Original subtitles

Oh, oh, how does it go? Oh...

-Oh! -Oh!

♪ Ozempic! ♪

In case you’ve been under a rock,

Ozempic is a new class of weight loss drug

that is delivering astonishing results.

These drugs have become all the rage in Hollywood.

From Golden Globe jokes...

And welcome to the 82nd Golden Globes...

Ozempic’s biggest night.

To testimonials from Oprah, Sharon Osborne,

and Amy Schumer, the secret is out.

Sharon: I lost 45, yeah. Yeah, it was 45 pounds.

Amy: A smaller portion? Like, shut the up.

You’re on Ozempic.

What’s the biggest game changer right now?

Everyone says the GLP-1s.

McDonald’s stock price is down again.

Some analysts think Ozempic is to blame.

It appears Ozempic and pharmaceutical knockoffs

are in such high demand, black market websites

have popped up overnight.

They’re basically churning out prescriptions like crazy.

It is the most radical transformation

that we’ve seen in the pharmacology of weight loss.

Ever.

We want to pop the pill that gives us all the effects of

exercise without actually exercising.

Like, everyone is shrinking.

People drink a whole heck of a lot less

on these medications.

The Ozempic effect, Ozempic face, Ozempic butt.

Ozempic can lead to loose breasts.

Is this how Ozempic works?

Do you lose weight because

you’re expelling everything in your soul?

Who’s monitoring it for side effects?

And who’s adjusting for your other medications?

Nobody.

This medication is not just an appetite suppressant.

It has a deep effect practically in every organ

in the body.

Impulse control is up, body inflammation down.

I think it will be probably one of the most

popular drugs of all time.

I’m Dr. Jason Fung.

I wrote several books, including The Obesity Code.

So a GLP-1 is a specific hormone in our body

that tells us essentially to stop eating.

The most well-known, the Ozempic,

slows down the movement of food in our stomach.

So therefore, if things are not moving out of our stomach,

they’re just sitting there, well,

you’re not gonna want to eat because, you know,

all that food is just sitting there.

There’s plenty of positives weight loss can have,

for sure. But this is a drug.

It’s much more complex than calories in, calories out.

I’m Dr. Alexandra Sowa.

I have been practicing obesity medicine

for over 10 years.

I am author of The Ozempic Revolution.

It is a revolution.

I don’t believe that there’s been anything else

in my lifetime of practicing medicine that’s

come out into the world that has had...

such a big impact and will continue to have

such a big impact.

The medication talks to our brain, and it says,

"You don’t need to be hungry all the time."

People will hear this and say, "Well,

why can’t I just naturally increase my native GLP-1?"

What’s very, very different is that the native GLP-1

lasts at most...

a minute or two,

while the synthetic version lasts

on a level of weeks.

We’re about to get to 50% of the population

suffering from obesity.

And GLP-1 medications are some of the most powerful

tools that we have to treat the obesity epidemic.

My name is Brian Murray.

I’m a registered massage therapist.

I’m 39 years old.

I started my Ozempic journey two, three months ago...

and it’s because my blood sugar was un...

unbridled.

I was diagnosed with type 2 diabetes when I was 38.

The average person’s blood sugar should be

about 5 to 7.

Once your blood sugar hits about 10 to 15,

you enter stroke territory and you can fall into

a diabetic coma just for fun.

My blood sugar did end up peaking at 27.9.

27 is bonkers high. I’m walking sugar.

Like, this is crazy.

I had three or four different medical professionals

literally look at me and be like,

"How are you still alive?"

The good news with the Ozempic for me,

is that it has completely balanced my blood sugar,

like, it’s undeniable.

This morning, my blood sugar is 5.4.

So, every Tuesday at 10.30 is Ozempic day for me.

Once you set the dosage, you lift...

you inject, and then you push

and hold the button.

It’ll click, click, click, click, click when it’s going.

And you count to six....

Done.

My name is Edna Sutherlen.

I’m a nurse.

In my 20s, I was very skinny.

And you know all the attention that you get

when you’re skinny,

and then suddenly because of age,

now you start gaining weight.

And then I went through a divorce.

So, I got depressed, and all I did was

eat and drink and party.

I wanted to lose weight, but I was feeling lazy,

not motivated to work out...

and eat healthy.

Everyone was talking about Ozempic,

and then suddenly celebrities were looking

slimmer and skinnier.

And then I was like, I’m gonna try it.

Is that you?

She was like, "Where are you?

Is that you?"

Edna: When I heard about Ozempic,

I thought it was like a gift from God.

The heaviest I got was 185 pounds.

And I’ve lost weight,

and now I’m 135 pounds.

Yeah.

Interviewer: So you’ve lost 50 pounds?

Edna: Yes. I don’t recognize that person.

That is not me.

Because I’m a nurse, I know that

if I had diabetes and they put me on it,

I’m going to have to take it. So I’m like,

I’m going to take it for weight loss then.

If it’s safe for somebody who has diabetes,

then it should be safe for me.

It’s a very tiny needle.

It doesn’t hurt, no.

I Googled online, "Ozempic."

I got this clinic where you put in your information,

they give you a virtual consultation,

and then they mail you the medication.

Yeah.

Interviewer: So you never saw a doctor?

Edna Sutherlen: No, ha. Online, like virtually.

Semaglutide, that’s another name for Ozempic.

Dr Jason Fung: There’s plenty of doctors

who are willing to make money by handing out

these prescriptions like candy.

You can do a five-minute questionnaire online,

never having seen a doctor, and some doctor will just

send you a prescription for Ozempic.

Edna: Don’t come stealing my Ozempic.

My name is Mike Israetel.

I am a sports scientist.

I’ve been competing in bodybuilding since 2013.

I compete in untested bodybuilding,

which means it’s a free-for-all for

how many drugs you can take.

We’re talking about pretty liberal doses of

all sorts of drugs. And so,

I’m kind of my own little mini science experiment.

In competitive bodybuilding,

you’re judged on roughly three criteria.

One is symmetry.

Another criteria is muscle size.

The more jacked and heavier you are and the more

billowing your pecs are, the better.

But the last one and by far the most important one for

winning shows is how little body fat you have,

how lean you are, and the only reliable way to

reduce body fat to its limit low levels is to eat

substantially less food than your body would want.

Your body was engineered by evolution

to try not to get lean,

’cause typically when you were lean,

that means you were gonna die of starvation really soon.

So on your way down to very low body fats in

bodybuilding, the hunger turns from non-existent to

inconvenient to driving you insane.

With Ozempic, most people think like,

"Wow, this is awesome.

I don’t have to suffer through hunger anymore."

You can get ultra, ultra, ultra, ultra-lean

to your best ability without hunger being

that really nasty factor.

Interviewer: So are you taking Ozempic right now?

Mike: Yes, oh yes, proudly and...

ever since I started taking these drugs,

I’ve never come off.

It is the most radical transformation that we’ve

seen in the pharmacology of weight loss... ever.

Your ability to lose weight can be

a test of your willpower.

Or you can take the ---- pill.

It is an enhancer. It is a liberator.

But I want to ask you the question...

Do you want to be a better version of yourself?

Whatever that means to you.

What if we had a little bit of help?

I think help is a good thing.

I think more than 75% of people who are overweight

will eventually try and successfully integrate

these drugs into practice. It just works.

There’s just no other way to say it.

It just works. It’s a miraculous feeling.

I’m Ben Greenfield.

I’m a coach, author, speaker, podcaster.

I’m sometimes accused of being a human guinea pig.

I prefer the term immersive journalist because

it sounds more professional.

I did experiment with injectable GLP-1s.

The reason that I tried them is honestly

the reason that I do a lot of stuff,

because I want to know what

what I’m talking about feels like

when I’m interviewing somebody on my podcast.

Trainer: That’s how we grow, that’s how we get that...

Ben: So I took GLP-1s in a

microdose format for a couple weeks,

one-tenth of a normal dosage.

Starting off, it controlled appetite...

shockingly well.

It went from mild appetite suppression to a

complete lack of desire to eat, period.

And, you get nauseous when you’re trying to eat

the foods that you normally like.

I would make myself my beautiful,

glorious morning blueberry coconut water smoothie.

And then just kind of sit there staring at it,

asking why the heck I made myself a smoothie.

And the other thing I should mention is that

I had gastric upset.

I was alternating between constipation and diarrhea

and, I think the biggest takeaway for me was that

it seems like you can get pretty good effects with

a smaller dose.

- Boom. - There you go.

That’s for now, man, good job.

Yeah.

At Nourish, we work with clients

across the whole food ecosystem.

The Ozempic effect is when people don’t eat as much.

Their plate gets smaller.

We’re certainly seeing...

the "snackification," I would say, of foods.

We’re seeing snack size

actually becoming the main course.

One of the first signals we got was Walmart in the U.S.

reporting on consumers who were

shopping at Walmart

and also purchasing their GLP-1 prescriptions

at the Walmart pharmacy.

And what they saw was snack foods go down,

whole foods go up.

They are focused on getting enough fiber,

getting enough nutrients, getting enough protein.

Dr. Jason Fung: There have been several studies

which show that people eat far less junk food,

less of the snacks, the salty snacks,

the sugary snacks.

They’re eating more vegetables.

Indeed, those people who take it

do change their diets and seem to make

really good choices in what they’re doing.

Brian: I’m the type of guy that I would get up,

go to the kitchen, open the pantry,

open the fridge, not hungry.

I’m just looking for something to eat.

And now, for some reason, I don’t want to do that.

It’s changed my snacking almost completely.

One of my favourite things, chocolate-covered almonds.

I love chocolate -covered almonds.

Every day after work, I would stop at the

grocery store and buy a bag of candy.

Now with the Ozempic, I don’t go in there.

I, I walk past.

My brain doesn’t say, go in and get some.

I just, I just- it’s invisible to me now.

Dr. Sowa: GLP-1s allow us to change

our entire relationship with food.

What you crave, what you want to eat.

It gives our brain freedom from

constantly thinking about eating.

It’s almost instant, and it gives

tremendous power back to the individual.

Joanne: We’ve also been tracking the obesity rate,

and it has been going up basically since the 50s.

It’s basically a hockey stick.

And this last year, for the first time,

it stopped growing and actually fell a little bit.

So every calorie that they eat has to count for more,

and the challenge for the food industry is finding

their share within that smaller plate size.

Being on Ozempic, I actually lost 35 pounds in a year.

I would have a little devil on this side,

a little angel on this side.

The devil would say, "Oh, you deserve it,

have the chips, have the chocolate."

There’s not that voice going on anymore saying like,

"Oh, it’s okay, just eat it."

It’s like it just completely disappeared.

Being in charge of such a big operation here,

it does give you a different view of the foods.

Our customer is actually pretty vocal

when it comes to trends,

and that’s how I know that trends are happening,

and that’s how we go and do recipe development.

Because we want to be the leader in the industry.

The current trend that we’re seeing is the GLP-1 trend.

Probably in the next three months,

we will develop another 10 to 15 dishes

that will be for that trend.

We are actually making 1,200 salads a day.

Bowls, where we do see the popularity go up

on the bowls. It’s very GLP-1 friendly.

GLP-1 recipes, they are high in protein.

They are smaller portions.

We will gear towards that feedback from the customer

’cause they’re asking for it.

Edna: Ozempic doesn’t let you eat fries, hamburgers.

If you bite it, and you just-

feel like you want to throw up.

You just can’t take it.

So, I use honey instead of sugar.

In the beginning, I experienced constipation...

and then I’d read about side effects,

where your gut gets paralyzed, I was like, uh-oh-

My gut is paralyzed.

I took laxatives, and it didn’t work, and I was like,

okay, this is how I die.

But then it started working and...

You lose maybe two pounds every two weeks.

I’m just hoping that there are no long-term side effects

because we are kind of pioneers.

I plan to be on it forever.

Ben: In the next five to ten years,

I think a ton of people are going to be on GLP-1s,

either at standard dosages or at micro-dosages.

I think it will be probably one of the most

popular drugs of all time.

Thank you so much for coming out.

I am Dr. Melissa Hershberg.

Ozempic, it is a game changer in medicine

for both diabetes and weight loss.

All of a sudden, patients would start to see ads like,

"Ozempic, ask your doctor."

So people slowly started coming in, saying,

"Okay, I’m asking my doctor. What is this?"

And then, it’s just blown up.

I remember 10 years ago when I started doing Botox,

people would be, you know, "Don’t tell anybody

I’m getting this done."

Fast forward 10 years, everybody’s like,

"Yeah, yeah, I’m going to my Botox appointment."

And I think we’re gonna see the same thing with Ozempic.

When people started losing so much weight on Ozempic,

phrases like Ozempic face and Ozempic butt became popular.

All of a sudden they look great.

They’ve lost weight.

But where did my facial fullness go?

Where did my perky butt go?

Because they’re losing fat

in their face and in their buttocks.

So, plastic surgery is booming,

and I don’t think that trend’s going anywhere.

Dr. Sowa: What’s remarkable about GLP-1 medications is

GLP-1 medications seem to affect the

reward pathway for not only food,

but also for drugs and alcohol and...

some other addictive behaviors.

That is the biggest thing I see on these medications.

Their brain tells them they don’t need it anymore.

I’m Dr. Greg Dillon.

I’m a psychiatrist in private practice in New York.

The notion of GLP-1s

treating other compulsions or addictions

that you might not be aware of or might not see

is bearing out all over the place.

Gambling is so prevalent because it’s thrown at us.

It’s on your phone.

There’s no question that we’re facing this at

way huger numbers than ever.

Where these medications could be really helpful is to...

derail that train car for a minute

and to make them feel,

now it’s not really giving me much of a rush at all.

Never mind, why do it?

Dr. Hershberg: I think we’re gonna see a lot more use of

this drug for things like gambling,

sports betting, porn addiction.

News: Porn.

It’s one of the world’s fastest growing addictions,

and young men are by far the most afflicted.

Dr. Dillon: Definitely the interest and the use of porn

in young men seems to be off the charts.

Patients who’ve come in on the GLP-1s for weight loss

have said that likely as a result of the GLP-1s,

it doesn’t give me the same rush,

it doesn’t give me the same thrill.

They also no longer have the craving.

So, having the opportunity for medication

that might break that cycle

that you can’t otherwise break could be really useful.

Dr Sowa: People drink a whole heck of a lot less on these

medications and their desire for alcohol...

diminishes or goes away completely.

Joanne: The Ozempic effect gets rid of

that reward centre around alcohol,

so what we’re seeing is people are

drinking a lot less.

So I could see the alcohol industry

continuing to shrink over time.

How’s it going? Good.

I’m Matt Johnston.

I’m CEO and co-founder of Collective Arts.

We’re a lifestyle beverage company.

We’re all about creativity.

Out of the site, we would do, on an annual basis,

about 15 million cans.

Cheers.

That’s delicious.

My whole career has been really about understanding

consumer needs and those evolving trends.

The Ozempic effect,

I can’t think of another trend that could cause

a category in the industry of food and beverage

to go through such rapid change.

But when you read reports that are saying 60%

reduction in alcohol consumption,

that’s pretty alarming.

And then you, you apply that

to the percentage of people that...

we expect will be interested in these drugs...

it’s exponential.

Luckily, we are already leaning in on

health and wellness,

and we’ve really built a whole side of our business

that is all about those trends,

so I think we are nicely ahead of the curve.

As you can see here,

this is our non-alcoholic lineup.

Botany Elixirs, we think,

are perfectly set up for the GLP-1 trend.

They’re wellness beverages: coconut water, fruit,

full of vitamins and adaptogens.

And we have leaned into the smaller cans

for more moderate consumption.

Dr. Sowa: We now have these medications entering

stage two and three trials for potentially using them

for the treatment of alcohol and drug abuse.

So, I think that’s very exciting.

My name is Susan Ruddie Spring,

and my business is The Wedding Dresser.

My team is a collective of fashion and

costume designers and makers.

We do super fashion-y Brooklyn brides.

We do very traditional brides.

But our biggest draw is the fact that

we can restyle and resize dresses.

We are seeing many more brides

who are using weight loss drugs and...

using them in a more ferocious fashion.

When someone has had a really large weight loss,

rather than just doing the normal,

which is taking in the side seams of the dress,

we’re often taking in the sides,

taking in the centre back seams.

So we’re literally taking the dress apart

at the seams and repatterning it.

Ozempic weight loss causes issues like loose skin,

saggy arms, that kind of thing.

Brides are now trying to hide their arms.

So we actually make something called a mitt,

and this will give them coverage so that

their loose skin is tucked in.

Ozempic can lead to loose breasts.

We’ve always seen brides lose some weight

during the process,

and they lose 5, 10, 15 pounds,

and most often they lose that

like right before the wedding.

But that’s a very different kind of weight loss

than what happens with Ozempic.

The brides tend to be losing more like 35, 40 pounds.

I have heard of weight losses up to 80 pounds.

We have perfected taking in dresses

up to 10 inches or more.

I communicate with a lot of other bridal specialists and

bridal shop owners through Facebook groups

and professional organizations,

and I’m already hearing of them being in crisis.

I see a world where...

if everybody’s on Ozempic,

there won’t be enough humans in the world

to alter those dresses.

I think the crisis is going to grow in the next few years

as more and more people are able to access these drugs.

And because of being able to access these drugs,

there’s more pressure on brides to be thin.

Dr. Sowa: Clothing is definitely being affected.

My patients are either not shopping because

they’re losing so much weight that they don’t even

know what size they’re in,

or they’re having to shop continuously.

My name’s Aileen Selkirk.

We are at Posh Boutique.

I’ve been in business for 44 years.

Every 10 pounds basically

brings you down a size.

If you lose 10 pounds...

you’re gonna go down one size.

If you lose 20 pounds,

you’re going down another size.

So here we have a large.

And here we have a smaller size,

extra small, which would be a size 4,

and that’s where this seems to be going.

I started to look at numbers the other night and from

last year to this year in terms of sizing,

and we definitely sold more smaller sizes

than we did the previous year.

And we’ve sold more belts

in the past year than we have sold

in probably five years because women are

slimming down and they want to show off their waist.

So belt sales, I think,

are going to increase even more.

I am Kelly Freeman.

I am Rory Lindo.

We are the owners of Doll Factory by Damsels.

Rory: So we’ve found that, you know,

if someone has lost a substantial amount of weight,

they’re probably gonna want to buy something new,

and we’re here for that.

We have dresses of all sizes,

and they’re pretty, they’re fun,

they’re lighthearted, they’re whimsical.

Kelly: This is a romper, and it has pockets.

This one is very pretty.

On average, we’re seeing maybe about two sizes

difference, and yeah, it’s exciting for them.

Rory: Is it the Ozempic effect? Maybe.

But what do they do with all those old clothes?

So we even started a program called Do It Again Dolls.

Kelly: It’s a whole thing where we sell,

they get a store credit.

Rory: So it’s trading in their old clothes

for new clothes.

Kelly: So it seems to be a win-win.

It’s great for us, too. Great for our community.

And great for people with fluctuating sizes.

Rory: And great for the environment.

Kelly: Yeah.

If any industry can keep up, the fashion industry,

we are like raccoons. We will survive.

You know, pandemics, recessions, whatever,

size changes, you know,

we’re willing to go with the flow.

Rory: Yeah, we’re adaptable. Kelly: Yeah.

Dr. Sowa: I just saw a patient last week

who was like,

"I have $10,000 worth of suits in my closet,

and I took them to the tailor,

and they said I’ve lost so much weight

that he can’t even take them in."

I’m Shawn Wells. I’m a biochemist.

I really feel like there’s room for the GLP-1s.

It’s a fascinating mechanism.

But I would like less of a cowboy approach,

a populational approach.

Let’s take the great experiment.

Let’s do it in big doses.

One scary effect that we’re seeing

is that these people are losing weight

faster than ever before, but they’re also losing

a disproportionate amount of muscle.

They’re also losing more bone.

When we’re losing a lot of muscle,

we tend to lose a lot of bone as well.

Joanne: A big issue with this is you’ll be healthier

in some ways but not in others.

And, you know, muscle is the number one thing

in terms of longevity as we get older to

protect ourselves from falling, breaking hips.

Dr. Sowa: Longevity is about strength, right?

You need to be able to get out of a chair easily

when you’re 85, 90 years old.

Joanne: I’ve been looking at some studies that show

that gym memberships actually go down

when people are on these drugs

and have successfully lost weight.

We’re people who like shortcuts,

who like comfort.

And so, if there’s a shortcut and

you don’t need to go to the gym,

that seems to be what a number of people are doing.

We’re about 1,500-plus studios, 68 countries,

and we’re continuing to grow.

I’m Tom Dowd, and I’m the CEO of F45.

Is Ozempic a magic pill?

I think the answer is gonna be no,

simply because you have to work out

and not lose muscle mass

because muscle mass is a longevity pill.

The concern is that when folks go on GLP-1s,

they’re eating less calories in total.

It’s critical for anyone using these drugs to be

consuming enough protein,

consuming the right type of nutrition, and also,

of course, strength training.

Dr. Sowa: Part of my work with patients

is saying, "Hey, I get it.

You need to reframe your relationship with the gym

that this isn’t about weight loss now.

This is about longevity, strength,

and overall health."

Joanne: Sarcopenia, which is the loss of muscle,

happens naturally as we age,

so if you have that coupled with these GLP-1 drugs,

we could be in for a real crisis,

a lot of seniors falling and breaking things

later in life.

Tom: We’re finding out that a lot of our members

are actually taking it.

They weren’t really talking about it.

So, for us, we embraced it because we want people

who are on it not to hide it.

We started offering it to our membership base.

So if you want to go on Ozempic or any other

GLP-1 drug through F45,

you have to go through a Teladoc service.

So, just like any other doctor visit,

you have to go through the same process with us.

I think it’s definitely gonna grow as more people

see other people with the results and

losing weight and working out more...

which is great for us.

My name is Peter Lund Madsen,

and we are in the centre of Copenhagen.

This city has changed a lot since the 90s

because everyone has gotten

much more wealthy in Denmark.

There’s a lot of cafes, there’s a lot of people.

Ozempic has also a part to play in this.

We have in Denmark a very, very big company.

Novo Nordisk is very important for the

financial growth in Denmark.

If it hadn’t been for Novo Nordisk,

we would not have had growth the last two years.

So it’s a very, very important

economical factor for Denmark.

Dr. Sowa: I’ve had a few patients who,

as soon as I put them on this medication years ago,

they immediately went and invested in the companies

because they knew that nothing in their lifetime of

60, 70 years had worked like this.

My name is Jens Juul Holst.

I am a professor of medical physiology

at the University of Copenhagen.

We found GLP-1 here in this laboratory.

This is really where it all happens,

where we are doing the analyses for the hormones.

We’re doing a lot of experiments to understand

the secretion of GLP-1.

So that’s what’s going on here.

All of this really started in ’72, ’73.

So it was extremely exciting.

But eventually, Novo Nordisk

began working on this.

And, therefore, potentially could do something

about obesity and the complications of obesity.

That’s when, you know,

the public became aware of this.

Peter: The molecule behind Ozempic was created and

invented by Novo Nordisk and Danish scientists.

And the way it happened is miraculous.

As it looks now, you have to take this drug

for the rest of your life.

So, it is a drug that will carry

an enormous demand in the future.

I think that in 5, 10 years, there will be

so many people in the Western world,

in the total world, who will be on this drug

or who would want to be on this drug.

A lot of big, big problems can be solved, maybe,

by this single molecule.

Shawn: And so, when we look at our population,

we have 93% metabolic dysfunction,

meaning our metabolism isn’t functioning optimally.

We’re aging faster biologically

than chronologically.

The majority of all diseases are not genetic in nature,

but metabolic in nature.

Cancer, Parkinson’s, coronary heart disease.

We’re actually heading towards type 3 diabetes,

which is diabetes of the brain,

which is also known as Alzheimer’s.

And that number is rising.

Dr. Sowa: There are a few mechanisms that are leading

to such a profound health benefit from GLP-1s.

So we are seeing improvement in cardiovascular outcomes,

kidney outcomes.

We are decreasing all sorts of inflammation,

and dysregulation, and leads to disease.

My name’s Daniel Drucker,

and I’ve been working on GLP-1,

which is the science that supported the

development of drugs like Ozempic.

I’ve been working for about 40 years.

What’s really caught everyone’s attention

are the effects beyond blood sugar control,

beyond weight loss.

Personally, I have a family history of

Alzheimer’s disease, as do many people,

and it’s fascinating to me that perhaps the drugs

might benefit people at risk for Alzheimer’s so,

we’re certainly spending a lot of time and effort

trying to figure out how that works.

We look at inflammation, for example.

How does GLP-1 talk to the immune system

to reduce inflammation and make people with

arthritis or metabolic liver disease feel healthier?

Is that directly talking to the immune system?

We have people telling us that they feel better,

and they have less brain fog,

and their arthritis is better after just one injection.

For example, rheumatoid arthritis.

This is the same hand from the same individual

now remarkably improved.

So we strongly suspect that GLP-1

is reducing inflammation independent of

its effects on body weight.

Jens: We can see now that it has

very powerful effects on inflammation.

Okay, we dampen inflammation,

and we have beneficial actions on

the blood vessels, where the risk of

developing dementia with a GLP-1 reduces the

occurrence of dementia by 50%,

as much as that.

Dr. Drucker: I think the greatest additional benefit

is the reduction of heart disease so,

reduction of heart attacks, strokes,

cardiovascular death, reducing the rate of dying

is obviously extremely important.

Dr. Sowa: And what we are seeing is that by improving

metabolic health with these medications,

we’re decreasing a whole host of diseases.

16 types of cancer, cardiovascular disease,

dementia, Alzheimer’s.

Dr. Drucker: And that’s really taken us all

by surprise, and it’s pretty exciting.

Lauren: Come with me!

This is New York Comedy Club, Upper West Side.

My name is Lauren Hope Krass.

I’m a body positive and fat liberationist...

stand-up comedian, podcaster.

And give it up right now for Lauren Hope Krass.

Hey!

Lauren: Thank you!

Oh, oh, oh!

Ozempic.

Like, it would just like be in your head.

I’m like, what is that?

Fat people in summer, we do not get along,

okay, we are mortal enemies.

Superman has kryptonite.

Fat people, we have Fahrenheit.

I think my issue was just with like

the mass marketing of like,

"Everybody take this.

If you’re fat, you have a disease.

You have to take this."

You know, it’s like, no, I don’t.

No, I don’t.

I mean, people are saying it.

They’re saying heroin chic is back

and you’re seeing it.

Body positivity is no longer trending,

which is terrifying.

Like, everyone is shrinking.

Hello and welcome to Belly Laughs.

This is your host, Lauren Hope Krass.

And today we’re gonna be talking about,

you guessed it... GLP-1s.

What you’re talking about is eradicating a demographic.

It’s so freaking stigmatizing and scary.

It’s like, oh, now that there is a proven way

to keep weight off,

I’m walking around in the world as a fat person,

and I’ve got other people looking at me like,

"You know, you don’t have to be like that?"

And it’s like, I know.

Fast forward five years,

and if half the country is walking around...

skinny and on their GLP-1s...

the microscope on fat people is gonna be even harsher.

And that’s where I come in to try to cut through

that anti-fat bias and to say,

fat people can do lots of amazing things.

And so, I love to interview plus size people

on the street and ask them like,

"How did you find this outfit?

What crazy hoops did you have to go through

to like look this cute?"

Hello, and welcome to another episode of Fat Fashion

with me, your host, Lauren Hope Krass.

Alexis, tell me about this beautiful,

floral winter jacket. Slay.

We got a twirl! It’s fabulous.

Alexis: I like an oversize glasses.

I usually do big hoops.

Today we’re doing medium.

Lauren: My message for fat people is, like,

you can do hot girl shit.

You know, like, you don’t have to...

spend the rest of your life trying to

shrink yourself into an impossible box.

Anyway, sorry, I’m getting, like, emotional,

but it’s fine.

If you want to take Ozempic, it’s okay, girl.

It’s okay.

But, like, it just, it makes me sad, like...

People are getting some issues that, you know,

it’s going to affect them for the rest of their lives.

And they go, "Oh, you’re fat, here’s a GLP-1,"

and then they send you on your way.

If half of the world is on Ozempic,

it’s gonna be boring.

Going to restaurants, going to parties,

get a little Ozempic-sized birthday cake.

Joanne: We’re seeing that people on these drugs

are not going out to restaurants as much.

I think it’s kind of sad, myself.

I think, you know, there’s the joy in food is-

and the sharing, like,

we connect as a species over food.

But I do see that a lot of people on these drugs,

they’re actually taking themselves out of

those social situations.

Dr. Fung: So imagine that you’re taking this drug now

where you simply don’t get any enjoyment

from your food.

That’s great because you’re losing weight.

But what about if you’re going to a big wedding?

Or it’s Thanksgiving or it’s Christmas?

As it goes on, month after month of this,

where you’re just not enjoying your food anymore...

I think it gets a little bit wearing.

Shawn: So the great experiment is on.

I see half the population being on GLP-1s.

I do see that going over 50%.

Maybe 93% of the population that’s metabolically

dysfunctional will be forced to have it.

Dr. Sowa: It’s my real hope that these medications start

to free us from this pattern where we have just gotten

heavier and heavier and unhealthier and unhealthier.

Brian: The Ozempic I would definitely say

is most likely a life saver.

Edna: After you lose weight, you realize

you gain a lot back.

You gain your happiness back, your confidence back.

Dr. Hershberg: People still have to remember that

this is a drug, this is a pharmaceutical drug.

You have to use it in the proper dose.

Dr. Sowa: I do not hope for a world in

a few generations where everyone’s on this shot.

Even though I love these drugs,

and I think that they are true miracle workers,

I do not want everyone to have to be on them.

Shawn: It’s hard to say what the downstream effects

of all of this are.

I’m not saying that GLP-1s are bad.

I’m saying that we need more data.

Everything is just happening in real time

on a massive level.

We are the great experiment.