Would you like to inspect the original subtitles? These are the user uploaded subtitles that are being translated:
1
00:00:06,940 --> 00:00:09,240
If you take the bits of a dead bacteria
2
00:00:09,240 --> 00:00:11,040
And introduce them into someone's body
3
00:00:11,220 --> 00:00:15,120
In all likelihood, the person's immune system is going to flare as if it's under attack.
4
00:00:15,460 --> 00:00:17,500
As harmless as dead bacteria might sound
5
00:00:17,580 --> 00:00:19,900
The body will still react as if it's being invaded.
6
00:00:20,260 --> 00:00:22,540
These dead bits are also known as endotoxin
7
00:00:22,620 --> 00:00:24,700
And are a major red flag for the immune system.
8
00:00:25,120 --> 00:00:27,540
When your immune system does find endotoxin in the body
9
00:00:27,760 --> 00:00:31,020
It will trigger the release of different proteins and physiological changes.
10
00:00:31,220 --> 00:00:32,800
It will make a person feel sick.
11
00:00:32,980 --> 00:00:35,880
Symptoms such as fever, nausea, headache, shivering
12
00:00:35,960 --> 00:00:39,300
Are caused by your immune system gearing up to fight off infections.
13
00:00:39,700 --> 00:00:41,960
This is known as the innate immune response.
14
00:00:42,360 --> 00:00:43,340
It's fantastic!
15
00:00:43,380 --> 00:00:47,680
You can take any person, inject them with endotoxin, and watch them feel terrible for a short while.
16
00:00:48,040 --> 00:00:49,900
And that's what scientists at Radboud University did!
17
00:00:50,240 --> 00:00:53,700
With over 100 people, mapping out a predictable innate immune response.
18
00:00:54,180 --> 00:00:58,280
Now, it wasn't believed that one could voluntarily influence the innate immune response.
19
00:00:58,500 --> 00:01:02,940
But that's exactly what happened when scientists at Radboud injected Wim Hof with endotoxin.
20
00:01:03,160 --> 00:01:04,580
Using the breathing method he developed
21
00:01:04,900 --> 00:01:08,320
He was able to dampen the immune response to the endotoxins presence
22
00:01:08,440 --> 00:01:10,040
By flooding himself with adrenaline.
23
00:01:10,300 --> 00:01:12,940
And stimulating the release of a key messaging protein.
24
00:01:12,940 --> 00:01:13,920
Interleukin 10.
25
00:01:14,160 --> 00:01:17,500
This was achieved through voluntarily influencing the autonomic nervous system.
26
00:01:17,820 --> 00:01:21,020
The same system that beats your heart, remembers to breathe for you...
27
00:01:21,220 --> 00:01:23,540
And prepares you to fight or flight in the face of danger.
28
00:01:23,740 --> 00:01:25,860
A system that for all intents and purposes
29
00:01:26,120 --> 00:01:27,400
Should not be controllable
30
00:01:27,420 --> 00:01:29,640
Because, if we did have control over this system
31
00:01:29,800 --> 00:01:33,340
We might forget to breathe or beat our hearts because we were thinking about...cake.
32
00:01:33,780 --> 00:01:36,720
Yet, this is exactly what happened in the case of Wim Hof.
33
00:01:37,080 --> 00:01:39,100
Voluntarily flooding his body with adrenaline.
34
00:01:39,360 --> 00:01:42,140
Deliberate influence over his autonomic nervous system.
35
00:01:42,540 --> 00:01:43,900
So what should be done?
36
00:01:44,060 --> 00:01:47,320
The possibility is that Wim Hof had different genetics from the average person
37
00:01:47,380 --> 00:01:49,920
Giving him the unique ability to withstand the endotoxin
38
00:01:50,240 --> 00:01:51,720
So a larger test was needed.
39
00:01:51,900 --> 00:01:55,280
With more participants, performing the same techniques designed by Hof.
40
00:01:55,780 --> 00:01:58,020
30 healthy male volunteers were gathered.
41
00:01:58,360 --> 00:02:00,240
18 of whom would be trained by Wim Hof.
42
00:02:00,240 --> 00:02:03,300
And the other 12 are the control to the larger endotoxin experiment.
43
00:02:03,620 --> 00:02:05,320
The 18 volunteers went to Poland
44
00:02:05,320 --> 00:02:09,800
To train in a mixture of meditation, cold exposure, and the breathing technique over 4 days.
45
00:02:10,199 --> 00:02:12,640
And would enjoy a gauntlet of swimming in freezing cold water.
46
00:02:12,760 --> 00:02:14,400
Standing and lying in the snow.
47
00:02:14,540 --> 00:02:19,420
And for the ultimate test, climb a mountain at the elevation of 1590 meters.
48
00:02:19,720 --> 00:02:22,120
With wind chills of -27° C.
49
00:02:22,440 --> 00:02:23,600
All done in shorts.
50
00:02:23,840 --> 00:02:25,100
Very nice shorts too!
51
00:02:25,300 --> 00:02:26,380
The kind you wear at the beach.
52
00:02:26,960 --> 00:02:30,980
Those who weren't trained - the control group, were injected with endotoxin.
53
00:02:31,260 --> 00:02:34,800
They exhibited the typical symptoms and reactions of the innate immune response.
54
00:02:35,200 --> 00:02:39,980
Not a fun thing to experience granted, but we suffer for science here...and yeah, they suffered...
55
00:02:40,340 --> 00:02:43,160
During the experiment a lot of information was kept track of.
56
00:02:43,280 --> 00:02:45,040
This included the composition of the blood.
57
00:02:45,220 --> 00:02:48,080
Cytokines, catecholamines, white blood cell count.
58
00:02:48,160 --> 00:02:51,200
And various physiological changes, such as heart rate and temperature.
59
00:02:51,700 --> 00:02:56,640
This group did not commit to any breathing techniques. Simply passively enduring the endo-toxemia.
60
00:02:56,860 --> 00:03:00,100
The trained group, on the other hand, did commit to the breathing techniques
61
00:03:00,100 --> 00:03:03,200
During the first 2.5 hours of the 8-hour experimentation.
62
00:03:03,680 --> 00:03:06,840
And, in the end, were successful in dampening their innate immune response.
63
00:03:06,960 --> 00:03:08,120
But what happened?
64
00:03:08,320 --> 00:03:09,260
Well, let's walk through this.
65
00:03:09,460 --> 00:03:13,020
There were lots of fun bits of information collected and I'll try to condense the more interesting parts.
66
00:03:13,280 --> 00:03:18,440
Firstly, most clearly, the trained group had a lot more adrenaline from the very start of the experiment
67
00:03:18,500 --> 00:03:19,520
Due to the breathing.
68
00:03:19,580 --> 00:03:20,940
As compared to the control.
69
00:03:21,060 --> 00:03:23,200
This burst of adrenaline from the very start
70
00:03:23,200 --> 00:03:25,800
Correlates nicely with the production of interleukin-10.
71
00:03:25,900 --> 00:03:29,660
An anti-inflammatory cytokine or cell messaging protein.
72
00:03:30,000 --> 00:03:31,540
Here's the control for comparison.
73
00:03:31,800 --> 00:03:32,920
It's a little flatter.
74
00:03:33,200 --> 00:03:36,140
The anti-inflammatory element of interleukin 10
75
00:03:36,140 --> 00:03:40,480
Is that it inhibits the release of other cytokines that contribute towards inflammation
76
00:03:40,820 --> 00:03:42,900
And mediation of the innate immune response.
77
00:03:43,060 --> 00:03:48,320
As a result, the trained group had a less pronounced release of these inflammatory proteins compared to the control.
78
00:03:48,460 --> 00:03:51,020
Had less acute symptoms, and recovered faster.
79
00:03:51,380 --> 00:03:53,920
Here are the cytokines kept track of in the control.
80
00:03:54,160 --> 00:03:55,900
Here in the trained group.
81
00:03:56,060 --> 00:03:57,720
Notice the difference in release.
82
00:03:57,780 --> 00:04:00,500
Far fewer in the trained group because of interleukin - 10.
83
00:04:01,020 --> 00:04:03,860
Now, even though the inflammatory response was suppressed
84
00:04:03,920 --> 00:04:05,640
White blood cells were not.
85
00:04:05,700 --> 00:04:08,800
Having adrenaline in the system actually stirred leukocytosis
86
00:04:08,900 --> 00:04:10,740
And increased of white blood cells in the blood.
87
00:04:11,060 --> 00:04:14,920
Here's a graph showing the controls white blood cell count over the 8-hour experiment
88
00:04:15,100 --> 00:04:16,760
As compared to the trained volunteers.
89
00:04:17,180 --> 00:04:20,080
Some of the categories of different white blood cells were also measured
90
00:04:20,180 --> 00:04:23,540
But the experiment was limited in that not all subtypes were counted.
91
00:04:23,960 --> 00:04:25,520
So, stirred from adrenaline
92
00:04:25,600 --> 00:04:28,840
It appears as though the immune system was still humming and working in the background.
93
00:04:29,140 --> 00:04:31,520
Despite a dampened inflammation response.
94
00:04:31,780 --> 00:04:35,400
Being able to dampen inflammation is also wonderful news on its own!
95
00:04:35,560 --> 00:04:37,360
It implies an interesting alternative
96
00:04:37,400 --> 00:04:40,720
To those who suffer from excessive or persistent inflammation.
97
00:04:41,140 --> 00:04:43,400
Especially when considering autoimmune diseases.
98
00:04:43,820 --> 00:04:48,180
The study of which this animation is based off is a precursor to more investigation.
99
00:04:48,600 --> 00:04:51,800
It had a small sample size, but the results were astonishing!
100
00:04:52,220 --> 00:04:54,520
The influence over the autonomic nervous system
101
00:04:54,520 --> 00:04:57,660
Was probably the most striking part that even Peter Pickers
102
00:04:57,660 --> 00:05:01,280
One of the scientists who orchestrated the study, expressed his surprise.
103
00:05:20,740 --> 00:05:22,260
If there's one thing this tells us
104
00:05:22,520 --> 00:05:25,780
Is that there are deeper layers of our bodies that we can consciously explore.
105
00:05:26,020 --> 00:05:27,560
A potential we should study.
106
00:05:27,660 --> 00:05:29,280
A potential within our biology.
107
00:05:29,540 --> 00:05:31,020
And it's all there in front of us.
108
00:05:31,240 --> 00:05:33,640
So, let's have fun exploring!
9642
Can't find what you're looking for?
Get subtitles in any language from opensubtitles.com, and translate them here.