Original subtitles

All known organisms are made up of cells.

Humans, of course, have lots of them.

Our skin, organs, bones... They are made of them.

Each cell has a nucleus at its center.

Inside they carry a map of each part of our body.

This is DNA, genes.

And there are many more things within each cell.

Every part of it, like the nucleus...

... has its own DNA.

Its name is: Mitochondria.

The main function of these Mitochondria...

... is the creation of energy.

But why are the Mitochondria here?

They have their own genes...

so they are also organisms.

Parasites-

A type of life form that invades our cells.

(Parasitism)

Mariko! Mariko!

Now...

We will see something very strange.

Humans inherit properties such as character or appearance.

But the Mitochondria are only transmitted by the mother.

The Mitochondria that each one of you carries in your body...

All of them come from your mothers.

So in the DNA of each Mitochondria...

the mothers of all of us are reflected.

We have discovered who was the Eve of mythology.

Let's go back about 200,000 years to a distant past.

We are in Africa.

It was here that Eve appeared.

The first human, the first woman to carry Mitochondria.

We call her: «Mitochondria Eve».

Why did you stop coming here?

I already explained it to you...

You have to come three times each week...

to take out everything your body does not need.

Yes... but I'm fed up.

In this school...

we study the inside of our bodies...

to understand how medicines work.

You can wash your hands and send the germs down the drain.

But the real fight against germs is inside you.

There are many types of tiny things living inside of us.

No way ...

That's so gross!

Yes, but I've already told you about the immune system...

Get that out of your head.

I don't believe it!

You can digest food only because there are bacteria in your intestines.

Yuck!

Hey! A snail!

Everyone, do you want me to tell you a cool story?

What story?

About the bugs inside the snail.

Again?

They make the shell of the snail hard.

So, in principle, they are good for the snail.

With a harder shell they can live longer.

But when the snail becomes big...

the bugs climb up to their horns.

Why?

Usually...

the snails prefer dark places, but now they come out with the sun.

The bugs make the horns swell...

and control them so that they can wiggle.

Why do they do that?

Only the birds of the sky know.

The horns look like an insect...

that the birds love to eat.

So...

What the bugs really want...

is to be able to get deep inside the stomach of the birds.

They make the birds eat the snail.

That's horrible!!

We finished the science class for today!

It's time to leave.

Has everything been clear?

Are we safe?

We have lots of germs living inside of us, right?

And will they also control us...

when we become older?

Do not worry.

We are superior beings, with a more complex way of life.

Come on!

We have had parasites, like microbes...

for a billion years.

But at this moment they have become something vital for us.

We move, we think..., all thanks to the Mitochondria.

The two parties have decided to live together in symbiosis.

Symbiosis -

Teacher!

Yes?

For us... is there some value...

the study of this Mitochondria?

We already know what anomalies are in the DNA of the Mitochondria...

They occur in cases such as Diabetes or Cirrhosis.

So, we can say that diseases are like energy losses.

Healthy mitochondria could grow and enter the dead cells.

Once the cellular activity is restored, this anomaly could be corrected.

This is what my study is based on.

Let's see some Mitochondria!

Thank you.

I still can not go home, I still have work to do.

And you can't postpone it?

I have to deliver this data.

We still work only with animals.

But very soon we could be ready to help the sick.

Oh! No!

You forgot...

Our...

First...

Anniversary.

I bought you a gift...

I feel stupid.

Don't worry, I half expected it.

I'm sorry.

See you soon...

Don't look at me like that!

Work hard.

I will leave as soon as possible!

I've been waiting for you for so long...

What wrong?

Nothing.

How was the conference, Doctor?

Very well, I think...

I have tried with this concentrate.

And what have you learned?

It is a tinted gel.

I agree.

Dr. Nagashima! The rat livers are improving!

The healthy cells that we introduced last week...

they have reversed atrophy.

These are from the last week.

At last!

Cultivate these cells and monitor the mitochondria.

Nagashima!

Do not make Miss Asakura work too hard.

She has to submit a project next month.

All right, sir.

There's no problem

I learn a lot by helping Prof. Nagashima.

I understand why you are so excited about mitochondria.

There must be so much to discover...

- Excuse us. - With your permission...

The Mitochondria have every time...

a different way of life, right? Like bacteria.

Yeah, so what?

The children were asking me...

if one day they could take control of a human body.

There is a theory that says...

Mitochondria do not have enough DNA to live by themselves.

But some can be transferred outside the nucleus.

Which means that some of the core genes...

... are associated with the Mitochondria.

Very good, but...

Have you become worried about the mitochondria?

«CULTIVATION OF LIVER CELLS».

Dr. Nagashima!

Are you a relative of Kiyomi Nagashima?

How is she...?

Very badly injured.

Will she recover from this?

She is suffering respiratory arrest due to a stroke.

They are operating now.

Please... Notify the rest of the family.

You are her husband, right?

Yes.

There was a massive cerebral hemorrhage.

We operated on her as soon as she arrived.

We have put her on assisted breathing.

She can not breathe on her own.

We have run tests with high doses of stimulants.

There is loss of brain activity...

and damage to her spine.

What are the chances of her coming out of the coma?

Sorry to tell you this...

but she is on the verge of brain death.

It's me...

Can you hear me?

Kiyomi.

You have to wake up!

Today is a great day...

Our first...

Toshiaki!

Kiyomi...

It's still early for you to leave us, like your mother...

This is the brain activity tonight.

This is six hours later.

All the tests are negative.

Her brain has stopped working.

It's definitive... she's clinically dead.

Mr. Nagashima.

This is Miss Odagiri, coordinator of transplants.

How are you?

Kyomi registered her kidneys as organs for transplant.

Transplants?

Kyomi was registered in the donor bank.

Did you know?

She registered about six months ago... almost without thinking.

Her kidney can save a patient with chronic kidney failure.

Unfortunately...

There is no kind of cure for that state.

The patient must undergo dialysis on a regular basis.

I assure you that your wife's kidney will go to a good cause.

I think we should respect her will...

if that's what she wanted...

Are you her father?

Could you sign for family consent in this document?

Could we, at least...

study if there is any incompatibility?

We have a possible kidney donor in the city.

A 25-year-old woman, brain dead from hemorrhage.

I compared the results of your HLA...

looking for a compatible receiver.

Your patient tops the list.

I understand.

There is no other possible receiver.

Can I make the request?

Sure, please...

I need some time.

The family has not yet agreed.

Which hospital is it?

Nurse...

Does this mean that Kiyomi is dead?

I come to beg you to allow the transplant.

His wife's compatibility tests have found a receiver.

Mr. Nagashima.

Mr. Nagashima, I understand how you feel...

but this was her last will.

The kidney is not going to be wasted.

Please, free the patient from her suffering.

She is a 12 year old girl.

Yoshizumi, from the Central Hospital.

Doctor, I'll take care of this.

Please, let us use that kidney.

Please Doctor... This goes against the rules!

She's just a little girl!

I want to cure her and let her live! Mr. Nagashima!

Mr. Nagashima!

Doctor!

Just listen to me! Please!

Mr. Nagashima!

Give it to me! I beg you!

I've already disappointed that girl before.

Two years ago, I did another kidney transplant.

I thought everything had gone well...

but in the end her body rejected it.

The girl trusted me...

and I failed.

Please!

Give me another chance!

Kiyomi is alive.

Kiyomi... she is not dead.

She is still alive!

Ok, I accept.

Really?

But with one condition...

I will give you the kidney if in exchange you give me the liver.

For what?

I'm not a doctor...

so I can't do the operation myself.

So, you will extract it and give it to me.

But...

What do you intend to do with it?

Mariko...

Mariko...

Can you trust me one more time?

Her heart has stopped.

11:31 a. m.

Time of death confirmed.

I could not do anything to save her.

We will start the operation now.

I beg you...

Please, Doctor...

What's going on here?

Hurry up.

33 minutes after death.

12:04 p.m.

Let's start the extraction.

Merry Christmas!

Take it ... next.

Give me two, please.

Here you go...

Two.

Today is my birthday... so give me two.

Really?

Kataoka... Kiyomi?

It is the same symbol as to write «Christmas Eve».

Happy Birthday.

Only one?

Give me a break!

What is it?

The students in the lab are nagging me.

They say...

I should do something to not let you escape.

Is that right...

Perhaps I might escape.

"I ..."

was waiting so long for you ...

I, too...

Since the first time...

that I saw you...

waited so long.

Let's get them out.

Something happened?

Nothing...

It's hot...

Your daughter will be fine.

We will prepare everything.

The doctor will arrive right away.

Doctor... what are you doing?

Doctor!

What's going on?

Extracting the liver.

We are not here for that!

No time to lose!

Quiet!

Wait here.

Here is your wife's liver.

Mr. Nagashima!

And what about the body of your wife?

Is everything alright?

Would you mind leaving me?

Get out of here!

Shouldn't you be with your wife?

Kiyomi... is here.

Time since the donor's death: 123 minutes.

69 minutes from extraction.

I am undertaking the transplant.

Time: 1:34 p.m.

The kidney...

Mariko...

We are taking her to a sterile room. Do not worry.

Everything went well.

Doctor!

This time... everything has gone great.

Thank you.

Kiyomi... Kiyomi...

We had not seen her so happy for many years.

They don't know how much I appreciate it...

... the people who donated it.

Doctor! It's Mariko ...!

Mariko... what's the matter with you?

It was just a dream.

It was not a dream!

It was just a nightmare, Mariko!

It was not a dream!

Everything will be fine... the Doctor is already here.

Calm down, Mariko...

Underneath!

It's calling out!

It's in my stomach!

Doctor, quickly take it out!

Quick! Take it out!

Quickly, take it out!

Mariko, Mariko!

The operation was a success!

There is nothing to worry about.

Be brave, Mariko...

You're fine... You're fine, Mariko...

That's right, Kiyomi...

Come on...

These are cells of the new kidney...

expanded 16,000 times.

What do you think about this?

I've never seen a Mitochondria like this.

The mitochondria ...

they are three times bigger...

... compared to their usual size.

Also... there is a greater amount.

And they are reproducing much faster every day.

We took this after the operation...

and it seemed very strange.

You gave the donor's liver to her husband, right?

What about it?

What is this, Kiyomi?

Kiyomi...

Kiyomi?

Can we talk about my project?

I am very busy.

Is there something about your wife...?

What do you think I know?

The cells of the kidney are growing like crazy!

Mr. Nagashima.

Nagashima, what happened to the liver?

What did you do with it?

Kiyomi is alive.

Do you think...

What was going to stop me while she was dying?

You will not be growing those cells, right?

No one else would have had to watch her die.

But...

I've found a way to keep Kiyomi alive.

But what's wrong with you?

Why are you cultivating your own wife's cells?

Each and every one of those cells...

... it's Kiyomi.

Are you crazy!

You kept Kiyomi alive until you transplanted the kidney...

to your patient.

And I made her live again by growing her cells.

What is the difference?

«The stimulation of peroxisomal enzymes springs...

from unsaturated fatty acids of the Mitochondria...

from the livers of rats ».

«The stimulation of peroxisomal enzymes springs...

«The stimulation of peroxisomal enzymes springs... from unsaturated fatty acids...

«... from the fatty acids of the Mitochondria... »

«... the fatty acids of the Mitochondria... »

«... from the fatty acids of the Mitochondria... »

«The stimulation of peroxisomal enzymes ... »

Eve: Liver-Cell Culturing

... the Kiyomi preparation ...

Kiyomi has spoken to me.

To ... shi ... a ... ki

Kiyomi?

Look at my body.

You remember...

... this body?

You had it near you so many times...

You loved only me.

It's me... Kiyomi.

Toshiaki.

I've waited so long for this moment.

For a billion years...

Give me your love...

A billion years' worth...

It's raining.

I can hear it saying Toshiaki again.

I could hear it the first time that I saw Toshiaki.

That mysterious voice.

Like a ringing in my ears.

I felt a strange heat feeling its way over my body...

...reaching out from inside.

My body feels hot, like my blood is going to burst...

and I can not breathe.

When Toshiaki talks to me about his work...

The voice inside of me seems to be pleased.

The word "Mitochondria" alone makes my heart throb violently...

and fills it with joy...

It's raging inside me.

I can't really understand it...

As it stands ...

I am ruled by that voice...

by that proud voice...

The only one you loved... It was me.

Kiyomi loved you...

because I made her.

I had her talk to you that Christmas...

with a voice that would make you fall in love.

Your breathing accelerated.

I had chosen you...

You would be...

... the one who could cultivate us.

You...

Who are you?

I had been waiting for you...

I'm scared... I'm scared... I'm scared... I'm scared...

Doctor?

I'm about to give my conference paper.

I want to relay something very important...

...for the good of humanity.

« We believe curative treatment will be possible... »

« ... by replacing abnormal genes with healthy mitochondrian genes. »

« Mitochondria are cytoplasmic organelles of all eukaryotic cells... »

« ... engaging in aerobic respiration. »

« And also, the source of most ASP in those cells. »

« However, your suggestion of it having curative effects to heal diseases ... »

« ... is still only a hypothesis, and has not been proven. »

« Injecting cells with healthy mitochondrian ... »

« ... has shown production of a new source of energy in the ailing cells. »

« The result is a so-called rejuvenation of the cells. Furthermore ... »

I was looking for you.

The condition of the girl is more unusual every day.

Her uterus is changing.

And it's also changing its cellular structure.

Thank you very much -

Next, Sachiko Asakura, from the National University of Biochemistry...

The subject is «Retinoid Receptors...

in the DNA Derivatives of the Mitochondria ».

Today ...

... you are fortunate to be the human beings who are going to hear me speak.

You will be the first to hear about the new world that will begin.

And I am also happy to be able to address human beings.

At last ...

the Mitochondria are going to be free.

What's wrong with that girl?

The Mitochondria is talking to us.

We have watched you since you were microorganisms.

We gave you the energy with which you have evolved.

We even remember your ancestor... Eve. The Mitochondria had already taken over.

We have waited a long time...

until this moment.

For a billion years ...

You... you're Eve, right?

You ...

... damn you!

This is not your thesis ...

Be silent!

We have power over the Mitochondria of your cells...

and we can control the energy that they transmit.

Mitochondrial energy converted into heat impulses ...

Thousands of volts!

But, it can't be true...! It's crazy!

We had to wait for humanity to evolve to this point.

You have done better than we thought...

but your mission is over.

Now...

We are going to take your place.

A new evolution will begin.

The transfer of a flawless sperm has already begun.

Our descendants will be... the definitive way of life.

Unfortunately...

you will not be here to see it blossom.

We... we will destroy all of you.

Asakura!

She is okay...

What have we done...

... me, and the mitochondria?

The mitochondria and I are going to have a child.

The sperm would have already been transferred, right?

So why can't the mitochondria produce a child using the sperm by itself?

My patient...

... her uterus is transforming.

Get out!!!

- Any problem? - No!

Mariko, what is the matter?

Get away!!

- Mariko! - Get away!!

- What's wrong? - Get away ...

Mariko, what's the matter with you?

Mariko.

So hot.

- Where? - I'm too hot!

So hot ...

What has happened?

Kiyomi's mitochondria can not reproduce on their own.

They need a womb.

They controlled Kiyomi to have her kidney donated.

They had everything planned from the start!

Even that I would cultivate her cells.

And what about my patient?

Mariko!

This way!

Mariko!

It's here...

It's here?

What's here?

Who the hell are you?

Stop this, Kiyomi!

Give me my daughter...!

Hold it!

Do not let it leave the building!

Doctor!

Doctor... help me...

I'm here... Doctor...

Mariko?

Doctor...

Doctor, I'm here...

Doctor...

Doctor, help me...

Doctor... I'm here.

Are you okay?

The rooftop...

Doctor!

My child grows inside of you.

Wait!

Let the girl leave!

Let her go!

Let that girl go, Kiyomi!

Do not meddle.

This is evolution.

The child that she is going to give birth to will be the pure "Mitochondria Eve".

Kiyomi?

Are you there?

We grew in strength...

... so, we took control while she was driving.

We shut down her nervous system. We caused the accident.

And as we expected... you cultivated her cells.

And we came into possession of the perfect formula.

Say goodbye... to humanity.

I can not forget you.

Neither do we.

Since I had to fall in love with you...

...it was difficult to train Kiyomi.

The first time I saw her...

«Christmas Eve».

The night you and Kiyomi met... we changed fate.

We created the Kiyomi that you loved.

But ... I saw her before that.

Kiyomi's first day of college...

on the Campus.

She was wearing a pink dress...

and a bright and innocent smile...

I stared at her...

thinking how wonderful it would be...

to be with her.

We made Kiyomi's heart beat hard for you.

We created her love for you.

Kiyomi...

Do not come near.

- Come to me. - STOP!

Come...

Come back with me...

Come back with me!

Stop!

Get away!

Let me hold you.

Toshiaki...

What happened?

You had a bad dream

Two, please.

Today's my birthday.

Kataoka... "Kiyomi"?

The same character as for "Christmas Eve".

Thanks, Santa.