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These are the user uploaded subtitles that are being translated: 1 00:00:00,080 --> 00:00:01,320 meet the 2 00:00:01,320 --> 00:00:04,120 axolot a Mexican salamander that 3 00:00:04,120 --> 00:00:06,399 scientists and the internet alike love 4 00:00:06,399 --> 00:00:08,840 for their amazing ability to regenerate 5 00:00:08,840 --> 00:00:13,280 Limbs and probably for that Derpy 6 00:00:13,730 --> 00:00:15,640 [Music] 7 00:00:15,640 --> 00:00:18,320 smile hi I'm Danielle defo and you're 8 00:00:18,320 --> 00:00:20,880 watching animal logic axotal are members 9 00:00:20,880 --> 00:00:23,720 of the Ambi stoad family and are native 10 00:00:23,720 --> 00:00:27,000 to a very small region in Mexico axelos 11 00:00:27,000 --> 00:00:29,640 were revered by Aztec and their capital 12 00:00:29,640 --> 00:00:31,920 city was built on islands and the lakes 13 00:00:31,920 --> 00:00:34,120 inhabited by the creatures but when the 14 00:00:34,120 --> 00:00:37,000 Spanish settled in 1521 they drained the 15 00:00:37,000 --> 00:00:39,920 lakes and built their city in its place 16 00:00:39,920 --> 00:00:42,680 a first step in driving Axel towards 17 00:00:42,680 --> 00:00:45,239 Extinction as Mexico's City continues to 18 00:00:45,239 --> 00:00:48,039 grow and pollute the Axel population is 19 00:00:48,039 --> 00:00:50,280 pushed further and further towards the 20 00:00:50,280 --> 00:00:52,879 brink today they can only be found in 21 00:00:52,879 --> 00:00:55,640 the wild in Mexico's Sochi milco Lake 22 00:00:55,640 --> 00:00:58,359 complex near Mexico City axolotes are 23 00:00:58,359 --> 00:01:00,359 unique among salamanders because they 24 00:01:00,359 --> 00:01:02,760 are neotenic which means that they reach 25 00:01:02,760 --> 00:01:04,320 adulthood without going through 26 00:01:04,320 --> 00:01:06,479 metamorphosis so they retain all of 27 00:01:06,479 --> 00:01:08,720 their juvenile features like us 28 00:01:08,720 --> 00:01:10,920 Millennials While most salamanders will 29 00:01:10,920 --> 00:01:12,640 grow up lose their gills and their 30 00:01:12,640 --> 00:01:14,640 dorsal fin as they get bigger and emerge 31 00:01:14,640 --> 00:01:17,240 onto land axotal will keep their 32 00:01:17,240 --> 00:01:19,280 feathery external gills and remain 33 00:01:19,280 --> 00:01:21,960 underwater permanently it is extremely 34 00:01:21,960 --> 00:01:24,320 rare but sometimes axotal will reach 35 00:01:24,320 --> 00:01:26,759 maturity and go through metamorphosis 36 00:01:26,759 --> 00:01:28,640 but even then they tend to keep to the 37 00:01:28,640 --> 00:01:30,600 water this has been a comp lished in the 38 00:01:30,600 --> 00:01:32,520 lab by injecting them with a shot of 39 00:01:32,520 --> 00:01:34,799 iodine after which they more closely 40 00:01:34,799 --> 00:01:36,799 resemble their relatives the tiger 41 00:01:36,799 --> 00:01:39,720 salamander axelos can get pretty big 42 00:01:39,720 --> 00:01:42,439 measuring around a foot or 30 cm long 43 00:01:42,439 --> 00:01:44,880 fully grown and they have long lives 44 00:01:44,880 --> 00:01:47,560 around 15 years in the wild but probably 45 00:01:47,560 --> 00:01:49,759 the most interesting thing about them is 46 00:01:49,759 --> 00:01:52,759 their intense ability to regenerate many 47 00:01:52,759 --> 00:01:54,680 amphibians do have the ability to 48 00:01:54,680 --> 00:01:57,079 regenerate but axotal blow the 49 00:01:57,079 --> 00:01:59,479 competition out of the water not only 50 00:01:59,479 --> 00:02:01,439 can they perfectly and seemingly 51 00:02:01,439 --> 00:02:04,240 endlessly regenerate limbs but they can 52 00:02:04,240 --> 00:02:07,240 also regenerate their spinal cord jaw 53 00:02:07,240 --> 00:02:10,679 tail and skin all without scarring no 54 00:02:10,679 --> 00:02:12,560 matter how many times you cut off their 55 00:02:12,560 --> 00:02:15,680 limbs they'll grow back perfectly every 56 00:02:15,680 --> 00:02:17,760 single time and you wouldn't even be 57 00:02:17,760 --> 00:02:19,200 able to tell that you would cut off 58 00:02:19,200 --> 00:02:21,360 their limbs in the first place you could 59 00:02:21,360 --> 00:02:23,879 also even cut out a chunk of their spine 60 00:02:23,879 --> 00:02:25,599 come back in a month and a half and 61 00:02:25,599 --> 00:02:27,760 they'll be no worse for wear they are 62 00:02:27,760 --> 00:02:29,879 also a thousand times more resist 63 00:02:29,879 --> 00:02:31,959 resistant to cancer than any other 64 00:02:31,959 --> 00:02:34,800 animal it works like this after the 65 00:02:34,800 --> 00:02:36,920 amputation the cells at the S of the 66 00:02:36,920 --> 00:02:39,519 amputation lose their identity so 67 00:02:39,519 --> 00:02:41,680 instead of being skin cells or blood 68 00:02:41,680 --> 00:02:44,640 cells they become similar to stem cells 69 00:02:44,640 --> 00:02:47,560 called plop poent cells and they're able 70 00:02:47,560 --> 00:02:49,920 to make any cell or tissue that the body 71 00:02:49,920 --> 00:02:52,599 would need to repair itself in this case 72 00:02:52,599 --> 00:02:54,239 they use the plop poent cells to 73 00:02:54,239 --> 00:02:56,200 generate all the cells and tissues 74 00:02:56,200 --> 00:02:59,000 needed to create new perfect limbs this 75 00:02:59,000 --> 00:03:00,640 phenomenon is a favorite among the 76 00:03:00,640 --> 00:03:02,480 scientific Community for its potential 77 00:03:02,480 --> 00:03:05,879 to help burn victims amputees and even 78 00:03:05,879 --> 00:03:08,120 cancer victims scientists have 79 00:03:08,120 --> 00:03:10,200 experimented with modifying the genetic 80 00:03:10,200 --> 00:03:12,640 makeup of axolotes to include the green 81 00:03:12,640 --> 00:03:15,000 fluorescent protein which is the protein 82 00:03:15,000 --> 00:03:17,599 that makes many jellyfish bioluminescent 83 00:03:17,599 --> 00:03:20,239 while not just making axotal look cooler 84 00:03:20,239 --> 00:03:22,239 the glowing protein allows scientists to 85 00:03:22,239 --> 00:03:24,480 see things inside the axotal that they 86 00:03:24,480 --> 00:03:27,319 couldn't before for example they'll tag 87 00:03:27,319 --> 00:03:29,360 cancerous cells with the protein and 88 00:03:29,360 --> 00:03:30,799 then they can actually see how it 89 00:03:30,799 --> 00:03:32,920 spreads throughout their bodies even 90 00:03:32,920 --> 00:03:35,280 more interesting is that axotal have 91 00:03:35,280 --> 00:03:38,280 plug andplay body parts you can amputate 92 00:03:38,280 --> 00:03:40,680 one Axel's leg and place it in another 93 00:03:40,680 --> 00:03:43,400 Axel and it'll attach itself it's 94 00:03:43,400 --> 00:03:45,360 especially interesting because you don't 95 00:03:45,360 --> 00:03:47,519 even need the whole limb just a few 96 00:03:47,519 --> 00:03:49,840 cells if you take cells from a neon 97 00:03:49,840 --> 00:03:52,000 aelole and place them on an amputated 98 00:03:52,000 --> 00:03:54,879 body of an albino aelole the albino 99 00:03:54,879 --> 00:03:57,680 aelole will actually grow a neon limb 100 00:03:57,680 --> 00:03:59,799 since their skin is quite translucent 101 00:03:59,799 --> 00:04:01,560 you can actually watch the neon green 102 00:04:01,560 --> 00:04:04,159 bone grow out of an otherwise white Axel 103 00:04:04,159 --> 00:04:06,439 lottle this has led to some fairly 104 00:04:06,439 --> 00:04:09,239 morally compromising work in a study 105 00:04:09,239 --> 00:04:11,480 published in Science magazine in 106 00:04:11,480 --> 00:04:13,640 1968 scientists were able to 107 00:04:13,640 --> 00:04:16,440 successfully transplant an aelole head 108 00:04:16,440 --> 00:04:19,040 onto the back of another axel autle one 109 00:04:19,040 --> 00:04:21,840 subject lived for 65 weeks after the 110 00:04:21,840 --> 00:04:24,440 operation with its second head growing 111 00:04:24,440 --> 00:04:26,560 right along with the first head what 112 00:04:26,560 --> 00:04:28,360 animal should I check out next please 113 00:04:28,360 --> 00:04:30,160 let me know in the comments if you want 114 00:04:30,160 --> 00:04:32,120 to support the show and get episodes a 115 00:04:32,120 --> 00:04:34,120 week early you can do so by signing up 116 00:04:34,120 --> 00:04:36,000 for a free trial of the video streaming 117 00:04:36,000 --> 00:04:38,360 app love nature be sure to subscribe for 118 00:04:38,360 --> 00:04:40,520 new episodes of animal logic every other 119 00:04:40,520 --> 00:04:42,800 week right here on YouTube thanks for 120 00:04:42,800 --> 00:04:44,860 watching 121 00:04:44,860 --> 00:04:47,889 [Music] 122 00:04:50,360 --> 00:04:53,519 [Music]8635

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