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how smallpox kills
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variola is highly infectious
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and catches a ride in small droplets you breathe in
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immediately
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it begins to infect the cells that line your throat
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and starts killing them to cause chaos
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why
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to trick your body into giving it a lift
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whenever cells in your body die of violent death
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your immune cells
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immediately stream to the site of infection
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to help out in this case
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that back fires horribly
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as immune cells begin cleaning up dead cells
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eating viruses and killing infected cells
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variola infects a crucial cell of your immune system
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your dendritic cells
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intelligent cells that gather information
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and leave the battlefield
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to get help they enter your lymphatic system
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a highway network that spans your entire body
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and connects hundreds of immune bases
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in these bases your heavy defenses are activated
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and should be the last place
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an enemy would want to invade
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but Variolo wants to get here
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for about 12 days
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the virus quietly infects civilian and immune cells
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jumping from cell to cell
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infecting more and more of them
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at some point a critical threshold is reached
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and variola starts its attack for real
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millions of viruses use the lymphatic highway
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to spill into your blood and organs
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infecting your whole body
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suddenly variola is everywhere
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but despite this global attack
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your adaptive immune system is struggling to wake up
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your immune cells look for
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and use critical transmitters
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called interference
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to mobilize the body against viruses
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interference as the name suggests interfere
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significantly slowing down virus infections
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but also
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quickly activating millions of anti virus weapons
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but variola is able to deactivate interference
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which stuns the anti virus side of your defense system
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other systems would usually help
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like the complement system
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a sort of mobile minefield that can destroy viruses
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but variola manages to shut this down too
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and so with little resistance
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variola spreads everywhere
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and infects billions of your cells all over your body
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among the infected are your capillaries
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the smallest blood vessels in your body
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which die in great numbers
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all this death activates an immune cell
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that you really don't need right now
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but that's attracted by death
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the neutrophil normally an efficient killer of invaders
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great and small
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it's not very effective against smallpox
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and even worse
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neutrophils fight by vomiting deadly chemicals
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which kills even more of yourselves
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on top of that they order inflammation
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fluids streaming from your blood vessels
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into your tissue all over your body
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as first millions then billions of yourselves die
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you get a rash that only gets worse and worse
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puss and a cellular junk fills it up
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as your body swells up with hundreds of lesions
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all over your skin and inside
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even on your organs
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all filled with billions of variola viruses
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now the critical phase begins as you fight for survival
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you burn up in a high fever
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thousands of battlegrounds drain your blood of fluid
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that streams into your tissue
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and organs blood clotting appears all over your body
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while floods of toxins from dead cells build up
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and can cause organs to fail
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your lungs fill up with fluid
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making it harder and harder to breathe
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one of two things happens now
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either your immune system wrestles back control
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heavy weapons have been dispatched
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killing infected cells
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cleaning up the thousands of infections one by one
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killing variolo wherever it can be found
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so you can slowly begin to recover
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the immune system will forever remember variola
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making you immune forever
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or you die overwhelmed by the infection
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and your immune system's panic
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reaction to the body wide infection
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about a third of people who can track smallpox
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don't survive and if you survive
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you're very likely branded by scars
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and may even lose your eyesight or hearing
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