All language subtitles for VICE S05E20 Autism Under the Lens

This week on Vice:

groundbreaking innovations
in managing autism.

Hey! Hey, Rey!

They're trying to shut down channels

'cause the world is really overwhelming.

I just can't take it.

It really was like somebody
had turned off a switch.

It was as if he was
looking right through me.

So, in our lifetimes,
will a child with autism

be able to walk into the hospital,

and walk out without autistic behaviors?

For some of them, I... I
believe this is totally possible.

Go, go, go!

We are not animals!

Autism spectrum diagnoses

have been on a steep
rise in recent years.

In fact, according to the CDC,

one in 68 American children born today

has autism in some form.

Now because of this,
the scientific community

is marshaling major resources
to figure out the origins

of the condition and how to treat it.

Back and dinosaur story! Four! Five...

We're in front of the Rebecca School

in the middle of Midtown Manhattan.

And we're here to meet some kids,

all different ages, who all have autism.

One, two! One, two, three, four!

♪ If your name is Colin, ♪

♪ get up and do a dance ♪

♪ If your name is Colin ♪

♪ Get up and do a dance ♪

♪ Run, run, run back to your seat ♪

♪ And give someone else a chance ♪

What's the experience of
being in this classroom

or being on the street
for these children?

Most of these kids don't have

an integrated sense of the world,

so it's a fractured experience.

So, you wonder why kids walk around
with their fingers in their ears...

- Mm-hmm.
- ... or they cover their eyes, or...

It's because they're
trying to shut down channels

'cause the world is really overwhelming.

If you don't know what
the important data is,

everything might be important.

So, a car horn might actually be

the thing you have to pay attention to.

Or the humming of a light bulb

might be the thing you
have to pay attention to.

If you can't figure
out what's important,

you have to pay attention to everything.

- I can't see!
- I can't see!

Oh! Oh, hey! Hey!

- Hey, Rey!
- What?

- Look!
- Do I sit over here?

No, no, no, no. Look.

- You seen this?
- Over here!

No, these!

- Look.
- Who are these people?

I actually have no idea.

Sol is one of those guys

who is always regulated up here.

Everything happens quickly.

What he doesn't have a chance to do

is really process what
he's gonna put back out.

I can't believe I
need to be on the show.

What would your show be called, Sol?

I have no idea.

What would it be called?

Have you seen the movie called
Kubo and the Two Strings?

I haven't seen that movie.

What about Iron Man 3?

Oh, yeah. That's a good one.

Did you see that movie?

I did. Did you?

- Yes!
- The movie guru.

I'm not movie guru!

Like the expert.

I am not a mo...

I am not an expert, okay?

Don't call me that!

- I just can't take it.
- I know you can't take it.

_

Can you please help me? I'm stuck.

Are you ready? Grab on, grab on.

Grab on, grab on.

Grab on.

You're free.

Oh. Way to go.

Thank you! You did it!

Man, you did so great!

Thank you for letting me out.

You're welcome.

Autism Spectrum Disorder,

or ASD,

has seen a 3,000 percent
increase in diagnoses

in the last 30 years.

You can't talk about
autism as a disease.

It's many, many different things,

and it's a range within
each of those things.

We sat down with Dr.
Jeremy Veenstra-Vanderweele,

or Dr. V, a psychiatrist
at Columbia University,

where he devotes most of his time

to pursuing new treatments for autism.

Autism Spectrum Disorder captures

difficulties with social communication,

and restricted repetitive behaviors

that sometimes have
this sensory quality,

that when they are
occurring in the same person,

can be approached with
common assessments.

Why has there been an
increase in identified cases?

So, we don't completely know.

And I mean, that's one of the
things about being in science...

that you have to admit when you
don't have complete knowledge.

Honestly, I think part of the
increase is a real increase.

And that may be

kids who are surviving
neonatal intensive care units...

- Hmm.
- ... who wouldn't have,

- Wow.
- 20, 30 years ago.

We know that those
kids are at higher risk.

It may be things like,
uh, advanced paternal age,

which we know is a risk factor.

Uh, some of it is a decrease in stigma.

So, when I first started
sitting in with people,

families didn't want to hear autism.

- Mm.
- They wanted to hear anything but autism.

And now because people understand

that early intervention can
make a substantial difference,

families are more willing to hear it,

and more likely to
hear it for that reason.

Griffin! Good morning!

Griffin Jaccoma was diagnosed
with autism five years ago

at the Center for Autism
and the Developing Brain,

where Dr. V treats children with ASD.

Come. Let's go. Let's wash up.

No?

Come on, let's go have some breakfast.

It's okay.

Look up. Ready.

What do you want to do, bubbles?

No. We're not standing.

Okay, lift up.

Wanna brush your teeth?

Let me see the bottom.

Yeah! Good job.

What's wrong?

You know what we can do?
We can go outside later.

Would you like to go outside?

Here's your talker.

Okay.

What do you want?

- Bagels.
- Oh, great.

What would take a
typical family 10 minutes,

it takes us 45 minutes.

You know, and so, these
kind of things are difficult,

but it's getting better.

You know, at least now he can
put his head through his shirt,

which may not seem like a
big deal to a typical family,

but to an autistic child

it's like, you know,

trying to have an 8-year-old,
7-year-old do algebra.

It's incredibly difficult.

Watch this. This is sort of fun.

Wanna play ball?

- All the sounds and all this vibration.
- Yeah.

And he's like in heaven now with that.

He's got the sunshine.

- He's got his Ring Pop.
- Yeah.

When did you first see signs

that something was
different about Griffin?

For me, it really was like
somebody had turned off a switch.

I left the house one morning,
and I came back after work,

and I went to have an
exchange with my child,

and, um, it was as if he
was looking right through me.

From that point, I really knew
that something was not right.

A friend encouraged me
to go and have him tested,

because she had had
challenges with her own son,

and I took her advice, and I'm...

I thank God that I did.

The first signs of autism
can be terrifying for parents,

but they can also vary greatly
from one child to the next.

Griffin was diagnosed at age two

by the Autism Diagnostic
Observation Schedule,

or ADOS,

which involves therapists observing

and scoring different behaviors,

and sets a numeric threshold,

for an autism diagnosis.

Standardized tests, like ADOS,

have created more reliable
and earlier autism diagnoses,

better assessment
methods are a key reason

for the rise in autism cases.

And that rise is pushing
the scientific community

to develop a whole new set of
ways to treat the condition.

Angry. Surprised.

Sad.

- Scared.
- Good.

The Autism Glass Project

is one effort from the tech sector

that builds on Google's technology

to teach children with ASD

how to perceive basic emotion,

they often miss in social interactions.

Autism Glass uses
artificial intelligence

to analyze facial expressions,

and then visually and
verbally describes the emotion.

- Happy.
- Good.

We went to Stanford University

to meet its creator, Catalin Voss.

What's running behind us
is a computer vision system

that recognizes emotions.

It's based on a face tracker

that tracks up to 100 fiducial
points within your face,

and then use a machine
learning classifier

to predict whether you're happy

or sad or something like that.

So this is, essentially,

how you developed Autism Glass.

Yeah, exactly.

I was working on, you know,

emotion recognition and
face tracking software.

And we realized, "Hey!

"This could help people who struggle

to identify social cues."

You know, we're spending time

building software
that can teach machines

how to recognize emotions.

There happen to be people

who struggle to identify
social cues in people's faces.

The Glass Project is focusing
on these fundamental emotions

that everybody must know, must learn.

Kids with autism don't
necessarily look to faces.

They're not getting
those neurons developed,

those layers of the onion peeled back

so they can proceed

into more complex social
scenarios on their own.

Why was it so important
to create a device

that parents could take home with them

as opposed to use in a therapy session?

It creates these opportunities
for natural engagements

between parent and child,
care provider and the child,

in ways that we almost
didn't initially anticipate.

Moms and Dads of children with autism

are, by far, the best
suited to teach their kids.

The changes that I have seen...

night and day differences!

Sarah, you're up! Dice!

I mean, almost immediately,

I would tell her, "Hey, can you
look at me?" and she'd look at me.

Before... short answers.

"Yeah, I'm fine." After...

she was able to have
confidence to speak back

without feeling like...

what she was gonna say was wrong.

And now she actually will
have a conversation with us.

That's so priceless.

Autism Glass could provide
much-needed relief to families,

and several other promising
experimental treatments

are already well under
way in clinical studies.

Harvard neurologist,
Dr. Alvaro Pascual-Leone

pioneered a technique called

Trans-Cranial Magnetic Stimulation,

or TMS.

TMS is a way to inject
current in the brain

without having to do surgery
and open up the skull.

A coil of wire outside the
head generates a magnetic field,

and that magnetic field
reaches the brain unimpeded.

It makes those cells that are targeted

fire in a different way.

It can either make them fire more

or be suppressed for
some period of time.

And that allows us

to figure out what causal role

a given brain area has
for a given behavior.

So, we're gonna go
into the TMS room here.

At Bradley Hospital,
Dr. Lindsay Oberman,

performs a TMS procedure
on 16-year-old Evan Theilig,

a high school student at
the high-functioning end

of the autism spectrum.

Help us to understand
what's going on in your mind

in, uh, in a social situation.

Every... like, if... well,
every time I ask a question,

I, like, before, like,
talking, I ask myself,

do I really care about
the outcome of this?

Like if... if I asked if someone...

if someone's having a good day or not,

do I actually care
whether they say yes or no?

Is it kind of like you over-analyze

what could be a very simple question

- that would start a conversation?
- Always.

It works great with math,

because you can... there's only...

there's, like, a logical limit

to how much you can over-analyze

before you already
have the answer, but...

with an English class,
since... I have...

you'd have to... I'd have to...

Like the assignment, like
the book that we were...

not book, but, like, the play
we were, like, looking at,

was the, uh, The Crucible.
Have you heard of that?

Yeah.

Yeah, I was having... have a, uh,

hard time reading, like,
reading it, because...

I guess the person who put it
in the, uh, the uh, textbook

didn't know the first thing
about actual formatting.

So, they used, like,
a stupid Serif font.

So I couldn't really get over that.

I'm gonna adjust this so that

it's comfortable for you, all right?

I believe you.

The brain is influenced
by everything we do...

by every experience we have,

by every thought we have,

by every action we take.

The concept of plasticity

is the idea that the brain
intrinsically is changing,

is modified by experience.

But also because of plasticity,

we may develop symptoms of disease.

If you have a more plastic brain,

well, you should be able
to acquire skills quicker,

to learn things faster.

But if you're influenced too
much by the experiences you have,

you run into this chain reaction

where the brain becomes
progressively noisy,

rather than progressively
better structured.

The benefits of TMS vary
greatly between participants,

but it's already shown
some extraordinary results.

One of Dr. Pascual-Leone's first
participants was John Robison,

who credits TMS with changing his life.

They were gonna do a
half-hour stimulation

and the effects would
last about half that long.

And they kept me there
another half hour or so

to make I didn't, like, just roll over

and die after the experiment.

And then they let me loose.

And... and I pulled
out onto the highway,

and I turned on the music.

I could hear every individual voice,

all the singers and the chorus.

I could hear each instrument.

I could... I could all see them
in my mind moving around the stage.

It was like I was
transported from the car

right into the concert.

And it was just, uh, just staggering.

And it was just so overwhelming,

it made me cry all the way home.

And I... I wrote the doctors,

I said, "That's some powerful mojo

you guys have in that thing."

After a series of TMS sessions,

Robison, like a number of others,

was able to gain a cognitive perspective

that has greatly broadened his ability

to read and recognize emotions.

Imagine that you are
a color-blind person,

and all your life,

you listen to people talk
about the beautiful blue sky,

and the pretty red dress,

and the deep green lawn.

And, um, and you saw the world
in different shades of gray,

and you... you looked
at that, and you said,

"This is bullshit.
They're just baiting me."

And imagine you go
into a scientists' lab,

and they do something to you

and they turn on color and you walk out,

and you say, "Holy shit. This is real.

They weren't lying to me.

I see that blue sky,

and I, now, I see the green lawn,

and... and... that must be
a... a red dress she has,

and a blue shirt, and a yellow shirt.

And they are beautiful."

And then it fades away.

But you know what, for
the rest of your life,

you're gonna know that was real,

and you're gonna
always react differently

than the day before it happened.

You'll never go back.

While emerging therapies
are already showing results,

many scientists believe that focusing

on the underlying
biology of the condition

will lead to the most
transformative treatments.

So far, scientists have discovered

hundreds of genes implicated in ASD,

and researchers are
tracking their effects

in an unexpected place.

We're headed toward Monkey Island,

which is just right off
the mainland of Puerto Rico.

There are over 1500 monkeys
that are roaming freely there.

The rhesus monkeys of Cayo Santiago

descend from an original colony

brought over from India
for research in 1938.

Today, the world's first
wild primate research facility

has become a genetics goldmine

for scientists studying autism.

What we've got here is

a kind of variation in behavior

that would be very
difficult to approximate

in any other kind of place.

Dr. Michael Platt is a neuroscientist

at the University of Pennsylvania.

He and his research team study

how the genetic makeup of each macaque

leads to unique behavioral traits.

How do you match genetics to behavior?

Each animal is unique in
the genes that they possess.

We are extracting DNA.

We then decode the
genome of these animals,

and then, at the same time,

we are doing intensive
behavioral observations.

If we can decode those genes,
and we can find those monkeys,

we can track, say, the
behavior of an animal

who's carrying a certain set of genes

that we think might be implicated

in various disorders like autism.

We can see whether their behavior is

systematically different
than other monkeys.

Now, we've identified
a few of the monkeys

who possess variance
in the number of genes

that the rest of the
population does not,

and these monkeys tend to
not fit in well in societies.

Behind us, sitting in this tree,

is a female named 42-L.

She tends to live on
the outskirts of groups.

She's never really fit in.

Uh, she has a daughter

who has also had difficulty
fitting into groups.

And the two of them both share

a variance in a number of genes

that we don't see in the
rest of the population,

and these genes have been implicated

in studies of autism in people.

Ultimately, to really
test it experimentally,

you would have to manipulate that gene

and demonstrate that you had

an effect on behavior...

- Mmm.
- ... down the line.

But now, there are efforts

to use very, you know, cutting-edge

techniques to actually
genetically alter these animals.

Scientists have been modifying
genes for some time now.

But the technology took
a giant leap forward

with the advent of CRISPR,

which allows them to actually
cut and paste genetic information

with pinpoint accuracy.

At MIT, Dr. Guoping Feng

is studying one of the more common genes

Shank3.

Shank3 is a very important gene

for developing
neuron-neuron connections.

If neuron do not connect properly,

the brain cannot function normally.

Clinical scientists discovered
that deletion of this gene

is linked directly to
Autism Spectrum Disorders.

In what ways are you using
CRISPR technology today?

CRISPR allows you to do

any kind of genetic mutations.

So, we can put in the human mutation

into that animal model to
mimic the human condition.

If you put two mice
together, normal mice,

they will immediately find each other...

sniffing, cuddling.

But if you put two Shank3
mutant mice together,

when they're getting
close to each other,

they will suddenly separate.

If we put a toy into their cages,

normal mice, then they
will go play with it.

They even will get on top of it.

Mutant mice, they
were suddenly startled.

They never will touch it.

They have a very hyper-sensitivity

of their whisker
system, which is their...

one of their primary sensory organs.

Dr. Feng observes

how the mice's outward behavior changes

and how the gene affects the
brain at the cellular level.

But he has goals beyond understanding

the mechanisms that cause autism.

How will this translate to
creating treatments for humans?

You can imagine people are very excited

about using CRISPR to
correct the mutations.

If we know the mutation,

now you supply a normal
copy of DNA template,

then that normal copy will go in

and replace the mutant.

Now, you correct the mutation.

Basically, you permanently
corrected the problem.

That's called a cure.

So, in our lifetimes,
will a child with autism

be able to walk into the hospital

for gene therapy,

and walk out without autistic behaviors?

For some of them, I... I
believe this is totally possible.

For many families, a cure for autism

is their greatest hope.

But a growing number of advocates,

within the autistic
community, think differently.

Autistic rights are human rights!

These voices call upon
the scientific community

to recognize neurological differences

as part of natural human diversity,

not as medical afflictions
that must be eradicated.

In 2010,

NIH spent about $217
million on autism research.

Of that, only one and a half percent

went towards research on
autistic adults and our needs.

I believe this is a civil rights issue,

and I believe that the
United States of America

can guarantee the civil
rights of all of its citizens.

One of those self-advocates
is John Robison.

Long before his autism diagnosis

and TMS treatment,

Robison had a successful
career as an audio engineer.

I got to working for, uh...

Pink Floyd's sound
company, Britannia Row.

And, um, this is one of the
bass amps from our system.

It's still got the old markings.

Pink Floyd Mark III amplifier.

Rock and roll relics now, anyway.

This was, uh, this was me with KISS.

♪ I wanna rock and roll all night ♪

So I built a bunch of stuff

for the 1980 KISS tour.

Really, every guitar in those years

that shot fire, shot rockets,

blew up, if it... if
it did something wild,

we kinda made it.

Sometimes people look
at me, and they think,

"Oh, well, Robison,
he's just a natural-born

electronic genius or something"

but that's not true.

What happened was,

I was rejected by people,

and I was, I felt,
accepted by electronics.

And... and I dropped out of school,

and I spent 10, 12, 15 hours
a day studying electronics,

and by the time I was 18 years old,

that was, you know, thousands
and thousands of hours.

So, the autism was the thing
that really hurt me as a boy,

but it also gave me my freedom.

Now Robison owns an auto repair shop

for luxury cars,

which he uses to run a mechanics school

for students with
developmental disabilities.

All this leather paneling
and woodwork and all?

All this is gonna come out.

We're gonna put racing seats in.

It's gonna be completely
gutted and bare.

It's gonna be a race car inside.

And while he credits TMS

for giving him the
social skills necessary

to be a public advocate
for the autistic community,

he lectures about the
benefits of neuro diversity.

What is neuro diversity?

Neuro diversity is the recognition

that there is a range of
neurological difference

that is a part of humanity.

We could take any other population.

We could take the Jewish population,

the Native American population,

the white male population,

and within that group,

we could find some people

who are really
intellectually challenged,

and some people who
are brilliant geniuses,

and most people who
are somewhere between.

And autistic people are the same.

We have some significant challenges,

but we have some significant gifts,

and it's time to move beyond the model

of autistic people as broken normals

and recognize us as what we are.

Thanks to this community activity,

we have scientists
coming out of the closet.

For us, this is like gay
rights in the '60s and '70s.

We now have scientists
that stand up and say,

"I'm autistic and I'm proud of it.

And I'm gonna help autistic people

because of my difference.

Not in spite of it, but because of it."

What advocates like
Robison are asking for,

is not to wipe autism off the map,

but to focus on developing solutions

for patients' day-to-day needs.

Where do you hope autism
research goes from here?

We need to shift towards
delivering benefit to us today.

And it's great to think
that we can head off

really profound disability
at some far future date,

but we have the ability
to solve problems right now

if we deploy the resources to do it.

And that's what I push scientists to do.

There are people with autism

who can speak for themselves,

and say what would improve their lives,

and I think we need to listen to that.

And I think we need to
think about ways to help.

At the same time, I work with a
lot of people who can't say that,

who can't speak up for themselves

and say what they would like.

What we have to do then is
to listen to their families,

and also, imagine
ourselves in their shoes

and what would improve their lives.

Ultimately that, at this point, means

research based in biology,

trying to understand what's
happening that leads to autism risk,

what we can do to lead
to better outcomes,

not just for people who are
able to speak for themselves.

Ten years ago, we have no
clue what causes autism,

now we have many genes to work on.

My feeling is that in
the next 10 to 15 years,

we will have some much
better treatment...

for the drug treatment, for
can cure some of the symptoms.

It's a still long way,

but I think the progress
is actually incredible.