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These are the user uploaded subtitles that are being translated: 1 00:00:13,000 --> 00:00:16,100 A disease that turns men into monsters. 2 00:00:16,760 --> 00:00:21,620 A medical establishment on the verge of collapse. 3 00:00:22,020 --> 00:00:26,320 A world consumed by fear. 4 00:00:27,600 --> 00:00:32,800 Could a real life zombie apocalypse wipe humanity from the face of the globe? 5 00:00:33,060 --> 00:00:36,560 This would be a virus that could cause civilization to collapse. 6 00:00:43,690 --> 00:00:50,510 Leading minds join forces to craft scientifically plausible scenarios of 7 00:00:50,510 --> 00:00:51,510 Armageddon. 8 00:00:52,810 --> 00:00:59,630 And find the secret to human salvation in the 9 00:00:59,630 --> 00:01:01,370 face of ultimate disaster. 10 00:01:13,480 --> 00:01:14,480 Let's drop him in. 11 00:01:14,520 --> 00:01:15,399 We're in. 12 00:01:15,400 --> 00:01:16,400 Okay. 13 00:01:21,880 --> 00:01:25,540 A lot of us have the impression that human beings have tamed Earth. 14 00:01:28,960 --> 00:01:30,980 That we are the masters of this planet. 15 00:01:31,980 --> 00:01:33,580 That, however, is an illusion. 16 00:01:39,320 --> 00:01:40,320 We're in tight. 17 00:01:40,860 --> 00:01:42,540 Good? Good. Now come on up here. 18 00:01:43,450 --> 00:01:47,390 An illusion that's pretty easily revealed when you look at what's 19 00:01:47,390 --> 00:01:49,290 right now in the field of infectious disease. 20 00:01:50,830 --> 00:01:56,090 Coming up on the morning. Grab the buoy. We are in an era of many emerging 21 00:01:56,090 --> 00:02:00,170 infectious diseases, and by that I mean diseases that we have never come into 22 00:02:00,170 --> 00:02:05,370 contact with or diseases that we have come into contact with but are appearing 23 00:02:05,370 --> 00:02:06,390 in some different way. 24 00:02:12,910 --> 00:02:17,270 They are increasing in frequency for some reason, and this is a huge problem. 25 00:02:20,150 --> 00:02:21,650 Looks like a humpback to me. 26 00:02:23,550 --> 00:02:26,870 These viruses can emerge from totally unexpected sources. 27 00:02:27,370 --> 00:02:28,470 Getting so close. 28 00:02:28,850 --> 00:02:30,930 We have no protection against them. 29 00:02:31,430 --> 00:02:37,650 There's no question. An unexpected virus that we have no immunity against, where 30 00:02:37,650 --> 00:02:40,670 there's no vaccines available, this kind of virus. 31 00:02:41,280 --> 00:02:42,900 Should emerge into the population. 32 00:02:43,500 --> 00:02:45,820 Yeah, it shouldn't be in the harbor unless it's sick. 33 00:02:46,260 --> 00:02:48,800 This would be a nightmare scenario for the world. 34 00:03:07,860 --> 00:03:09,920 In a tragic incident this morning. 35 00:03:10,350 --> 00:03:14,290 A humpback whale attacked a sailboat in Provincetown Harbor, killing a 48 -year 36 00:03:14,290 --> 00:03:16,570 -old sailing instructor and his 19 -year -old students. 37 00:03:16,950 --> 00:03:20,310 The whale then swam in circles for two hours before beating itself. 38 00:03:21,110 --> 00:03:25,030 The Massachusetts Department of Fish and Wildlife, assisted by teachers and 39 00:03:25,030 --> 00:03:29,050 students from Woods Hole Oceanographic Institute, are now performing a 40 00:03:30,390 --> 00:03:33,790 This whale attacked a sailboat, which is very unusual. 41 00:03:34,010 --> 00:03:38,890 So we're hoping to find a clue to that behavior, especially in the brain of the 42 00:03:38,890 --> 00:03:39,890 whale. 43 00:03:40,590 --> 00:03:44,110 One theory is that the whale may have been suffering from an illness that 44 00:03:44,110 --> 00:03:45,150 affected its behavior. 45 00:03:55,550 --> 00:03:57,270 Where do new diseases come from? 46 00:03:59,550 --> 00:04:03,190 There are several sources, but one of the most common is from other species. 47 00:04:04,810 --> 00:04:06,010 The animal kingdom. 48 00:04:06,410 --> 00:04:08,390 These are referred to as zoonotic diseases. 49 00:04:13,870 --> 00:04:19,510 We have many dramatic diseases that have come into the human population, 50 00:04:19,709 --> 00:04:22,089 usually from other species. 51 00:04:26,510 --> 00:04:32,270 Ebola is one that's very famous. SARS, which spread a little bit more, which 52 00:04:32,270 --> 00:04:36,130 originated probably in bats. We were almost certain about that. 53 00:04:37,090 --> 00:04:42,900 When we think about zoonotic diseases, diseases that are spread from animals, 54 00:04:42,900 --> 00:04:48,900 think about some kind of transmission path, the person and the animal coming 55 00:04:48,900 --> 00:04:49,900 direct contact. 56 00:04:53,680 --> 00:05:00,560 So is there a scenario where people are dissecting a whale which has died 57 00:05:00,560 --> 00:05:01,560 on a beach? 58 00:05:01,580 --> 00:05:07,020 Could someone then become infected, especially if a person has cuts? 59 00:05:07,320 --> 00:05:09,140 Absolutely, there would be a way. 60 00:05:11,180 --> 00:05:12,340 Well, it's a messy process. 61 00:05:13,100 --> 00:05:16,600 I got a small cut on my finger, but that happens. 62 00:05:25,940 --> 00:05:28,160 So what would a doomsday virus look like? 63 00:05:29,780 --> 00:05:34,180 Well, there is one virus that stands out. If it was just changed or mutated 64 00:05:34,180 --> 00:05:37,520 slightly, it wouldn't just cause the death of millions of people, but it 65 00:05:37,520 --> 00:05:38,960 create a virtual army. 66 00:05:39,360 --> 00:05:40,440 Of zombie -like victims. 67 00:05:41,540 --> 00:05:44,380 It would be the ultimate doomsday infection. 68 00:05:44,780 --> 00:05:46,860 That virus is rabies. 69 00:05:52,900 --> 00:05:56,460 Rabies is a virus that infects all mammals. 70 00:05:58,040 --> 00:06:04,960 No other virus does this, has such a wide range of 71 00:06:04,960 --> 00:06:06,020 hosts that it can infect. 72 00:06:07,380 --> 00:06:10,740 It's usually spread by the bite of an animal that's infected. 73 00:06:13,100 --> 00:06:18,280 The scary thing about the virus is it really heads towards the nervous system. 74 00:06:19,300 --> 00:06:24,540 Once the rabies virus gets into a nerve cell, it redirects the function of the 75 00:06:24,540 --> 00:06:27,040 cell to start replicating the virus. 76 00:06:28,080 --> 00:06:29,560 Slowly but surely... 77 00:06:30,140 --> 00:06:36,100 You get viral replication up through all of the nerves into the spinal cord in 78 00:06:36,100 --> 00:06:37,100 the brain. 79 00:06:40,820 --> 00:06:46,620 Almost everybody who shows signs of the disease we call rabies dies. 80 00:06:46,920 --> 00:06:48,800 It's essentially a death sentence. 81 00:06:51,980 --> 00:06:56,880 The brain cells that regulate the muscles of breathing basically are 82 00:06:56,880 --> 00:06:58,460 and your... 83 00:06:58,940 --> 00:07:02,100 paralyzed and not able to breathe, and that's the method of death. 84 00:07:06,680 --> 00:07:09,560 The speed with which rabies kills people is terrifying. 85 00:07:10,040 --> 00:07:13,740 What's also terrifying is what happens to rabies victims before they die. 86 00:07:13,980 --> 00:07:19,960 In many ways, rabies is a kind of zombie -like or zombie -making disease because 87 00:07:19,960 --> 00:07:20,960 it eats the brain. 88 00:07:22,580 --> 00:07:26,340 When it hits the brain, that's when the problems begin. 89 00:07:27,160 --> 00:07:28,820 That's when the symptoms begin. 90 00:07:29,720 --> 00:07:36,120 Anxiety ridden, hallucinations, foaming at the mouth, people as well as animals. 91 00:07:37,180 --> 00:07:42,460 The animal now attacks other animals. The animal becomes vicious. 92 00:07:46,020 --> 00:07:51,920 When rabies starts to destroy cells that are responsible for inhibiting 93 00:07:51,920 --> 00:07:54,160 aggressive behavior, anything can happen. 94 00:07:55,880 --> 00:08:01,420 So why don't we hear more about rabies? Why isn't rabies a virus that makes us 95 00:08:01,420 --> 00:08:02,420 scared? 96 00:08:03,640 --> 00:08:08,220 Firstly, it's not transmitted easily. You have to be bitten. You have to be 97 00:08:08,220 --> 00:08:14,160 scratched. You have to have an animal slobber on you who has rabies. Then you 98 00:08:14,160 --> 00:08:15,160 can catch the virus. 99 00:08:15,920 --> 00:08:19,580 But what if rabies changed or mutated? 100 00:08:19,900 --> 00:08:23,740 What if the virus somehow developed the ability to spread more easily? 101 00:08:25,610 --> 00:08:29,110 But not just through bodily fluids like saliva, but through the air. 102 00:08:30,210 --> 00:08:32,070 That would change everything. 103 00:08:32,750 --> 00:08:34,950 This is what scientists worry about. 104 00:08:37,669 --> 00:08:42,450 I mean, this would be a virus that could cause civilization to collapse. 105 00:09:24,780 --> 00:09:27,540 Is rabies the most dangerous virus on the planet? 106 00:09:31,100 --> 00:09:36,940 It's only not considered the most dangerous virus because it's not 107 00:09:36,940 --> 00:09:37,940 easily. 108 00:09:40,380 --> 00:09:44,600 If a new strain of rabies developed, one that could be transferred through the 109 00:09:44,600 --> 00:09:48,020 air, that could be the deadliest virus this planet has ever seen. 110 00:10:02,230 --> 00:10:03,230 Where's the other one? 111 00:10:03,370 --> 00:10:04,370 It's right over here. 112 00:10:11,730 --> 00:10:13,370 They're both suffering from the same symptoms. 113 00:10:13,890 --> 00:10:19,730 It doesn't make a lot of sense to me, but... This could be rabies. 114 00:10:28,550 --> 00:10:32,710 Two people detained yesterday by Falmouth police were found dead in their 115 00:10:32,710 --> 00:10:36,630 this morning. They had been arrested separately on charges of disorderly 116 00:10:36,630 --> 00:10:37,630 conduct. 117 00:10:37,710 --> 00:10:40,930 Autopsies are currently underway to determine the cause of death. 118 00:10:46,130 --> 00:10:50,410 To diagnose rabies, you actually have to be thinking of it, because you have to 119 00:10:50,410 --> 00:10:54,790 use special stains to look at it in the brain, or you have to culture it in 120 00:10:54,790 --> 00:10:57,210 special media to see if you have the virus. 121 00:10:57,660 --> 00:11:02,280 If you look in the brain of rabies patients in autopsy, 122 00:11:02,360 --> 00:11:09,180 you can see deposits of virus where the 123 00:11:09,180 --> 00:11:15,440 virus has actually been growing and obviously destroyed cells in the brain. 124 00:11:19,340 --> 00:11:23,640 Autopsy results have revealed that the man and woman found dead in the Falmouth 125 00:11:23,640 --> 00:11:26,940 jail Tuesday morning had been infected with the rabies virus. 126 00:11:27,530 --> 00:11:31,650 A medical investigation is now underway to determine how they contacted the 127 00:11:31,650 --> 00:11:35,550 disease and what connection, if any, there is between the two cases. 128 00:11:38,950 --> 00:11:41,750 We've done a great job of controlling rabies in the Western world. 129 00:11:41,990 --> 00:11:45,870 So if two people contracted rabies at the same time, alarm bells would go off. 130 00:11:47,210 --> 00:11:50,010 One of the first things that would happen is that public health officials 131 00:11:50,010 --> 00:11:51,850 look for the common links between the two cases. 132 00:11:52,750 --> 00:11:56,970 It's incredibly important to figure out exactly what the source was because you 133 00:11:56,970 --> 00:11:59,090 need to prevent other people from getting sick. 134 00:12:01,430 --> 00:12:06,910 Just basic detective work, trying to find people who may be infected or may 135 00:12:06,910 --> 00:12:11,750 been exposed by interviewing, finding out who they were in contact with. 136 00:12:12,030 --> 00:12:16,650 Since the diagnosis is made after death, you would probably have to be talking 137 00:12:16,650 --> 00:12:20,790 to the family members to find out what the patient's been doing. 138 00:12:21,360 --> 00:12:26,140 We ask them tons of questions, and we try to figure out a common source. 139 00:12:29,500 --> 00:12:32,420 Rabies, as far as we know, infects all mammals. 140 00:12:35,560 --> 00:12:41,500 That includes mammals on land, and it includes mammals in the water. 141 00:12:45,120 --> 00:12:48,600 We know marine mammals, such as seals, have contracted rabies before. 142 00:12:49,290 --> 00:12:51,470 Whales have never tested positive for the virus. 143 00:12:53,290 --> 00:12:57,390 But under the right circumstances, it's certainly possible that they could. 144 00:13:16,300 --> 00:13:19,660 Where could a new, more contagious version of the rabies virus come from? 145 00:13:23,500 --> 00:13:27,920 Viruses change all the time in nature, but there's another way that they can 146 00:13:27,920 --> 00:13:28,920 change. 147 00:13:30,420 --> 00:13:32,720 And that is by our own hands. 148 00:13:36,520 --> 00:13:40,460 Human beings manipulate disease -causing agents in laboratories all the time. 149 00:13:41,450 --> 00:13:45,090 Some of these experiments have led to great medical achievements, like 150 00:13:45,090 --> 00:13:47,010 or even in the fight against cancer. 151 00:13:47,490 --> 00:13:49,410 Cancer killing viruses. 152 00:13:49,930 --> 00:13:54,490 There are many labs who are working on this, and it's very successful right 153 00:13:54,590 --> 00:13:58,870 This is why viruses are mainly genetically engineered today. 154 00:14:01,890 --> 00:14:07,470 But there are also experiments that make viruses more dangerous and more deadly. 155 00:14:07,950 --> 00:14:11,090 And those are the kind that can create an end -of -the -world scenario. 156 00:14:12,130 --> 00:14:16,590 Those experiments really do happen, probably more often than we'd like to 157 00:14:17,670 --> 00:14:23,050 All of the work we do with infectious diseases obviously can save many lives, 158 00:14:23,150 --> 00:14:29,830 but could also be twisted by people who may want to use it for harming others. 159 00:14:33,230 --> 00:14:38,330 Any technology can be used for both good and nefarious purposes. 160 00:14:45,210 --> 00:14:51,790 After the Second World War, Britain, the former Soviet Union, the United 161 00:14:51,790 --> 00:14:55,010 States, they all had some form of biological weapons program. 162 00:14:57,830 --> 00:15:03,080 Then, in the early 1970s, The Biological Weapons Convention outlawed these types 163 00:15:03,080 --> 00:15:05,320 of experiments, but that didn't mean it stopped. 164 00:15:06,620 --> 00:15:08,800 The Soviets just continued in secret. 165 00:15:09,500 --> 00:15:13,740 They developed this huge network of labs that they called biopreparate. 166 00:15:13,860 --> 00:15:18,980 Something like 30 ,000 employees continued to produce bioweapons in these 167 00:15:21,920 --> 00:15:25,700 For years, they kept this all secret, but in 1979, there was an accident. 168 00:15:28,280 --> 00:15:31,440 Anthrax spores leaked out of one of the labs into the surrounding community. 169 00:15:34,420 --> 00:15:36,580 More than 60 Soviet citizens died. 170 00:15:36,800 --> 00:15:39,540 It was the worst known human anthrax outbreak in history. 171 00:15:42,560 --> 00:15:45,880 It was simple human error that caused that anthrax outbreak. 172 00:15:47,500 --> 00:15:51,760 But who's to say that someone else's human error wouldn't cause an even worse 173 00:15:51,760 --> 00:15:52,760 outbreak? 174 00:16:15,330 --> 00:16:19,310 Even with strict precautions in place, there are many ways materials like this 175 00:16:19,310 --> 00:16:20,770 can escape a controlled environment. 176 00:16:21,490 --> 00:16:25,870 You can't safeguard 100 % of the time, not when people are involved and 177 00:16:25,870 --> 00:16:26,870 can be made. 178 00:16:27,850 --> 00:16:29,950 Take a deadly transmissible agent. 179 00:16:32,620 --> 00:16:37,280 Add the possibility of human error, and you now have the recipe for the worst 180 00:16:37,280 --> 00:16:39,180 disease outbreak we've ever seen. 181 00:17:06,440 --> 00:17:07,259 What's up, Dave? 182 00:17:07,260 --> 00:17:08,839 Hey, what's up, David? How you feeling, man? 183 00:17:09,300 --> 00:17:15,079 At this point, a genetically modified virus, deadly and easily spread, has 184 00:17:15,079 --> 00:17:20,480 its way out of the lab and into the environment. A virus, modified and so 185 00:17:20,480 --> 00:17:23,839 that it now threatens to extinguish the entire human race. 186 00:17:24,119 --> 00:17:28,280 People wouldn't just get sick and die. They could transform into zombie -like 187 00:17:28,280 --> 00:17:32,080 madmen, spreading violence along with the disease. 188 00:17:33,340 --> 00:17:39,450 If the rabies virus developed a way to be transmitted from person to person. 189 00:17:47,430 --> 00:17:50,670 That would be an apocalyptic catastrophe. 190 00:18:12,010 --> 00:18:15,690 So if someone were to modify rabies to make it easier to spread between people, 191 00:18:15,830 --> 00:18:16,830 how would they do it? 192 00:18:18,890 --> 00:18:22,990 This would have to be a virus that infected the upper respiratory tract. 193 00:18:23,190 --> 00:18:28,230 And this would be done by making it transmitted through aerosols, through 194 00:18:28,230 --> 00:18:31,150 coughing, through sneezing. 195 00:18:33,850 --> 00:18:38,230 A great example of an airborne disease is influenza. 196 00:18:40,440 --> 00:18:45,020 Influenza is spread incredibly easy from person to person. If you're standing 197 00:18:45,020 --> 00:18:51,200 anywhere near somebody who has influenza, you can get it simply from 198 00:18:51,200 --> 00:18:53,140 that comes out of their mouth when they're talking. 199 00:18:53,540 --> 00:18:57,900 The act of normal human speech can carry thousands of germs just on the moisture 200 00:18:57,900 --> 00:18:58,900 of your breath. 201 00:19:02,740 --> 00:19:08,600 If rabies became transmissible like the flu, you'd have a killer cocktail on 202 00:19:08,600 --> 00:19:09,529 your hands. 203 00:19:09,530 --> 00:19:16,330 People will be coughing, sneezing, 100 ,000 virus particles get released into 204 00:19:16,330 --> 00:19:17,109 the air. 205 00:19:17,110 --> 00:19:21,870 Everybody in that room could potentially come down with rabies. 206 00:19:24,710 --> 00:19:29,750 From a single event, one person can infect a lot of people, and they can go 207 00:19:29,750 --> 00:19:33,730 to infect many, many, many people, and then they can go on to infect many, many 208 00:19:33,730 --> 00:19:34,649 people. 209 00:19:34,650 --> 00:19:36,650 The growth is exponential. 210 00:19:41,930 --> 00:19:48,530 If rabies were to spread like that, it would spread without any kind of 211 00:19:48,530 --> 00:19:49,530 restriction. 212 00:19:50,970 --> 00:19:54,150 If you don't think it's possible, just look what happened during the flu 213 00:19:54,150 --> 00:19:55,150 epidemic of 1918. 214 00:19:57,770 --> 00:20:02,190 Millions of people died when the pandemic of 1918 occurred. 215 00:20:05,510 --> 00:20:10,670 Probably as many as 100 million people died throughout the world. 216 00:20:13,130 --> 00:20:19,630 From this one strain of the virus, in five weeks of this virus, more people 217 00:20:19,630 --> 00:20:21,390 than died from the Black Plague. 218 00:20:21,630 --> 00:20:26,790 More people died in five weeks than died in 25 years of HIV. 219 00:20:30,670 --> 00:20:34,930 So if we had a version of the rabies virus that spread as easily as the flu, 220 00:20:34,930 --> 00:20:37,370 would the medical establishment prevent a pandemic from happening? 221 00:20:37,950 --> 00:20:41,730 Well, chances are they couldn't, because they probably wouldn't even know it was 222 00:20:41,730 --> 00:20:45,600 happening. Rabies is a difficult virus to detect. 223 00:20:46,560 --> 00:20:52,220 Before it reaches the brain, there are no symptoms. You feel perfectly normal. 224 00:20:52,480 --> 00:20:57,360 During this phase, if the virus was able to be transmitted from person to 225 00:20:57,360 --> 00:21:03,080 person, then you could potentially be transmitting this virus to people 226 00:21:03,080 --> 00:21:04,940 even knowing that you had the virus. 227 00:21:05,220 --> 00:21:09,400 And it could potentially take months before the first symptoms appear. 228 00:21:09,800 --> 00:21:15,230 And until then, You would just be carrying on your normal life, subways, 229 00:21:15,450 --> 00:21:19,310 airplanes, supermarkets. 230 00:21:36,110 --> 00:21:40,130 So what will happen when the disease finally begins to show itself? 231 00:21:41,930 --> 00:21:44,510 A person would first start experiencing flu -like symptoms. 232 00:21:44,790 --> 00:21:50,230 You feel malaise. You feel tired. You feel like you have sort of a viral 233 00:21:50,230 --> 00:21:55,010 infection. Then the virus would start manifesting its brain symptoms. 234 00:21:56,770 --> 00:21:58,530 That's when the problems begin. 235 00:22:10,960 --> 00:22:14,280 We've had five cases in the last hour. Fever, slight constipation, trouble 236 00:22:14,280 --> 00:22:16,900 swallowing. They're highly agitated, yelling, screaming. 237 00:22:17,120 --> 00:22:18,540 They won't distill. We don't know what to do. 238 00:22:22,080 --> 00:22:23,800 I'm calling security. 239 00:22:24,100 --> 00:22:25,100 Call the police. 240 00:22:26,160 --> 00:22:32,460 I can imagine how natural cases of rabies would look like a zombie. 241 00:22:34,480 --> 00:22:39,720 Please get out. The similarities are very interesting in the destruction of 242 00:22:39,720 --> 00:22:42,860 brain, the way people's behavior changes. 243 00:22:43,120 --> 00:22:47,360 And when you put a lot of people together, it's a very tragic thing to 244 00:22:48,600 --> 00:22:52,200 Yes, hello, this is the ER. We cannot see any more patients tonight. 245 00:23:26,440 --> 00:23:30,720 operators in Toronto, Los Angeles, New York, and other major North American 246 00:23:30,720 --> 00:23:32,640 cities are overwhelmed tonight. 247 00:23:34,160 --> 00:23:36,000 I'm so scared. 248 00:23:37,120 --> 00:23:42,900 After a string of violent assaults led to an explosion of new cases of rabies. 249 00:23:45,660 --> 00:23:50,140 Authorities are asking people not to approach anyone who could be rabid, even 250 00:23:50,140 --> 00:23:51,380 friends and family. 251 00:23:58,710 --> 00:24:03,650 This outbreak comes on the heels of an announcement that a highly contagious 252 00:24:03,650 --> 00:24:09,070 airborne strain of the rabies virus has infected people in at least 18 253 00:24:09,070 --> 00:24:15,890 countries. Some are calling it a... The media will get 254 00:24:15,890 --> 00:24:20,190 right on top of this and report it. They'll have medical experts on. 255 00:24:20,700 --> 00:24:25,340 There'll be reports from the CDC in Atlanta as to what's being done. 256 00:24:27,780 --> 00:24:34,400 It's necessary in order to get people to do whatever can be done to slow the 257 00:24:34,400 --> 00:24:37,760 infection and the hope would be to stop the infection. 258 00:24:38,020 --> 00:24:42,280 But all of these things, unfortunately, will frighten people. 259 00:24:56,010 --> 00:25:00,430 There's no cure for rabies. Once you develop symptoms, it's universally 260 00:25:00,790 --> 00:25:02,230 But there is a vaccine. 261 00:25:03,110 --> 00:25:05,830 The vaccine can prevent people from getting rabies infection. 262 00:25:06,190 --> 00:25:09,810 But the rabies vaccine can also be used for something called post -exposure 263 00:25:09,810 --> 00:25:14,290 prophylaxis. So even if you're exposed to the rabies virus, if you get the 264 00:25:14,290 --> 00:25:18,090 vaccine in time, it can prevent infection and prevent the onset of 265 00:25:18,550 --> 00:25:25,310 But once you have symptoms, even the first symptoms, that's it. 266 00:25:25,840 --> 00:25:31,780 The only treatment now is make yourself comfortable because it's the end. You're 267 00:25:31,780 --> 00:25:32,780 going to die. 268 00:25:34,260 --> 00:25:36,520 We have arrived at a critical moment. 269 00:25:37,420 --> 00:25:40,060 How many do you have in the hot zone? 270 00:25:45,960 --> 00:25:48,920 Because we have this vaccine, one of the first things that public health 271 00:25:48,920 --> 00:25:52,600 officials would do is to administer the vaccine to people who are exposed to the 272 00:25:52,600 --> 00:25:55,500 rabies virus or at risk of being exposed to the rabies virus. 273 00:25:55,820 --> 00:25:59,480 It's one thing to have an effective vaccine. It's quite another to be able 274 00:25:59,480 --> 00:26:03,420 administer that vaccine to millions or even billions of people in a very rapid 275 00:26:03,420 --> 00:26:08,240 fashion. Right now, they keep the number of doses pretty low. There are not that 276 00:26:08,240 --> 00:26:12,200 many people who have the potential to become infected by rabies every year. 277 00:26:12,320 --> 00:26:13,320 There's only... 278 00:26:13,680 --> 00:26:16,000 A number of doses that range in the thousands. 279 00:26:16,540 --> 00:26:19,540 Hospitals have a few doses. Clinics have a few doses. 280 00:26:22,220 --> 00:26:27,120 The problem with the vaccine is, A, we don't have enough of it, and B, it takes 281 00:26:27,120 --> 00:26:28,360 a while to produce. 282 00:26:29,020 --> 00:26:31,600 Large amounts of rabies virus would have to be grown. 283 00:26:32,460 --> 00:26:35,060 The virus would have to be isolated and inactivated. 284 00:26:35,380 --> 00:26:39,500 Then it has to be formulated with stabilizers and preservatives. This 285 00:26:39,500 --> 00:26:40,500 does not happen quickly. 286 00:26:42,440 --> 00:26:47,700 We don't have much capacity for making a lot of vaccine. If there were a big 287 00:26:47,700 --> 00:26:53,480 rabies outbreak, it would take literally months to be able to make a vaccine to 288 00:26:53,480 --> 00:26:55,100 protect the uninfected. 289 00:27:00,260 --> 00:27:05,080 But even once the vaccine is ready, you'll have a whole new set of problems 290 00:27:05,080 --> 00:27:05,879 your hands. 291 00:27:05,880 --> 00:27:11,380 When you're facing a mass illness, There are huge ethical and social problems 292 00:27:11,380 --> 00:27:15,040 that come with it. First of all, who gets the vaccine if there's a limited 293 00:27:15,040 --> 00:27:19,140 supply? I think 294 00:27:19,140 --> 00:27:25,560 there's no question that there would be a panic 295 00:27:25,560 --> 00:27:28,820 among people to try to get a hold of a vaccine. 296 00:27:46,060 --> 00:27:49,680 Everyone wants to live. They're going to want their families to live. 297 00:27:49,880 --> 00:27:56,660 These kinds of situations in which there's a limited amount of cure and a 298 00:27:56,660 --> 00:28:02,060 huge number of people who need it never work out well for most people. 299 00:28:05,660 --> 00:28:09,640 Remember, in this scenario, the rabies infecting the world isn't normal rabies, 300 00:28:09,640 --> 00:28:13,520 but something created in a laboratory to be more transmissible and more deadly. 301 00:28:14,000 --> 00:28:18,600 Would this virus be the same as the rabies strains that are now around? 302 00:28:19,440 --> 00:28:20,440 Possibly not. 303 00:28:20,740 --> 00:28:27,660 So that rabies virus would not be affected by the vaccine. People 304 00:28:27,660 --> 00:28:30,680 who were vaccinated and thought they were protected would not be. 305 00:28:31,880 --> 00:28:37,920 If they started dying from rabies, then this would amplify 306 00:28:37,920 --> 00:28:39,440 the catastrophe. 307 00:28:48,780 --> 00:28:49,780 close to 1 billion. 308 00:28:50,240 --> 00:28:54,240 Several governments in Africa, South America, and Asia have simply ceased 309 00:28:54,240 --> 00:28:56,340 functioning after officials fled their posts. 310 00:28:58,180 --> 00:29:03,160 Fearing infection, vigilantes across the globe have taken it upon themselves to 311 00:29:03,160 --> 00:29:05,320 execute rabies sufferers on Sunday. 312 00:29:06,780 --> 00:29:11,200 The parties warn this does little to stem the tide of infection and is only 313 00:29:11,200 --> 00:29:12,380 adding to the bloodshed. 314 00:29:16,620 --> 00:29:19,960 So what could we do if the vaccination strategy failed? 315 00:29:20,360 --> 00:29:23,900 We might turn to some of the oldest techniques in history for preventing 316 00:29:23,900 --> 00:29:26,220 epidemics, quarantine and isolation. 317 00:29:27,720 --> 00:29:32,280 But how do you quarantine a population of billions that has basically turned 318 00:29:32,280 --> 00:29:33,280 into zombies? 319 00:29:35,880 --> 00:29:42,860 What can we do at this point? There's a worldwide pandemic of our own 320 00:29:42,860 --> 00:29:45,580 making. It's turning people into virtual zombies. 321 00:29:46,090 --> 00:29:47,990 There's no vaccine. There's no cure. 322 00:29:48,190 --> 00:29:51,330 What can we do now to save ourselves from extinction? 323 00:30:06,590 --> 00:30:10,870 Please pay careful attention to this message. Now protect yourself and your 324 00:30:10,870 --> 00:30:11,870 family. 325 00:30:14,160 --> 00:30:17,220 There are two classic ways that we use to reduce the spread of infectious 326 00:30:17,220 --> 00:30:18,340 diseases in populations. 327 00:30:18,920 --> 00:30:22,640 The first method is quarantine, where people who may have been exposed to the 328 00:30:22,640 --> 00:30:25,900 disease but are not yet showing symptoms have their movements restricted. 329 00:30:29,840 --> 00:30:33,940 The second method is isolation, where people who have symptoms of the disease 330 00:30:33,940 --> 00:30:36,440 are removed from the population to prevent further spread. 331 00:30:47,470 --> 00:30:51,670 broadcast at least 32 countries have imposed strict quarantine restrictions 332 00:30:51,670 --> 00:30:58,390 within their borders the u .s surgeon general is 333 00:30:58,390 --> 00:31:03,090 asking anyone living in a community with even one reported rabies case to stay 334 00:31:03,090 --> 00:31:04,090 indoors 335 00:31:10,950 --> 00:31:15,090 Quarantine is when you put a person who's not yet sick, they're still well, 336 00:31:15,090 --> 00:31:18,410 they've been exposed, you isolate them, you prevent them from going out. 337 00:31:19,490 --> 00:31:24,350 The problem then becomes, those people can't go out to get food, those people 338 00:31:24,350 --> 00:31:29,330 can't go out to do their laundry, those people can't go out to do anything. 339 00:31:29,790 --> 00:31:34,990 Plans have to be made to make sure that those people are fed and they have 340 00:31:34,990 --> 00:31:37,510 enough water to drink, clothes to wear. 341 00:31:39,150 --> 00:31:44,030 It gets very, very hard to enforce because people don't like to be cooped 342 00:31:44,030 --> 00:31:45,030 a long time. 343 00:31:45,270 --> 00:31:51,250 I think that there's a philosophy that if you feel well, you are well. You 344 00:31:51,250 --> 00:31:52,189 feel sick. 345 00:31:52,190 --> 00:31:56,590 You don't think you are sick. You don't see the point of having to sit at home 346 00:31:56,590 --> 00:31:57,590 for days. 347 00:31:57,770 --> 00:32:00,830 But you could be sick and you could infect others. 348 00:32:03,110 --> 00:32:08,510 If you have a virus that's easily transmitted from person to person, A 349 00:32:08,510 --> 00:32:11,570 quarantine may very well not be effective. 350 00:32:12,030 --> 00:32:15,350 That's been tried for influenza virus over the years. 351 00:32:15,630 --> 00:32:16,810 It doesn't work. 352 00:32:18,610 --> 00:32:23,110 And in this scenario, quarantining seemingly healthy individuals would 353 00:32:23,110 --> 00:32:24,110 the easy part. 354 00:32:24,250 --> 00:32:27,690 Trying to isolate people who are already showing symptoms would be even more 355 00:32:27,690 --> 00:32:28,690 difficult. 356 00:32:32,130 --> 00:32:36,930 Isolation is when you prevent somebody from going out who is known to have the 357 00:32:36,930 --> 00:32:43,200 disease. Anyone who was identified as getting sick would have to be isolated 358 00:32:43,200 --> 00:32:48,560 a central site. They would use things like VA hospitals or other government 359 00:32:48,560 --> 00:32:49,560 facilities. 360 00:32:51,240 --> 00:32:55,380 What you have to factor in now is that the people you're trying to isolate, 361 00:32:55,380 --> 00:32:56,780 can be irrational and violent. 362 00:33:01,940 --> 00:33:06,930 If the volume of sick people were heavy enough, they would overwhelm any 363 00:33:06,930 --> 00:33:11,090 facility that was available, and there were agitated people who were not 364 00:33:11,090 --> 00:33:15,330 adhering to their isolation, that system would break down. 365 00:33:16,510 --> 00:33:22,630 As law enforcement fall prey to this illness, there'll be a breakdown of law 366 00:33:22,630 --> 00:33:24,130 order in our society. 367 00:33:26,650 --> 00:33:32,010 And that becomes a self -perpetuating, vicious cycle in which eventually 368 00:33:32,010 --> 00:33:33,130 everything is destroyed. 369 00:33:37,480 --> 00:33:40,920 With rabid people overflowing into the street, we're going to have to switch 370 00:33:40,920 --> 00:33:41,920 strategies immediately. 371 00:33:57,300 --> 00:34:02,440 There's always the possibility of reverse quarantine, where people who are 372 00:34:02,440 --> 00:34:05,180 get together and keep out people who are sick. 373 00:34:06,190 --> 00:34:11,790 There's a phrase called cordon sanitaire, which refers to the idea of 374 00:34:11,790 --> 00:34:16,590 off an entire community, city, town from interaction with the outside world. 375 00:34:16,670 --> 00:34:18,550 Nobody can go in and nobody can go out. 376 00:34:20,389 --> 00:34:27,190 In 1918, during the famous Spanish flu, one town, 377 00:34:27,350 --> 00:34:34,190 Gunnison, Colorado, actually decided that it did not want to have the flu 378 00:34:34,190 --> 00:34:35,190 come. 379 00:34:35,850 --> 00:34:38,690 So it posted armed guards. 380 00:34:38,909 --> 00:34:44,050 Everybody stayed in town. No one had yet caught the flu, and no one was allowed 381 00:34:44,050 --> 00:34:47,190 to leave. If they left, they were not allowed to come back. 382 00:34:47,610 --> 00:34:53,330 Gunnison managed to escape the influenza, but those were very draconian 383 00:34:53,330 --> 00:34:55,389 measures, very carefully enforced. 384 00:34:57,150 --> 00:35:01,330 The problem is the ability to contain one... 385 00:35:01,800 --> 00:35:04,920 cluster of people in one town may be very, very difficult. 386 00:35:09,300 --> 00:35:14,180 Every community right now relies on every other community. To think that you 387 00:35:14,180 --> 00:35:20,200 just band some of your neighbors together in an isolated place and 388 00:35:20,200 --> 00:35:22,340 is, I think, very wishful thinking. 389 00:35:22,740 --> 00:35:26,500 Good morning. Can I see some ID, please? Can you keep out people who are 390 00:35:26,500 --> 00:35:27,780 infected? We're Joe Connor. 391 00:35:28,700 --> 00:35:29,960 Joe Connor, good to go. 392 00:35:30,460 --> 00:35:31,520 Thank you very much, sir. Please. 393 00:35:32,620 --> 00:35:37,260 If infected people are showing signs of aggression, this is going to be a 394 00:35:37,260 --> 00:35:38,260 difficult situation. 395 00:35:40,300 --> 00:35:41,300 Now, 396 00:35:41,560 --> 00:35:45,280 part of the problem in dealing with the infected is you have a mixed bag. People 397 00:35:45,280 --> 00:35:46,780 at various stages of the disease. 398 00:35:47,940 --> 00:35:52,880 Some might be semi -rational, while others might be hostile and 399 00:35:53,020 --> 00:35:56,060 You're also going to have people that are sick, but don't realize they're 400 00:35:59,080 --> 00:36:03,420 demanding food, shelter, and protection from a virus they already have. 401 00:36:44,840 --> 00:36:46,900 Can we really create a rabies -free zone? 402 00:36:48,920 --> 00:36:53,700 There is one unusual manifestation of rabies disease and it could prove useful 403 00:36:53,700 --> 00:36:55,300 in establishing rabies -free zones. 404 00:36:55,700 --> 00:37:02,480 There is one symptom that humanity could conceivably use to protect itself. 405 00:37:17,320 --> 00:37:21,420 Everything we usually use to combat disease is failing in this scenario. 406 00:37:21,980 --> 00:37:26,560 Vaccinations aren't working, isolation isn't working, quarantine isn't working. 407 00:37:26,760 --> 00:37:32,960 So all we've got left is to try to keep the rabid people at bay, away from 408 00:37:32,960 --> 00:37:33,960 healthy people. 409 00:37:35,400 --> 00:37:39,500 And one way we might be able to do that successfully is by using water. 410 00:37:42,540 --> 00:37:46,460 It's well documented that rabies infection causes hydrophobia, a fear of 411 00:37:46,660 --> 00:37:50,080 We don't really know why, but because rabies infects nerve cells that control 412 00:37:50,080 --> 00:37:53,740 the throat muscles, swallowing can become difficult and even painful. 413 00:37:55,460 --> 00:37:59,120 It's this difficulty swallowing that causes people with rabies to foam at the 414 00:37:59,120 --> 00:38:00,120 mouth. 415 00:38:00,860 --> 00:38:03,600 This is because even swallowing saliva becomes difficult. 416 00:38:03,920 --> 00:38:08,380 So it's very normal when you see water, you swallow to reflex. 417 00:38:09,000 --> 00:38:14,040 But if you have trouble swallowing, then every time you see water and you can't 418 00:38:14,040 --> 00:38:16,440 swallow, you become scared of water. 419 00:38:21,180 --> 00:38:28,160 With mass quantities of water, you could conceivably prevent people with rabies 420 00:38:28,160 --> 00:38:34,560 from entering communities, towns, buildings, anything like that. 421 00:38:35,960 --> 00:38:38,300 Of course, there's no guarantee that this would work. 422 00:38:38,590 --> 00:38:39,590 It is a long shot. 423 00:38:40,290 --> 00:38:44,590 But hydrophobia is one of the most consistent and potent symptoms among 424 00:38:44,590 --> 00:38:45,590 sufferers. 425 00:38:46,450 --> 00:38:50,330 But even if the most successfully kept out rabid people, it might not be a 426 00:38:50,330 --> 00:38:54,590 rabies -free zone because the virus might find a way to get in. 427 00:39:01,930 --> 00:39:06,250 Transmission of rabies could occur in ways that we would never even think of. 428 00:39:06,920 --> 00:39:11,040 Remember, infectious agents can mutate. Viruses have been known to change in the 429 00:39:11,040 --> 00:39:12,100 wild during outbreaks. 430 00:39:13,000 --> 00:39:19,940 As a virus mutates, we have no idea of where its limits could 431 00:39:19,940 --> 00:39:26,840 be. You can imagine that it could become even more transmissible and it could 432 00:39:26,840 --> 00:39:28,880 continue to jump species. 433 00:39:29,320 --> 00:39:33,760 The real danger is that the virus could find its way into other species that we 434 00:39:33,760 --> 00:39:34,760 can't control. 435 00:39:38,800 --> 00:39:44,040 A virus like this could be carried by mosquitoes or ticks or mice. At that 436 00:39:44,040 --> 00:39:49,480 point, the idea of isolation and quarantine would be much more difficult. 437 00:39:54,020 --> 00:39:57,320 Once that happens, no place on Earth is safe from the virus. 438 00:39:59,920 --> 00:40:04,800 After the virus finds its way into each rabies -free zone, you'd see the same 439 00:40:04,800 --> 00:40:06,180 pattern over and over and over again. 440 00:40:07,880 --> 00:40:10,240 and until humans are teetering on the verge of extinction. 441 00:40:23,800 --> 00:40:28,560 So, is there really a chance of survival in this kind of rabid zombie 442 00:40:28,560 --> 00:40:29,560 apocalypse? 443 00:40:30,400 --> 00:40:35,080 There might be one hope for humanity to avoid extinction, something that's been 444 00:40:35,080 --> 00:40:36,080 with us all along. 445 00:40:37,480 --> 00:40:42,660 There may be some hope in a situation like this because of the phenomenon of 446 00:40:42,660 --> 00:40:43,660 natural immunity. 447 00:40:44,940 --> 00:40:51,840 Natural immunity is when an individual or some group are naturally immune 448 00:40:51,840 --> 00:40:56,720 to a disease, meaning they can be exposed to it and they will not get 449 00:40:57,020 --> 00:41:00,220 We all have resistance to different infectious diseases. 450 00:41:01,070 --> 00:41:05,990 Some of these are genes that, you know, we were lucky enough to get from our 451 00:41:05,990 --> 00:41:08,330 parents that may protect us. 452 00:41:08,810 --> 00:41:15,710 About 10 % of northern Europeans are resistant to HIV. Even though they're in 453 00:41:15,710 --> 00:41:19,350 the presence of the virus, they don't become infected. 454 00:41:19,610 --> 00:41:23,570 They're not becoming infected because the virus doesn't have the ability to 455 00:41:23,570 --> 00:41:24,570 into their cells. 456 00:41:25,570 --> 00:41:28,310 Because their cells are different. 457 00:41:33,640 --> 00:41:38,560 So what if there are a group of people alive today that are immune to rabies? 458 00:41:38,840 --> 00:41:45,420 There is some suggestion that in the Peruvian rainforest, there are 459 00:41:45,420 --> 00:41:51,160 some groups that are very isolated who have natural immunity to rabies. 460 00:41:52,460 --> 00:41:57,500 They will not get sick when exposed to it. Part of their immune system is 461 00:41:57,500 --> 00:42:01,340 somehow primed to fight off that infection. 462 00:42:02,570 --> 00:42:06,370 If they have the antibodies to rabies, it means that they've been exposed to 463 00:42:06,370 --> 00:42:10,850 virus. But they're still alive. They didn't get a vaccine, but they're alive. 464 00:42:11,210 --> 00:42:18,050 Then, if you look hundreds of years in the future, the people who populate 465 00:42:18,050 --> 00:42:23,990 the planet will all be descendants from these small pockets of people who manage 466 00:42:23,990 --> 00:42:25,910 to live when everyone else dies. 467 00:42:26,830 --> 00:42:30,450 Maybe humanity could get a second chance there. 468 00:42:36,810 --> 00:42:41,610 I think we really need to feel humble in the face of the microscopic world. 469 00:42:41,890 --> 00:42:48,710 Very shortly before the HIV epidemic, someone declared the war 470 00:42:48,710 --> 00:42:53,850 on infectious diseases to be won. And I think that when we get too arrogant 471 00:42:53,850 --> 00:42:59,130 about our ability to control the microscopic world, we are actually 472 00:42:59,130 --> 00:43:00,130 disaster. 473 00:43:01,070 --> 00:43:05,790 It's dangerous to think that we're invulnerable, and it's a healthy 474 00:43:05,790 --> 00:43:10,110 consider how a series of events, none of them outlandish on their own, could 475 00:43:10,110 --> 00:43:12,670 come together to threaten everything we know. 476 00:43:14,590 --> 00:43:18,950 It's always valuable to imagine, to discuss and debate these worst -case 477 00:43:18,950 --> 00:43:22,850 scenarios, because that is how we are going to prepare ourselves for whatever 478 00:43:22,850 --> 00:43:23,850 the future may bring. 43183

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