,557 --> 00:13:20,342
Who knows what else
he did?
297
00:13:20,516 --> 00:13:22,518
What if this is the opposite
of an auto-immune condition?
298
00:13:22,692 --> 00:13:23,954
What if
he's done something
299
00:13:24,128 --> 00:13:25,347
that lowers his resistance
to infection?
300
00:13:25,521 --> 00:13:27,784
Then we'd be seeing
more opportunistic infections
301
00:13:27,958 --> 00:13:29,133
of the lungs and skin.
302
00:13:29,307 --> 00:13:31,353
If you lived
another 1,000 years,
303
00:13:31,527 --> 00:13:33,094
would you be with
the same person at the end
304
00:13:33,268 --> 00:13:34,573
as at the beginning?
305
00:13:34,747 --> 00:13:35,487
No.No.
306
00:13:37,098 --> 00:13:38,708
No, if you assume
monogamy.
307
00:13:38,882 --> 00:13:40,710
I mean, that puts too much
strain on a relationship.
308
00:13:40,884 --> 00:13:42,538
Is one person supposed to
be everything to another,
309
00:13:42,712 --> 00:13:44,496
all the time,
for 1,000 years?
310
00:13:44,670 --> 00:13:48,500
Apparently Jesus agrees.
On monogamy.
311
00:13:48,674 --> 00:13:50,763
He said that, in Heaven,
there'll be no more marriages.
312
00:13:50,938 --> 00:13:54,071
I guess humans can't sustain
a relationship that long.
313
00:13:54,245 --> 00:13:55,464
You read
the New Testament, too?
314
00:13:55,638 --> 00:13:58,206
And the Qur'an.
And other things.
315
00:13:58,380 --> 00:13:59,511
It's like
you're a stalker.
316
00:13:59,685 --> 00:14:01,992
It's like you and God had
an acrimonious divorce.
317
00:14:02,166 --> 00:14:05,778
What if he caused
neurofibromatosis?
318
00:14:05,953 --> 00:14:07,955
Microscopic tumors forming
on the nerve sheath?
319
00:14:08,129 --> 00:14:09,347
Mm. Possible,
but there'd have been
320
00:14:09,521 --> 00:14:10,435
some evidence
of Schwann cell growth
321
00:14:10,609 --> 00:14:12,220
around his colon.
322
00:14:12,394 --> 00:14:14,439
Would you still love your wife
in 1,000 years?
323
00:14:16,920 --> 00:14:18,966
You have three answers.
That should be enough.
324
00:14:19,140 --> 00:14:20,968
Park's marriage failed
in far less time,
325
00:14:21,142 --> 00:14:22,447
and Enrique
doesn't even try.
326
00:14:22,621 --> 00:14:24,101
Asher is an...
327
00:14:24,275 --> 00:14:25,711
Unknown quantity.
328
00:14:25,886 --> 00:14:27,191
You're committed.
329
00:14:27,365 --> 00:14:28,453
You've made promises.
330
00:14:31,326 --> 00:14:33,284
I've made promises
based on
331
00:14:33,458 --> 00:14:37,114
an understood
human life-span, Murphy.
332
00:14:37,288 --> 00:14:40,291
Most likely diagnosis is
autoimmune polyneuropathy.
333
00:14:40,465 --> 00:14:41,727
It damaged the enteral
ganglion nerve
334
00:14:41,902 --> 00:14:43,512
and led to
the perforations.
335
00:14:43,686 --> 00:14:45,818
Start him on steroids
and immunosuppressants.
336
00:14:45,993 --> 00:14:47,211
Dr. Andrews.
337
00:14:47,385 --> 00:14:49,431
So, you wouldn't
have gotten married
338
00:14:49,605 --> 00:14:51,302
if you thought
it would be forever.
339
00:14:51,476 --> 00:14:53,870
You expect all relationships
to fail over time.
340
00:14:54,044 --> 00:14:55,219
It's just a question
of how long?
341
00:14:57,308 --> 00:14:59,832
I love her now.
342
00:15:00,007 --> 00:15:04,228
I intend to love her
as long as I live.
343
00:15:04,402 --> 00:15:08,493
But, eventually,
everything breaks.
344
00:15:17,763 --> 00:15:18,982
I always go back
to comfort reading
345
00:15:19,156 --> 00:15:20,505
when I'm in
the hospital.
346
00:15:20,679 --> 00:15:22,290
Cozy mysteries
in little English villages,
347
00:15:22,464 --> 00:15:24,031
where nothing bad happens
to anyone we like.
348
00:15:26,511 --> 00:15:28,209
We've gotten
your results back.
349
00:15:28,383 --> 00:15:28,992
When will
your husband be...
350
00:15:29,166 --> 00:15:30,167
Is it cancer?
351
00:15:32,822 --> 00:15:33,779
Yes.
352
00:15:36,434 --> 00:15:38,959
Thyroid carcinoma.
353
00:15:39,133 --> 00:15:40,743
We're gonna do
a complete imaging series
354
00:15:40,917 --> 00:15:41,526
to pinpoint
just how advanced...
355
00:15:41,700 --> 00:15:44,268
Treatment?
356
00:15:44,442 --> 00:15:47,271
Surgery to remove some or all
of your thyroid
357
00:15:47,445 --> 00:15:49,708
is usually the first line
of defense.
358
00:15:49,882 --> 00:15:52,581
Sometimes, we can wait,
but given the hematoma
359
00:15:52,755 --> 00:15:56,541
was probably caused
by the tumor
invading nearby vasculatures,
360
00:15:56,715 --> 00:15:59,109
we should probably do it
in the next few days.[WHEEZES]
361
00:15:59,283 --> 00:16:02,025
Later, there'll be radioactive
iodine treatment...
362
00:16:02,199 --> 00:16:03,461
[WHEEZES]
363
00:16:03,635 --> 00:16:04,941
Panic attack?
364
00:16:05,115 --> 00:16:07,944
[WHEEZING]
365
00:16:11,252 --> 00:16:12,470
Her trachea's deviated
to the right.
366
00:16:12,644 --> 00:16:14,603
The tumor's compressing it.
We're doing surgery now.
367
00:16:14,777 --> 00:16:16,561
[GROANING]
368
00:16:20,826 --> 00:16:23,568
[MONITOR BEEPING]
369
00:16:27,485 --> 00:16:28,878
What happened?
The nurse just said "surgery."
370
00:16:29,052 --> 00:16:31,315
Was it the hematoma?
371
00:16:31,489 --> 00:16:32,577
It's more serious.
372
00:16:34,623 --> 00:16:36,799
I... It's not cancer...
373
00:16:36,973 --> 00:16:38,844
Again.
374
00:16:39,019 --> 00:16:41,760
Thyroid carcinoma.
375
00:16:41,934 --> 00:16:44,676
We've removed her thyroid.
She's doing well.
376
00:16:44,850 --> 00:16:46,287
We're looking into
potential causes...
377
00:16:46,461 --> 00:16:48,593
Genetic, environmental.
378
00:16:48,767 --> 00:16:51,683
There may be a deeper issue
that we can find and address.
379
00:17:02,477 --> 00:17:06,089
I can't do this.
380
00:17:06,263 --> 00:17:09,005
You've done it before.
381
00:17:09,179 --> 00:17:11,138
You'll do it
this time.
382
00:17:16,578 --> 00:17:19,407
Do you know
what it's like...
383
00:17:19,581 --> 00:17:20,669
To wake up every morning
and know your wife
384
00:17:20,843 --> 00:17:21,844
might not be here
next year?
385
00:17:24,238 --> 00:17:27,676
All those treatments...
386
00:17:27,850 --> 00:17:31,027
They all... They all have this
little tag attached to them
387
00:17:31,201 --> 00:17:34,161
that says,
"Because she might die."
388
00:17:34,335 --> 00:17:38,034
And you see them
put those gloves on
389
00:17:38,208 --> 00:17:39,166
before they hook up
the chemo.
390
00:17:39,340 --> 00:17:42,299
You know why
they do that.
391
00:17:42,473 --> 00:17:43,648
It's because
it's poison.
392
00:17:46,042 --> 00:17:49,524
And you sit there...
393
00:17:49,698 --> 00:17:52,614
And you watch them
shove poison
into the person you love.
394
00:17:52,788 --> 00:17:55,921
And why?
395
00:17:56,096 --> 00:17:57,880
Because she might die.
396
00:18:00,578 --> 00:18:02,972
We're killing her
because she might die.
397
00:18:08,020 --> 00:18:09,065
Go for a run.
398
00:18:09,239 --> 00:18:12,199
Go punch a wall.
399
00:18:12,373 --> 00:18:13,809
You need to release
some endorphins.
400
00:18:13,983 --> 00:18:15,419
My release is my job.
401
00:18:15,593 --> 00:18:17,204
That's why I love it.
402
00:18:17,378 --> 00:18:20,250
My work requires
total focus.
403
00:18:20,424 --> 00:18:21,599
And every minute
I'm working
404
00:18:21,773 --> 00:18:24,341
is a minute
I'm not thinking about...
405
00:18:24,515 --> 00:18:25,342
Losing her.
406
00:18:31,305 --> 00:18:32,262
I have to go.
407
00:18:38,660 --> 00:18:41,663
Your pain and weakness
are consistent with
polyneuropathy,
408
00:18:41,837 --> 00:18:44,492
treatable with steroids
and immunosuppressants.
409
00:18:44,666 --> 00:18:47,016
If you live 1,000 years,
will you still love Sophie?
410
00:18:49,888 --> 00:18:51,063
Yes.
411
00:18:51,238 --> 00:18:53,022
How can you be sure?
412
00:18:53,196 --> 00:18:55,677
People change.
You expect to change.
413
00:18:55,851 --> 00:18:59,028
Sophie and I
will change together.
414
00:18:59,202 --> 00:19:00,160
We'll go through
the same adventures
415
00:19:00,334 --> 00:19:01,378
and learn
the same lessons.
416
00:19:01,552 --> 00:19:04,120
What if you go through
the same adventures
417
00:19:04,294 --> 00:19:05,469
and learn
different lessons?
418
00:19:05,643 --> 00:19:08,646
Even if we did, whoever,
whatever we become,
419
00:19:08,820 --> 00:19:10,648
Sophie will always
be beautiful.
420
00:19:10,822 --> 00:19:13,521
I mean, she could turn into
a machine or a set of pixels
421
00:19:13,695 --> 00:19:16,350
or a giant purple flower,
and she'll still be beautiful,
422
00:19:16,524 --> 00:19:18,743
because it's part of
her essential nature.
423
00:19:22,660 --> 00:19:24,662
But if you don't know
how you'll change,
424
00:19:24,836 --> 00:19:26,273
you don't know
how you'll change.
425
00:19:26,447 --> 00:19:29,058
Shaun.
426
00:19:29,232 --> 00:19:30,494
We'll let you
get some rest.
427
00:19:30,668 --> 00:19:32,409
The steroids should make you
feel a lot better.
428
00:19:38,937 --> 00:19:44,029
Why didn't you ever mention
you had an ex-husband?
429
00:19:44,204 --> 00:19:48,077
Shaun, I've barely
thought about him in years.
430
00:19:48,251 --> 00:19:51,733
I didn't mention him
because he's not important.
431
00:19:51,907 --> 00:19:55,084
I know.
That's the problem.
432
00:19:55,258 --> 00:19:58,261
At one time, you felt he was
important enough to your life
433
00:19:58,435 --> 00:20:01,612
to marry him, and now
you barely think of him.
434
00:20:01,786 --> 00:20:05,225
You make long-term plans,
you have expectations,
435
00:20:05,399 --> 00:20:07,096
and then something
happens to you,
436
00:20:07,270 --> 00:20:11,535
and suddenly you're
a different person.
437
00:20:11,709 --> 00:20:16,758
I know you don't like change,
but it's not all bad.
438
00:20:16,932 --> 00:20:21,241
After all, you are working to
change yourself all the time.
439
00:20:21,415 --> 00:20:27,203
I'm working to be a better
surgeon, a better boyfriend,
440
00:20:27,377 --> 00:20:29,249
better at the things
I've chosen,
441
00:20:29,423 --> 00:20:31,381
but this...
442
00:20:31,555 --> 00:20:32,513
Other change...
It's unpredictable.
443
00:20:32,687 --> 00:20:33,688
You don't choose it.
444
00:20:33,862 --> 00:20:36,125
It just comes at you.
445
00:20:36,299 --> 00:20:38,910
Oh, it's like hurricanes
before 1873,
446
00:20:39,084 --> 00:20:41,086
when the Army Signal Corps
first put up flags
447
00:20:41,261 --> 00:20:42,566
to warn people
storms were coming.
448
00:20:42,740 --> 00:20:45,613
Before that, houses were
flattened, lives destroyed,
449
00:20:45,787 --> 00:20:47,223
and there was no way to see
it was heading for you.
450
00:20:47,397 --> 00:20:50,052
Shaun.
451
00:20:50,226 --> 00:20:53,273
Our relationship will not end
in natural disaster.
452
00:20:53,447 --> 00:20:54,839
It did begin in one.
453
00:20:57,538 --> 00:21:00,323
I'm going to look in
on my patient.
454
00:21:00,497 --> 00:21:02,064
Okay.
455
00:21:09,767 --> 00:21:13,031
Blood and saliva will tell us
if there's a genetic cause,
456
00:21:13,205 --> 00:21:14,990
and the samples
we take from your house
457
00:21:15,164 --> 00:21:16,470
will tell us if there's
something environmental.
458
00:21:18,733 --> 00:21:22,302
I know it's s... Stupid.
459
00:21:22,476 --> 00:21:25,130
I've almost felt guilty
for my cancer,
460
00:21:25,305 --> 00:21:28,873
like I arbitrarily decided
to be sick and burdensome.
461
00:21:31,746 --> 00:21:33,269
Do the people
you're close to
462
00:21:33,443 --> 00:21:35,880
ever act like
you're a burden to them?
463
00:21:36,054 --> 00:21:36,881
You mean Alan.
464
00:21:39,319 --> 00:21:41,669
He's scared.
465
00:21:41,843 --> 00:21:45,716
He takes the exit he's got
and he turns to his work.
466
00:21:45,890 --> 00:21:47,109
You're okay with that?
467
00:21:55,204 --> 00:21:57,162
I accept this compromise.
468
00:21:57,337 --> 00:21:58,338
That's not the hard part.
469
00:21:58,512 --> 00:22:00,557
The hard part is...
470
00:22:00,731 --> 00:22:03,995
Not knowing.
471
00:22:04,169 --> 00:22:08,348
Each new thing that happens,
I worry, "Is this it?
472
00:22:08,522 --> 00:22:11,829
"Is this where
I lose him?
473
00:22:12,003 --> 00:22:13,265
"Is this where
he breaks?"
474
00:22:20,925 --> 00:22:23,232
CLAIRE: So, this is
boiled coffee.
475
00:22:23,406 --> 00:22:25,103
Some people call it
"Turkish coffee,"
476
00:22:25,277 --> 00:22:28,150
or "Greek coffee,"
or "Egyptian coffee"...
477
00:22:28,324 --> 00:22:29,456
Because we need to
take ownership
478
00:22:29,630 --> 00:22:30,631
and put things
in categories.
479
00:22:30,805 --> 00:22:32,415
Yeah.
480
00:22:32,589 --> 00:22:34,243
You actually live
in this thing,
481
00:22:34,417 --> 00:22:36,332
in the hospital
parking garage?
482
00:22:36,506 --> 00:22:37,420
Why not?
483
00:22:37,594 --> 00:22:38,943
Convenient for work.
484
00:22:39,117 --> 00:22:41,598
When I want to spend
a few days off
the beaten track,
485
00:22:41,772 --> 00:22:43,687
it's convenient
for that, too.
486
00:22:43,861 --> 00:22:46,647
Ooh. I'm gonna get
three sips in this.
487
00:22:46,821 --> 00:22:48,039
But three
really great sips.
488
00:22:50,477 --> 00:22:52,261
That's how I try
to live my life...
489
00:22:52,435 --> 00:22:55,960
Try to appreciate, savor,
not pass by.
490
00:22:59,703 --> 00:23:02,880
Is that what
the polyamory is about?
491
00:23:03,054 --> 00:23:05,448
Does it really work,
or is it one of those
theories about life
492
00:23:05,622 --> 00:23:07,145
that people
regret later?
493
00:23:07,319 --> 00:23:08,538
No regrets so far.
494
00:23:08,712 --> 00:23:10,322
Mm-hmm.
No, I guess not.
495
00:23:10,497 --> 00:23:13,413
Not while you're young
and having fun.
496
00:23:13,587 --> 00:23:14,675
It is fun,
497
00:23:14,849 --> 00:23:16,241
but not for the reasons
that you're thinking.
498
00:23:16,416 --> 00:23:18,809
It isn't about sex.
499
00:23:18,983 --> 00:23:21,682
It's about commitment,
emotional connection.
500
00:23:21,856 --> 00:23:23,945
The joy I'm sure you get
out of a relationship,
501
00:23:24,119 --> 00:23:25,120
I get a little more.
502
00:23:25,294 --> 00:23:27,383
Also, I have to give
a little more.
503
00:23:27,557 --> 00:23:29,646
But that's meaningful,
too.
504
00:23:29,820 --> 00:23:32,519
Hmm.
505
00:23:32,693 --> 00:23:34,303
Do you mind if I
ask you something,
506
00:23:34,477 --> 00:23:35,565
since we're
getting personal?
507
00:23:39,656 --> 00:23:41,528
Sure.
508
00:23:41,702 --> 00:23:43,486
What's your favorite
misheard song lyric?
509
00:23:45,662 --> 00:23:48,012
[LAUGHS]
510
00:23:52,277 --> 00:23:53,322
This is nice.
511
00:23:55,716 --> 00:23:58,109
I'm glad it's
not a date.
512
00:23:58,283 --> 00:23:59,763
Me, too.
513
00:23:59,937 --> 00:24:01,069
I don't believe
in those categories.
514
00:24:06,683 --> 00:24:08,468
[MACHINE BEEPING]He reported widespread
bilateral pain,
515
00:24:08,642 --> 00:24:09,556
then he keeled over.
516
00:24:09,730 --> 00:24:10,992
B.P. dropped to 80
over palp.
517
00:24:11,166 --> 00:24:12,254
I'll order a vasopressor.
518
00:24:12,428 --> 00:24:14,082
Already did.Good.
519
00:24:14,256 --> 00:24:17,912
We need an EKG, CBC, and chest
images, and a new diagnosis.
520
00:24:18,086 --> 00:24:20,610
Whatever he caused
with CRISPR,
it's not just neuropathy.
521
00:24:20,784 --> 00:24:22,046
Something else
is killing him.
522
00:24:30,577 --> 00:24:32,274
What if he's caused something
that mimics
523
00:24:32,448 --> 00:24:33,580
carcinomatous
autonomic neuropathy?
524
00:24:33,754 --> 00:24:36,017
It explains the B.P.
and bowel issue.
525
00:24:36,191 --> 00:24:38,367
That doesn't explain
the sensory issue
that led to the frostbite.
526
00:24:42,066 --> 00:24:43,851
A connective
tissue disorder?
527
00:24:44,025 --> 00:24:44,982
That would have shown up
on the scans.
528
00:24:45,156 --> 00:24:45,635
His chest looks normal.
529
00:24:51,946 --> 00:24:52,729
Maybe we can't think
of the answer
530
00:24:52,903 --> 00:24:54,339
because there is
no answer.
531
00:24:54,514 --> 00:24:56,211
We keep trying to jam it
into these categories we know,
532
00:24:56,385 --> 00:24:57,473
the diseases
that we know.
533
00:24:57,647 --> 00:25:00,258
But this never
existed before.
534
00:25:00,432 --> 00:25:02,173
He created a new combination
of genetic code.
535
00:25:02,347 --> 00:25:04,349
That means a new combination
of symptoms.
536
00:25:04,524 --> 00:25:06,569
DR ANDREWS:
So, we shouldn't be looking at
what fits the picture,
537
00:25:06,743 --> 00:25:07,918
but at what's closest to
the picture,
538
00:25:08,092 --> 00:25:09,920
so we can at least
figure out a treatment.
539
00:25:10,094 --> 00:25:13,794
And what it's closest to
is amyloidosis.
540
00:25:13,968 --> 00:25:16,536
This isn't
an autoimmune neuropathy,
541
00:25:16,710 --> 00:25:19,060
so the nerves must be under
attack by something else.
542
00:25:19,234 --> 00:25:21,192
Something like amyloid disease
could leave deposits
543
00:25:21,366 --> 00:25:23,673
along the nerves,
causing the symptoms
we've seen.
544
00:25:23,847 --> 00:25:25,283
Where do we look
for those deposits?
545
00:25:25,457 --> 00:25:27,111
The spleen.
546
00:25:33,988 --> 00:25:35,250
Drink all 8 ounces.
547
00:25:35,424 --> 00:25:38,383
We talked.
We had a few laughs.
548
00:25:38,558 --> 00:25:40,037
Well,
sounds date-y to me.
549
00:25:40,211 --> 00:25:41,473
[GROANS]
550
00:25:41,648 --> 00:25:43,040
I don't think Enrique's
a player.
551
00:25:43,214 --> 00:25:44,825
No, he's kind of the opposite
of a player.
552
00:25:44,999 --> 00:25:47,088
With him, emotional connection
is the point.
553
00:25:47,262 --> 00:25:49,438
He's trying to live
some idealistic fantasy
554
00:25:49,612 --> 00:25:51,048
where everyone is nice
and no one is jealous.
555
00:25:51,222 --> 00:25:52,876
I am so staying away.
556
00:25:53,050 --> 00:25:54,312
Well, of course.
557
00:25:54,486 --> 00:25:55,096
Once I heard
"emotional connection,"
558
00:25:55,270 --> 00:25:56,880
I knew the game was over.
559
00:25:57,054 --> 00:25:58,273
What does that mean?
560
00:25:58,447 --> 00:26:00,362
I'm against emotion?
561
00:26:00,536 --> 00:26:02,059
[CHUCKLES] I'm not the one
with "cold-hearted bitch"
562
00:26:02,233 --> 00:26:04,148
as my social media hashtag.
563
00:26:04,322 --> 00:26:05,323
She's an
excellent doctor.
564
00:26:05,497 --> 00:26:06,934
Every time
you've loved somebody,
565
00:26:07,108 --> 00:26:08,588
it's ended in disappointment
or death...
566
00:26:08,762 --> 00:26:09,806
Sometimes both.
567
00:26:09,980 --> 00:26:11,329
It's like a reflex now.
568
00:26:11,503 --> 00:26:14,245
You just expect that
everything ends badly,
so why start?
569
00:26:14,419 --> 00:26:17,814
So, despite the many
practical reasons
not to go out
570
00:26:17,988 --> 00:26:19,511
with a first-year,
this is all about me?
571
00:26:19,686 --> 00:26:23,080
Is that a diamond ring?
572
00:26:23,254 --> 00:26:24,473
I mean, it's pretty.
573
00:26:24,647 --> 00:26:26,083
Our patient caught
her fiance cheating.
574
00:26:26,257 --> 00:26:27,911
Big fight.
He demanded the ring back.
575
00:26:28,085 --> 00:26:29,434
She swallowed it.
576
00:26:29,609 --> 00:26:31,175
I did.
577
00:26:31,349 --> 00:26:31,959
You don't even know
if this is "going out,"
578
00:26:32,133 --> 00:26:33,700
and that's the point.
579
00:26:33,874 --> 00:26:35,615
It doesn't matter
what Enrique's offering.
580
00:26:35,789 --> 00:26:37,704
Whether it's friendship or
romance, you're not investing.
581
00:26:37,878 --> 00:26:39,401
You're risk-averse.
582
00:26:39,575 --> 00:26:42,273
Your portfolio right now
is entirely in T-Bills
and money market.
583
00:26:42,447 --> 00:26:43,797
I have no idea
what that means.
584
00:26:43,971 --> 00:26:45,233
And it's too bad,
because a guy
that can make you laugh
585
00:26:45,407 --> 00:26:47,148
might be just what you need
right now.
586
00:26:47,322 --> 00:26:49,629
It's progressed to
your large intestine.
587
00:26:49,803 --> 00:26:52,457
Here's a plastic bag.
Put it over the toilet seat.
588
00:26:52,632 --> 00:26:53,633
You'll have every opportunity
to recover your property.
589
00:26:58,550 --> 00:27:01,466
Don't run away
from a chance at love.
590
00:27:01,641 --> 00:27:04,687
It's a date...
591
00:27:04,861 --> 00:27:05,862
Maybe.
592
00:27:06,036 --> 00:27:06,646
I don't know.
593
00:27:06,820 --> 00:27:07,647
Oh.
594
00:27:09,910 --> 00:27:11,607
OLIVIA: Her house
is full of T.C.E.,
595
00:27:11,781 --> 00:27:12,739
a side effect
from chip-making
596
00:27:12,913 --> 00:27:14,915
back in Silicon Valley's
early days.
597
00:27:15,089 --> 00:27:16,786
So, they move away
from their toxic home,
598
00:27:16,960 --> 00:27:18,048
and hopefully
things get a little better.
599
00:27:18,222 --> 00:27:19,659
Probably not much.
600
00:27:19,833 --> 00:27:21,356
She also has a genetic
predisposition.
601
00:27:21,530 --> 00:27:23,314
It's both?
602
00:27:23,488 --> 00:27:24,794
She shouldn't go outside
in a rainstorm.
603
00:27:26,883 --> 00:27:28,580
How do you tell a woman
that her third cancer
604
00:27:28,755 --> 00:27:29,669
likely won't be close
to her last?
605
00:27:33,585 --> 00:27:35,718
Unfortunately,
this is a teaching moment.
606
00:27:38,982 --> 00:27:41,332
Dr. Allen,
after 12 hours on duty,
607
00:27:41,506 --> 00:27:44,161
I can report that
your inserts came through.
608
00:27:44,335 --> 00:27:46,163
Check your e-mail.
You'll find my testimonial.
609
00:27:46,337 --> 00:27:47,295
[EXHALES SHARPLY]
610
00:27:47,469 --> 00:27:48,122
Claire. Olivia.
611
00:27:55,085 --> 00:27:56,434
[EXHALES SHARPLY]
612
00:27:56,608 --> 00:27:59,524
And if you're right,
what will you do?
613
00:27:59,699 --> 00:28:02,310
We'll treat the symptoms
with targeted drug therapies.
614
00:28:02,484 --> 00:28:04,529
There really isn't a disease,
as such, that we can address.
615
00:28:04,704 --> 00:28:05,792
Ow.
616
00:28:12,102 --> 00:28:13,016
The pain shifted?
617
00:28:13,190 --> 00:28:15,627
Yeah.
Oh.
618
00:28:15,802 --> 00:28:17,673
Never mind about
the ultrasound.
619
00:28:17,847 --> 00:28:19,196
It'll be easier to check
for deposits after
the organ's been removed.
620
00:28:19,370 --> 00:28:20,850
After it's...Yeah.
621
00:28:21,024 --> 00:28:21,982
His spleen's about to rupture.
Call a transport team.
622
00:28:24,201 --> 00:28:26,595
[ALARM BEEPING]
623
00:28:26,769 --> 00:28:27,857
[GRUNTS]
624
00:28:35,212 --> 00:28:37,998
It's called
Li-Fraumeni Syndrome... LFS.
625
00:28:38,172 --> 00:28:39,826
An inherited
predisposition
626
00:28:40,000 --> 00:28:42,916
to developing a wide range
of cancers.
627
00:28:43,090 --> 00:28:44,569
Yes, there was a toxin
in your environment
628
00:28:44,744 --> 00:28:46,223
that likely played a role
in this,
629
00:28:46,397 --> 00:28:48,356
but there will be other
triggers in the future.
630
00:28:48,530 --> 00:28:51,098
Your body
is super sensitive
631
00:28:51,272 --> 00:28:52,882
and will respond with tumors
for the rest of your life.
632
00:29:00,890 --> 00:29:03,501
I know that's a shock,
633
00:29:03,675 --> 00:29:06,330
but here's what
you should know...
634
00:29:06,504 --> 00:29:09,333
Most cancers are treatable
if found early enough.
635
00:29:13,337 --> 00:29:15,775
We know the most common
associated with LFS,
636
00:29:15,949 --> 00:29:18,168
and we can
do surveillance,
637
00:29:18,342 --> 00:29:23,434
nip anything in the bud
before it becomes a problem.
638
00:29:23,608 --> 00:29:27,308
It may not seem this way now,
but this is good.
639
00:29:27,482 --> 00:29:29,353
We know what
we're dealing with.
640
00:29:29,527 --> 00:29:31,878
We're warned,
and we'll be ready.
641
00:29:40,364 --> 00:29:41,844
He won't be able
to handle this.
642
00:29:47,589 --> 00:29:49,809
DR ANDREWS: Liver, pancreas,
other organs look normal.
643
00:29:49,983 --> 00:29:51,419
Ah.
644
00:29:51,593 --> 00:29:54,596
But there are
calcified lesions
along these nerves.
645
00:29:54,770 --> 00:29:56,511
He's gonna be
in pain like this
for the rest of his life.
646
00:29:56,685 --> 00:29:57,904
SHAUN: No.
647
00:29:58,078 --> 00:29:59,819
There's a reasonable chance
it'll get worse
648
00:29:59,993 --> 00:30:01,168
as time goes on.
649
00:30:01,342 --> 00:30:03,648
I need my sharp-blunt
curved scissors.
650
00:30:03,823 --> 00:30:05,389
ENRIQUE: What if we
used CRISPR
to reverse CRISPR?
651
00:30:07,565 --> 00:30:10,177
Researchers have identified
a protein in certain bacteria
652
00:30:10,351 --> 00:30:12,440
that inhibits CRISPR.
653
00:30:12,614 --> 00:30:14,572
What if we insert the DNA
that makes that protein
654
00:30:14,746 --> 00:30:15,922
into our
patient's genome?
655
00:30:16,096 --> 00:30:17,706
That would deactivate
the CRISPR gene.
656
00:30:17,880 --> 00:30:19,142
ASHER: So, CRISPR messed
him up permanently,
657
00:30:19,316 --> 00:30:20,927
and you think we should
do more of it?
658
00:30:21,101 --> 00:30:22,537
I don't know.
Our patient is a risk-taker.
659
00:30:22,711 --> 00:30:24,452
We'd need
a delivery mechanism.
660
00:30:24,626 --> 00:30:26,758
The code would have to be
introduced through a virus...
661
00:30:26,933 --> 00:30:29,283
A virus that specifically
targets nerves.
662
00:30:31,502 --> 00:30:33,113
Polio targets nerves.
663
00:30:33,287 --> 00:30:35,071
Because this isn't
risky enough.
664
00:30:35,245 --> 00:30:36,812
Polio is such
a dangerous virus
665
00:30:36,986 --> 00:30:38,509
because it's so good
at penetrating
the nervous system.
666
00:30:56,876 --> 00:30:57,746
Dr. Murphy?
667
00:31:02,316 --> 00:31:07,364
She's going to be
this way... Forever.
668
00:31:07,538 --> 00:31:10,367
She'll have good periods
and bad periods.
669
00:31:10,541 --> 00:31:14,458
But she will always
have to be on her guard.
670
00:31:14,632 --> 00:31:18,332
Is she always gonna have to be
on guard against you, too?
671
00:31:18,506 --> 00:31:20,073
What does that mean?
672
00:31:20,247 --> 00:31:22,423
Chronic illness puts strain
on relationships.
673
00:31:22,597 --> 00:31:25,643
Statistically,
it is more often
the man who can't handle it.
674
00:31:25,817 --> 00:31:27,950
Our marriage is none
of your business.
675
00:31:28,124 --> 00:31:29,865
Her health
is my business.
676
00:31:30,039 --> 00:31:31,475
And your behavior
adds to her stress.
677
00:31:34,696 --> 00:31:38,134
You look at her,
and you imagine she's gone,
and that is hard.
678
00:31:38,308 --> 00:31:39,048
I get it.
679
00:31:41,921 --> 00:31:45,446
She thinks the same thing
when she looks at you.
680
00:31:45,620 --> 00:31:48,318
I never complain to her.
I know it's nobody's fault.
681
00:31:48,492 --> 00:31:51,017
You don't think she knows you
have trouble with all this?
682
00:31:51,191 --> 00:31:53,236
Every time
something new happens,
683
00:31:53,410 --> 00:31:56,326
she wonders,
is this the straw
684
00:31:56,500 --> 00:31:59,808
that is gonna break
your marriage?
685
00:31:59,982 --> 00:32:02,593
You've got her living in a
constant state of uncertainty.
686
00:32:02,767 --> 00:32:06,249
That is practically
the definition of stress.
687
00:32:06,423 --> 00:32:09,992
So, this is the "straighten up
and fly right" lecture.
688
00:32:10,166 --> 00:32:11,167
No.
689
00:32:12,995 --> 00:32:16,477
I am...
690
00:32:16,651 --> 00:32:22,874
I'm telling you to consider
how best to time your divorce.
691
00:32:23,049 --> 00:32:25,442
There are gonna be
a lot of new issues
dropping on Hannah,
692
00:32:25,616 --> 00:32:27,227
and if you're gonna end up
leaving anyway,
693
00:32:27,401 --> 00:32:28,576
you should start
planning now.
694
00:32:28,750 --> 00:32:29,881
I don't want to leave
my wife.
695
00:32:30,056 --> 00:32:32,754
My best advice?
696
00:32:32,928 --> 00:32:36,671
Help her through
this next round of treatment
as best you can,
697
00:32:36,845 --> 00:32:39,891
and then get out.
698
00:32:40,066 --> 00:32:43,547
It's hard living with someone
who needs so much.
699
00:32:43,721 --> 00:32:47,247
I know you feel
there is a point
where you have nothing left,
700
00:32:47,421 --> 00:32:50,206
where you're ready
to break.
701
00:32:50,380 --> 00:32:55,037
Just... Don't break
when she needs you most.
702
00:32:57,039 --> 00:32:58,562
Get out
before that happens.
703
00:33:20,454 --> 00:33:22,804
Reading an article
that's five years old?
704
00:33:22,978 --> 00:33:25,502
Dr. Glassman was once involved
in an experimental attempt
705
00:33:25,676 --> 00:33:28,070
to treat Parkinson's
with CRISPR technology.
706
00:33:28,244 --> 00:33:29,637
It failed.
707
00:33:29,811 --> 00:33:31,639
So, it's both old
and it didn't work?
708
00:33:31,813 --> 00:33:33,989
Dr. Glassman
likes his failures
to be informative.
709
00:33:34,163 --> 00:33:36,035
That's why his articles
are longer.
710
00:33:36,209 --> 00:33:37,645
Do you worry about losing
the people you love?
711
00:33:44,739 --> 00:33:47,089
Because we can't stop
ourselves from changing,
712
00:33:47,263 --> 00:33:49,396
which means we might
stop loving someone,
713
00:33:49,570 --> 00:33:50,788
or they might stop
loving us.
714
00:33:50,962 --> 00:33:53,095
It is a very bad thing.
715
00:33:53,269 --> 00:33:54,618
It is.
716
00:33:58,187 --> 00:34:02,670
So, no one can
ever feel... Safe.
717
00:34:02,844 --> 00:34:06,239
How can you keep going
if you never feel safe?
718
00:34:11,070 --> 00:34:13,159
Well, sometimes, not changing
is just as dangerous.
719
00:34:16,771 --> 00:34:20,514
So, how do you know
when to do what?
720
00:34:20,688 --> 00:34:22,907
[CHUCKLES]
721
00:34:23,082 --> 00:34:24,518
If you find
the answer to that,
let me know.
722
00:34:31,177 --> 00:34:32,961
I have it.You do?
723
00:34:33,135 --> 00:34:36,182
Dr. Glassman used
varicella zoster virus
724
00:34:36,356 --> 00:34:38,923
as the delivery mechanism,
which didn't work.
725
00:34:39,098 --> 00:34:40,708
His first choice
was herpes simplex,
726
00:34:40,882 --> 00:34:42,753
but the technology
was not up
727
00:34:42,927 --> 00:34:44,364
to putting their DNA package
into it.
728
00:34:44,538 --> 00:34:46,714
The technology
has improved.
729
00:34:46,888 --> 00:34:47,671
It can be done.
730
00:34:52,285 --> 00:34:54,374
[GRUNTS]
731
00:34:54,548 --> 00:34:55,984
Using conventional
treatments,
732
00:34:56,158 --> 00:34:58,029
there's nothing more
we can do for you.
733
00:34:58,204 --> 00:35:00,249
The pain will be permanent,
and it could get worse.
734
00:35:02,295 --> 00:35:07,169
Well, I've not been one to be
limited by the conventional.
735
00:35:07,343 --> 00:35:09,519
We think we can reverse
the CRISPR.
736
00:35:09,693 --> 00:35:11,826
You want to
reverse what I did?
My telomerase change?
737
00:35:12,000 --> 00:35:13,349
They want to
stop your pain.
738
00:35:13,523 --> 00:35:15,525
Soph, it's temporary.
739
00:35:15,699 --> 00:35:17,310
What is it, 40 years?
740
00:35:17,484 --> 00:35:19,964
That's nothing.
Our real lives are
ahead of us.
741
00:35:20,139 --> 00:35:22,576
Hey, look, as long as this
doesn't kill me,
742
00:35:22,750 --> 00:35:25,187
I've made the right choice,
no matter how bad things get.
743
00:35:25,361 --> 00:35:26,362
No.
744
00:35:28,103 --> 00:35:33,021
I was willing to exercise
for hours and fast,
745
00:35:33,195 --> 00:35:35,719
to give up all sugar
and alcohol
746
00:35:35,893 --> 00:35:38,069
and do all the other things
that we needed to do
747
00:35:38,244 --> 00:35:43,292
to get to a future that I knew
might never come.
748
00:35:43,466 --> 00:35:47,209
But now, you're asking me
to watch you suffer
749
00:35:47,383 --> 00:35:48,732
for the rest
of your life.
750
00:35:58,089 --> 00:36:02,398
You're the one
who embraces change.
751
00:36:02,572 --> 00:36:07,969
So, change to the person
who can be happy with me...
752
00:36:08,143 --> 00:36:09,362
Here and now.
753
00:36:18,893 --> 00:36:20,764
Doctors, would you mind
waiting outside?
754
00:36:27,728 --> 00:36:30,948
Why did she want us
to leave?
755
00:36:31,122 --> 00:36:32,863
I think she's delivering
an ultimatum.
756
00:36:33,037 --> 00:36:34,778
[MATT BERNINGER'S
ONE MORE SECONDPLAYS]
757
00:36:44,005 --> 00:36:45,833
♪♪ The last time...
758
00:36:46,007 --> 00:36:47,748
Are you sure
about this?
759
00:36:47,922 --> 00:36:50,185
It seems there's always
something else
760
00:36:50,359 --> 00:36:51,578
that I have to give up.
761
00:36:54,450 --> 00:36:57,453
But this isn't like sugar
or cigarettes.
762
00:36:57,627 --> 00:36:59,803
You won't get over this
in a hurry.
763
00:36:59,977 --> 00:37:01,936
No.
764
00:37:02,110 --> 00:37:03,633
Not in 1,000 years.
765
00:37:06,723 --> 00:37:13,556
♪♪ And the way we talked
Last night
766
00:37:13,730 --> 00:37:15,863
Are you gonna
be okay?
767
00:37:16,037 --> 00:37:17,343
I'm fine.
768
00:37:17,517 --> 00:37:20,128
Alan's at work, but there
should be a taxi waiting.
769
00:37:20,302 --> 00:37:23,349
I won't say goodbye,
Dr. Browne,
770
00:37:23,523 --> 00:37:26,569
'cause I'll probably be
seeing you again pretty soon.
771
00:37:26,743 --> 00:37:29,050
♪♪ Baby, don't lie to me
772
00:37:29,224 --> 00:37:32,053
I sent your cab away.
773
00:37:32,227 --> 00:37:35,056
I'm sorry
I wasn't here sooner.
774
00:37:35,230 --> 00:37:38,668
I had to present a proposal
to my partners.
775
00:37:38,842 --> 00:37:42,193
♪♪ Just give me
A little more time
776
00:37:42,368 --> 00:37:44,935
♪♪ Give me a little bit
Of warning
777
00:37:45,109 --> 00:37:46,110
♪♪ Baby, I'm gonna be fine
778
00:37:46,285 --> 00:37:48,025
I'm selling them my share
of the business.
779
00:37:48,199 --> 00:37:51,768
♪♪ When I figure out
Where I'm going
780
00:37:51,942 --> 00:37:54,205
Is... Is there something else
you want to do?
781
00:37:54,380 --> 00:37:55,816
♪♪ Why can't
You just tell me
782
00:37:55,990 --> 00:37:56,991
Yes.
783
00:37:57,165 --> 00:37:59,385
♪♪ What you're doing here?
784
00:37:59,559 --> 00:38:00,690
I want to be
your husband.
785
00:38:04,128 --> 00:38:08,611
♪♪ Don't be cruel,
If you're leaving me
786
00:38:08,785 --> 00:38:12,615
I realized I was so...
787
00:38:12,789 --> 00:38:17,925
Afraid of losing you
in the future...
788
00:38:18,099 --> 00:38:19,056
I was losing you now.
789
00:38:19,230 --> 00:38:21,450
[SNIFFLES]
790
00:38:21,624 --> 00:38:24,627
♪♪ Give me one more second
To dry my eyes
791
00:38:24,801 --> 00:38:27,369
♪♪ Give me one more day
To realize
792
00:38:27,543 --> 00:38:30,677
♪♪ Smoke's in our eyes
Or in the distance
793
00:38:30,851 --> 00:38:33,332
♪♪ Either way,
We're gonna miss it
794
00:38:33,506 --> 00:38:35,899
♪♪ Give me one more year
To get back on track
795
00:38:36,073 --> 00:38:38,946
♪♪ Give me one more life
To win you back
796
00:38:39,120 --> 00:38:42,253
♪♪ Smoke's in our eyes
Or in the distance
797
00:38:42,428 --> 00:38:46,780
♪♪ Either way,
We're gonna miss it
798
00:38:46,954 --> 00:38:49,130
Sorry.
799
00:38:49,304 --> 00:38:51,001
I hear your VC contact
decided to quit the business.
800
00:38:54,265 --> 00:38:55,397
He did the right thing.
801
00:39:00,010 --> 00:39:02,491
♪♪ Baby, don't lie to me
802
00:39:02,665 --> 00:39:05,581
You know...
803
00:39:05,755 --> 00:39:08,454
My feet
are killing me.
804
00:39:08,628 --> 00:39:11,892
♪♪ If it ain't me, come on
805
00:39:12,066 --> 00:39:15,417
♪♪ Just give me
A little more time
806
00:39:15,591 --> 00:39:17,854
♪♪ Give me a little bit
Of warning
807
00:39:18,028 --> 00:39:20,640
♪♪ Baby, I'm gonna be fine
808
00:39:20,814 --> 00:39:22,293
♪♪ When I figure out where
809
00:39:22,468 --> 00:39:25,427
♪♪ Give me one more second
To dry my eyes
810
00:39:25,601 --> 00:39:28,038
♪♪ Give me one more day
To realize
811
00:39:28,212 --> 00:39:31,041
♪♪ Smoke's in our eyes
Or in the distance
812
00:39:31,215 --> 00:39:33,696
I'm open.
To being friends.
813
00:39:33,870 --> 00:39:35,176
That's great.
814
00:39:35,350 --> 00:39:38,440
I'm open, too,
to wherever this goes.
815
00:39:38,614 --> 00:39:41,138
It's going
to friendship.
816
00:39:41,312 --> 00:39:42,966
Understood.
817
00:39:43,140 --> 00:39:44,577
But life is
about change,
818
00:39:44,751 --> 00:39:46,274
which means, one day,
you might change your mind.
819
00:39:46,448 --> 00:39:48,232
And if you did,
I'd be open to that, too.
820
00:39:48,407 --> 00:39:49,756
It's not gonna happen.
821
00:39:53,107 --> 00:39:53,847
Okay.
822
00:39:58,329 --> 00:39:59,766
[SIGHS]
823
00:40:15,129 --> 00:40:17,218
First, there should be
no soap involved.
824
00:40:17,392 --> 00:40:19,350
Also, we need to stay
at one end of the shower,
825
00:40:19,525 --> 00:40:22,049
so we don't accidentally knock
into the temperature control.
826
00:40:22,223 --> 00:40:25,269
What changed
your mind?
827
00:40:25,444 --> 00:40:28,316
I've been thinking about
change over time.
828
00:40:28,490 --> 00:40:30,100
I spoke with people
and also graphed
829
00:40:30,274 --> 00:40:31,580
several possibilities
for us,
830
00:40:31,754 --> 00:40:33,234
using time as
the horizontal axis
831
00:40:33,408 --> 00:40:34,801
and change as
the vertical.
832
00:40:34,975 --> 00:40:38,065
I realized that the problem
isn't really change.
833
00:40:38,239 --> 00:40:42,112
It's whether two people change
in the same direction.
834
00:40:42,286 --> 00:40:43,940
We want to keep
our coordinates
close to each other
835
00:40:44,114 --> 00:40:47,030
for the rest
of our lives.
836
00:40:47,204 --> 00:40:50,120
We certainly do.
837
00:40:50,294 --> 00:40:52,993
But people sometimes
do drift apart.
838
00:40:53,167 --> 00:40:54,647
Yes.
839
00:40:54,821 --> 00:40:56,475
You need a warning
when you and your partner
840
00:40:56,649 --> 00:40:58,346
might be starting
to veer off,
841
00:40:58,520 --> 00:41:00,130
so you can both
change course a little.
842
00:41:00,304 --> 00:41:01,958
You don't want
a surprise realization
when it's too late.
843
00:41:02,132 --> 00:41:03,786
Surprises are awful.
844
00:41:03,960 --> 00:41:06,528
The U.S. Army Signal Corps
used flags to warn
of hurricanes.
845
00:41:06,702 --> 00:41:08,530
I brought us this.
846
00:41:08,704 --> 00:41:11,620
[CHUCKLES]
A cowbell?
847
00:41:11,794 --> 00:41:14,710
If you see us heading
in different directions,
848
00:41:14,884 --> 00:41:16,233
you ring it.
849
00:41:16,407 --> 00:41:18,322
Do we really need a bell?
Can't I just tell you?
850
00:41:18,497 --> 00:41:20,020
[BELL CLANGS]
851
00:41:20,194 --> 00:41:21,935
Oh! When you ring it,
I'll pay attention.
852
00:41:22,109 --> 00:41:23,284
I really hate
the sound.
853
00:41:23,458 --> 00:41:27,244
Only in emergencies.
854
00:41:27,418 --> 00:41:31,466
I've already moved
the shampoo bottles.
855
00:41:31,640 --> 00:41:33,337
What?
856
00:41:33,512 --> 00:41:34,991
♪♪ Give me one more second
to dry my eyes
857
00:41:35,165 --> 00:41:36,210
Oh.
858
00:41:36,384 --> 00:41:38,386
You mean now?
859
00:41:38,560 --> 00:41:41,868
♪♪ Smoke's in our eyes
Or in the distance
860
00:41:42,042 --> 00:41:43,783
Don't worry about putting
the bottles back.
861
00:41:43,957 --> 00:41:44,958
I'll do it later.
862
00:41:45,132 --> 00:41:46,046
[LAUGHS]
863
00:41:46,220 --> 00:41:48,309
I love you.
864
00:41:48,483 --> 00:41:51,138
It's no trouble.
I remember where they all go.
865
00:41:51,312 --> 00:41:53,401
♪♪ Smoke's in our eyes
Or in the distance
866
00:41:53,575 --> 00:41:55,838
♪♪ Either way,
We're gonna miss it
867
00:41:58,232 --> 00:41:59,668
[CAR ALARM BEEPS]
868
00:41:59,842 --> 00:42:01,409
♪♪ Give me one more second
To dry my eyes
869
00:42:01,583 --> 00:42:04,412
♪♪ Give me one more day
To realize
870
00:42:04,586 --> 00:42:07,676
♪♪ Smoke's in our eyes
Or in the distance
871
00:42:07,850 --> 00:42:10,549
♪♪ Either way,
We're gonna miss it
872
00:42:10,723 --> 00:42:13,290
♪♪ Give me one more year
To get back on track
873
00:42:13,464 --> 00:42:16,337
♪♪ Give me one more life
To win you back
874
00:42:16,511 --> 00:42:19,558
♪♪ Smoke's in our eyes
Or in the distance
875
00:42:19,732 --> 00:42:21,734
♪♪ Either way,
We're gonna miss it
876
00:42:27,217 --> 00:42:28,392
♪♪ When it's gone ♪♪
61017
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