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Deadly diseases that strike without
warning and spread across the planet.
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The Black Death killed millions upon
millions of people.
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Almost like a zombie death.
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Lethal biological weapons of mass
destruction.
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00:00:19,690 --> 00:00:26,450
Anthrax, botulism, tularemia, I call
them the chess pieces of doom, and
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00:00:26,450 --> 00:00:27,790
mysterious viruses.
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that may rival the worst plagues in
history.
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Hopefully, we'll conquer whatever
happens together.
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Throughout human history, deadly
pandemics have arisen, devastating local
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populations before spreading across the
entire world, crippling economies,
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destroying societies, and leaving mass
death in their wake.
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Are these global pandemics simply acts
of God?
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caused by natural forces beyond our
control?
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Or does mankind bear much of the blame,
as well as hold the key to the ultimate
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cure?
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Perhaps the truth can be found in
America's book of secrets.
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March 11th, 2020.
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The World Health Organization announces
that the outbreak of COVID -19, also
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known as the novel coronavirus, has
become a global pandemic.
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As the number of cases and deaths caused
by the lethal virus surge higher and
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higher, day after day, countries around
the world struggle to provide
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care for the unprecedented wave of
patients that need treatment.
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The COVID -19 pandemic is honestly the
biggest public health emergency of our
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lifetime. And it has been sobering to
see how quickly a disease like that can
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spread around the world.
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When I go to work and I see a line
outside of the emergency department,
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there's not enough ICU nurses,
respiratory therapists, even medication,
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to help the patients who are suffering
from novel coronavirus.
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The hospitals become overwhelmed, and so
patients who needed the care for COVID
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may not get the best care. And in
addition, all the other patients who
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may not be cared for appropriately.
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When a pandemic starts, so many people
are going to be infected.
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And unfortunately, many people will
suffer and die.
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So being on the front line, I realized
what a pandemic can do to
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so many people, my colleagues and
myself.
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By October of 2020, more than one
million people had died from COVID -19
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worldwide, making it the worst pandemic
in more than a century.
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The devastation caused by this disease
is a sobering reminder of the dire
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threat. posed by viruses.
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A virus is an intracellular parasite
that enters the host and
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basically hijacks the host cell's
machinery to create more viral proteins
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and more viral particles and spreads
itself that way.
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They take over our cells, they use our
own bodies to reproduce, and then...
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They'll cause destruction in many of the
organs in our body.
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With COVID -19, we're dealing with
something completely new.
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And so I think there's a lot of lessons
learned we have here.
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I think we learned how important it is
to have rapid diagnostics.
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I wrote an article not too long ago
about the military battlefield lessons.
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We talk about the war against COVID.
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You need to have intelligence
preparation in the battlefield. You need
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what's the battle space.
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Entire U .S. is a battle space. You need
to deny the enemy, conceal and cover.
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How do you do that? You do that with
diagnostics.
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As the COVID -19 virus raged across the
globe and nations joined in an
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unprecedented effort to contain it, the
answer to one daunting question proved
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both mysterious and elusive.
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Just exactly where did this virus come
from?
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The best science that we have says that
the virus that causes COVID -19 probably
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started in animals somewhere in China.
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Might have been a bat, might have been
some other type of animal.
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It was very likely, in my opinion, that
this virus came probably from a bat,
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because we know there are multiple
coronaviruses that circulate in bats.
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And then from there, it went to humans
and person -to -person spread and then
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amplified.
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I think actually what would help to
solve this mystery is really to have an
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international unbiased team that
actually goes to try to trace back the
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of the virus back to that first patient
zero.
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And that's the best way to solve this
mystery. But we'll have to see whether
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that'll ever happen.
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Most human diseases that we're worried
about actually start in animals.
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Some deadly viruses that infect humans
that have animal origins are Ebola,
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smallpox, influenza, the virus that
causes COVID -19, rabies,
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Nipah virus, which causes encephalitis
in some parts of the world, and
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the list goes on and on.
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Despite the opinions of some that COVID
-19 spread from animals to humans,
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numerous experts, including Robert
Redfield, the former head of the CDC,
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begun to speculate that it may have
escaped from an experimental lab in
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China.
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If that is the case, then just how could
such a disastrous event occur?
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There are four ways a pathogen could
escape, quote, unquote, escape a lab.
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The first would be through some type of
aerosol release through one of the vents
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into the atmosphere.
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The second is if an animal were infected
and then somehow got out of the lab.
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A third way would be if someone were
intentionally to try to steal something
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take it out of the lab.
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And then the fourth is that someone
who's working in the laboratory gets
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inadvertently infected and then they go
out into the community not realizing
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they're potentially contagious, they get
ill, they can spread it.
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Washington, D .C.
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October 2nd, 2020.
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President Donald J. Trump tests positive
for COVID -19, joining a growing list
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of world leaders infected by the
potentially deadly virus.
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Although President Trump recovers within
10 days, his exposure demonstrates the
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grave risk that disease has posed to
heads of state.
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And in fact, national security experts.
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are increasingly concerned about the
threat of pandemics being used as
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weapons. A bioweapon is an infectious
disease agent like a bacteria or a virus
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that somebody chooses to use for what I
call nefarious purposes.
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So it's something that they might grow
and then try to expose people to either
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to cause fear and panic or to get people
sick.
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There are certain properties that some
pathogens have that lend themselves more
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favorably to serving as a weapon. So
something that's available, something
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could be grown up in large quantities,
something stable in the environment such
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that it can be released over a large
population, whether it's a battlefield
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city environment.
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The CDC calls them the Category A threat
agents.
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Things like anthrax.
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botulism, plague, tularemia, smallpox,
and viral hemorrhagic fevers. I
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call them the chess pieces of doom. The
case fatality rates for these different
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category A agents range from tularemia
with about 30 % death rate up to
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something like Ebola, which is 90 %
fatal without countermeasures.
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Smallpox is a really interesting
bioweapon because smallpox has been
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It doesn't occur naturally anymore, but
we also have a population of people who
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really have never been vaccinated
against it, and that makes us really
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vulnerable. So smallpox is probably my
number one worry, and then anthrax is my
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number two because there has been a
previous bioterrorism event in the U .S.
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involving anthrax.
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In 2001, there was a bioterrorism attack
on U .S. soil.
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spread in letters that were sent to the
U .S. Post Office, and they got a lot of
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people sick.
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But just how likely is the prospect of a
devastating virus being used as a
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bioweapon?
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There are those who claim that not only
is it possible, but that it already
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happened centuries ago, during the
deadliest pandemic in recorded history.
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May 26, 2021.
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The Democratic Republic of Congo.
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Health officials report that 11 victims
have died from the bubonic plague.
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The government moves quickly to contain
the outbreak, providing the sick with
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powerful antibiotics.
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A treatment that didn't exist 700 years
ago, when the disease touched off the
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worst pandemic in history.
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The Black Death is really the pandemic
that eclipses all others.
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I mean, it killed millions upon millions
of people in medieval Europe beginning
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in the 14th century.
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The Black Death lasted from about 1347
to
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1349, 1350.
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Roughly a third of the European
population died.
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Italy was devastated.
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England was.
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France was.
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The stories behind it just, they send
chills up my spine. It almost sounds
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an episode of zombie death.
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Big, orange, like balls on their hands
and arms.
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The fingers were green.
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We know now that this was something
called Yersinia pestis.
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This is a bacteria.
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So it's easy for me to say now, it's
Yersinia pestis.
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They didn't know that back then.
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Despite not understanding the exact
mechanism by which the disease spread,
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people in the Middle Ages sensed that
the Black Death could afflict anyone who
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came into contact with it.
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This knowledge gave rise to one of the
earliest known examples of personal
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protective equipment, or PPE.
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The plague doctor outfit was essentially
a medieval hazmat suit. It had a
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kind of very hard covering so that the
doctor wouldn't be sprayed with bodily
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fluids. And then there was a beak, which
was filled with flowers or
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herbs or anything that smelled nice to
keep the stench of death away from the
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doctor, with the idea being that...
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bad smells or miasma is really what was
causing people to get sick.
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It was the best hypothesis they had.
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The Black Death, now known as the
Bubonic Plague, has been studied by
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and scientists for centuries in order to
better understand its destructive
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power.
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And it's a power that was actually
unleashed on a medieval battlefield.
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becoming one of the earliest known forms
of biological warfare.
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Khafa, Crimea, 1346.
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For three years, this port city on the
Black Sea, part of the Republic of
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was under siege from Mongolian Tartar
invaders.
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This is an old walled city, And inside
the city were Genoese.
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And Tatar invaders came and laid siege
to the city.
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They surrounded the city. But then there
was an outbreak, a plague amongst the
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Tatar ranks.
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The Mongol population was starting to
get very sick.
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And whether this is a form of
biochemical warfare, psychological
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both, what they ended up doing was...
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catapulting the corpses of their people
over the walls of Caffa and landing on
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the Genoese people repeatedly.
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And the Genoese defenders eventually
started having their own outbreaks of
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plague within the city.
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The Black Death was actually used as
kind of an early bioweapon. That would
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actually incredibly efficient because
the town under siege is a place where
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people packed very closely together.
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So that disease could spread from dead
bodies and spread to the defenders.
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The use of the black death in warfare
underscores the deadly potential of a
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pandemic being utilized as a bioweapon.
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And today in the United States, it is a
scenario that some believe the federal
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government must be ready for.
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Now more than ever.
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If we had a very, very severe pandemic,
one that was extremely deadly, much more
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so than we'll be faced with COVID -19.
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The continuity of government would be
one of the biggest questions we'd have
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face. The continuity of government
apparatus is gigantic. We don't see it,
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it's made up of the airplanes and the
bunkers and the procedures for moving
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successors to the presidency and the
communication systems that nets it all
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together.
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It's a multi -billion dollar a year
operation, but that operation has really
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been created to deal with two very
distinct scenarios.
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Nuclear war or a terrorist attack on
Washington. That's it.
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And so when coronavirus came along, I
think that the people behind continuity
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government didn't quite know what to do.
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whole model had to basically be thrown
away.
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If members of Congress got sick, if the
president or the vice president got
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sick, if the successors to the
presidency under the Constitution were
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unavailable, what exactly were the
rules?
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It will be very interesting as we move
forward in the world of emergency
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preparedness and continuity of
government, whether they deal with a
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a very different way.
208
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That's the challenge of the future.
209
00:16:08,110 --> 00:16:12,030
What would happen if a pandemic were to
strike down a country's leader?
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00:16:12,390 --> 00:16:14,250
Could it change the course of history?
211
00:16:15,270 --> 00:16:18,730
Some historians argue that it has
already happened.
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00:16:19,230 --> 00:16:23,470
It helped to sow the seeds for the
greatest war the world has ever known.
213
00:16:29,870 --> 00:16:31,050
Breivik Mission, Alaska.
214
00:16:31,820 --> 00:16:32,820
1997.
215
00:16:34,140 --> 00:16:39,580
Pathologist Dr. Johan Hulten excavates
an indigenous village graveyard,
216
00:16:39,760 --> 00:16:43,360
searching for something that has eluded
scientists for decades.
217
00:16:43,840 --> 00:16:50,780
The cause of the 1918 influenza
pandemic, also known as the
218
00:16:50,780 --> 00:16:51,820
Spanish flu.
219
00:16:53,900 --> 00:16:57,440
Johan Hulten had heard about...
220
00:16:57,920 --> 00:17:02,160
a town about 80 miles outside of Nome in
Alaska called Brevik Mission.
221
00:17:02,660 --> 00:17:09,060
And it had had a population of about 80,
of which almost all of them had been
222
00:17:09,060 --> 00:17:10,720
killed from the 1918 flu.
223
00:17:11,819 --> 00:17:18,780
So he got the approval to disinter some
of the bodies in the hopes
224
00:17:18,780 --> 00:17:24,440
that the permafrost had preserved the
flu virus and that they could research
225
00:17:25,060 --> 00:17:27,060
And he found the corpse.
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00:17:27,560 --> 00:17:32,680
of a woman who had been morbidly obese.
227
00:17:33,040 --> 00:17:39,840
But it was, in fact, not the permafrost
that preserved the virus, but
228
00:17:39,840 --> 00:17:42,060
her fat storage.
229
00:17:43,940 --> 00:17:48,960
They removed some of that lung tissue,
and from that they were able to then
230
00:17:48,960 --> 00:17:53,720
that to the CDC where we were able to
understand it better, sequence the
231
00:17:53,760 --> 00:17:56,200
that is, understand the genetic code of
that virus.
232
00:17:57,390 --> 00:18:02,890
After successfully sequencing the virus
that caused the Spanish flu, scientists
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00:18:02,890 --> 00:18:08,210
were finally able to unlock the secrets
of the most severe pandemic of the 20th
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00:18:08,210 --> 00:18:09,210
century.
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00:18:09,870 --> 00:18:15,550
So the virus was able to reproduce
itself very quickly and make the host
236
00:18:15,550 --> 00:18:20,130
very quickly as well, and also very
readily pass between people.
237
00:18:20,900 --> 00:18:25,500
But there was no one sort of magic
bullet, I guess, if you will, that made
238
00:18:25,500 --> 00:18:29,500
incredibly powerful. In fact, it was
more like a perfect storm of all these
239
00:18:29,500 --> 00:18:34,060
different features when put together,
created this extremely virulent virus.
240
00:18:34,580 --> 00:18:37,560
It was referred to in 1918 as purple
death.
241
00:18:37,760 --> 00:18:42,240
So that was a terrible virus. We were
able to recover it, understand it.
242
00:18:42,520 --> 00:18:47,080
And then from that, we're able to make
diagnostics, treatments and vaccines
243
00:18:47,080 --> 00:18:48,740
can help prevent that from happening
again.
244
00:18:50,250 --> 00:18:55,390
However, while thankfully medical
science has developed the technology to
245
00:18:55,390 --> 00:19:01,330
protect us from the Spanish flu today,
when it first struck in 1918, it quickly
246
00:19:01,330 --> 00:19:05,610
spread across the globe, leaving
millions dead in its wake.
247
00:19:06,510 --> 00:19:12,090
The 1918 virus was much more dangerous,
much more virulent than COVID -19.
248
00:19:12,770 --> 00:19:16,910
People could die in as little as 12
hours after the first symptoms.
249
00:19:19,740 --> 00:19:22,640
The people who were dying were young.
250
00:19:23,420 --> 00:19:26,220
The peak age for death was in the 20s.
251
00:19:26,580 --> 00:19:29,900
Children were dying in enormous numbers.
252
00:19:31,000 --> 00:19:37,300
So 95 % or so of the excess mortality
was people younger than 65.
253
00:19:38,120 --> 00:19:40,220
Exactly the opposite of today.
254
00:19:41,880 --> 00:19:46,620
The 1918 virus killed somewhere between
50 and 100 million people.
255
00:19:47,110 --> 00:19:52,670
If you adjust for population, that would
be the equivalent of 225 to 450 million
256
00:19:52,670 --> 00:19:53,850
people today.
257
00:19:55,730 --> 00:19:59,610
In 1918, the U .S., of course, was at
war.
258
00:20:00,430 --> 00:20:06,110
And the focus of the government was
entirely on the war and nothing else.
259
00:20:06,670 --> 00:20:12,810
The government was quite willing, to put
it bluntly, to lie and to put the best
260
00:20:12,810 --> 00:20:13,950
face on everything.
261
00:20:14,810 --> 00:20:19,150
Woodrow Wilson, the president, never
even made any public statement of any
262
00:20:19,150 --> 00:20:20,430
about the pandemic.
263
00:20:21,950 --> 00:20:26,930
Woodrow Wilson may not have taken the
pandemic seriously, but he was not
264
00:20:26,930 --> 00:20:27,930
to its effects.
265
00:20:28,790 --> 00:20:34,590
Wilson contracted the influenza virus
during the Paris Peace Conference at the
266
00:20:34,590 --> 00:20:36,230
end of World War I.
267
00:20:37,630 --> 00:20:42,650
Woodrow Wilson had put together what
were known as 14 points.
268
00:20:43,950 --> 00:20:49,310
toward the end of World War I, where the
world leaders were meeting in Paris.
269
00:20:50,890 --> 00:20:57,850
And his 14 points were essentially how
we can work with Germany so something
270
00:20:57,850 --> 00:21:04,790
like this never happens again. And it
was very progressive, especially for its
271
00:21:04,790 --> 00:21:07,550
day, and he really stood by it.
272
00:21:09,680 --> 00:21:16,500
Now, Woodrow Wilson also traveled to
Paris on the same ship that had
273
00:21:16,500 --> 00:21:20,360
shipped many, many sick soldiers
overseas.
274
00:21:21,420 --> 00:21:25,660
So while he was in Paris, Wilson became
very sick.
275
00:21:26,360 --> 00:21:33,140
Everybody around him remarked on how his
mind was affected, how he
276
00:21:33,140 --> 00:21:35,980
couldn't function, he couldn't process
information.
277
00:21:36,600 --> 00:21:38,560
He was physically weak.
278
00:21:39,130 --> 00:21:43,670
And he insisted on returning to the
negotiations while he was still set.
279
00:21:44,890 --> 00:21:50,770
During the peace talks, President Wilson
had argued that America and its allies
280
00:21:50,770 --> 00:21:54,190
should not punish Germany by imposing a
crippling war settlement.
281
00:21:55,530 --> 00:22:00,630
But due to his weakened condition,
Wilson was unable to fight for less
282
00:22:00,630 --> 00:22:05,090
punishment than the one ultimately
brought against the nation of Germany.
283
00:22:05,690 --> 00:22:08,630
And the course of history was
irrevocably altered.
284
00:22:10,170 --> 00:22:12,670
Clemenceau, the French prime minister,
hated Germany.
285
00:22:13,790 --> 00:22:19,330
Germany was blamed for the war, had
reparations, had territory stripped from
286
00:22:19,390 --> 00:22:25,610
The peace treaty was so bad that almost
every historian says that the treaty was
287
00:22:25,610 --> 00:22:32,510
a significant force in the rise of the
Nazis and leading to World
288
00:22:32,510 --> 00:22:33,510
War II.
289
00:22:33,960 --> 00:22:40,080
You could definitely make an argument
that it then led to a person like Adolf
290
00:22:40,080 --> 00:22:42,140
Hitler, charismatic,
291
00:22:42,900 --> 00:22:43,900
nationalist,
292
00:22:44,520 --> 00:22:50,780
dramatic, all the things that people who
are
293
00:22:50,780 --> 00:22:56,160
suffering, who are poor, who are broke,
who are starving, can look to someone
294
00:22:56,160 --> 00:22:58,580
like that and see a potential leader.
295
00:23:00,810 --> 00:23:06,570
If the Spanish flu of 1918 can teach
mankind anything, it's to always be
296
00:23:06,570 --> 00:23:07,570
prepared.
297
00:23:07,770 --> 00:23:09,430
But how do we get ready?
298
00:23:10,710 --> 00:23:15,930
Some say that to battle future
pandemics, we would need to have an
299
00:23:15,930 --> 00:23:18,230
monitoring the world for emerging
diseases.
300
00:23:18,550 --> 00:23:22,490
They would race to the site of an
outbreak, delivering vital on -the
301
00:23:22,490 --> 00:23:26,230
information to scientists that could
fast -track treatments and vaccines.
302
00:23:27,570 --> 00:23:28,890
Well, it turns out...
303
00:23:29,310 --> 00:23:35,330
Such teams do exist, and they're known
as the disease detectives.
304
00:23:40,690 --> 00:23:45,550
Philadelphia, Pennsylvania, July 21,
1976.
305
00:23:47,170 --> 00:23:52,730
More than 2 ,000 U .S. military veterans
gather at the Bellevue Stratford Hotel
306
00:23:52,730 --> 00:23:57,150
for an annual three -day convention of
the American Legion.
307
00:23:58,760 --> 00:24:05,320
In the days following the event, 182 of
the Legionnaires fall ill with a new
308
00:24:05,320 --> 00:24:07,040
unidentified form of pneumonia.
309
00:24:08,500 --> 00:24:13,980
As doctors struggle to make sense of the
mysterious illness, 29 people develop
310
00:24:13,980 --> 00:24:16,920
severe symptoms and perish.
311
00:24:19,100 --> 00:24:21,300
It was an unexplained pneumonia.
312
00:24:21,600 --> 00:24:24,960
We couldn't figure out what it was. None
of the normal things that cause
313
00:24:24,960 --> 00:24:26,760
pneumonia turned out to be the cause.
314
00:24:28,140 --> 00:24:33,100
To solve the mystery, the Centers for
Disease Control called upon America's
315
00:24:33,100 --> 00:24:38,160
first line of defense against emerging
pandemics, the Epidemic Intelligence
316
00:24:38,160 --> 00:24:41,520
Service, or EIS.
317
00:24:42,080 --> 00:24:47,800
The Epidemic Intelligence Service was
established in 1951, and the reason why
318
00:24:47,800 --> 00:24:52,080
came to be is that there were concerns
about biological threats to the people
319
00:24:52,080 --> 00:24:53,080
the United States.
320
00:24:53,160 --> 00:24:56,180
And so the program was put together so
we'd have a workforce.
321
00:24:56,800 --> 00:25:00,980
ready to deploy to investigate any
possible biological warfare or threats
322
00:25:00,980 --> 00:25:02,020
against the United States.
323
00:25:03,280 --> 00:25:07,620
Essentially, they are kind of like FBI
agents, only instead of going after
324
00:25:07,620 --> 00:25:09,120
criminals and terrorists, they go after
disease.
325
00:25:09,760 --> 00:25:14,580
So when an outbreak, especially a sort
of outbreak of unknown origin, pops up
326
00:25:14,580 --> 00:25:18,460
the U .S. or sometimes around the world,
the CDC will send in epidemiologists
327
00:25:18,460 --> 00:25:23,600
from the service to figure out what's
going on. And the CDC's disease
328
00:25:23,600 --> 00:25:25,280
are the best in the world at this.
329
00:25:27,120 --> 00:25:33,500
The Legionnaire outbreak in 1976 sparked
nationwide fear about the unknown
330
00:25:33,500 --> 00:25:36,660
disease that had claimed the lives of 29
victims.
331
00:25:37,660 --> 00:25:41,200
So the disease detectives raced to solve
the mystery.
332
00:25:41,860 --> 00:25:46,640
They scoured the hotel where the
Legionnaires had held their convention,
333
00:25:46,640 --> 00:25:51,840
discovered a mysterious bacterium in the
hotel's air conditioning system, and
334
00:25:51,840 --> 00:25:55,240
took samples of it to be analyzed at the
Centers for Disease Control.
335
00:25:56,880 --> 00:26:01,680
And so they sent those specimens to CDC,
and they were able to characterize an
336
00:26:01,680 --> 00:26:03,460
unusual bacillus.
337
00:26:03,860 --> 00:26:08,240
And they found this thing that's now
called Legionella, or Legionnaire's
338
00:26:08,240 --> 00:26:11,980
disease. And so that's something that's
in water.
339
00:26:12,260 --> 00:26:14,920
It's very different than other bacterial
causes.
340
00:26:15,660 --> 00:26:18,760
You can find it in cooling towers that
are on top of buildings.
341
00:26:19,580 --> 00:26:22,180
You can find it in whirlpool spas.
342
00:26:23,139 --> 00:26:25,880
sometimes the swimming pools and other
sources of water.
343
00:26:26,840 --> 00:26:31,420
And when people walk past it, they
breathe in those droplets, and then they
344
00:26:31,420 --> 00:26:35,460
the bacteria deep in their lungs, and
then they get a bad pneumonia, and it
345
00:26:35,460 --> 00:26:36,460
be fake.
346
00:26:37,540 --> 00:26:41,300
Our disease detectives are looking at
how can they intervene to ensure upon
347
00:26:41,300 --> 00:26:42,480
safety of the public.
348
00:26:43,080 --> 00:26:47,180
And then after they've investigated and
they've collected information and they
349
00:26:47,180 --> 00:26:50,020
think that they might know an
intervention, the next step is obviously
350
00:26:50,020 --> 00:26:51,020
communicate that.
351
00:26:51,980 --> 00:26:57,360
The rapid discovery of Legionella
bacterium brought the potential outbreak
352
00:26:57,360 --> 00:26:58,360
halt.
353
00:26:58,480 --> 00:27:03,400
Thanks to the information provided by
the EIS disease detectives, air
354
00:27:03,400 --> 00:27:07,820
conditioning units and water systems
across the country were retrofitted to
355
00:27:07,820 --> 00:27:08,920
minimize the risk.
356
00:27:10,860 --> 00:27:15,580
The program has evolved quite a bit
since 1951 when it was originally just
357
00:27:15,580 --> 00:27:17,020
physicians and all males.
358
00:27:17,400 --> 00:27:20,520
So now we include not just physicians
but nurses.
359
00:27:21,680 --> 00:27:24,080
veterinarians, PhD -level scientists.
360
00:27:24,440 --> 00:27:30,540
It's a real diverse skill set of people
that are prepared to deploy and respond
361
00:27:30,540 --> 00:27:31,860
to emerging threats.
362
00:27:32,920 --> 00:27:37,760
EIF leaders have not only expanded their
membership to include experts in
363
00:27:37,760 --> 00:27:42,760
different fields of research and
technology, they've also expanded to
364
00:27:42,760 --> 00:27:45,380
operate all around the world.
365
00:27:46,620 --> 00:27:52,930
However... They must accept potentially
deadly risks to their own health in the
366
00:27:52,930 --> 00:27:53,930
process.
367
00:27:54,710 --> 00:28:01,070
There was an outbreak I participated in
in Uganda where I went in a cave that
368
00:28:01,070 --> 00:28:06,130
was full of thousands and thousands of
bats that might be infected with Marburg
369
00:28:06,130 --> 00:28:08,450
virus, which is a deadly virus related
to Ebola.
370
00:28:09,570 --> 00:28:11,870
And I really geared up when I went in
there.
371
00:28:12,470 --> 00:28:14,210
Not only was I wearing...
372
00:28:14,880 --> 00:28:19,040
battery -operated respirator to help me
breathe pure air. I had to wear a helmet
373
00:28:19,040 --> 00:28:21,780
because I might hit my head on the rocks
in the cave.
374
00:28:22,020 --> 00:28:27,080
And I actually had to wear snake chaps
because there were snakes in that cave,
375
00:28:27,200 --> 00:28:30,800
including spitting cobras, that you
wanted to protect yourself against.
376
00:28:31,000 --> 00:28:33,760
And that's what has made it so
particularly dangerous.
377
00:28:34,960 --> 00:28:41,580
Disease detectives myself have been
involved in SARS in 2003, West Nile
378
00:28:42,170 --> 00:28:48,910
Ebola in 2014 -15, Zika, and now most
recently the emergence of COVID
379
00:28:48,910 --> 00:28:55,190
-19. They're the smart people we put out
into the field in order to figure
380
00:28:55,190 --> 00:28:57,130
things out as quickly as possible.
381
00:28:57,690 --> 00:29:03,130
For our disease detectives, collecting
the most valid and reliable evidence is
382
00:29:03,130 --> 00:29:04,129
their top priority.
383
00:29:04,130 --> 00:29:07,710
Not collecting data for the sake of
publication or fame.
384
00:29:08,170 --> 00:29:09,810
They're collecting this information.
385
00:29:10,600 --> 00:29:13,420
so that there can be public health
action taken.
386
00:29:13,820 --> 00:29:18,120
They're ready on a moment's notice to
deploy to any new or emerging public
387
00:29:18,120 --> 00:29:19,120
health threat.
388
00:29:21,460 --> 00:29:26,660
What happens if the disease detectives
are too late and a major epidemic is
389
00:29:26,660 --> 00:29:27,660
already spreading?
390
00:29:28,240 --> 00:29:33,300
Do epidemiologists have the means to
predict where a virus might go and
391
00:29:33,300 --> 00:29:35,040
it before it spirals out of control?
392
00:29:36,500 --> 00:29:37,920
It's entirely possible.
393
00:29:38,730 --> 00:29:44,610
And one of the most promising tools just
might turn out to be a video game.
394
00:29:49,210 --> 00:29:51,390
September 13th, 2005.
395
00:29:52,810 --> 00:29:54,070
Irvine, California.
396
00:29:55,410 --> 00:30:00,950
Video game developer Blizzard
Entertainment introduces a surprise
397
00:30:00,950 --> 00:30:04,890
popular online role -playing game, World
of Warcraft.
398
00:30:05,550 --> 00:30:07,150
A virtual virus.
399
00:30:07,770 --> 00:30:11,350
with the potential to infect characters
within the game's fantasy universe.
400
00:30:12,150 --> 00:30:16,450
They call the virus Corrupted Blood.
401
00:30:16,990 --> 00:30:22,510
The Corrupted Blood experience in World
of Warcraft was essentially a new patch
402
00:30:22,510 --> 00:30:23,510
for the game.
403
00:30:24,010 --> 00:30:28,090
Corrupted Blood was intended to be sort
of an inconvenience to these extremely
404
00:30:28,090 --> 00:30:32,430
powerful players as they battled a demon
in this particular setting within the
405
00:30:32,430 --> 00:30:33,430
game.
406
00:30:33,580 --> 00:30:39,100
And it was intended to slow these very
powerful players down and make it more
407
00:30:39,100 --> 00:30:41,100
challenging to battle the demon.
408
00:30:41,320 --> 00:30:45,840
However, the corrupted blood feature did
not stay contained within that special
409
00:30:45,840 --> 00:30:47,680
battleground for very strong players.
410
00:30:48,280 --> 00:30:52,840
In fact, it would spread unintentionally
because players infected with the
411
00:30:52,840 --> 00:30:57,140
corrupted blood would leave the
battleground and then expose themselves
412
00:30:57,140 --> 00:31:00,600
players that were less powerful. And
those players were extremely susceptible
413
00:31:00,600 --> 00:31:01,780
the corrupted blood and then would die.
414
00:31:04,430 --> 00:31:10,590
This corrupted blood episode was
essentially a digital pandemic, and it
415
00:31:10,590 --> 00:31:11,910
the players by surprise.
416
00:31:13,130 --> 00:31:19,650
At the time, the more than 5 million
World of Warcraft players around the
417
00:31:19,650 --> 00:31:25,450
were rocked by the corrupted blood virus
raging through the game as it began
418
00:31:25,450 --> 00:31:27,070
killing off their characters.
419
00:31:28,110 --> 00:31:29,730
But curiously...
420
00:31:30,580 --> 00:31:35,180
Scientists noted that there were eerie
similarities between this digital
421
00:31:35,180 --> 00:31:38,060
pandemic and the real outbreak.
422
00:31:38,760 --> 00:31:41,960
When you were infected with this virus,
you had to stay away from the other
423
00:31:41,960 --> 00:31:46,520
players. You had to socially distance or
else the other player will get
424
00:31:46,520 --> 00:31:47,520
infected.
425
00:31:48,000 --> 00:31:51,640
And there are many different types of
players. Some have a lot of points.
426
00:31:52,680 --> 00:31:54,320
Some didn't have a lot of points.
427
00:31:55,580 --> 00:31:59,240
And when you had the virus, your life
force will deplete.
428
00:31:59,850 --> 00:32:05,230
So, of course, the individuals that
don't have enough coins were the first
429
00:32:05,230 --> 00:32:11,170
pass away, while individuals who
collected more coins or coins, they
430
00:32:11,170 --> 00:32:12,170
do better.
431
00:32:12,410 --> 00:32:16,930
And no matter what happened in this
game, it seemed like the virus kept on
432
00:32:16,930 --> 00:32:17,930
spreading.
433
00:32:18,250 --> 00:32:22,470
In fact, animals could even get infected
in the game.
434
00:32:24,970 --> 00:32:28,470
The corrupted blood pandemic lasted for
nearly a month.
435
00:32:28,990 --> 00:32:32,970
before the World of Warcraft designers
retooled the virus to stop its spread.
436
00:32:33,710 --> 00:32:36,250
A virtual vaccine, if you will.
437
00:32:37,030 --> 00:32:39,550
But that was not the end of the story.
438
00:32:39,930 --> 00:32:45,910
Because in September of 2007, scientists
from Tufts University published a
439
00:32:45,910 --> 00:32:50,930
research paper which suggested that
virtual games like World of Warcraft
440
00:32:50,930 --> 00:32:54,210
untapped resource in the study of
pandemics.
441
00:32:56,270 --> 00:33:00,030
The unique thing about the World of
Warcraft simulation is that it was a
442
00:33:00,030 --> 00:33:04,570
potential new type of opportunity to
understand and maybe even predict the
443
00:33:04,570 --> 00:33:08,290
different ways that human behavior might
influence the spread of a pandemic.
444
00:33:08,550 --> 00:33:13,550
So, for example, during the outbreak,
the developers imposed a quarantine to
445
00:33:13,550 --> 00:33:17,910
to get players to stay within those
particular areas to help slow the spread
446
00:33:17,910 --> 00:33:20,930
the corrupted blood feature, but they
ignored it.
447
00:33:21,490 --> 00:33:25,770
I think the take -home message is that
What once was just a video game or
448
00:33:25,770 --> 00:33:30,270
entertainment turned out to be something
that maybe can be studied.
449
00:33:31,350 --> 00:33:36,690
And that was interesting. It wasn't just
the game itself, but how the players
450
00:33:36,690 --> 00:33:38,510
reacted to the virus.
451
00:33:39,570 --> 00:33:42,530
How people thought during a pandemic.
452
00:33:43,050 --> 00:33:44,130
What did they do?
453
00:33:45,730 --> 00:33:50,870
In the years since the corrupted blood
incident, the use of computer
454
00:33:50,870 --> 00:33:52,670
to help fight real pandemics.
455
00:33:53,230 --> 00:33:59,650
has evolved these sophisticated digital
tools are now referred to as
456
00:33:59,650 --> 00:34:06,390
mathematical models the model is really
just trying to
457
00:34:06,390 --> 00:34:13,350
predict the future using specific
assumptions about where the disease
458
00:34:13,350 --> 00:34:18,070
might be going in terms of the outbreak
so you take what's known as best you can
459
00:34:18,860 --> 00:34:23,679
and look at various scenarios and
numbers, and you throw that into some
460
00:34:23,679 --> 00:34:27,260
a formula, and it can give you some
sense of where the outbreak is going.
461
00:34:27,880 --> 00:34:33,860
Mathematical models can be used to help
predict things like how fast a virus
462
00:34:33,860 --> 00:34:36,800
will spread, how many individuals will
be affected.
463
00:34:37,760 --> 00:34:42,020
How efficacious these different sorts of
methods of slowing the spread might be,
464
00:34:42,179 --> 00:34:45,820
whether it's a quarantine or just
limiting certain types of services.
465
00:34:46,060 --> 00:34:49,600
How much hospital capacity will be
needed in these different scenarios.
466
00:34:50,060 --> 00:34:53,860
Those are all things that models can
help public health officials gauge.
467
00:34:56,239 --> 00:35:01,660
At their best, mathematical models can
only offer theories as to what might
468
00:35:01,660 --> 00:35:04,540
happen as a pandemic spreads across the
world.
469
00:35:05,260 --> 00:35:08,900
But could a viral threat emerge for
which no data exists at all?
470
00:35:09,340 --> 00:35:14,500
How do we prepare for a virus that's not
of this Earth?
471
00:35:20,780 --> 00:35:23,300
July 24th, 1969.
472
00:35:25,540 --> 00:35:29,120
900 miles southwest of Hawaii in the
Pacific Ocean.
473
00:35:30,200 --> 00:35:33,640
Four days after achieving their historic
moon landing.
474
00:35:34,250 --> 00:35:39,290
the Apollo 11 astronauts splash down
inside their space capsule and are
475
00:35:39,290 --> 00:35:40,950
recovered by the U .S. Navy.
476
00:35:42,890 --> 00:35:47,010
But instead of being allowed to
immediately reunite with their
477
00:35:47,010 --> 00:35:48,050
families to celebrate,
478
00:35:48,970 --> 00:35:54,870
Neil Armstrong, Buzz Aldrin, and Michael
Collins are placed in a strict two
479
00:35:54,870 --> 00:35:55,870
-week quarantine.
480
00:35:56,530 --> 00:35:57,630
The reason?
481
00:35:58,270 --> 00:36:03,350
NASA's fears that the men might possibly
have contracted a lunar virus.
482
00:36:04,140 --> 00:36:05,700
and brought it back to Earth.
483
00:36:07,120 --> 00:36:10,200
These were the first time astronauts
were actually going to another planetary
484
00:36:10,200 --> 00:36:12,020
body, staying there, and then coming
back.
485
00:36:12,820 --> 00:36:16,160
It's absolutely feasible that a
biological contaminant of some kind
486
00:36:16,160 --> 00:36:17,580
back with astronauts.
487
00:36:18,620 --> 00:36:22,640
They quarantined the astronauts from
that first mission, and they also
488
00:36:22,640 --> 00:36:27,840
back moon rocks and tried grinding them
up, extracting them, feeding them to
489
00:36:27,840 --> 00:36:30,660
every type of life that they could think
of to see if there were any ill
490
00:36:30,660 --> 00:36:31,660
effects.
491
00:36:32,520 --> 00:36:37,940
In the end, concerns that the Apollo 11
astronauts brought back any kind of
492
00:36:37,940 --> 00:36:41,660
lunar infection thankfully turned out to
be a false alarm.
493
00:36:42,520 --> 00:36:47,640
But why would NASA worry that bacteria
and viruses might exist in the freezing
494
00:36:47,640 --> 00:36:49,580
vacuum of space in the first place?
495
00:36:50,080 --> 00:36:55,700
The answer lies in the controversial
theory of panspermia, which suggests
496
00:36:55,700 --> 00:37:00,720
microbial life, including potential
viruses, can be found throughout the
497
00:37:01,530 --> 00:37:07,050
including on moons, asteroids, comets,
and alien planets.
498
00:37:08,430 --> 00:37:15,130
Panspermia is essentially derived from
Greek roots, pans meaning everywhere,
499
00:37:15,130 --> 00:37:16,770
spermata meaning seed.
500
00:37:17,970 --> 00:37:22,550
So panspermia essentially means seeds of
life everywhere.
501
00:37:22,810 --> 00:37:29,450
The concept is that life seeds are
distributed widely across the entire
502
00:37:29,450 --> 00:37:30,450
universe.
503
00:37:30,860 --> 00:37:36,620
And whenever conditions are correct, are
appropriate, on a planet safe like the
504
00:37:36,620 --> 00:37:41,300
Earth, then life is deposited and life
gets started.
505
00:37:42,600 --> 00:37:48,440
According to the theory of panspermia,
space microbes trapped in meteors and
506
00:37:48,440 --> 00:37:51,140
comets regularly rain down on Earth.
507
00:37:52,400 --> 00:37:57,020
We have some hundred tons of cometary
debris.
508
00:37:57,790 --> 00:38:00,490
coming into the Earth's atmosphere all
the time.
509
00:38:00,770 --> 00:38:07,710
So I think there had to be a continuing
influx of bacteria and
510
00:38:07,710 --> 00:38:14,210
also viruses and major epidemics
throughout history have started suddenly
511
00:38:14,210 --> 00:38:18,010
and disappeared equally suddenly.
512
00:38:18,960 --> 00:38:24,940
And I think the most reasonable
explanation is that bacteria, viruses,
513
00:38:25,080 --> 00:38:30,340
and maybe even other organisms could
have been introduced from outside and
514
00:38:30,340 --> 00:38:33,600
caused these huge pandemics of disease.
515
00:38:34,980 --> 00:38:40,580
The idea that pandemics could come to
Earth from space is a fascinating and
516
00:38:40,580 --> 00:38:41,760
chilling theory.
517
00:38:42,760 --> 00:38:46,180
However, the much more sobering reality
518
00:38:46,890 --> 00:38:50,930
is that the grave threat of deadly
global infections is alive and well.
519
00:38:51,350 --> 00:38:55,730
A fact driven home by COVID -19.
520
00:39:00,050 --> 00:39:01,830
Summer 2020.
521
00:39:03,010 --> 00:39:06,590
Every nation had to face an indisputable
fact.
522
00:39:07,130 --> 00:39:09,510
The virus was everywhere.
523
00:39:10,270 --> 00:39:13,810
And the death toll was mounting.
524
00:39:15,060 --> 00:39:20,320
Doctors, scientists, and political
leaders focused on one critical goal,
525
00:39:20,820 --> 00:39:25,260
developing a vaccine to combat COVID
-19.
526
00:39:26,360 --> 00:39:29,040
There are multiple challenges to
developing vaccines.
527
00:39:29,480 --> 00:39:35,480
The most basic is identifying the
appropriate antigen or protein to use
528
00:39:35,480 --> 00:39:36,500
actually will be protective.
529
00:39:36,960 --> 00:39:40,960
And if you think about it, it took us 50
years to get an Ebola vaccine.
530
00:39:41,420 --> 00:39:43,560
We still don't have a vaccine for HIV.
531
00:39:44,190 --> 00:39:45,690
So this can take a long time.
532
00:39:46,890 --> 00:39:51,150
But we were very fortunate now that we
identified the right virus.
533
00:39:51,870 --> 00:39:57,890
We knew it was part of the coronavirus
family. It was new, hence the word
534
00:39:58,230 --> 00:40:03,830
But we knew what we wanted to fight
against, which was the spike protein.
535
00:40:04,450 --> 00:40:07,450
Once we knew that, the science kicked
in.
536
00:40:08,610 --> 00:40:10,810
On December 11, 2020.
537
00:40:11,880 --> 00:40:16,800
The world breathed a collective sigh of
relief when the U .S. Food and Drug
538
00:40:16,800 --> 00:40:19,980
Administration approved the first
coronavirus vaccine.
539
00:40:20,940 --> 00:40:27,180
This breakthrough was quickly followed
by additional approved vaccines, and
540
00:40:27,180 --> 00:40:32,160
for the future began to emerge as
hundreds of millions were immunized
541
00:40:32,160 --> 00:40:33,160
globe.
542
00:40:34,580 --> 00:40:39,040
Actually, when you have such a
concentrated effort and funding,
543
00:40:39,770 --> 00:40:44,730
It's amazing to watch how quickly we've
developed new vaccines for this brand
544
00:40:44,730 --> 00:40:45,730
new disease.
545
00:40:45,790 --> 00:40:50,470
That's really incredible, having that
will and the money to do it and the
546
00:40:50,470 --> 00:40:51,470
scientific basis.
547
00:40:53,530 --> 00:40:58,530
If I had one wish from this pandemic, it
would be that everyone, including
548
00:40:58,530 --> 00:41:00,510
myself, we learn from our mistakes.
549
00:41:01,330 --> 00:41:06,390
And of course, we always need to work
together and not be divided.
550
00:41:07,150 --> 00:41:12,210
Because if we don't communicate, we'll
never get the input of all the
551
00:41:12,210 --> 00:41:17,650
individuals, whether it be the doctor
who travels to Alaska, whether it be the
552
00:41:17,650 --> 00:41:19,990
epidemiologist who plays a video game.
553
00:41:20,890 --> 00:41:22,690
Everyone's opinion counts.
554
00:41:23,030 --> 00:41:27,990
So hopefully we'll continue to
communicate and we'll be in this and
555
00:41:27,990 --> 00:41:29,550
whatever happens together.
556
00:41:33,350 --> 00:41:37,750
If recent events have taught us
anything, It's that the threat of deadly
557
00:41:37,750 --> 00:41:39,450
pandemics may never be eliminated.
558
00:41:39,910 --> 00:41:42,490
So, here are the questions that remain.
559
00:41:43,510 --> 00:41:45,190
How will the next one arrive?
560
00:41:45,890 --> 00:41:48,990
Is it possible that we can prevent it
before it happens?
561
00:41:49,270 --> 00:41:52,550
And if not, will we be ready to contain
it?
562
00:41:53,450 --> 00:41:58,190
Some of these answers will only come
with time, while the others could remain
563
00:41:58,190 --> 00:42:02,730
hidden in America's book of secrets.
50806
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