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These are the user uploaded subtitles that are being translated: 1 00:00:01,664 --> 00:00:04,365 Freeman: Everyone has a beginning. 2 00:00:04,367 --> 00:00:07,569 [ Baby crying ] 3 00:00:07,571 --> 00:00:10,004 But when does that beginning begin? 4 00:00:11,807 --> 00:00:15,610 Is it the instant two cells fuse together? 5 00:00:17,179 --> 00:00:20,348 Or the moment we enter the world? 6 00:00:20,350 --> 00:00:23,618 Scientists and religious leaders don't agree 7 00:00:23,620 --> 00:00:27,488 on when the first spark of life occurs. 8 00:00:27,490 --> 00:00:29,557 Is life just biology 9 00:00:29,559 --> 00:00:32,160 or does our sense of consciousness 10 00:00:32,162 --> 00:00:35,263 dictate whether we are truly alive? 11 00:00:36,799 --> 00:00:39,434 If we can create consciousness, 12 00:00:39,436 --> 00:00:46,207 can we build life out of nonlife and understand when life begins? 13 00:00:52,214 --> 00:00:57,218 Space, time, life itself. 14 00:00:59,355 --> 00:01:03,591 The secrets of the cosmos lie through the wormhole. 15 00:01:03,593 --> 00:01:07,593 Subtital By RA_One 17 00:01:16,472 --> 00:01:19,474 Life is a miracle. 18 00:01:19,476 --> 00:01:23,077 That's a word we use when we are moved by something 19 00:01:23,079 --> 00:01:26,347 and when we don't understand how it happens. 20 00:01:26,349 --> 00:01:29,217 Nine months before a child is born, 21 00:01:29,219 --> 00:01:31,252 it's just a handful of cells, 22 00:01:31,254 --> 00:01:33,221 no more complex, apparently, 23 00:01:33,223 --> 00:01:36,190 than the bacteria that live on our skin. 24 00:01:36,192 --> 00:01:40,061 Both these clumps of cells have genes. 25 00:01:40,063 --> 00:01:42,063 They both reproduce. 26 00:01:42,065 --> 00:01:45,767 One turns into something we value greatly. 27 00:01:45,769 --> 00:01:48,569 The other just makes us sick. 28 00:01:48,571 --> 00:01:51,305 But they are both miracles -- 29 00:01:51,307 --> 00:01:56,344 a collection of chemicals with a mysterious spark of life. 30 00:01:58,180 --> 00:02:01,582 Did you ever make your own lunches growing up? 31 00:02:01,584 --> 00:02:04,185 I used to make peanut butter sandwiches. 32 00:02:04,187 --> 00:02:08,723 Every once in a while, I'd find a moldy slice of bread. 33 00:02:08,725 --> 00:02:12,260 "Where did this green fuzz come from?" I wondered. 34 00:02:12,262 --> 00:02:16,164 Just seemed to have appeared from thin air. 35 00:02:16,166 --> 00:02:19,434 I wondered what would happen if I left it alone. 36 00:02:19,436 --> 00:02:23,838 Would the mold keep growing into a fuzzy mold monster? 37 00:02:29,745 --> 00:02:31,379 It didn't. 38 00:02:31,381 --> 00:02:36,217 It was alive, but not in the way I was. 39 00:02:36,219 --> 00:02:41,556 What was it inside me that made me grow into a boy? 40 00:02:48,731 --> 00:02:51,199 Maureen Condic is a biologist 41 00:02:51,201 --> 00:02:54,135 at the University of Utah School of Medicine. 42 00:02:54,137 --> 00:02:57,238 She spends her weekends traversing 43 00:02:57,240 --> 00:02:59,507 the Wasatch Mountains of Utah, 44 00:02:59,509 --> 00:03:03,311 where life springs up all around her. 45 00:03:03,313 --> 00:03:04,545 Condic: As a biologist, 46 00:03:04,547 --> 00:03:06,047 it's always fascinating to come to the mountains, 47 00:03:06,049 --> 00:03:09,117 because there's such a diversity of life around you, 48 00:03:09,119 --> 00:03:14,155 and it all comes into being in radically different ways. 49 00:03:14,157 --> 00:03:16,791 Freeman: All organisms reproduce, 50 00:03:16,793 --> 00:03:19,694 but they have different ways of doing it. 51 00:03:19,696 --> 00:03:22,897 The Aspen trees that pervade the mountains of Utah 52 00:03:22,899 --> 00:03:24,665 clone themselves. 53 00:03:24,667 --> 00:03:30,171 Offspring grow as shoots from the roots of more mature trees, 54 00:03:30,173 --> 00:03:33,207 creating growths that are really the same tree 55 00:03:33,209 --> 00:03:36,043 grown over and over again. 56 00:03:36,045 --> 00:03:38,412 Some worms, on the other hand, 57 00:03:38,414 --> 00:03:41,649 create their next generations in a different way. 58 00:03:43,552 --> 00:03:46,354 Condic: There's a whole class of worms known as planaria. 59 00:03:46,356 --> 00:03:49,123 They reproduce by attaching the back of their body to a rock 60 00:03:49,125 --> 00:03:51,192 and stretching themselves out 61 00:03:51,194 --> 00:03:53,394 until they literally tear themselves in two. 62 00:03:53,396 --> 00:03:57,431 And then each of the two halves produce a full worm. 63 00:03:57,433 --> 00:04:00,802 Freeman: Nature offers myriad ways for life to begin. 64 00:04:01,737 --> 00:04:05,139 But the one that fascinates Maureen 65 00:04:05,141 --> 00:04:07,842 is the way it happens for you and me. 66 00:04:07,844 --> 00:04:12,113 And, no, it doesn't involve a stork. 67 00:04:12,115 --> 00:04:14,115 Condic: So, human life comes into existence 68 00:04:14,117 --> 00:04:16,584 in just a fraction of a second. 69 00:04:16,586 --> 00:04:18,586 You have a human egg and a human sperm, 70 00:04:18,588 --> 00:04:21,522 and their sole purpose in life is to find each other and fuse. 71 00:04:21,524 --> 00:04:24,158 So, they come together, and in that one instant, 72 00:04:24,160 --> 00:04:29,197 you create a new kind of cell -- a one-celled human embryo. 73 00:04:29,199 --> 00:04:33,701 Freeman: This new cell has its own genetic code, its own DNA, 74 00:04:33,703 --> 00:04:38,239 that is a unique mixture of the egg and the sperm. 75 00:04:38,241 --> 00:04:39,941 Condic: And within this single cell, 76 00:04:39,943 --> 00:04:41,843 there's a complete plan for development. 77 00:04:41,845 --> 00:04:43,978 Development doesn't create that information. 78 00:04:43,980 --> 00:04:45,613 It's there from the very beginning. 79 00:04:45,615 --> 00:04:49,650 Freeman: From her understanding of embryology, 80 00:04:49,652 --> 00:04:53,788 Maureen concludes that the life of a unique human individual 81 00:04:53,790 --> 00:04:56,190 begins within the 1/4 of a second 82 00:04:56,192 --> 00:05:00,561 it takes the sperm and the egg to unite. 83 00:05:00,563 --> 00:05:02,530 That single-celled embryo 84 00:05:02,532 --> 00:05:05,433 contains an elaborate instruction manual 85 00:05:05,435 --> 00:05:11,172 with all of the information needed to create a human being. 86 00:05:11,174 --> 00:05:12,640 You can think of it like 87 00:05:12,642 --> 00:05:18,212 a camping tent that builds itself. 88 00:05:18,214 --> 00:05:20,248 So, our tent is self-assembling because it has 89 00:05:20,250 --> 00:05:23,050 all of the parts it needs to put itself together 90 00:05:23,052 --> 00:05:26,654 and because it has a set of instructions built into it 91 00:05:26,656 --> 00:05:30,625 that allow it to assemble into its final state. 92 00:05:30,627 --> 00:05:32,560 Freeman: Life is like this tent, 93 00:05:32,562 --> 00:05:37,698 only a billion times more complex. 94 00:05:37,700 --> 00:05:41,602 After the single-celled embryo is formed, 95 00:05:41,604 --> 00:05:43,938 it takes a journey down the fallopian tubes 96 00:05:43,940 --> 00:05:45,139 to the uterus, 97 00:05:45,141 --> 00:05:48,676 where it begins the process of cell division, 98 00:05:48,678 --> 00:05:53,147 from 2 cells to 4 to 8 to 16 and so on. 99 00:05:53,149 --> 00:05:54,615 After about one week, 100 00:05:54,617 --> 00:05:57,718 the embryo arrives at the uterine wall 101 00:05:57,720 --> 00:05:59,887 and implants itself. 102 00:05:59,889 --> 00:06:02,823 A week later, the cells of the embryo 103 00:06:02,825 --> 00:06:07,628 begin to reorganize themselves into a primitive body. 104 00:06:07,630 --> 00:06:09,230 After three weeks, 105 00:06:09,232 --> 00:06:12,566 the beginning of the nervous system is in place. 106 00:06:12,568 --> 00:06:16,404 As days go on, cells continue to multiply, 107 00:06:16,406 --> 00:06:20,574 blood vessels form, the heart starts to beat, 108 00:06:20,576 --> 00:06:22,743 the backbone takes shape, 109 00:06:22,745 --> 00:06:25,913 arms and legs begin to bulge out. 110 00:06:25,915 --> 00:06:27,548 During that time, 111 00:06:27,550 --> 00:06:31,485 the formation of the brain begins. 112 00:06:31,487 --> 00:06:33,521 Condic: The cells and tissues of the embryo 113 00:06:33,523 --> 00:06:36,824 undergo these amazingly complex cellular gymnastics 114 00:06:36,826 --> 00:06:39,660 to give rise to structures, organs, 115 00:06:39,662 --> 00:06:42,964 complex relationships that turn that flat embryo 116 00:06:42,966 --> 00:06:46,434 into something that has form. 117 00:06:52,274 --> 00:06:54,709 Freeman: Maureen's biological understanding 118 00:06:54,711 --> 00:06:56,644 of the development of a human embryo 119 00:06:56,646 --> 00:06:58,512 leaves her with little doubt 120 00:06:58,514 --> 00:07:02,817 about when a new human life begins. 121 00:07:02,819 --> 00:07:07,221 We all trace our own origins back to this single cell 122 00:07:07,223 --> 00:07:09,824 that came into existence at sperm-egg fusion. 123 00:07:09,826 --> 00:07:12,760 It's something we should try to understand 124 00:07:12,762 --> 00:07:14,462 as a process of self-discovery, 125 00:07:14,464 --> 00:07:17,131 as a process of understanding our natures. 126 00:07:17,133 --> 00:07:18,833 This is where we began. 127 00:07:18,835 --> 00:07:22,737 Freeman: But not all scientists trace an individual's origins 128 00:07:22,739 --> 00:07:25,606 back to just two cells. 129 00:07:27,609 --> 00:07:32,313 In fact, some scientists believe within one individual 130 00:07:32,315 --> 00:07:35,983 there could be the ghosts of multiple lives, 131 00:07:35,985 --> 00:07:38,219 that life on earth is an unbreakable chain of events 132 00:07:38,221 --> 00:07:41,655 where one generation and the next 133 00:07:41,657 --> 00:07:44,058 are blurred together. 134 00:07:44,060 --> 00:07:47,161 Gammill: When I was a kid, I would go and visit my grandfather, 135 00:07:47,163 --> 00:07:49,463 and he used to play chess, and I would go and watch him, 136 00:07:49,465 --> 00:07:51,866 and I grew up learning to play with him... 137 00:07:51,868 --> 00:07:52,867 Pawn to G-4. 138 00:07:56,204 --> 00:07:58,039 ...and then my father also taught my son, 139 00:07:58,041 --> 00:07:59,673 and now my son and I play. 140 00:08:03,078 --> 00:08:04,412 [ Distorted voice ] Checkmate. 141 00:08:04,414 --> 00:08:07,648 I think there's an interesting parallel between chess 142 00:08:07,650 --> 00:08:09,750 that was passed from one generation to another, 143 00:08:09,752 --> 00:08:11,852 and what we know biologically now 144 00:08:11,854 --> 00:08:14,588 is the passage of cells between generations. 145 00:08:17,125 --> 00:08:19,126 Freeman: Dr. Hilary Gammill 146 00:08:19,128 --> 00:08:21,896 from the Fred Hutchinson Cancer Research Center 147 00:08:21,898 --> 00:08:23,631 believes individual lives 148 00:08:23,633 --> 00:08:26,600 are more interwoven than we ever imagined. 149 00:08:27,836 --> 00:08:30,504 She wonders if inside all of us 150 00:08:30,506 --> 00:08:32,840 there are traces of our relatives, 151 00:08:32,842 --> 00:08:35,943 dating back generations. 152 00:08:35,945 --> 00:08:38,312 Gammill: My area of focus is on the exchange of cells 153 00:08:38,314 --> 00:08:40,748 between a mother and fetus during pregnancy. 154 00:08:40,750 --> 00:08:42,483 The classic textbooks used to state 155 00:08:42,485 --> 00:08:44,285 that there was absolutely no contact 156 00:08:44,287 --> 00:08:46,253 between the fetal blood and the maternal blood -- 157 00:08:46,255 --> 00:08:48,589 they were just protected in separate compartments. 158 00:08:48,591 --> 00:08:52,893 Freeman: For years, scientists thought when the placenta forms, 159 00:08:52,895 --> 00:08:55,563 it acts as an impenetrable barrier 160 00:08:55,565 --> 00:08:57,832 between the mother and the fetus, 161 00:08:57,834 --> 00:08:59,366 so nothing as large 162 00:08:59,368 --> 00:09:01,335 as a foreign cell with foreign genes 163 00:09:01,337 --> 00:09:03,204 could pass through -- 164 00:09:03,206 --> 00:09:06,140 baby's DNA stays within the baby, 165 00:09:06,142 --> 00:09:09,243 and mom's DNA stays with the mom. 166 00:09:13,748 --> 00:09:16,784 By peering into the bloodstreams of mothers, 167 00:09:16,786 --> 00:09:20,654 Hilary and her team have discovered something remarkable. 168 00:09:20,656 --> 00:09:23,357 When they sampled just a teaspoon 169 00:09:23,359 --> 00:09:25,259 of blood from the mothers, 170 00:09:25,261 --> 00:09:29,163 they found dozens and dozens of foreign cells floating around, 171 00:09:29,165 --> 00:09:32,299 cells from the mothers' babies. 172 00:09:33,635 --> 00:09:37,037 So, we actually understand now that throughout pregnancy, 173 00:09:37,039 --> 00:09:40,574 there is bidirectional exchange of information cells and DNA 174 00:09:40,576 --> 00:09:42,176 between the mother and the fetus. 175 00:09:42,178 --> 00:09:48,415 Freeman: Hilary's work shows the placenta is not at all impenetrable. 176 00:09:48,417 --> 00:09:50,618 It's more like a sieve. 177 00:09:50,620 --> 00:09:52,052 There are miniscule holes 178 00:09:52,054 --> 00:09:54,989 that let cells out and let cells in. 179 00:09:54,991 --> 00:09:59,393 These foreign cells can survive in our bodies for decades. 180 00:09:59,395 --> 00:10:00,928 It's an exchange that happens 181 00:10:00,930 --> 00:10:03,030 not only between mother and fetus. 182 00:10:03,032 --> 00:10:06,700 Cells from other relatives may sneak in, too. 183 00:10:06,702 --> 00:10:10,371 It is theoretically possible that we could have cells 184 00:10:10,373 --> 00:10:12,506 that are exchanged from multiple different sources -- 185 00:10:12,508 --> 00:10:14,642 you know, older siblings 186 00:10:14,644 --> 00:10:16,777 and certainly mothers and fetuses, 187 00:10:16,779 --> 00:10:19,446 but past generations, as well. 188 00:10:19,448 --> 00:10:23,317 Freeman: When a mother acquires cells from a fetus, 189 00:10:23,319 --> 00:10:25,419 she could pass on these baby cells 190 00:10:25,421 --> 00:10:26,720 to her next child. 191 00:10:26,722 --> 00:10:28,822 A younger sibling could have cells 192 00:10:28,824 --> 00:10:31,825 from the body of an older sibling. 193 00:10:31,827 --> 00:10:34,995 These cells are more than just a curiosity. 194 00:10:34,997 --> 00:10:36,997 They can act as soldiers in the body 195 00:10:36,999 --> 00:10:39,433 and combat disease... 196 00:10:39,435 --> 00:10:42,069 Those cells can be active against cancer cells 197 00:10:42,071 --> 00:10:43,304 that develop in the recipient. 198 00:10:43,306 --> 00:10:46,140 Freeman: ...But not all of these exchanged cells 199 00:10:46,142 --> 00:10:48,008 protect and defend. 200 00:10:48,010 --> 00:10:49,410 When our immune system 201 00:10:49,412 --> 00:10:51,879 detects these foreign cells in the bloodstream, 202 00:10:51,881 --> 00:10:55,482 it may decide to attack them. 203 00:10:55,484 --> 00:10:58,152 Gammill: These small numbers of foreign cells 204 00:10:58,154 --> 00:10:59,720 that are persistent in an individual 205 00:10:59,722 --> 00:11:02,523 are associated with disease states, 206 00:11:02,525 --> 00:11:05,192 like autoimmune diseases like systemic sclerosis. 207 00:11:06,595 --> 00:11:08,295 The exchange of cells 208 00:11:08,297 --> 00:11:11,265 may have both positive and negative consequences 209 00:11:11,267 --> 00:11:13,701 for the health of the individuals involved. 210 00:11:16,171 --> 00:11:18,339 Freeman: The presence of cells from our relatives 211 00:11:18,341 --> 00:11:21,008 could change the course of our entire lives, 212 00:11:21,010 --> 00:11:24,278 making us all more interconnected 213 00:11:24,280 --> 00:11:26,513 than we ever thought possible. 214 00:11:26,515 --> 00:11:29,316 Gammill: Understanding that cells are exchanged 215 00:11:29,318 --> 00:11:32,486 commonly between individuals, 216 00:11:32,488 --> 00:11:35,656 I think, blurs the borders between those individuals 217 00:11:35,658 --> 00:11:37,558 so that the beginning of one life 218 00:11:37,560 --> 00:11:40,461 and the end of another life are a little bit less clear. 219 00:11:42,297 --> 00:11:44,965 Freeman: The life of some parts of our bodies 220 00:11:44,967 --> 00:11:48,902 actually begins before our sperm and egg have ever met, 221 00:11:48,904 --> 00:11:51,038 but one doctor in Stockholm 222 00:11:51,040 --> 00:11:52,906 wants to push the beginning of life 223 00:11:52,908 --> 00:11:54,341 in the other direction. 224 00:11:54,343 --> 00:12:00,981 He believes we cannot be alive until we know we are alive. 225 00:12:03,467 --> 00:12:05,502 When does human life begin? 226 00:12:06,737 --> 00:12:09,306 In this age of in vitro fertilization 227 00:12:09,308 --> 00:12:10,840 and prenatal medicine, 228 00:12:10,842 --> 00:12:14,010 it's a question that scientists and doctors 229 00:12:14,012 --> 00:12:15,845 struggle to answer every day. 230 00:12:17,014 --> 00:12:20,050 Perhaps there's another way to approach the question. 231 00:12:20,052 --> 00:12:23,486 How do you know if someone is home? 232 00:12:23,488 --> 00:12:28,825 You knock on the door, see if someone answers. 233 00:12:31,662 --> 00:12:34,631 When Dr. Hugo Lagercrantz was a younger man, 234 00:12:34,633 --> 00:12:37,000 his life was stressful. 235 00:12:38,336 --> 00:12:40,303 [ Baby crying ] 236 00:12:42,740 --> 00:12:45,475 He was the director of the neonatal intensive care unit 237 00:12:45,477 --> 00:12:47,677 at the Astrid Lindgren Children's Hospital 238 00:12:47,679 --> 00:12:49,479 in Stockholm, 239 00:12:49,481 --> 00:12:53,416 where he monitored fetuses and newborn babies. 240 00:12:53,418 --> 00:12:56,186 Fetal monitoring was quite new at that time. 241 00:12:56,188 --> 00:12:57,387 There were a lot of false alarms, 242 00:12:57,389 --> 00:12:59,689 so [chuckles] it was distressing. 243 00:12:59,691 --> 00:13:03,093 Freeman: But Hugo's patients experienced far more stress 244 00:13:03,095 --> 00:13:05,128 than he ever did -- 245 00:13:05,130 --> 00:13:08,198 not the mothers, the babies. 246 00:13:08,200 --> 00:13:12,535 Lagercrantz: Being born is the most stressful event in life, 247 00:13:12,537 --> 00:13:15,005 particularly if you're born in the natural way. 248 00:13:16,407 --> 00:13:18,008 Freeman: When we are born, 249 00:13:18,010 --> 00:13:20,377 we're taken from our warm, safe womb 250 00:13:20,379 --> 00:13:22,779 and thrown into the world. 251 00:13:23,948 --> 00:13:27,751 It's the most dramatic day of our lives, 252 00:13:27,753 --> 00:13:32,689 but it's a day we don't even remember. 253 00:13:35,326 --> 00:13:36,960 This made Hugo wonder, 254 00:13:36,962 --> 00:13:40,163 "When do babies become aware of what's going on? 255 00:13:40,165 --> 00:13:42,866 When does consciousness begin?" 256 00:13:42,868 --> 00:13:48,371 He thinks we can look for clues by looking at fish. 257 00:13:48,373 --> 00:13:50,740 Lagercrantz: Now there is a new law in Sweden 258 00:13:50,742 --> 00:13:53,610 that you're not allowed to use hooks when you're fishing. 259 00:13:53,612 --> 00:13:55,311 The idea is that they think 260 00:13:55,313 --> 00:13:57,914 that the fish may be conscious and suffer, 261 00:13:57,916 --> 00:14:00,350 and certainly the fish reacts to pain, 262 00:14:00,352 --> 00:14:03,620 but I don't think the fish is conscious about pain. 263 00:14:03,622 --> 00:14:07,590 It's more kind of a reflex. 264 00:14:09,060 --> 00:14:10,627 Freeman: According to Hugo, 265 00:14:10,629 --> 00:14:14,130 fish cannot experience the psychological aspect of pain 266 00:14:14,132 --> 00:14:16,266 because they lack the brain circuitry 267 00:14:16,268 --> 00:14:18,401 called thalamocortical connections. 268 00:14:18,403 --> 00:14:19,903 Thank you. 269 00:14:22,306 --> 00:14:24,040 Thalamocortical connections 270 00:14:24,042 --> 00:14:26,576 operate like a switchboard in the human brain. 271 00:14:26,578 --> 00:14:32,749 Whenever we see, hear, touch, smell, or taste something, 272 00:14:32,751 --> 00:14:36,753 electrical signals go from our sensory organs to the cortex 273 00:14:36,755 --> 00:14:41,691 so our brains can process what we experience in the world. 274 00:14:41,693 --> 00:14:44,260 These thalamocortical connections 275 00:14:44,262 --> 00:14:46,463 are crucial for consciousness 276 00:14:46,465 --> 00:14:48,565 because we believe that consciousness -- 277 00:14:48,567 --> 00:14:53,470 at least high consciousness -- is localized in the cortex, 278 00:14:53,472 --> 00:14:57,474 and if what you see, what you hear, what you sense 279 00:14:57,476 --> 00:15:00,110 doesn't reach the cortex, 280 00:15:00,112 --> 00:15:01,611 then you cannot be conscious about it. 281 00:15:01,613 --> 00:15:05,181 Freeman: Hugo is now a neonatal researcher 282 00:15:05,183 --> 00:15:08,284 and studies when human brains develop these connections. 283 00:15:09,453 --> 00:15:13,790 When does the first spark of consciousness happen? 284 00:15:13,792 --> 00:15:17,961 Donato, a 4-day-old full-term baby, 285 00:15:17,963 --> 00:15:20,897 is here to help Hugo find out. 286 00:15:20,899 --> 00:15:24,467 There are several criteria for consciousness. 287 00:15:24,469 --> 00:15:26,436 One is being awake 288 00:15:26,438 --> 00:15:30,039 and then to be aware of your body 289 00:15:30,041 --> 00:15:32,842 and then, of course, to be aware what you see 290 00:15:32,844 --> 00:15:35,178 and hear and smell, et cetera. 291 00:15:35,180 --> 00:15:38,815 Freeman: Hugo and his team connect Donato to an instrument 292 00:15:38,817 --> 00:15:40,784 that measures blood flow in his brain. 293 00:15:40,786 --> 00:15:42,218 [ Monitor beeping ] 294 00:15:43,954 --> 00:15:46,589 When Donato is exposed to certain stimuli, 295 00:15:46,591 --> 00:15:48,324 Hugo can tell 296 00:15:48,326 --> 00:15:50,260 if the baby's brain is receiving signals 297 00:15:50,262 --> 00:15:52,262 and processing the outside world. 298 00:15:55,766 --> 00:15:58,501 Milk is a scent Donato is used to, 299 00:15:58,503 --> 00:16:02,138 which is why he shows little blood flow. 300 00:16:02,140 --> 00:16:06,442 Vanilla, on the other hand, is a pleasant surprise, 301 00:16:06,444 --> 00:16:09,479 causing the blood flow in the brain to spike. 302 00:16:09,481 --> 00:16:11,047 [ Monitor beeping ] 303 00:16:11,049 --> 00:16:12,882 Lagercrantz: With vanilla, it indicates 304 00:16:12,884 --> 00:16:16,186 that the baby reacted in the cortex to this smell. 305 00:16:18,088 --> 00:16:22,492 Freeman: When Hugo gives Donato a whiff of a toxic odor, like acetone, 306 00:16:22,494 --> 00:16:24,828 he has a very negative reaction. 307 00:16:24,830 --> 00:16:26,996 His blood flow goes down, 308 00:16:26,998 --> 00:16:31,568 even below where he started before he smelled the milk. 309 00:16:31,570 --> 00:16:35,839 It tells us that the baby seems to be conscious 310 00:16:35,841 --> 00:16:37,974 of the good and bad smell, 311 00:16:37,976 --> 00:16:39,709 which, I think, is very important 312 00:16:39,711 --> 00:16:42,312 from an evolutionary point of view. 313 00:16:42,314 --> 00:16:44,047 For survival, I mean, you must be able 314 00:16:44,049 --> 00:16:46,749 to differentiate between what is good for you 315 00:16:46,751 --> 00:16:49,319 and what is poisonous or not good for you. 316 00:16:51,488 --> 00:16:53,089 Freeman: Hugo's study proves 317 00:16:53,091 --> 00:16:56,559 that even a 4-day-old baby is already conscious, 318 00:16:56,561 --> 00:16:59,863 but what about before we reach full-term? 319 00:16:59,865 --> 00:17:02,098 Testing for consciousness in fetuses 320 00:17:02,100 --> 00:17:05,101 is too invasive with current medical technology, 321 00:17:05,103 --> 00:17:06,836 so Hugo tries to get clues 322 00:17:06,838 --> 00:17:12,175 by studying premature infants born as young as 22 weeks. 323 00:17:12,177 --> 00:17:16,613 I would say that after 25, 26 weeks 324 00:17:16,615 --> 00:17:19,482 that they seem to have some degree of consciousness, 325 00:17:19,484 --> 00:17:22,585 but before that, there are very few signs 326 00:17:22,587 --> 00:17:24,787 that they are conscious. 327 00:17:25,956 --> 00:17:29,659 Freeman: Hugo's research has led him to believe 328 00:17:29,661 --> 00:17:34,063 that a baby cannot be conscious until it is about 25 weeks old. 329 00:17:34,065 --> 00:17:37,233 So, is this when life begins? 330 00:17:37,235 --> 00:17:40,737 I think before consciousness has developed, 331 00:17:40,739 --> 00:17:43,306 you are not a person, actually. 332 00:17:43,308 --> 00:17:46,476 I think this is the time when life begins. 333 00:17:49,480 --> 00:17:51,581 Freeman: But one child psychologist thinks the beginning of life 334 00:17:51,583 --> 00:17:53,049 comes much later... 335 00:17:54,518 --> 00:17:56,653 ...later than you could ever imagine. 336 00:18:01,930 --> 00:18:03,531 Mark Twain once wrote, 337 00:18:03,533 --> 00:18:07,334 "Man is the only animal that blushes... 338 00:18:07,336 --> 00:18:09,236 or needs to." 339 00:18:09,238 --> 00:18:12,673 Blushing is a uniquely human reaction, 340 00:18:12,675 --> 00:18:14,075 one that stems 341 00:18:14,077 --> 00:18:16,510 from our high level of self-awareness, 342 00:18:16,512 --> 00:18:18,846 but babies don't blush. 343 00:18:18,848 --> 00:18:22,216 It's something they have to learn. 344 00:18:22,218 --> 00:18:28,322 Does human life only truly begin when we become self-conscious? 345 00:18:28,324 --> 00:18:32,193 Philippe Rochat is a child psychologist 346 00:18:32,195 --> 00:18:33,761 at Emory University. 347 00:18:33,763 --> 00:18:36,363 He has spent his career 348 00:18:36,365 --> 00:18:40,134 embarrassing himself in the name of science. 349 00:18:40,902 --> 00:18:44,405 So, if I have my sticker on the forehead 350 00:18:44,407 --> 00:18:47,742 and I see people giving me looks, okay, 351 00:18:47,744 --> 00:18:50,678 I'm gonna start to be unsettled and concerned. 352 00:18:50,680 --> 00:18:52,880 I mean, something is wrong about myself. 353 00:18:52,882 --> 00:18:58,085 I think that to be human is to be concerned about reputation. 354 00:18:58,087 --> 00:19:00,421 At the psychological and cultural level, 355 00:19:00,423 --> 00:19:03,691 life begins, indeed, in humans 356 00:19:03,693 --> 00:19:06,627 with the emergence of self-consciousness -- 357 00:19:06,629 --> 00:19:08,295 blushing, embarrassment, and shame. 358 00:19:12,534 --> 00:19:15,035 Freeman: Humans have developed a social brain. 359 00:19:15,037 --> 00:19:17,204 We are the only species 360 00:19:17,206 --> 00:19:20,441 that do things like wear clothes and jewelry. 361 00:19:20,443 --> 00:19:22,977 Monkeys don't wear makeup. 362 00:19:22,979 --> 00:19:24,845 We are the only species 363 00:19:24,847 --> 00:19:29,984 that is profoundly concerned with how the world sees us. 364 00:19:29,986 --> 00:19:31,952 According to Philippe, 365 00:19:31,954 --> 00:19:35,089 only when a child develops this concern 366 00:19:35,091 --> 00:19:39,093 is he fully human and psychologically alive. 367 00:19:41,863 --> 00:19:42,863 Rochat: Okay. 368 00:19:42,865 --> 00:19:44,431 Come in. 369 00:19:44,433 --> 00:19:48,369 Philippe is the head of the Emory Infant and Child Lab, 370 00:19:48,371 --> 00:19:51,772 where he is trying to detect when children become aware 371 00:19:51,774 --> 00:19:54,708 of how they are perceived by the world. 372 00:19:54,710 --> 00:19:56,310 You can sit here. Okay. 373 00:19:56,312 --> 00:19:59,980 He says a first sign is when a child feels 374 00:19:59,982 --> 00:20:02,850 the pressure to go along with a crowd. 375 00:20:02,852 --> 00:20:04,718 Meet 1-year-old Booker. 376 00:20:04,720 --> 00:20:07,488 Hey, Booker, we're gonna play. 377 00:20:07,490 --> 00:20:08,756 Philippe and Booker's mother 378 00:20:08,758 --> 00:20:10,825 have pink stickers on their foreheads. 379 00:20:10,827 --> 00:20:12,860 Look -- this is goo-goo. 380 00:20:12,862 --> 00:20:14,328 Rochat: So, we create this social norm. 381 00:20:14,330 --> 00:20:18,365 Then we place the mark on the kid's head 382 00:20:18,367 --> 00:20:21,135 unbeknownst to him, surreptitiously, 383 00:20:21,137 --> 00:20:24,638 and we look at the child's reaction 384 00:20:24,640 --> 00:20:29,410 when he sees that he, too, has a mark on the forehead. 385 00:20:31,513 --> 00:20:34,381 Freeman: If Booker's brain has developed an awareness 386 00:20:34,383 --> 00:20:36,150 of what other people think of him, 387 00:20:36,152 --> 00:20:38,152 he will leave the sticker on his head 388 00:20:38,154 --> 00:20:40,020 to fit in with the others... 389 00:20:41,723 --> 00:20:43,424 ...but Booker is more concerned 390 00:20:43,426 --> 00:20:45,259 with getting the pesky sticker off his head 391 00:20:45,261 --> 00:20:48,896 than he is with fitting in. 392 00:20:48,898 --> 00:20:50,431 Okay, Kayden, 393 00:20:50,433 --> 00:20:52,666 are you comfortable there, huh? 394 00:20:52,668 --> 00:20:54,668 But when Philippe tries the same test 395 00:20:54,670 --> 00:20:56,303 on 4-year-old Kayden, 396 00:20:56,305 --> 00:20:59,506 he gets a very different reaction. 397 00:21:03,645 --> 00:21:08,883 Kayden basically freezes in front of his own image. 398 00:21:08,885 --> 00:21:13,520 He noticed that we all have a sticker on the forehead, 399 00:21:13,522 --> 00:21:17,024 and he leaves the sticker on. 400 00:21:17,026 --> 00:21:19,393 So, there's this idea of conformity. 401 00:21:21,029 --> 00:21:24,098 They care about their own image and self-presentation. 402 00:21:24,100 --> 00:21:28,569 This is something that emerges by two to three years of age. 403 00:21:29,337 --> 00:21:31,138 Freeman: It's a big milestone, 404 00:21:31,140 --> 00:21:33,140 but Philippe's research has shown 405 00:21:33,142 --> 00:21:37,645 that even a 3-year-old is not yet fully self-aware. 406 00:21:37,647 --> 00:21:38,812 What?! 407 00:21:38,814 --> 00:21:41,115 Paper on my head? 408 00:21:41,117 --> 00:21:43,083 There is still another level 409 00:21:43,085 --> 00:21:45,886 of psychological development to reach. 410 00:21:45,888 --> 00:21:48,555 Okay. Look. I have some cups here. 411 00:21:48,557 --> 00:21:50,257 I think they are beautiful. 412 00:21:50,259 --> 00:21:52,993 This is 4-year-old Sidney. 413 00:21:52,995 --> 00:21:54,728 I'm gonna build something with them. 414 00:21:54,730 --> 00:21:57,898 Sidney watches as Philippe builds what he is calling 415 00:21:57,900 --> 00:22:00,634 the most beautiful sculpture in the world. 416 00:22:00,636 --> 00:22:02,069 Whoa! 417 00:22:02,071 --> 00:22:04,505 But it's very fragile, huh? 418 00:22:04,507 --> 00:22:06,807 I'm not sure it's gonna hold, 419 00:22:06,809 --> 00:22:11,011 but I'm gonna get some glue to put the cups together. 420 00:22:11,013 --> 00:22:13,480 So, don't touch it, okay? 421 00:22:13,482 --> 00:22:15,082 I'll be right back. 422 00:22:17,819 --> 00:22:20,788 As Sidney patiently waits for Philippe to return with glue 423 00:22:20,790 --> 00:22:23,490 to secure the precious work of art, 424 00:22:23,492 --> 00:22:27,094 Philippe secretly pulls a transparent fish wire 425 00:22:27,096 --> 00:22:29,263 that is connected to a bottom cup. 426 00:22:35,103 --> 00:22:37,171 And the question is, is to what extent 427 00:22:37,173 --> 00:22:39,940 the child will show concern 428 00:22:39,942 --> 00:22:42,810 that he's gonna be seen as responsible 429 00:22:42,812 --> 00:22:44,912 for the collapsing of the sculpture. 430 00:22:46,081 --> 00:22:48,649 Freeman: Sidney is not fazed by the tragic collapse 431 00:22:48,651 --> 00:22:52,186 because he does not care if he looks like the culprit. 432 00:22:52,188 --> 00:22:54,054 Everything okay? 433 00:22:54,056 --> 00:22:55,723 Oh! What happened? 434 00:22:55,725 --> 00:22:57,558 Did you touch it? 435 00:22:57,560 --> 00:22:58,959 No. 436 00:22:58,961 --> 00:23:01,495 He's not concerned with how Philippe will perceive him. 437 00:23:02,797 --> 00:23:04,965 When Philippe plays the same trick 438 00:23:04,967 --> 00:23:07,067 on 5-year-old Milo... 439 00:23:10,705 --> 00:23:12,973 That was scary. 440 00:23:12,975 --> 00:23:15,843 ...he takes action and tries to rebuild the pyramid 441 00:23:15,845 --> 00:23:17,077 before Philippe returns. 442 00:23:21,349 --> 00:23:25,819 Rochat: And what we've seen with Milo and other 5-year-olds 443 00:23:25,821 --> 00:23:27,221 is the great concern... 444 00:23:28,823 --> 00:23:31,792 ...about how are they gonna be perceived and judged, 445 00:23:31,794 --> 00:23:33,093 which is a huge step 446 00:23:33,095 --> 00:23:35,462 in the development of consciousness. 447 00:23:43,204 --> 00:23:45,606 Freeman: Philippe's tests chart the development 448 00:23:45,608 --> 00:23:48,008 of a fully conscious brain. 449 00:23:48,010 --> 00:23:50,811 Just as a fetus develops in stages 450 00:23:50,813 --> 00:23:54,782 from a single cell to a baby over the course of nine months, 451 00:23:54,784 --> 00:23:57,751 consciousness in the brain grows in stages, too. 452 00:23:59,888 --> 00:24:03,390 Philippe believes consciousness comes to full-term 453 00:24:03,392 --> 00:24:05,159 after about five years... 454 00:24:05,161 --> 00:24:06,493 What happened? 455 00:24:06,495 --> 00:24:08,429 It just fell by itself. 456 00:24:08,431 --> 00:24:09,897 How is that possible? 457 00:24:09,899 --> 00:24:14,001 ...and to him, it's the mark of when we are truly alive. 458 00:24:14,003 --> 00:24:16,470 Why don't we put it back together? 459 00:24:18,173 --> 00:24:19,740 Rochat: What it means to be alive? 460 00:24:19,742 --> 00:24:23,877 I think it's not to be a robot and not to be a machine. 461 00:24:25,346 --> 00:24:29,249 To be alive is more than sensing the world, 462 00:24:29,251 --> 00:24:32,419 but to be alive is to feel the world. 463 00:24:35,223 --> 00:24:38,092 To say that a child's life does not begin 464 00:24:38,094 --> 00:24:42,763 until he becomes self-conscious has radical implications. 465 00:24:42,765 --> 00:24:44,965 A 4-year-old is not alive, 466 00:24:44,967 --> 00:24:48,735 but a newborn piece of machinery might be... 467 00:24:48,737 --> 00:24:51,872 If it can think on its own. 468 00:25:04,419 --> 00:25:07,888 Even a child can tell that a spider is alive... 469 00:25:09,224 --> 00:25:10,991 ...and a rock is not... 470 00:25:12,127 --> 00:25:16,130 ...but what if a lifeless object became a life-form? 471 00:25:19,567 --> 00:25:23,771 Can life begin inside something that's dead? 472 00:25:23,773 --> 00:25:25,773 Good afternoon. Thank you for coming. 473 00:25:25,775 --> 00:25:29,810 I'm here to do a presentation on Project Annabelle. 474 00:25:29,812 --> 00:25:33,313 Freeman: Kate Izhikevich is on a serious mission. 475 00:25:33,315 --> 00:25:38,519 She has a plan to build the first ever living machine. 476 00:25:38,521 --> 00:25:41,054 I've always wanted a chihuahua, and I've always had a thing 477 00:25:41,056 --> 00:25:42,689 that I wanted to name it -- Annabelle. 478 00:25:42,691 --> 00:25:45,492 Freeman: She is facing her toughest critic yet -- 479 00:25:45,494 --> 00:25:48,829 renowned computational neuroscientist 480 00:25:48,831 --> 00:25:53,700 Eugene Izhikevich, also known as dad. 481 00:25:53,702 --> 00:25:56,837 I decided that, what if I could make a dog that was robotic? 482 00:25:56,839 --> 00:25:59,339 Eugene: Kate has been asking me for a real dog 483 00:25:59,341 --> 00:26:01,775 since she was three years old, 484 00:26:01,777 --> 00:26:03,277 and for the last two years, 485 00:26:03,279 --> 00:26:05,546 she has been asking me for a robotic dog. 486 00:26:05,548 --> 00:26:07,381 So, no mess. It eats and poops out batteries. 487 00:26:07,383 --> 00:26:10,217 Kate thinks that Project Annabelle is possible 488 00:26:10,219 --> 00:26:12,352 because I do computational neuroscience 489 00:26:12,354 --> 00:26:15,389 and I build artificial nervous systems for robots. 490 00:26:15,391 --> 00:26:16,723 Kate: I hope Project Annabelle 491 00:26:16,725 --> 00:26:18,992 will become my dad's first priority. 492 00:26:18,994 --> 00:26:19,960 Thank you. 493 00:26:22,897 --> 00:26:27,000 Freeman: Kate thinks her dad is the best man for the job. 494 00:26:27,002 --> 00:26:29,970 Eugene has built the most detailed computer model 495 00:26:29,972 --> 00:26:31,538 of the human brain -- 496 00:26:31,540 --> 00:26:33,273 100 billion neurons 497 00:26:33,275 --> 00:26:36,777 and almost 1 quadrillion synapses. 498 00:26:36,779 --> 00:26:41,281 His ultimate goal is to create consciousness 499 00:26:41,283 --> 00:26:43,784 in an artificial nervous system. 500 00:26:43,786 --> 00:26:45,919 He thinks it could be the beginning 501 00:26:45,921 --> 00:26:50,123 of a new life-form, one never before seen on earth. 502 00:26:50,125 --> 00:26:53,260 I don't believe that consciousness is something 503 00:26:53,262 --> 00:26:56,430 that only has to be part of a human brain. 504 00:26:56,432 --> 00:27:00,434 I think we can create computer programs for robots 505 00:27:00,436 --> 00:27:02,369 that possess this property. 506 00:27:02,371 --> 00:27:04,371 Freeman: Eugene and his team 507 00:27:04,373 --> 00:27:06,640 think they have found a way to do this. 508 00:27:06,642 --> 00:27:09,543 Instead of giving robots step-by-step instructions 509 00:27:09,545 --> 00:27:11,912 with a program to make them move, 510 00:27:11,914 --> 00:27:14,248 they want their robots to figure out how to move 511 00:27:14,250 --> 00:27:15,849 and learn on their own, 512 00:27:15,851 --> 00:27:19,353 just like living, conscious beings. 513 00:27:19,355 --> 00:27:21,255 They are building their robots' electronic brains 514 00:27:21,257 --> 00:27:24,658 modeled on biological ones. 515 00:27:24,660 --> 00:27:28,829 Somebody says, "What's the most important concept in the brain?" 516 00:27:28,831 --> 00:27:30,597 I would say it's the neuron. 517 00:27:31,900 --> 00:27:33,934 Freeman: Neurons are the brain cells 518 00:27:33,936 --> 00:27:36,403 that help conscious, biological beings, 519 00:27:36,405 --> 00:27:38,805 like these dogs, learn. 520 00:27:38,807 --> 00:27:42,342 We may think biscuits are the key to a dog's learning, 521 00:27:42,344 --> 00:27:46,547 but it's actually the neurons in his brain. 522 00:27:46,549 --> 00:27:50,684 When a dog learns how to fetch, the neurons in his brain 523 00:27:50,686 --> 00:27:53,854 fire spikes of electricity that create pathways. 524 00:27:54,789 --> 00:27:56,790 As he practices more and more, 525 00:27:56,792 --> 00:27:59,726 his neurons fire faster and faster 526 00:27:59,728 --> 00:28:02,296 and electricity flows more efficiently 527 00:28:02,298 --> 00:28:04,197 down the new pathway. 528 00:28:04,199 --> 00:28:05,332 [ Dog panting ] 529 00:28:05,334 --> 00:28:06,767 [ Dog barks ] 530 00:28:06,769 --> 00:28:09,202 [ Dog barks ] 531 00:28:09,204 --> 00:28:12,806 Eugene and his team of roboticists 532 00:28:12,808 --> 00:28:15,042 are building artificial networks of neurons 533 00:28:15,044 --> 00:28:19,079 that fire spikes of electricity and create favored pathways 534 00:28:19,081 --> 00:28:22,849 just like the neurons in a biological brain. 535 00:28:22,851 --> 00:28:25,552 They wanted to see what would happen 536 00:28:25,554 --> 00:28:27,888 if they wired these spiking neurons 537 00:28:27,890 --> 00:28:29,590 to a robotic body. 538 00:28:29,592 --> 00:28:33,527 Could a robot learn how to move and become aware of its body 539 00:28:33,529 --> 00:28:35,629 and its environment all by itself? 540 00:28:37,298 --> 00:28:40,267 Could a robot become conscious? 541 00:28:42,737 --> 00:28:44,304 Eugene: Our approach to robotics 542 00:28:44,306 --> 00:28:47,140 is quite different from the standard approach. 543 00:28:47,142 --> 00:28:48,375 We don't program robots. 544 00:28:48,377 --> 00:28:50,477 We endow them with artificial nervous systems 545 00:28:50,479 --> 00:28:52,112 and their own experiences. 546 00:28:52,114 --> 00:28:55,048 For example, a robot starts by moving their hands 547 00:28:55,050 --> 00:28:56,717 and moving their necks 548 00:28:56,719 --> 00:28:58,885 and just exploring their own body, 549 00:28:58,887 --> 00:29:01,955 and after that, users -- people -- can teach the robots 550 00:29:01,957 --> 00:29:04,992 the same way as they teach dogs and cats different tricks -- 551 00:29:04,994 --> 00:29:06,393 with reward and punishment. 552 00:29:06,395 --> 00:29:10,130 Freeman: Eugene and his team use different body shapes 553 00:29:10,132 --> 00:29:14,167 to see how many kinds of movements a robot can learn. 554 00:29:15,570 --> 00:29:18,872 This robot is trying to learn how to stand up. 555 00:29:18,874 --> 00:29:21,975 Its artificial brain is telling its body how to move. 556 00:29:23,311 --> 00:29:25,479 Eugene: They look alive, 557 00:29:25,481 --> 00:29:27,981 and some of the demos that I show to my daughter 558 00:29:27,983 --> 00:29:30,350 look so creepy that she's said 559 00:29:30,352 --> 00:29:31,918 that we're torturing a baby robot. 560 00:29:34,656 --> 00:29:37,824 Freeman: By endowing Eugene's artificial brains with a body 561 00:29:37,826 --> 00:29:40,293 and letting them explore the world, 562 00:29:40,295 --> 00:29:44,164 these robots acquire experience... 563 00:29:44,166 --> 00:29:46,600 They development behaviors. 564 00:29:46,602 --> 00:29:48,769 Are they becoming alive? 565 00:29:48,771 --> 00:29:52,072 You can imagine a situation when you have a set of robots 566 00:29:52,074 --> 00:29:54,875 having access to raw materials. 567 00:29:54,877 --> 00:29:58,645 You can even hypothesize that it's possible for these robots 568 00:29:58,647 --> 00:30:00,747 to kind of create copies of themselves, 569 00:30:00,749 --> 00:30:02,182 and then such a community of robots 570 00:30:02,184 --> 00:30:05,552 would act as a life system. 571 00:30:05,554 --> 00:30:07,087 Freeman: Perhaps the day will come 572 00:30:07,089 --> 00:30:11,158 when one of Eugene's robots will feel emotion, 573 00:30:11,160 --> 00:30:13,527 maybe even blush. 574 00:30:13,529 --> 00:30:17,831 Artificial life will then be indistinguishable 575 00:30:17,833 --> 00:30:18,999 from our own... 576 00:30:20,334 --> 00:30:22,703 ...but building robots may not be the only way 577 00:30:22,705 --> 00:30:24,471 to create new life on earth. 578 00:30:25,506 --> 00:30:27,641 One scientist in Denmark 579 00:30:27,643 --> 00:30:29,976 is searching for the perfect recipe. 580 00:30:29,978 --> 00:30:33,647 He thinks the ingredients to produce new life-forms 581 00:30:33,649 --> 00:30:35,749 are right under our noses. 582 00:30:37,098 --> 00:30:40,868 If we build robots that become self-aware, 583 00:30:41,370 --> 00:30:46,840 then humanity will have created an entirely new form of life. 584 00:30:46,842 --> 00:30:50,410 It will be the first time in billions of years 585 00:30:50,412 --> 00:30:53,980 that something nonliving became living, 586 00:30:53,982 --> 00:30:59,085 but there might be another way to create brand-new life-forms, 587 00:30:59,087 --> 00:31:04,124 not in a robot, but in a petri dish. 588 00:31:10,464 --> 00:31:11,731 Martin Hanczyc 589 00:31:11,733 --> 00:31:13,767 from the University of Southern Denmark 590 00:31:13,769 --> 00:31:16,503 is trying to figure out when life begins 591 00:31:16,505 --> 00:31:19,472 by going back to a time when life was simpler. 592 00:31:20,608 --> 00:31:25,378 As a biochemist, he knows that in order to understand life, 593 00:31:25,380 --> 00:31:27,947 he has to look at the simplest form 594 00:31:27,949 --> 00:31:31,017 that appeared on earth a very long time ago. 595 00:31:31,019 --> 00:31:33,453 Hanczyc: When we think about the origin of life, 596 00:31:33,455 --> 00:31:36,156 there must've been a very interesting transition 597 00:31:36,158 --> 00:31:38,391 from material that we wouldn't consider living 598 00:31:38,393 --> 00:31:39,693 that gave rise to organize 599 00:31:39,695 --> 00:31:42,762 what we would call life or biology. 600 00:31:42,764 --> 00:31:45,131 So, it's a big mystery, and it's a fascinating mystery. 601 00:31:48,269 --> 00:31:51,771 Freeman: How can inanimate objects become animate? 602 00:31:51,773 --> 00:31:57,510 What sparked the transition from nonliving to living? 603 00:31:57,512 --> 00:32:00,714 Martin's work as a biochemist inspires him 604 00:32:00,716 --> 00:32:03,550 to ask that question wherever he looks. 605 00:32:05,219 --> 00:32:08,154 Hanczyc: So, what we're looking at here is an old windmill. 606 00:32:08,156 --> 00:32:13,827 It's from, I think, the 1830s, and we are considering 607 00:32:13,829 --> 00:32:15,795 whether an artificial construction like this 608 00:32:15,797 --> 00:32:18,298 has any similarity to living systems. 609 00:32:18,300 --> 00:32:21,368 Living systems have a body, they have a metabolism, 610 00:32:21,370 --> 00:32:23,803 and they have some sort of inheritable information. 611 00:32:23,805 --> 00:32:27,807 Freeman: Clearly, this windmill has a body. 612 00:32:27,809 --> 00:32:29,476 It has a metabolism 613 00:32:29,478 --> 00:32:31,244 that takes wind energy from the outside 614 00:32:31,246 --> 00:32:34,381 and uses it as power, 615 00:32:34,383 --> 00:32:36,716 and it has inheritable information. 616 00:32:38,419 --> 00:32:40,887 Hanczyc: There is a blueprint for this that has information 617 00:32:40,889 --> 00:32:42,655 about how to put the parts together 618 00:32:42,657 --> 00:32:45,525 to make a functional windmill. 619 00:32:49,063 --> 00:32:53,800 Freeman: Humans can use these blueprints and create modern windmills. 620 00:32:53,802 --> 00:32:55,735 In a sense, you could say 621 00:32:55,737 --> 00:32:58,905 that windmills have evolved and multiplied. 622 00:32:58,907 --> 00:33:02,809 However, something important is missing. 623 00:33:02,811 --> 00:33:07,280 Windmills cannot grow all by themselves. 624 00:33:07,282 --> 00:33:09,983 They rely on humans to assemble them, 625 00:33:09,985 --> 00:33:15,655 but the first forms of life must've assembled themselves. 626 00:33:15,657 --> 00:33:17,891 Martin wanted to see 627 00:33:17,893 --> 00:33:20,994 if he could find a recipe made of nonliving materials 628 00:33:20,996 --> 00:33:25,131 that could build itself a body and become alive. 629 00:33:25,133 --> 00:33:28,802 We think one of the key steps in the origin of life 630 00:33:28,804 --> 00:33:32,038 is actually the self-assembly of molecules together. 631 00:33:34,708 --> 00:33:37,977 Freeman: Martin wondered what kind of chemicals 632 00:33:37,979 --> 00:33:40,113 might behave like this. 633 00:33:40,115 --> 00:33:42,715 He realized he had to look no further 634 00:33:42,717 --> 00:33:46,319 than the kitchen pantry -- oil. 635 00:33:46,321 --> 00:33:50,657 As we all know, when you combine oil and water, 636 00:33:50,659 --> 00:33:52,859 they don't mix, 637 00:33:52,861 --> 00:33:55,829 but the combination forces the oil molecules 638 00:33:55,831 --> 00:33:59,332 to self-assemble and form big droplets. 639 00:33:59,334 --> 00:34:01,334 [ Oil molecules cheering ] 640 00:34:01,336 --> 00:34:04,037 These are the bodies Martin decided to use 641 00:34:04,039 --> 00:34:06,039 for his lab-made life. 642 00:34:06,041 --> 00:34:07,807 [ Oil molecules scream ] 643 00:34:09,677 --> 00:34:14,347 Hanczyc: So, when we make an oil droplet in a dish, nothing happens. 644 00:34:14,349 --> 00:34:15,982 You just get a nice, spherical oil drop 645 00:34:15,984 --> 00:34:18,852 that just sits there in the dish, 646 00:34:18,854 --> 00:34:20,987 but the key was how to, then, 647 00:34:20,989 --> 00:34:23,690 power some sort of movement of the system. 648 00:34:23,692 --> 00:34:25,291 We wanted to put in a metabolism. 649 00:34:26,861 --> 00:34:29,996 Freeman: Martin injected his oil droplets with molecules 650 00:34:29,998 --> 00:34:31,998 that break down into soap bubbles 651 00:34:32,000 --> 00:34:33,366 when they encounter water. 652 00:34:34,668 --> 00:34:37,136 The bubbles spread from the middle of the droplets 653 00:34:37,138 --> 00:34:40,406 to the edge, pushing them around like a motor. 654 00:34:41,709 --> 00:34:43,676 It's a working metabolism. 655 00:34:43,678 --> 00:34:46,746 You could say it's almost alive. 656 00:34:46,748 --> 00:34:50,517 Hanczyc: We were very excited when we saw this 657 00:34:50,519 --> 00:34:53,520 because not only does it work, but it worked rather quickly. 658 00:34:53,522 --> 00:34:57,290 Freeman: Martin has successfully created a self-assembling body 659 00:34:57,292 --> 00:35:00,827 that can metabolize and move on its own. 660 00:35:00,829 --> 00:35:05,865 Next, he arranged for a little oil-droplet soiree. 661 00:35:05,867 --> 00:35:08,868 Could he mimic the process of reproduction? 662 00:35:08,870 --> 00:35:11,037 Hanczyc: And it's interesting 663 00:35:11,039 --> 00:35:14,073 that when we put more than one droplet into an experiment, 664 00:35:14,075 --> 00:35:17,710 they tend to follow one another, almost like a dance. 665 00:35:18,779 --> 00:35:21,648 Freeman: The oil droplets are being social, 666 00:35:21,650 --> 00:35:23,783 and we all know what a little mingling 667 00:35:23,785 --> 00:35:25,852 and some good chemistry can lead to. 668 00:35:27,521 --> 00:35:29,222 Each droplet is giving out a chemical signal, 669 00:35:29,224 --> 00:35:30,957 and therefore the droplets 670 00:35:30,959 --> 00:35:32,859 are able to communicate with each other 671 00:35:32,861 --> 00:35:34,594 through this kind of chemical language. 672 00:35:34,596 --> 00:35:39,299 Freeman: But even if one of Martin's droplets meets "the one," 673 00:35:39,301 --> 00:35:42,368 what about inheritable information? 674 00:35:42,370 --> 00:35:45,271 Do they have a genetic blueprint? 675 00:35:45,273 --> 00:35:48,041 We are thinking of how to address this question 676 00:35:48,043 --> 00:35:51,177 of inheritance and genetic information. 677 00:35:51,179 --> 00:35:54,213 One way to do it is to take some lessons from biology 678 00:35:54,215 --> 00:35:56,983 and put something in like RNA or DNA, 679 00:35:56,985 --> 00:35:58,885 but we're thinking of more primitive ways 680 00:35:58,887 --> 00:36:02,522 of understanding the emergence of information. 681 00:36:02,524 --> 00:36:04,290 Freeman: Martin is still working 682 00:36:04,292 --> 00:36:07,193 on recipes for inheritable information, 683 00:36:07,195 --> 00:36:09,162 and he's on the brink 684 00:36:09,164 --> 00:36:11,998 of creating a living organism from nonliving materials. 685 00:36:13,601 --> 00:36:14,734 If there is a line 686 00:36:14,736 --> 00:36:16,703 between the living and nonliving systems, 687 00:36:16,705 --> 00:36:18,671 then it must be a very blurry line. 688 00:36:22,042 --> 00:36:26,012 Freeman: From artificial cells to artificial neurons, 689 00:36:26,014 --> 00:36:30,283 scientists are creating new life with their own hands, 690 00:36:30,285 --> 00:36:32,352 but one former physicist 691 00:36:32,354 --> 00:36:35,355 thinks there could be another version of life arising, 692 00:36:35,357 --> 00:36:38,558 growing out of the collective experience 693 00:36:38,560 --> 00:36:40,760 of all of humanity. 694 00:36:43,866 --> 00:36:45,600 Life on earth began 695 00:36:45,602 --> 00:36:48,670 as a simple cycle of chemical reactions 696 00:36:48,672 --> 00:36:51,473 in a bubbling, primordial pond. 697 00:36:51,775 --> 00:36:54,375 Four billion years later, 698 00:36:54,377 --> 00:36:57,846 those chemical reactions have spread across the planet 699 00:36:57,848 --> 00:37:00,114 and have become so complex 700 00:37:00,116 --> 00:37:04,519 that they can think and talk, like me, 701 00:37:04,521 --> 00:37:07,055 but something new is happening. 702 00:37:07,057 --> 00:37:11,526 Connections between computers have spread worldwide, 703 00:37:11,528 --> 00:37:14,462 forming a dense electronic web, 704 00:37:14,464 --> 00:37:20,702 and now these global networks -- one electronic, one chemical -- 705 00:37:20,704 --> 00:37:22,670 are interacting. 706 00:37:22,672 --> 00:37:25,807 A new life could be about to begin 707 00:37:25,809 --> 00:37:30,645 on a scale unlike anything earth has ever known. 708 00:37:34,116 --> 00:37:37,118 Evolutionary cyberneticist Francis Heylighen 709 00:37:37,120 --> 00:37:39,087 at the free University of Brussels 710 00:37:39,089 --> 00:37:45,326 thinks humanity is giving birth, and this baby is big. 711 00:37:45,328 --> 00:37:47,762 Heylighen: If we look at global society, 712 00:37:47,764 --> 00:37:50,999 at all the seven billion people on this planet, 713 00:37:51,001 --> 00:37:55,236 people become more and more connected into a coherent being. 714 00:37:57,840 --> 00:37:59,941 The Internet gives you immediate access 715 00:37:59,943 --> 00:38:02,010 to all the important ideas. 716 00:38:02,012 --> 00:38:05,380 Nowadays, ideas travel the ocean. 717 00:38:05,382 --> 00:38:07,949 They can do that with almost the speed of light. 718 00:38:07,951 --> 00:38:09,817 That means the speed is comparable 719 00:38:09,819 --> 00:38:12,120 to the speed that the neurons in our brain use 720 00:38:12,122 --> 00:38:13,888 to talk to each other. 721 00:38:16,358 --> 00:38:18,626 Freeman: The global network that connects all of us 722 00:38:18,628 --> 00:38:22,163 facilitates massive amounts of information sharing, 723 00:38:22,165 --> 00:38:24,999 information that has unveiled secrets 724 00:38:25,001 --> 00:38:28,002 that explain how our universe works. 725 00:38:28,004 --> 00:38:31,606 The Large Hadron Collider at Cern, for example, 726 00:38:31,608 --> 00:38:34,809 could not have detected the elusive Higgs boson 727 00:38:34,811 --> 00:38:37,779 without the ability to share tremendous amounts of data 728 00:38:37,781 --> 00:38:40,648 across the globe at great speeds. 729 00:38:44,086 --> 00:38:46,888 Heylighen: If Galileo could immediately have talked 730 00:38:46,890 --> 00:38:48,756 with all his colleagues, 731 00:38:48,758 --> 00:38:52,894 I'm sure that science would've developed much more quickly. 732 00:38:55,965 --> 00:38:57,999 Freeman: Francis and his team of computer scientists 733 00:38:58,001 --> 00:39:00,635 have invented a mathematical model 734 00:39:00,637 --> 00:39:02,971 to measure what the Internet is doing. 735 00:39:02,973 --> 00:39:05,440 Their goal is to find out 736 00:39:05,442 --> 00:39:08,610 whether it is becoming a global brain. 737 00:39:08,612 --> 00:39:12,680 Heylighen: In the mathematical model, like in all scientific models, 738 00:39:12,682 --> 00:39:15,016 you make a kind of simplification of reality. 739 00:39:15,018 --> 00:39:16,951 Instead of having a real person, 740 00:39:16,953 --> 00:39:19,387 you will have a small computer program 741 00:39:19,389 --> 00:39:22,590 that in some way behaves like a real person. 742 00:39:24,560 --> 00:39:27,629 Freeman: Francis' models are like global fMRIs, 743 00:39:27,631 --> 00:39:31,366 where people act like the neurons in a giant brain. 744 00:39:33,268 --> 00:39:36,204 Just as neurons learn by firing back and forth, 745 00:39:36,206 --> 00:39:40,675 people fire information to one another electronically. 746 00:39:40,677 --> 00:39:43,778 Francis believes as connections between people 747 00:39:43,780 --> 00:39:45,279 increase in number and strength, 748 00:39:45,281 --> 00:39:48,516 our global brain will become more intelligent. 749 00:39:48,518 --> 00:39:49,684 Hmm. 750 00:39:51,520 --> 00:39:54,689 Heylighen: You see that the network of connections -- 751 00:39:54,691 --> 00:39:57,592 it's getting better at what it needs to do. 752 00:39:57,594 --> 00:39:59,293 New connections are created, 753 00:39:59,295 --> 00:40:03,498 old connections that are no longer useful disappear, 754 00:40:03,500 --> 00:40:06,034 and the whole thing is constantly self-organizing. 755 00:40:06,036 --> 00:40:09,303 Freeman: Francis' work has shown him 756 00:40:09,305 --> 00:40:12,807 that our global brain is adapting, learning. 757 00:40:12,809 --> 00:40:16,044 Humanity and the Internet are merging 758 00:40:16,046 --> 00:40:19,213 to become a giant, living being. 759 00:40:21,383 --> 00:40:24,652 He compares this beginning of global life 760 00:40:24,654 --> 00:40:25,987 to the beginning of life 761 00:40:25,989 --> 00:40:28,790 for his 9-year-old daughter, Nia. 762 00:40:30,125 --> 00:40:33,628 This is a picture of Nia in the womb. 763 00:40:33,630 --> 00:40:35,797 She had a rudimentary brain, 764 00:40:35,799 --> 00:40:38,166 but the brain was basically a bunch of cells. 765 00:40:38,168 --> 00:40:40,835 There was no interconnection -- 766 00:40:40,837 --> 00:40:44,906 learning and experiencing over the months and the years 767 00:40:44,908 --> 00:40:47,909 to find what are the right connections. 768 00:40:47,911 --> 00:40:50,445 She started out as this bunch of cells, 769 00:40:50,447 --> 00:40:54,916 but then she gradually developed into a smart, intelligent, 770 00:40:54,918 --> 00:40:59,020 adventurous little girl that likes to climb in trees. 771 00:41:00,923 --> 00:41:03,291 Freeman: A single cell in Nia's body 772 00:41:03,293 --> 00:41:06,327 doesn't know what to do on its own. 773 00:41:06,329 --> 00:41:07,895 It is the coordinated effort 774 00:41:07,897 --> 00:41:09,997 of the billions of neurons in her brain 775 00:41:09,999 --> 00:41:13,768 that tells her leg muscles how to climb a tree trunk 776 00:41:13,770 --> 00:41:15,136 and tells her arm muscles 777 00:41:15,138 --> 00:41:18,005 how to propel herself from branch to branch. 778 00:41:19,208 --> 00:41:21,843 Francis believes humans and the web 779 00:41:21,845 --> 00:41:23,945 are working together in the same way. 780 00:41:25,447 --> 00:41:27,648 If life begins with a brain, 781 00:41:27,650 --> 00:41:32,487 then humanity has just climbed to a new level of awareness. 782 00:41:33,956 --> 00:41:36,958 Heylighen: It is the beginning of consciousness 783 00:41:36,960 --> 00:41:38,559 at the global level 784 00:41:38,561 --> 00:41:41,362 that we see with the emergence of the Internet. 785 00:41:41,364 --> 00:41:44,699 So, it is a kind of a beginning of life. 786 00:41:44,701 --> 00:41:47,301 Freeman: A human being cannot survive without a brain, 787 00:41:47,303 --> 00:41:51,139 a brain cannot survive without a body, 788 00:41:51,141 --> 00:41:54,308 and now the body of humanity and the brain of the web 789 00:41:54,310 --> 00:41:58,780 may be evolving into a superintelligent organism. 790 00:41:59,982 --> 00:42:03,117 Could it be the beginning of a new form of life? 791 00:42:04,887 --> 00:42:07,188 When does life begin? 792 00:42:08,857 --> 00:42:11,192 We now know there are several answers 793 00:42:11,194 --> 00:42:12,794 to this question. 794 00:42:12,796 --> 00:42:15,530 When sperm and egg meet, 795 00:42:15,532 --> 00:42:18,900 they create a new and unique genetic blueprint. 796 00:42:18,902 --> 00:42:23,838 Life takes another leap forward when creatures become conscious, 797 00:42:23,840 --> 00:42:27,308 be they babies, toddlers, or robots. 798 00:42:27,310 --> 00:42:31,112 And when all those individual life-forms merge, 799 00:42:31,114 --> 00:42:34,816 becoming part of a global superorganism, 800 00:42:34,818 --> 00:42:38,252 life on earth will advance one more step, 801 00:42:38,254 --> 00:42:41,122 and perhaps, one day, 802 00:42:41,124 --> 00:42:45,927 that new life-form will ask where its life began 803 00:42:45,929 --> 00:42:49,597 and what miracles are yet to be born. 804 00:42:49,622 --> 00:42:54,622 Subtital By RA_One63698

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