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♪ ♪
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♪ ♪
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ADRIAN PRIMEAUX:
To me, peyote is a
very intimate
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medicinal herb.
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ALBERT GARCIA-ROMEU:
Psychedelic-assisted treatments
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allow us to reinvent ourselves.
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YASMIN HURD:
They're allowing the brain
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to see itself.
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NARRATOR:
In the 1960s,
psychedelic drugs were famous
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for their mind-bending
recreational effects,
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but today, they might offer hope
for treating
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devastating conditions
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from addiction, to PTSD,
to depression.
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LEN CAMPBELL:
I didn't take psilocybin
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to go find Martians.
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I needed to work with
scientists
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to be able to stop
smoking cigarettes.
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And it worked.
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EVAN CRAIG:
I was on antidepressants for
about four years prior.
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And I haven't been on any since.
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(laughs)
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I haven't felt sadness.
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NARRATOR:
How is this possible?
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Scientists are searching for
answers within the brain,
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where psychedelics
alter consciousness
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and can open the mind
to positive change.
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It's like reprogramming the
operating system of a computer.
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You're getting down to
very basic, code-level changes.
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FRED BARRETT:
We observe a radical change
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in the way that brain regions
talk to each other.
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BILL RICHARDS:
It's not only that these
states of consciousness
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are beautiful and inspiring.
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They seem to have
therapeutic power.
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KATHLEEN KRAL:
The psilocybin
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shifted my perception
from negativity to positivity.
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NARRATOR:
The research is cutting-edge,
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but early results
from clinical trials offer hope.
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SCOTT OSTROM:
You don't forget
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the breakthrough moments
that you had,
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and you don't forget
what you learned.
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They stay a part of you.
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JON KOSTAS:
I haven't drank since
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my very first session.
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It worked almost like
an antibiotic,
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where I did this treatment
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and then I was done.
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NARRATOR:
"Can Psychedelics Cure?"
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Right now, on "NOVA."
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♪ ♪
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NARRATOR:
Psychedelics:
LSD, magic mushrooms, peyote.
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These powerful,
mind-expanding substances
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fueled the '60s counter-culture.
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For some, they're powerfully
transformative-- even spiritual.
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CAMPBELL:
It was a spiritual experience
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that I'd never had in my life.
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It has probably changed me
forever.
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NARRATOR:
But for others,
terrifying and dangerous.
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MARCELA OT'ALORA G.:
They felt that I was having
a psychotic episode.
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I was hospitalized.
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NARRATOR:
And ultimately,
they were criminalized.
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RICHARD NIXON:
We must wage total war against
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public enemy number one,
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the problem of dangerous drugs.
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♪ ♪
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NARRATOR:
But today, a growing number
of clinicians
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argue that there's another side
to psychedelics.
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MANISH AGRAWAL:
The psilocybin therapy
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has been the most powerful tool
I've seen.
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I said, "Wow.
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"I feel like I've been treating
trauma with stone tools,
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and there's the
state-of-the-art treatment."
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NARRATOR:
That they have the potential
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to heal the mind as a treatment
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for addiction,
depression, and PTSD.
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ROBIN CARHART-HARRIS:
They have this big effect,
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opening the mind and the brain
up
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for change.
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The good that can come out of
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the responsible use
of these substances
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is quite amazing, really.
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♪ ♪
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NARRATOR:
It's an about-face
that few saw coming.
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RACHEL YEHUDA:
How do you shift
from a position of,
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"These drugs are illegal,
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these drugs are bad for you,"
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to, "These drugs are
therapeutic,
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"this is the way that you heal
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from mental illness"?
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NARRATOR:
What are these drugs doing
to patients' minds
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to give some doctors such hope
for their potential?
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♪ ♪
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♪ ♪
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KOSTAS:
I grew up in New York City.
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It was fairly easy to,
to get access to alcohol,
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through friends,
we'd go to a corner deli.
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And that all started probably
around 12, 13 years old.
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It would take a couple
of drinks to feel anything
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or feel good.
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But then, a couple of years
later,
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those two drinks wouldn't
cut it,
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or three drinks wouldn't cut it,
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and I'd need more to get to
where I was before,
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when I first started drinking.
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I wouldn't drink every night.
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I was more of a binge drinker,
so I'd pick my battles.
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But during one of those nights,
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it would be about 23 drinks
in a night.
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NARRATOR:
Over the years,
Jon Kostas struggled to quit.
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KOSTAS:
I went to my first
AA meeting at 16.
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I tried AA for years.
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I tried rehab.
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I tried different
pharmaceutical drugs.
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I've been practicing psychiatry
for 21 years,
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focusing on addiction.
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And Jon came to me
in his early 20s,
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and he probably was the worst
case of alcohol use disorder
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I'd ever seen
for someone his age.
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He'd go on these terrible
benders that he was starting
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to experience alcohol
withdrawal,
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which is very rare for somebody
in their early 20s,
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and I was very scared that
he was going to have
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a premature death because of
how much he was drinking.
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NARRATOR:
Worried that Jon was at risk
of death,
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psychiatrist Stephen Ross helped
him enroll in a clinical trial
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at N.Y.U. with his colleague
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psychiatrist
Michael Bogenschutz,
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who was testing a controversial
experimental treatment
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for alcohol use disorder
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using psychedelics.
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During a series of carefully
designed therapy sessions
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over 12 weeks, Jon received two
doses of a hallucinogenic drug.
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His addiction to
a recreational drug
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would be treated with
what most people think of
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as another recreational drug,
psilocybin,
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which is classified
as a schedule one narcotic,
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right alongside heroin.
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♪ ♪
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Psilocybin is the mind-altering
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molecule found
in magic mushrooms.
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They were introduced
to American popular culture
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in 1957 by a Wall Street banker
named R. Gordon Wasson,
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who wrote about them in an
article for "Life" magazine.
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These fungi have been used
by Indigenous peoples
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in the Americas
for thousands of years.
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Psilocybin is just one of
a family of substances
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often called psychedelics.
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They include mescaline,
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found in the North American
cactus peyote,
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as well as synthetic chemicals
like LSD and MDMA.
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Users report that these drugs
bring about
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an altered state of
consciousness,
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sometimes accompanied by
hallucinations
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or heightened sensitivity
to colors, sounds, and patterns.
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BARRETT:
The entire range of possible
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visual experiences can be
encountered.
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Walls breathing,
illusory movement--
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seeing movement in a carpet
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when the carpet's not really
moving.
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NARRATOR:
Many also report a loss of ego
accompanied by
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profound feelings of empathy
and connection to others,
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even the entire universe.
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And what's perhaps most unusual
about these drugs
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is that after the experience of
the so-called trip,
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users often feel changed
in positive ways.
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Though there are
clear differences
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between psychedelics, they all,
with the exception of MDMA,
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act in a similar way
in the brain.
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Each of the active molecules
fits like a key into a lock
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by binding to a specific protein
in the nerve cells
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of the human brain called the
serotonin 2a receptor,
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and this can alter perceptions
and even consciousness itself.
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And that's central
for producing
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their subjective states,
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including mystical states
of consciousness
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and these unusual states
of mind.
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NARRATOR:
The drugs are very powerful.
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And for some people,
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the experience of going
on a consciousness-altering trip
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that they can't control or stop
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can be very challenging
or frightening.
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KOSTAS:
I was afraid of psychedelics.
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I never experimented with them
growing up
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because I was too afraid.
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I heard all the bad stories
of having a bad trip,
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or I thought I could go
permanently crazy.
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Or if you stare at the sun,
you'll go blind.
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And so,
when I raised those concerns
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with the doctors at N.Y.U.,
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they said, "Listen, that's
totally normal going into it,
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"but this is incredibly safe
to do.
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"We've already
properly screened you,
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"and you're mentally
and physically fit
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to go through this."
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NARRATOR:
Patients with a personal
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or family history of psychiatric
disorders like schizophrenia,
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bipolar, or psychotic disorders
are deemed to be too at risk
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for the treatment.
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BOGENSCHUTZ:
There's a possibility that
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classic psychedelics
could precipitate
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a psychotic episode
or a psychotic disorder
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in someone who was predisposed.
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And that hasn't happened
in any of the trials to date,
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but it, uh, you know, it remains
a concern.
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Would you like to state
your intention for...
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NARRATOR:
In trials like this one,
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the drug is part of a larger
plan to help participants
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address specific issues,
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and each psychedelic trip
is facilitated by a therapist.
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When Jon took his first
psilocybin trip in an effort
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to curb his cravings
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for alcohol,
the experience was powerful.
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KOSTAS:
There were a few
monumental experiences
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that I saw during this.
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(bird calling in distance)
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There was a glass bottle,
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a liquor bottle,
in the middle of the desert,
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and all of a sudden, the glass
disintegrated into the sand,
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back into the desert,
and just vanished.
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And I thought that was
pretty powerful symbolism
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that my addiction
was leaving me.
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And pretty much after that, I
had felt this is going to work.
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♪ ♪
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NARRATOR:
Jon stopped drinking after
his first dosing session.
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KOSTAS:
It worked almost like
an antibiotic,
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where I was sick,
I had a disease,
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I went in, saw the doctors,
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did this treatment,
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and then I was done.
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I don't have to see doctors.
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I'm not on any, uh,
prescriptions.
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I don't go to any
support groups.
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I live without the addiction,
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which I never thought
would be possible.
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♪ ♪
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NARRATOR:
The N.Y.U. study recruited
93 patients who were
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randomly assigned psilocybin
or a placebo.
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All the participants received
psychotherapy
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over the 12-week
treatment period.
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00:11:41,933 --> 00:11:46,100
Jon's case is
particularly dramatic.
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But the results overall
have been encouraging.
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ROSS:
The psilocybin plus
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psychotherapy group had a
50% reduction in drinking
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compared to just the group
that got psychotherapy alone.
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BOGENSCHUTZ:
It's a large difference,
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it's a clinically meaningful
difference,
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and if these effects sizes
hold up,
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it's a much larger effect
248
00:12:05,266 --> 00:12:08,766
than we've seen in
any of the medications
249
00:12:08,766 --> 00:12:12,233
that are currently approved
for alcohol use disorder.
250
00:12:13,766 --> 00:12:15,633
NARRATOR:
Doctors are trying
to understand
251
00:12:15,633 --> 00:12:18,066
why psychedelic-assisted
therapy might be more effective
252
00:12:18,066 --> 00:12:21,100
than currently available
treatments.
253
00:12:21,100 --> 00:12:23,066
They think that the
key difference may be
254
00:12:23,066 --> 00:12:26,433
in the way that psychedelics
can allow the brain to change,
255
00:12:26,433 --> 00:12:30,200
rather than simply suppressing
symptoms such as craving.
256
00:12:30,200 --> 00:12:33,466
♪ ♪
257
00:12:33,466 --> 00:12:36,266
Our brains are composed of
billions of nerve cells
258
00:12:36,266 --> 00:12:38,666
that branch out like trees.
259
00:12:38,666 --> 00:12:41,100
They carry messages between
each other
260
00:12:41,100 --> 00:12:43,666
and connect different regions,
which are like departments
261
00:12:43,666 --> 00:12:46,233
with different functions.
262
00:12:46,233 --> 00:12:48,500
Such as the amygdala,
the department where
263
00:12:48,500 --> 00:12:52,100
the emotions associated
with memories are stored.
264
00:12:52,100 --> 00:12:56,600
The striatum, the office of
reward and habitual behavior.
265
00:12:56,600 --> 00:13:00,366
And at the highest level,
the prefrontal cortex,
266
00:13:00,366 --> 00:13:04,933
like a front office overseeing
them all and making decisions.
267
00:13:04,933 --> 00:13:08,333
So, in the normal brain,
you can say especially
268
00:13:08,333 --> 00:13:11,366
in, in adults,
the prefrontal cortex
269
00:13:11,366 --> 00:13:13,100
has this top-down control.
270
00:13:13,100 --> 00:13:18,766
We control our emotions,
we control, you know,
271
00:13:18,766 --> 00:13:20,933
our, our habits,
through very strong
272
00:13:20,933 --> 00:13:25,133
prefrontal cortical activity.
273
00:13:25,133 --> 00:13:26,400
NARRATOR:
Yasmin Hurd is a neuroscientist
274
00:13:26,400 --> 00:13:30,266
who studies the effects of drugs
on the brain.
275
00:13:30,266 --> 00:13:34,400
She's found that alcohol
can erode the nerve cells
276
00:13:34,400 --> 00:13:36,800
that connect departments.
277
00:13:36,800 --> 00:13:39,166
HURD:
With alcohol,
these branches retract.
278
00:13:39,166 --> 00:13:40,400
They shrink.
279
00:13:40,400 --> 00:13:42,600
And that then diminishes
communication
280
00:13:42,600 --> 00:13:44,933
between the brain regions.
281
00:13:44,933 --> 00:13:48,700
So, the amygdala is much more
hypersensitive
282
00:13:48,700 --> 00:13:52,400
to context associated with
the, the drug, such as alcohol.
283
00:13:52,400 --> 00:13:55,000
It's, like, acting on its own.
284
00:13:55,000 --> 00:13:59,200
NARRATOR:
If the amygdala goes rogue,
285
00:13:59,200 --> 00:14:02,800
the result can be irresistible
cravings leading to decisions
286
00:14:02,800 --> 00:14:06,400
that put alcohol ahead of
everything else,
287
00:14:06,400 --> 00:14:10,466
even ignoring pleas from
the front office to stop.
288
00:14:10,466 --> 00:14:12,633
Habitual behavior takes over.
289
00:14:12,633 --> 00:14:16,733
They stop thinking about
what may be the bad outcome.
290
00:14:16,733 --> 00:14:18,400
So their executive control
is diminished.
291
00:14:21,566 --> 00:14:24,700
NARRATOR:
But when Jon took psilocybin,
292
00:14:24,700 --> 00:14:27,733
he seemed to get control
over his cravings.
293
00:14:27,733 --> 00:14:32,033
Somehow, the front office
re-established its authority.
294
00:14:32,033 --> 00:14:37,000
The research is still early,
but scientists do know
295
00:14:37,000 --> 00:14:40,400
that psychedelics activate
specific serotonin receptors
296
00:14:40,400 --> 00:14:42,366
in the brain involved in mood
297
00:14:42,366 --> 00:14:45,133
and unusual states
of consciousness.
298
00:14:45,133 --> 00:14:49,633
One idea is that activating
these receptors may also lead
299
00:14:49,633 --> 00:14:53,566
to new nerve cell connections--
even growth.
300
00:14:53,566 --> 00:14:56,933
Perhaps that is the key.
301
00:14:56,933 --> 00:15:00,900
HURD:
It's hypothesized that
psychedelics will restore
302
00:15:00,900 --> 00:15:04,400
the branches in these trees
303
00:15:04,400 --> 00:15:08,833
that we know are impacted by
alcohol use disorder.
304
00:15:08,833 --> 00:15:13,100
So, by restoring and allowing
the branches to grow again,
305
00:15:13,100 --> 00:15:16,466
that improves communication
once again in the brain.
306
00:15:16,466 --> 00:15:20,066
NARRATOR:
But stimulating
serotonin receptors
307
00:15:20,066 --> 00:15:22,500
or expanding nerve cell
connections
308
00:15:22,500 --> 00:15:25,400
can't be the full explanation.
309
00:15:25,400 --> 00:15:28,633
After all, the drug cocaine
also increases
310
00:15:28,633 --> 00:15:30,600
nerve cell connections.
311
00:15:30,600 --> 00:15:34,100
But there may be
a critical difference.
312
00:15:34,100 --> 00:15:37,466
HURD:
Cocaine will also increase
the projections, these branches,
313
00:15:37,466 --> 00:15:38,866
but it's too many.
314
00:15:38,866 --> 00:15:41,633
One thing about
how psychedelics are used
315
00:15:41,633 --> 00:15:45,933
as compared to cocaine, is that
cocaine, it's habitual behavior.
316
00:15:45,933 --> 00:15:47,233
They're using it chronically.
317
00:15:47,233 --> 00:15:49,766
It can produce perhaps
too much growth.
318
00:15:49,766 --> 00:15:53,900
So, with psychedelics, it seems
that the growth may be,
319
00:15:53,900 --> 00:15:55,666
you know, it's not too much,
it's not too little--
320
00:15:55,666 --> 00:15:57,066
it's just right.
321
00:15:57,066 --> 00:16:00,700
Like the Goldilocks effect,
in a way.
322
00:16:00,700 --> 00:16:03,766
NARRATOR:
One factor that Jon attributes
his sobriety to
323
00:16:03,766 --> 00:16:07,033
is the mystical experience
he went through,
324
00:16:07,033 --> 00:16:11,600
which is often a hallmark
of a psychedelic journey.
325
00:16:11,600 --> 00:16:13,133
KOSTAS:
Something definitely happened,
326
00:16:13,133 --> 00:16:15,966
because my relationship
with alcohol changed.
327
00:16:15,966 --> 00:16:17,500
And I don't think about it
328
00:16:17,500 --> 00:16:23,000
and have the same emotions
I used to have towards alcohol.
329
00:16:23,000 --> 00:16:24,300
ROLAND GRIFFITHS:
People ended up
330
00:16:24,300 --> 00:16:28,700
having experiences that
they rated as among
331
00:16:28,700 --> 00:16:29,933
the most personally meaningful
332
00:16:29,933 --> 00:16:32,600
and spiritually significant
experiences
333
00:16:32,600 --> 00:16:35,366
of their entire lifetimes.
334
00:16:35,366 --> 00:16:38,566
And I think that's a really
important element
335
00:16:38,566 --> 00:16:43,400
that kind of stamps in
the enduring attributions
336
00:16:43,400 --> 00:16:46,166
made to these experiences.
337
00:16:46,166 --> 00:16:48,433
Because they're profound
experiences
338
00:16:48,433 --> 00:16:52,400
felt to be precious,
felt to be absolutely true.
339
00:16:52,400 --> 00:16:56,233
And that accounts for
why, months, years later,
340
00:16:56,233 --> 00:16:59,666
people are often reflecting back
on that experience
341
00:16:59,666 --> 00:17:01,800
and can tap in and draw from it.
342
00:17:01,800 --> 00:17:04,100
♪ ♪
343
00:17:04,100 --> 00:17:07,633
NARRATOR:
The idea that one or two doses
of a mind-altering drug
344
00:17:07,633 --> 00:17:10,666
could create such a profound
impact
345
00:17:10,666 --> 00:17:13,566
with potentially beneficial
results is not new.
346
00:17:13,566 --> 00:17:16,000
Western medical research
into psychedelics
347
00:17:16,000 --> 00:17:18,700
began in the 1940s, not long
after
348
00:17:18,700 --> 00:17:22,833
the accidental discovery
of lysergic acid diethylamide,
349
00:17:22,833 --> 00:17:24,433
or LSD.
350
00:17:24,433 --> 00:17:29,300
In 1943, Swiss chemist Albert
Hofmann was working with ergot,
351
00:17:29,300 --> 00:17:33,366
a potentially poisonous fungus
sometimes found on wheat, oats,
352
00:17:33,366 --> 00:17:36,266
and rye, which had been used
for medicinal purposes
353
00:17:36,266 --> 00:17:38,233
for centuries.
354
00:17:38,233 --> 00:17:41,866
Ergot poisoning was known
to constrict blood vessels.
355
00:17:41,866 --> 00:17:44,900
Hofmann was hoping to isolate
a chemical compound
356
00:17:44,900 --> 00:17:48,100
that would reduce the risk of
fatal bleeding in childbirth.
357
00:17:48,100 --> 00:17:51,400
In the process,
he accidentally absorbed
358
00:17:51,400 --> 00:17:53,733
a miniscule amount of LSD,
359
00:17:53,733 --> 00:17:55,700
possibly through his fingertips,
360
00:17:55,700 --> 00:17:59,033
ultimately launching him
on what some would call
361
00:17:59,033 --> 00:18:03,333
the world's first acid trip.
362
00:18:03,333 --> 00:18:07,666
"Kaleidoscopic, fantastic
images surged in on me,
363
00:18:07,666 --> 00:18:10,700
"alternating, variegated,
opening
364
00:18:10,700 --> 00:18:14,433
"and then closing themselves
in circles and spirals,
365
00:18:14,433 --> 00:18:18,400
"exploding in colored fountains,
rearranging and hybridizing
366
00:18:18,400 --> 00:18:22,266
themselves in a constant flux."
367
00:18:22,266 --> 00:18:26,166
Word got out about
this mind-expanding substance,
368
00:18:26,166 --> 00:18:29,033
and the lab began synthesizing
and shipping samples
369
00:18:29,033 --> 00:18:31,166
to research centers
around the world.
370
00:18:31,166 --> 00:18:35,933
Initially, scientists thought
psychedelics like LSD
371
00:18:35,933 --> 00:18:38,033
could be used to explore
schizophrenia,
372
00:18:38,033 --> 00:18:40,800
since a person's tripping
experience mimicked
373
00:18:40,800 --> 00:18:43,966
some aspects of psychosis.
374
00:18:43,966 --> 00:18:46,066
But then they observed
that some patients,
375
00:18:46,066 --> 00:18:48,766
including those with
alcohol use disorder,
376
00:18:48,766 --> 00:18:50,300
reported feelings
of transcendence
377
00:18:50,300 --> 00:18:55,266
or spiritual epiphanies that
helped them to quit drinking.
378
00:18:55,266 --> 00:18:57,400
I was so curious that the most
studied indication
379
00:18:57,400 --> 00:18:59,166
was the use of LSD
to treat alcoholism.
380
00:18:59,166 --> 00:19:02,800
It turns out there was this
huge body of research
381
00:19:02,800 --> 00:19:06,466
from the 1940s to the 1970s.
382
00:19:06,466 --> 00:19:08,000
And it was a big part
of psychiatry.
383
00:19:08,000 --> 00:19:09,700
There were 40,000 participants
treated.
384
00:19:09,700 --> 00:19:12,533
It was hailed as a wonder drug.
385
00:19:12,533 --> 00:19:15,200
NARRATOR:
But as scientific research
continued,
386
00:19:15,200 --> 00:19:19,066
some efforts took a dark turn.
387
00:19:19,066 --> 00:19:22,766
The C.I.A. attempted to
weaponize LSD
388
00:19:22,766 --> 00:19:25,666
with top secret projects
like MKUltra,
389
00:19:25,666 --> 00:19:28,433
in which they experimented
on volunteers
390
00:19:28,433 --> 00:19:31,500
and unsuspecting government
employees to see if minds
391
00:19:31,500 --> 00:19:36,400
could be controlled, memories
erased, people programmed.
392
00:19:36,400 --> 00:19:40,866
And then LSD escaped the lab.
393
00:19:40,866 --> 00:19:44,500
♪ ♪
394
00:19:44,500 --> 00:19:48,333
Ken Kesey, the author of "One
Flew Over the Cuckoo's Nest,"
395
00:19:48,333 --> 00:19:52,866
was one of the C.I.A.
research volunteers.
396
00:19:52,866 --> 00:19:55,966
RICK DOBLIN:
Ken Kesey first got exposed
to LSD in a C.I.A. experiment.
397
00:19:55,966 --> 00:19:58,733
And then later,
he became one of the leaders
398
00:19:58,733 --> 00:20:00,266
of the hippies.
399
00:20:00,266 --> 00:20:02,766
You know, he helped the Grateful
Dead, began at the Acid Tests,
400
00:20:02,766 --> 00:20:05,233
the Merry Pranksters.
401
00:20:05,233 --> 00:20:07,966
So, the history of the C.I.A.,
and the mind control,
402
00:20:07,966 --> 00:20:10,533
and the nefarious uses
of psychedelics, are interwoven
403
00:20:10,533 --> 00:20:13,800
into the cultural story
of psychedelics.
404
00:20:13,800 --> 00:20:16,533
Uh, the first experience
I had was with
405
00:20:16,533 --> 00:20:18,266
seven little mushrooms
in Mexico.
406
00:20:18,266 --> 00:20:22,133
NARRATOR:
In 1966, the former Harvard
psychology professor
407
00:20:22,133 --> 00:20:23,500
Timothy Leary
408
00:20:23,500 --> 00:20:27,833
promoted psychedelic drugs
as a means of personal
409
00:20:27,833 --> 00:20:29,700
and cultural transformation,
urging youth to...
410
00:20:29,700 --> 00:20:34,100
Turn on, tune in, drop out.
411
00:20:34,100 --> 00:20:35,700
(crowd cheers and applauds)
412
00:20:35,700 --> 00:20:37,266
ROSS:
Timothy Leary became the
pied piper of psychedelics.
413
00:20:37,266 --> 00:20:41,633
And it so alarmed the
Nixon government at the time,
414
00:20:41,633 --> 00:20:44,366
Nixon declared Timothy Leary the
most dangerous man in America,
415
00:20:44,366 --> 00:20:47,200
declared war on drugs.
416
00:20:47,200 --> 00:20:51,333
America's public enemy
number one is drug abuse.
417
00:20:51,333 --> 00:20:53,333
And enacted the Controlled
Substance Act in 1970,
418
00:20:53,333 --> 00:20:55,366
which kind of erased them
from the history books.
419
00:20:58,066 --> 00:21:01,233
NARRATOR:
The act classified drugs
like heroin, cannabis,
420
00:21:01,233 --> 00:21:02,666
and psychedelics as having
421
00:21:02,666 --> 00:21:04,766
the highest potential
for addiction and abuse.
422
00:21:04,766 --> 00:21:07,600
ROSS:
The whole war on drugs
423
00:21:07,600 --> 00:21:09,433
wasn't really a war against,
like,
424
00:21:09,433 --> 00:21:11,666
stopping people from
using drugs.
425
00:21:11,666 --> 00:21:13,433
If you declare war on drugs,
you should declare war
426
00:21:13,433 --> 00:21:15,466
on alcohol and tobacco,
the most damaging ones.
427
00:21:15,466 --> 00:21:18,200
They were absented from
the Controlled Substance Act.
428
00:21:18,200 --> 00:21:20,133
He went after psychedelics,
429
00:21:20,133 --> 00:21:21,566
which are really not
addictive at all.
430
00:21:23,133 --> 00:21:26,066
NARRATOR:
The latest revelations about
the benefits
431
00:21:26,066 --> 00:21:28,933
aren't surprising to many
Indigenous populations,
432
00:21:28,933 --> 00:21:31,100
who have venerated plant-based
psychedelics
433
00:21:31,100 --> 00:21:33,733
for thousands of years.
434
00:21:33,733 --> 00:21:37,266
In many cultures,
psychedelics have been used
435
00:21:37,266 --> 00:21:39,600
in rites of passage
and to gain wisdom--
436
00:21:39,600 --> 00:21:41,566
usually administered in specific
437
00:21:41,566 --> 00:21:46,100
religious and healing
ceremonies.
438
00:21:46,100 --> 00:21:48,666
In North America,
439
00:21:48,666 --> 00:21:52,066
some Indigenous peoples use
peyote,
440
00:21:52,066 --> 00:21:54,333
a cactus that grows in
Northern Mexico
441
00:21:54,333 --> 00:21:56,933
and a small region
of South Texas.
442
00:21:56,933 --> 00:22:00,400
PRIMEAUX:
I am Adrian Primeaux.
443
00:22:00,400 --> 00:22:05,466
I come from five generations
of peyote people,
444
00:22:05,466 --> 00:22:07,000
myself being the sixth
and then my son
445
00:22:07,000 --> 00:22:09,766
being the seventh generation.
446
00:22:09,766 --> 00:22:13,633
(speaking Native language):
447
00:22:13,633 --> 00:22:15,100
(in English):
To me,
448
00:22:15,100 --> 00:22:18,966
peyote is a very intimate
medicinal herb.
449
00:22:18,966 --> 00:22:22,700
We use it as a guide,
we use it as a means
450
00:22:22,700 --> 00:22:24,133
to synchronize
with the universe.
451
00:22:24,133 --> 00:22:28,033
My grandparents explained to me
at a very young age
452
00:22:28,033 --> 00:22:32,500
that we could acquire any means
of success through medicine
453
00:22:32,500 --> 00:22:35,933
and peyote if we approached it
with the right intent.
454
00:22:35,933 --> 00:22:40,700
NARRATOR:
Peyote use can touch on
many aspects of life.
455
00:22:40,700 --> 00:22:44,366
PRIMEAUX:
How this medicine is able
to heal,
456
00:22:44,366 --> 00:22:47,833
there's a lot of complex facets.
457
00:22:47,833 --> 00:22:51,000
Within Indigenous forms
of thought, we believe that,
458
00:22:51,000 --> 00:22:53,800
like, the spirit exists
somewhere
459
00:22:53,800 --> 00:22:56,133
back there in the subconscious,
it's connected to the universe.
460
00:22:56,133 --> 00:23:00,833
So, this plant medicines
helps you reach those depths
461
00:23:00,833 --> 00:23:04,100
of your ability to manifest
whatever it is
462
00:23:04,100 --> 00:23:05,466
you can picture in your mind.
463
00:23:05,466 --> 00:23:08,300
Maybe you're picturing
pain going away.
464
00:23:08,300 --> 00:23:10,566
Maybe you're picturing
your cancer going away.
465
00:23:10,566 --> 00:23:12,400
Maybe you're picturing
your body being healthy.
466
00:23:12,400 --> 00:23:13,566
Maybe you're picturing
education.
467
00:23:13,566 --> 00:23:15,566
Whatever it is that
you're picturing,
468
00:23:15,566 --> 00:23:19,600
your subconscious brain has that
power to create that for you.
469
00:23:19,600 --> 00:23:22,366
And this medicine is just
a tool to help you
470
00:23:22,366 --> 00:23:24,366
to reach that point.
471
00:23:24,366 --> 00:23:26,766
(chanting in Native language)
472
00:23:26,766 --> 00:23:29,833
HURD:
When we think about how Native
people
473
00:23:29,833 --> 00:23:31,800
have used these substances,
474
00:23:31,800 --> 00:23:33,200
it was a ritual.
475
00:23:33,200 --> 00:23:36,466
So there's something still
really important
476
00:23:36,466 --> 00:23:39,700
about the setting,
the ritualistic aspect.
477
00:23:39,700 --> 00:23:42,466
That you can see this
positive outcome,
478
00:23:42,466 --> 00:23:46,066
you can hear the positivity
around you.
479
00:23:46,066 --> 00:23:49,200
All of that then gets encoded
into the brain
480
00:23:49,200 --> 00:23:51,933
in a manner that, when you're
not
481
00:23:51,933 --> 00:23:53,233
in that hallucinogenic
state,
482
00:23:53,233 --> 00:23:54,600
it still stays with you.
483
00:23:54,600 --> 00:23:56,366
♪ ♪
484
00:23:56,366 --> 00:24:03,033
NARRATOR:
A peyote cactus can take over
ten years to reach maturity.
485
00:24:03,033 --> 00:24:05,833
Since the arrival of Europeans,
Native American tribes
486
00:24:05,833 --> 00:24:08,033
have often been persecuted
for peyote use
487
00:24:08,033 --> 00:24:10,000
and had limited access
to the plant.
488
00:24:10,000 --> 00:24:13,766
Now commercial interests
and poachers are putting
489
00:24:13,766 --> 00:24:18,066
pressure on
peyote's fragile ecosystem.
490
00:24:18,066 --> 00:24:20,166
♪ ♪
491
00:24:20,166 --> 00:24:23,600
Recently, a philanthropist
purchased 605 acres
492
00:24:23,600 --> 00:24:26,000
of peyote land here in
South Texas
493
00:24:26,000 --> 00:24:29,000
to provide access for members of
the Native American Church,
494
00:24:29,000 --> 00:24:31,766
which teaches Native American
traditions,
495
00:24:31,766 --> 00:24:34,166
sometimes elements
of Christianity,
496
00:24:34,166 --> 00:24:37,066
and regards peyote
as a sacrament.
497
00:24:37,066 --> 00:24:38,366
STEVEN BENALLY:
In order to
498
00:24:38,366 --> 00:24:42,833
assure that this medicine
is going to be available,
499
00:24:42,833 --> 00:24:45,200
we have to have some kind of
500
00:24:45,200 --> 00:24:50,633
direct connection
with this land.
501
00:24:50,633 --> 00:24:53,600
And this land, I think,
is an answer to a prayer
502
00:24:53,600 --> 00:24:55,433
from years ago
503
00:24:55,433 --> 00:25:00,200
that there will be medicine
for our children.
504
00:25:00,200 --> 00:25:02,500
♪ ♪
505
00:25:02,500 --> 00:25:07,166
SANDOR IRON ROPE:
This land now means the world
to all of us.
506
00:25:07,166 --> 00:25:10,433
Mother Earth and what she
has provided us.
507
00:25:10,433 --> 00:25:12,033
This represents the future.
508
00:25:12,033 --> 00:25:15,500
It's about what you are
gonna teach your children,
509
00:25:15,500 --> 00:25:17,166
your grandchildren,
510
00:25:17,166 --> 00:25:19,166
and what you're gonna
leave behind.
511
00:25:19,166 --> 00:25:23,400
The essence of, of generational
responsibilities, you know.
512
00:25:23,400 --> 00:25:27,533
Words cannot suffice
what the spirit feels
513
00:25:27,533 --> 00:25:31,033
in connecting with this land.
514
00:25:31,033 --> 00:25:36,433
NARRATOR:
Psychedelic-assisted therapy
is still in its early stages,
515
00:25:36,433 --> 00:25:39,933
but scientists are inspired
by Indigenous practitioners'
516
00:25:39,933 --> 00:25:42,500
careful and non-recreational
use
517
00:25:42,500 --> 00:25:43,900
of these powerful substances.
518
00:25:43,900 --> 00:25:48,700
One concept that the
emerging use in therapy shares
519
00:25:48,700 --> 00:25:51,666
with Indigenous practices
is the importance of taking
520
00:25:51,666 --> 00:25:53,933
these psychoactive substances
521
00:25:53,933 --> 00:25:57,200
only in the right environment
and frame of mind.
522
00:25:57,200 --> 00:25:59,533
YEHUDA:
We know that like any drug,
523
00:25:59,533 --> 00:26:03,700
including aspirin,
that is in our medicine cabinet,
524
00:26:03,700 --> 00:26:07,433
the use of any drug not in the
way it was designed to be used
525
00:26:07,433 --> 00:26:11,833
can be harmful and even
catastrophic.
526
00:26:11,833 --> 00:26:13,833
So when we talk about
psychedelics,
527
00:26:13,833 --> 00:26:15,166
the setting is very important.
528
00:26:15,166 --> 00:26:18,266
Not just the preparation,
not just the integration,
529
00:26:18,266 --> 00:26:19,600
but your safety.
530
00:26:19,600 --> 00:26:22,666
Who you're with,
what your intention is,
531
00:26:22,666 --> 00:26:25,800
what is the physical
environment.
532
00:26:25,800 --> 00:26:27,800
NARRATOR:
The setting plays a crucial role
533
00:26:27,800 --> 00:26:32,100
in a psychedelic-assisted
therapy experience.
534
00:26:32,100 --> 00:26:34,566
No detail is overlooked in this
physical space,
535
00:26:34,566 --> 00:26:37,033
and the mindset, or intention,
536
00:26:37,033 --> 00:26:40,100
a person brings to the session
is of paramount importance,
537
00:26:40,100 --> 00:26:43,366
just as it is when Indigenous
people
538
00:26:43,366 --> 00:26:45,733
prepare for the use of peyote.
539
00:26:45,733 --> 00:26:48,333
CRAIG:
My intentions were just to
540
00:26:48,333 --> 00:26:50,233
go in with an open mind.
541
00:26:50,233 --> 00:26:53,633
Whether it be a good trip or a
bad trip, just experience it.
542
00:26:53,633 --> 00:26:57,966
My intention
was self-exploration,
543
00:26:57,966 --> 00:27:02,533
self-understanding,
and openness.
544
00:27:03,800 --> 00:27:05,366
KRAL:
My intention was
545
00:27:05,366 --> 00:27:08,566
to see the face of God.
546
00:27:08,566 --> 00:27:10,466
ERIC GOSS:
My intention was to take
547
00:27:10,466 --> 00:27:14,400
my experience of having cancer
at age 11
548
00:27:14,400 --> 00:27:18,533
and transform it into something
neutral,
549
00:27:18,533 --> 00:27:20,533
or even something positive.
550
00:27:20,533 --> 00:27:23,333
My intention was
to have no intentions.
551
00:27:23,333 --> 00:27:26,300
I wanted to be open to
accepting
552
00:27:26,300 --> 00:27:28,233
whatever the experience would
give to me.
553
00:27:38,366 --> 00:27:40,233
NARRATOR:
What draws these
patients together
554
00:27:40,233 --> 00:27:42,866
is a common enemy: cancer.
555
00:27:42,866 --> 00:27:44,666
AGRAWAL:
I've had the privilege of being
556
00:27:44,666 --> 00:27:46,433
with you guys all this last
year.
557
00:27:46,433 --> 00:27:48,266
NARRATOR:
Here in Rockville, Maryland,
558
00:27:48,266 --> 00:27:51,333
oncologist Manish Agrawal is
the first doctor
559
00:27:51,333 --> 00:27:53,766
in the country to run a
psychedelic-assisted
560
00:27:53,766 --> 00:27:55,266
clinical trial treating
depression
561
00:27:55,266 --> 00:27:58,133
and other mental health impacts
of cancer
562
00:27:58,133 --> 00:27:59,500
with group therapy.
563
00:27:59,500 --> 00:28:01,933
CRAIG:
I was having really bad
564
00:28:01,933 --> 00:28:06,233
monthly depressive episodes
where I would just cry all day.
565
00:28:06,233 --> 00:28:09,700
NARRATOR:
As many as a third of patients
with a cancer diagnosis
566
00:28:09,700 --> 00:28:12,766
will experience major depressive
disorder.
567
00:28:12,766 --> 00:28:15,900
But perhaps because it exists in
the shadow
568
00:28:15,900 --> 00:28:17,966
of a cancer diagnosis,
569
00:28:17,966 --> 00:28:20,333
the condition is
rarely acknowledged.
570
00:28:20,333 --> 00:28:23,666
AGRAWAL:
I've been an oncologist for
almost 20 years.
571
00:28:23,666 --> 00:28:26,033
And I've been taking care of
patients
572
00:28:26,033 --> 00:28:28,233
and there's an aspect of that
care that was really missing.
573
00:28:28,233 --> 00:28:30,700
You know, we take care of the
physical aspects,
574
00:28:30,700 --> 00:28:33,333
but then I close the door, and I
know so many, um,
575
00:28:33,333 --> 00:28:35,900
important issues are really
unaddressed.
576
00:28:36,900 --> 00:28:39,866
WOMAN:
I wanted to start with something
to help us center.
577
00:28:39,866 --> 00:28:41,833
Just like to invite you
to close your eyes.
578
00:28:41,833 --> 00:28:46,166
AGRAWAL:
I think healing is
bringing the body, the mind,
579
00:28:46,166 --> 00:28:47,866
the emotion,
the spirit back home,
580
00:28:47,866 --> 00:28:51,000
to where you feel comfortable
with it again.
581
00:28:51,000 --> 00:28:52,266
And so,
582
00:28:52,266 --> 00:28:55,166
you can't just fix the physical
pain,
583
00:28:55,166 --> 00:28:56,866
and then people are healed.
584
00:28:56,866 --> 00:28:58,500
It doesn't work that way.
585
00:28:59,666 --> 00:29:02,300
NARRATOR:
Building on pioneering
clinical trials
586
00:29:02,300 --> 00:29:05,000
at N.Y.U., U.C.L.A., and Johns
Hopkins,
587
00:29:05,000 --> 00:29:09,166
Manish saw that it was important
to treat the depression
588
00:29:09,166 --> 00:29:12,233
as part of treating the cancer.
589
00:29:12,233 --> 00:29:14,000
AGRAWAL:
That sort of whole-person care.
590
00:29:14,000 --> 00:29:16,000
And that in order to take care
of someone,
591
00:29:16,000 --> 00:29:17,533
in order for them to feel good,
592
00:29:17,533 --> 00:29:18,933
it's not just killing the
cancer.
593
00:29:18,933 --> 00:29:21,100
♪ ♪
594
00:29:21,100 --> 00:29:24,000
NARRATOR:
Manish was surprised
by the results.
595
00:29:24,000 --> 00:29:26,200
AGRAWAL:
To be honest with you,
the numbers were so good
596
00:29:26,200 --> 00:29:29,966
that I wouldn't believe it
if I wasn't with every session.
597
00:29:29,966 --> 00:29:32,500
I saw every person
go through here.
598
00:29:32,500 --> 00:29:34,700
We treated 30 people.
599
00:29:34,700 --> 00:29:38,466
And 82% had more than a 50%
reduction
600
00:29:38,466 --> 00:29:40,000
in their depression symptoms.
601
00:29:40,000 --> 00:29:41,566
When we measured quality of
life,
602
00:29:41,566 --> 00:29:45,133
we measured anxiety,
all of those were improved.
603
00:29:45,133 --> 00:29:49,800
CRAIG:
The experience just kind of
made me more aware of myself,
604
00:29:49,800 --> 00:29:51,833
and the space that I take up in
the world,
605
00:29:51,833 --> 00:29:54,900
and the energy that I put out
into the world,
606
00:29:54,900 --> 00:29:56,566
and how that affects people,
too.
607
00:29:56,566 --> 00:29:59,266
GOSS:
Prior to the dosing,
608
00:29:59,266 --> 00:30:01,766
I had this tendency to get
caught up
609
00:30:01,766 --> 00:30:03,966
in distressing thoughts related
to the cancer.
610
00:30:03,966 --> 00:30:07,933
I noticed a subtle shift, in
that,
611
00:30:07,933 --> 00:30:10,766
while distressing
thoughts would still come up,
612
00:30:10,766 --> 00:30:13,666
I was able to let them go for
the first time ever.
613
00:30:13,666 --> 00:30:17,833
I don't feel the need to follow
them.
614
00:30:17,833 --> 00:30:20,066
NARRATOR:
While Eric's endless
distressing thoughts
615
00:30:20,066 --> 00:30:22,333
and Jon Kostas's alcohol use
disorder
616
00:30:22,333 --> 00:30:24,666
may seem to have nothing in
common,
617
00:30:24,666 --> 00:30:28,966
some see a possible similarity
at work in the brain.
618
00:30:30,266 --> 00:30:31,800
MATTHEW JOHNSON:
These different disorders,
619
00:30:31,800 --> 00:30:34,433
I've really thought of them all
as forms of addiction.
620
00:30:34,433 --> 00:30:36,300
So whether we're talking about
depression
621
00:30:36,300 --> 00:30:39,500
or what we normally
think of as addiction,
622
00:30:39,500 --> 00:30:41,266
these are all just forms
623
00:30:41,266 --> 00:30:44,333
of being stuck in
a suboptimal pattern.
624
00:30:44,333 --> 00:30:47,433
It's being stuck in a narrowed
mental repertoire,
625
00:30:47,433 --> 00:30:49,633
a narrowed pattern of behaviors.
626
00:30:51,400 --> 00:30:53,966
NARRATOR:
In patients with depression,
627
00:30:53,966 --> 00:30:56,533
scientists have noticed an
abnormal increase in activity
628
00:30:56,533 --> 00:30:58,500
in a network of different
regions in the brain
629
00:30:58,500 --> 00:31:01,900
called the default mode network.
630
00:31:01,900 --> 00:31:06,500
JOHNSON:
The default mode network refers
to this pattern of activity
631
00:31:06,500 --> 00:31:09,000
across a number of brain areas
632
00:31:09,000 --> 00:31:12,200
that is strongly associated
633
00:31:12,200 --> 00:31:16,600
with thinking about oneself,
um, thinking about one's past,
634
00:31:16,600 --> 00:31:20,766
um, projecting oneself
mentally into the future.
635
00:31:22,066 --> 00:31:24,033
NARRATOR:
The default mode network
activates
636
00:31:24,033 --> 00:31:26,600
when a person is introspective,
637
00:31:26,600 --> 00:31:30,100
and, under normal circumstances,
becomes less active
638
00:31:30,100 --> 00:31:34,133
when a person shifts their
attention to the outside world.
639
00:31:34,133 --> 00:31:35,766
But brain studies show
640
00:31:35,766 --> 00:31:38,266
that under the influence of a
psychedelic,
641
00:31:38,266 --> 00:31:41,166
the default mode network is
quieted,
642
00:31:41,166 --> 00:31:42,966
while other regions of the brain
643
00:31:42,966 --> 00:31:44,866
increase communication with
each other.
644
00:31:46,400 --> 00:31:50,633
A mathematical model captures
a normal brain's activity.
645
00:31:50,633 --> 00:31:54,033
In contrast, a brain under the
influence of psilocybin
646
00:31:54,033 --> 00:31:57,866
reveals a dramatic increase in
global communication.
647
00:31:57,866 --> 00:32:00,166
Thousands of new connections
form,
648
00:32:00,166 --> 00:32:04,200
linking brain regions that don't
normally talk to each other.
649
00:32:04,200 --> 00:32:08,133
CARHART-HARRIS:
One analogy I've used
for how psychedelics work
650
00:32:08,133 --> 00:32:10,700
in the brain is the snow globe.
651
00:32:10,700 --> 00:32:13,666
When you pick up a snow globe,
you know,
652
00:32:13,666 --> 00:32:17,133
the snow's settled at
the bottom, it's sort of fixed,
653
00:32:17,133 --> 00:32:20,300
and then you pick it up, shake
it, and things jiggle around
654
00:32:20,300 --> 00:32:22,466
and there's randomness and a
kind of chaos,
655
00:32:22,466 --> 00:32:24,100
if you want, in the system.
656
00:32:25,666 --> 00:32:27,400
NARRATOR:
The user experiences this
657
00:32:27,400 --> 00:32:30,400
as an altered and heightened
sense of awareness.
658
00:32:32,066 --> 00:32:35,066
But what causes this?
659
00:32:35,066 --> 00:32:37,733
BARRETT:
Early in our functional brain
imaging studies of psychedelics,
660
00:32:37,733 --> 00:32:40,833
scientists were finding that the
default mode network
661
00:32:40,833 --> 00:32:43,566
was turning down or turning off
during these experiences.
662
00:32:43,566 --> 00:32:45,933
And that was a really
good place to start.
663
00:32:45,933 --> 00:32:49,566
But we began to then look
one layer deeper.
664
00:32:49,566 --> 00:32:51,633
Why was the default mode
network turning off?
665
00:32:51,633 --> 00:32:55,833
NARRATOR:
New research led
neuroscientist Fred Barrett
666
00:32:55,833 --> 00:32:59,733
to investigate a region of the
brain called the claustrum.
667
00:32:59,733 --> 00:33:01,900
BARRETT:
The claustrum is a really thin
668
00:33:01,900 --> 00:33:04,633
sheet of gray matter in the
brain,
669
00:33:04,633 --> 00:33:09,266
tucked deep within each of the
hemispheres of the brain.
670
00:33:09,266 --> 00:33:11,300
Recent animal models have shown
671
00:33:11,300 --> 00:33:13,266
that it is incredibly highly
connected
672
00:33:13,266 --> 00:33:15,466
to just about every other region
of the brain.
673
00:33:15,466 --> 00:33:18,566
Understanding that the
receptors targeted
674
00:33:18,566 --> 00:33:22,200
by psychedelic drugs are also
really densely expressed
675
00:33:22,200 --> 00:33:24,866
in the claustrum,
we began to wonder
676
00:33:24,866 --> 00:33:27,600
whether the claustrum may be at
the center
677
00:33:27,600 --> 00:33:29,533
of psychedelic effects.
678
00:33:30,733 --> 00:33:34,600
NARRATOR:
Fred believes the claustrum's
central location and shape
679
00:33:34,600 --> 00:33:36,333
suggest it regulates
communication
680
00:33:36,333 --> 00:33:39,400
between the departments.
681
00:33:39,400 --> 00:33:41,433
BARRETT:
When it's functioning normally,
682
00:33:41,433 --> 00:33:44,900
the claustrum is essentially
acting like a switchboard.
683
00:33:44,900 --> 00:33:47,700
It's trying to help other brain
regions figure out
684
00:33:47,700 --> 00:33:49,866
when to turn on
and when to turn off.
685
00:33:49,866 --> 00:33:52,900
But when we experience a
psychedelic drug,
686
00:33:52,900 --> 00:33:56,100
we believe that it's binding to
specific receptors
687
00:33:56,100 --> 00:33:57,700
in the claustrum
688
00:33:57,700 --> 00:34:01,366
and somehow disrupting or
disorganizing the claustrum.
689
00:34:01,366 --> 00:34:04,833
It's almost as if the
switchboard walks away.
690
00:34:04,833 --> 00:34:08,366
What happens next is that we
seem to observe
691
00:34:08,366 --> 00:34:11,866
a radical change in the way
692
00:34:11,866 --> 00:34:13,400
that brain regions talk to each
other.
693
00:34:13,400 --> 00:34:16,333
And it may be within this
context
694
00:34:16,333 --> 00:34:19,100
that we're experiencing
learning
695
00:34:19,100 --> 00:34:22,933
and a possible even
rewiring of the circuits
696
00:34:22,933 --> 00:34:25,266
that govern our behavior.
697
00:34:25,266 --> 00:34:28,000
And it may be that it's
that radical reorganization
698
00:34:28,000 --> 00:34:31,200
that allows people to encounter
new psychological insights
699
00:34:31,200 --> 00:34:33,566
that they hadn't encountered
before.
700
00:34:33,566 --> 00:34:36,733
NARRATOR:
Fred thinks the claustrum's
sudden abdication of control
701
00:34:36,733 --> 00:34:40,166
may help explain why rigid
behavior
702
00:34:40,166 --> 00:34:43,166
and thought patterns have a shot
at resetting.
703
00:34:43,166 --> 00:34:44,533
JOHNSON:
It's almost like they've seen
704
00:34:44,533 --> 00:34:47,366
this, like, kind of
grand menu within their mind
705
00:34:47,366 --> 00:34:48,933
that they weren't aware of.
706
00:34:48,933 --> 00:34:51,633
That this, this greater number
of possibilities
707
00:34:51,633 --> 00:34:52,766
that they can explore.
708
00:34:52,766 --> 00:34:55,633
GOSS:
It took a while to recover.
709
00:34:55,633 --> 00:34:59,400
I was having headaches
and muscle pains.
710
00:34:59,400 --> 00:35:02,466
But it was the best headache
I'd ever had in my life.
711
00:35:02,466 --> 00:35:07,033
Because it told me that the
psilocybin was working.
712
00:35:07,033 --> 00:35:09,866
It was actually physically
restructuring my brain,
713
00:35:09,866 --> 00:35:14,266
something that I never imagined
could happen before.
714
00:35:14,266 --> 00:35:17,100
It's like, uh, reprogramming
715
00:35:17,100 --> 00:35:19,533
the operating system of a
computer.
716
00:35:19,533 --> 00:35:23,066
You're getting down to very
basic, code-level changes
717
00:35:23,066 --> 00:35:27,133
that can enduringly change
someone going forward.
718
00:35:28,633 --> 00:35:31,900
NARRATOR:
As of 2022, there were more than
a dozen clinical trials
719
00:35:31,900 --> 00:35:36,266
underway involving psilocybin
and MDMA.
720
00:35:36,266 --> 00:35:38,400
♪ ♪
721
00:35:38,400 --> 00:35:40,500
Early efforts to revive this
research
722
00:35:40,500 --> 00:35:42,866
began with individuals like
Rick Doblin,
723
00:35:42,866 --> 00:35:45,266
who founded the
Multidisciplinary Association
724
00:35:45,266 --> 00:35:49,333
for Psychedelic Studies, or
MAPS, in 1986,
725
00:35:49,333 --> 00:35:52,533
to facilitate research
into the therapeutic benefits
726
00:35:52,533 --> 00:35:54,166
of psychedelics with a focus
727
00:35:54,166 --> 00:35:58,933
on MDMA, or ecstasy, for
post-traumatic stress disorder.
728
00:35:58,933 --> 00:36:03,533
One of the reasons that
MDMA is so successful in therapy
729
00:36:03,533 --> 00:36:06,866
is the way in which it builds a
certain
730
00:36:06,866 --> 00:36:11,400
self-confidence,
a self-acceptance.
731
00:36:11,400 --> 00:36:14,433
MDMA can increase the hormone
oxytocin,
732
00:36:14,433 --> 00:36:17,433
and that oxytocin is
really important for bonding.
733
00:36:17,433 --> 00:36:20,033
That may be why that
therapeutic bond,
734
00:36:20,033 --> 00:36:22,600
the setting that they have,
735
00:36:22,600 --> 00:36:27,166
all induce these positive
emotional mood states.
736
00:36:27,166 --> 00:36:28,933
DOBLIN:
People under the influence of
MDMA
737
00:36:28,933 --> 00:36:33,300
are able to feel more
connected, both to themselves,
738
00:36:33,300 --> 00:36:34,666
to their inner world,
739
00:36:34,666 --> 00:36:36,300
and also to the people that
they're with.
740
00:36:38,333 --> 00:36:41,700
NARRATOR:
But these feelings of
connectedness and love,
741
00:36:41,700 --> 00:36:43,866
paired with an altered mental
state,
742
00:36:43,866 --> 00:36:46,733
can make participants
uniquely vulnerable.
743
00:36:46,733 --> 00:36:49,933
There is concern among
researchers
744
00:36:49,933 --> 00:36:53,066
about how to ensure patient
safety.
745
00:36:53,066 --> 00:36:56,600
And there are not yet universal
guidelines or a code of ethics
746
00:36:56,600 --> 00:36:58,900
for administering this kind of
therapy.
747
00:37:00,300 --> 00:37:03,633
In addition, unlike LSD and
psilocybin,
748
00:37:03,633 --> 00:37:05,966
MDMA has stimulant properties
749
00:37:05,966 --> 00:37:09,333
that can lead to toxic side
effects.
750
00:37:09,333 --> 00:37:12,333
MDMA, because it impacts on
dopamine or adrenaline,
751
00:37:12,333 --> 00:37:15,633
it has a stimulant properties
to it, it can induce
752
00:37:15,633 --> 00:37:17,700
chills,
753
00:37:17,700 --> 00:37:20,666
it can induce nausea,
it can increase heart rate,
754
00:37:20,666 --> 00:37:24,066
people even thinking that
they're having heart attacks.
755
00:37:25,700 --> 00:37:28,766
NARRATOR:
Since 2000,
more than 200 PTSD patients,
756
00:37:28,766 --> 00:37:32,066
including survivors
of interpersonal violence,
757
00:37:32,066 --> 00:37:33,866
disasters,
758
00:37:33,866 --> 00:37:37,300
and combat, have received
MDMA-assisted therapy
759
00:37:37,300 --> 00:37:39,033
in MAPS clinical trials.
760
00:37:40,400 --> 00:37:44,233
One of those patients
is Scott Ostrom.
761
00:37:44,233 --> 00:37:47,500
In 2006, he was deployed to
Fallujah, Iraq,
762
00:37:47,500 --> 00:37:51,033
where he engaged
in multiple combat missions.
763
00:37:52,600 --> 00:37:54,866
OSTROM:
Real war is scary.
764
00:37:54,866 --> 00:37:58,133
You play for keeps and
everything's unexpected.
765
00:37:58,133 --> 00:38:01,233
You know,
you go there highly trained
766
00:38:01,233 --> 00:38:03,700
and as physically fit as you
can be,
767
00:38:03,700 --> 00:38:05,533
but a lot of it's, you know,
luck.
768
00:38:06,766 --> 00:38:10,266
NARRATOR:
On the front lines,
Scott was under constant threat,
769
00:38:10,266 --> 00:38:14,266
and would go on to develop PTSD.
770
00:38:14,266 --> 00:38:16,600
ROSS:
We know that at its core,
771
00:38:16,600 --> 00:38:19,366
PTSD involves the amygdala and
overactivation of the amygdala.
772
00:38:20,733 --> 00:38:22,933
The amygdala's the fear
center of the brain,
773
00:38:22,933 --> 00:38:25,700
and it keeps us alive; it keeps
us away from being killed.
774
00:38:25,700 --> 00:38:29,800
But it's the main pathological
construct in PTSD.
775
00:38:29,800 --> 00:38:32,066
You have an overactive amygdala.
776
00:38:32,066 --> 00:38:34,733
People respond to neutral
stimuli.
777
00:38:34,733 --> 00:38:36,266
Like, a door slamming
778
00:38:36,266 --> 00:38:38,600
can remind them of being in
combat.
779
00:38:38,600 --> 00:38:41,600
So, innocuous stimuli trigger
this exaggerated fear response.
780
00:38:43,100 --> 00:38:47,633
HURD:
MDMA seems to calm the
amygdala.
781
00:38:47,633 --> 00:38:51,600
By having people not be so
hypersensitive
782
00:38:51,600 --> 00:38:54,466
to negative emotional state,
783
00:38:54,466 --> 00:38:58,700
the prefrontal cortex now can
dampen the amygdala,
784
00:38:58,700 --> 00:39:00,766
reduce its, its hypersensitivity
785
00:39:00,766 --> 00:39:03,866
to distress,
786
00:39:03,866 --> 00:39:06,900
to old memories that would cause
787
00:39:06,900 --> 00:39:09,366
the amygdala to be overactive.
788
00:39:10,800 --> 00:39:13,166
ROSS:
Your prefrontal cortex is
really important.
789
00:39:13,166 --> 00:39:14,966
It's the most evolved part of
our brain,
790
00:39:14,966 --> 00:39:16,766
and it helps you say,
791
00:39:16,766 --> 00:39:18,366
"You know what?
The trauma's in the past.
792
00:39:18,366 --> 00:39:20,166
It's not happening now."
793
00:39:20,166 --> 00:39:22,566
And it allows you to rationally
think through something
794
00:39:22,566 --> 00:39:24,366
and make executive decisions.
795
00:39:24,366 --> 00:39:26,200
People with PTSD,
796
00:39:26,200 --> 00:39:27,900
they're just stuck in this,
like,
797
00:39:27,900 --> 00:39:30,800
fight-or-flight reactive thing.
798
00:39:32,233 --> 00:39:34,033
NARRATOR:
Scott qualified for a
clinical trial
799
00:39:34,033 --> 00:39:35,400
with MDMA-assisted therapy,
800
00:39:35,400 --> 00:39:39,766
which helped him to
confront traumatic memories.
801
00:39:39,766 --> 00:39:42,933
YEHUDA:
If you think of your
mind as kind of a hallway
802
00:39:42,933 --> 00:39:45,033
where there are a lot of doors,
803
00:39:45,033 --> 00:39:47,300
and you try very hard to walk
down the hallway
804
00:39:47,300 --> 00:39:50,866
and not
be triggered by bad stuff
805
00:39:50,866 --> 00:39:53,233
that you know
is behind those doors.
806
00:39:53,233 --> 00:39:56,500
One of the things that happens
with MDMA is, you say,
807
00:39:56,500 --> 00:39:58,500
"I wonder what would happen if I
opened that door.
808
00:39:58,500 --> 00:40:01,166
Maybe it's not so terrible."
809
00:40:03,033 --> 00:40:08,200
OSTROM:
I started seeing this, like,
spinning, black, oily ball,
810
00:40:08,200 --> 00:40:10,100
and it started off in the
distance,
811
00:40:10,100 --> 00:40:11,566
and then it would grow,
812
00:40:11,566 --> 00:40:14,433
and get closer to me
and closer to me.
813
00:40:14,433 --> 00:40:16,466
And then when it would get
close enough
814
00:40:16,466 --> 00:40:19,066
for me to kind of realize that
it was this spinning black ball,
815
00:40:19,066 --> 00:40:21,466
I would say, like, "What are
you, what are you doing here?"
816
00:40:21,466 --> 00:40:22,866
And it would retreat away.
817
00:40:22,866 --> 00:40:24,266
Instead of asking it what it
was,
818
00:40:24,266 --> 00:40:25,700
as soon as I surrendered to it,
819
00:40:25,700 --> 00:40:27,933
and I surrendered to the
feeling that it gave me
820
00:40:27,933 --> 00:40:29,900
on the inside and I let that
anxiety grow,
821
00:40:29,900 --> 00:40:34,333
it started to open up in
different layers like an onion.
822
00:40:35,466 --> 00:40:37,833
And when I got to the center,
823
00:40:37,833 --> 00:40:41,233
I relived a memory of a phone
call that I had with my dad
824
00:40:41,233 --> 00:40:42,800
when I was overseas in Iraq.
825
00:40:44,466 --> 00:40:47,400
What I had said to him was,
"Dad, I'm really scared.
826
00:40:47,400 --> 00:40:49,800
They said some of us
aren't coming home."
827
00:40:49,800 --> 00:40:53,233
And my dad had said to me,
"Don't worry, Scott.
828
00:40:53,233 --> 00:40:55,800
"You're highly trained.
829
00:40:55,800 --> 00:40:58,366
"You're with the best guys the
Marine Corps has to offer,
830
00:40:58,366 --> 00:41:01,500
and don't worry, your training
is going to take over."
831
00:41:01,500 --> 00:41:04,066
All of a sudden, I realized
832
00:41:04,066 --> 00:41:07,466
that's where this shift
happened.
833
00:41:07,466 --> 00:41:09,866
I had become this other person
that I needed to become,
834
00:41:09,866 --> 00:41:13,366
that I had to become, to survive
those combat deployments.
835
00:41:14,733 --> 00:41:18,900
The only thing I could think to
name that person was the Bully.
836
00:41:18,900 --> 00:41:21,300
NARRATOR:
Taking his father's words
to heart,
837
00:41:21,300 --> 00:41:25,600
Scott let his training
take over to become the Bully.
838
00:41:25,600 --> 00:41:29,900
But the Bully could not shield
him from the pain of loss.
839
00:41:29,900 --> 00:41:32,133
One thing that was really tough
840
00:41:32,133 --> 00:41:35,633
was not being able to save
someone that I felt close to.
841
00:41:35,633 --> 00:41:40,066
The vehicle that he was riding
in, um,
842
00:41:40,066 --> 00:41:41,900
ran over an anti-tank mine.
843
00:41:41,900 --> 00:41:44,100
(explosion roars)
844
00:41:44,100 --> 00:41:48,233
I had ran up to the vehicle
shortly after that explosion,
845
00:41:48,233 --> 00:41:50,166
and the vehicle had caught fire.
846
00:41:51,933 --> 00:41:55,266
My friend was trying to get out
of the passenger seat,
847
00:41:55,266 --> 00:41:58,766
and he couldn't, and I couldn't
get to the passenger door.
848
00:41:58,766 --> 00:42:01,033
My body wouldn't let me get any
closer,
849
00:42:01,033 --> 00:42:05,633
because the fire was too hot,
and he burned alive.
850
00:42:07,100 --> 00:42:09,933
There was nothing I could do.
851
00:42:09,933 --> 00:42:12,833
NARRATOR:
Nightmares of the war
followed Scott home,
852
00:42:12,833 --> 00:42:15,400
along with painful regret.
853
00:42:15,400 --> 00:42:18,400
OSTROM:
I felt a lot of guilt for
854
00:42:18,400 --> 00:42:23,566
not being able to save him.
855
00:42:23,566 --> 00:42:27,100
And for a long time,
I punished myself for that.
856
00:42:28,700 --> 00:42:33,266
My interpersonal relationships
were completely down the tubes.
857
00:42:33,266 --> 00:42:36,233
I had high-risk behaviors like
getting into fights,
858
00:42:36,233 --> 00:42:39,333
self-medicating with drugs,
alcohol,
859
00:42:39,333 --> 00:42:41,666
being just aggressive
and martial in general.
860
00:42:42,833 --> 00:42:45,233
And after, like,
three-and-a-half years
861
00:42:45,233 --> 00:42:46,666
of having
nightmares every night,
862
00:42:46,666 --> 00:42:48,800
I really started to kind of
fall apart.
863
00:42:51,600 --> 00:42:54,366
NARRATOR:
Scott wasn't alone
in his desperation.
864
00:42:54,366 --> 00:42:59,533
Every day, almost 20 military
veterans die by suicide.
865
00:42:59,533 --> 00:43:04,400
Current treatments for PTSD
are of limited benefit.
866
00:43:05,600 --> 00:43:08,200
After identifying the Bully
within him,
867
00:43:08,200 --> 00:43:10,800
after the first MDMA
dosing session,
868
00:43:10,800 --> 00:43:13,533
Scott had another breakthrough
in a subsequent session
869
00:43:13,533 --> 00:43:16,466
with his therapist, Marcela
Ot'alora,
870
00:43:16,466 --> 00:43:19,533
and Scott's dog, Tim.
871
00:43:19,533 --> 00:43:20,933
OSTROM:
Marcela was sitting in her chair
872
00:43:20,933 --> 00:43:24,800
and I was spooning Tim
on the rug.
873
00:43:24,800 --> 00:43:29,900
And Marcela had just told me,
"Well, would it be okay
874
00:43:29,900 --> 00:43:32,700
"if you asked the Bully
875
00:43:32,700 --> 00:43:35,966
if Scott can take over for a
little while?"
876
00:43:35,966 --> 00:43:38,366
And being in the state that I
was in, I was, like,
877
00:43:38,366 --> 00:43:40,933
"Hm, I don't know,
I guess I'll give it a shot."
878
00:43:40,933 --> 00:43:44,500
So, I had an unconscious
conversation with the Bully,
879
00:43:44,500 --> 00:43:48,300
where I was able to ask if it
was okay
880
00:43:48,300 --> 00:43:50,300
if I took over for a little
while, Scott took over.
881
00:43:50,300 --> 00:43:52,166
OT'ALORA:
Right, and it was more, like,
882
00:43:52,166 --> 00:43:56,200
can he step out,
to the side for a moment
883
00:43:56,200 --> 00:43:58,500
to see who else was there,
884
00:43:58,500 --> 00:44:01,400
to see what other parts of Scott
are there?
885
00:44:01,400 --> 00:44:06,400
And it was just this beautiful
time of being able to connect.
886
00:44:06,400 --> 00:44:11,333
And I think after that, you
didn't call him a bully anymore.
887
00:44:13,000 --> 00:44:16,366
NARRATOR:
The MDMA helped Scott
to reframe the guilt he felt
888
00:44:16,366 --> 00:44:19,766
over not being able to save his
friend's life.
889
00:44:19,766 --> 00:44:21,933
OSTROM:
You don't forget the
breakthrough moments
890
00:44:21,933 --> 00:44:24,300
that you had, and you don't
forget what you learned.
891
00:44:24,300 --> 00:44:26,166
They stay a part of you.
892
00:44:26,166 --> 00:44:28,600
So no, MDMA is not something
you microdose,
893
00:44:28,600 --> 00:44:30,966
it's not something you have to
take all the time.
894
00:44:30,966 --> 00:44:35,533
Um, it's, it's just the key
895
00:44:35,533 --> 00:44:38,933
that fits
into the psychotherapy lock.
896
00:44:38,933 --> 00:44:40,033
The psychedelic-induced
experience
897
00:44:40,033 --> 00:44:41,966
can help a person get unstuck
898
00:44:41,966 --> 00:44:45,533
in a way that's
not just, just being told it,
899
00:44:45,533 --> 00:44:47,333
but really experiencing it
firsthand,
900
00:44:47,333 --> 00:44:49,333
and I think that's where there's
a lot of power
901
00:44:49,333 --> 00:44:50,933
in these experiences.
902
00:44:52,066 --> 00:44:53,333
NARRATOR:
Remarkably,
903
00:44:53,333 --> 00:44:56,600
nearly 70% of participants
in phase three
904
00:44:56,600 --> 00:44:59,366
of the MAPS
MDMA-assisted therapy trials
905
00:44:59,366 --> 00:45:01,200
no longer qualify
906
00:45:01,200 --> 00:45:04,000
for a PTSD diagnosis.
907
00:45:04,000 --> 00:45:05,200
DOBLIN:
We learned that
MDMA-assisted therapy
908
00:45:05,200 --> 00:45:07,400
works in combat-related PTSD.
909
00:45:07,400 --> 00:45:09,633
It works in the hardest cases.
910
00:45:09,633 --> 00:45:12,533
And it works regardless
of the cause of PTSD.
911
00:45:12,533 --> 00:45:17,400
So our phase three studies are
PTSD from any cause,
912
00:45:17,400 --> 00:45:19,766
and if we manage to get FDA
approval,
913
00:45:19,766 --> 00:45:23,066
it will be for PTSD
from any cause.
914
00:45:24,233 --> 00:45:26,033
NARRATOR:
Rick Doblin thinks
that the treatment
915
00:45:26,033 --> 00:45:28,733
could be beneficial to many more
people,
916
00:45:28,733 --> 00:45:32,400
including some who struggle
with stressful experiences
917
00:45:32,400 --> 00:45:35,366
that aren't easily associated
with PTSD,
918
00:45:35,366 --> 00:45:38,133
like bullying
and systemic racism.
919
00:45:39,133 --> 00:45:41,700
But introducing psychedelic
therapies
920
00:45:41,700 --> 00:45:45,966
to communities of color brings
a special set of challenges.
921
00:45:45,966 --> 00:45:48,500
MONNICA WILLIAMS:
Because this is a new treatment,
922
00:45:48,500 --> 00:45:50,566
because it's connected to
research,
923
00:45:50,566 --> 00:45:52,266
and because it's connected to a
substance
924
00:45:52,266 --> 00:45:54,533
that's been stigmatized due to
being illegal,
925
00:45:54,533 --> 00:45:57,866
a lot of people of color
are very wary.
926
00:45:57,866 --> 00:46:00,300
The African-American community
has suffered a great deal
927
00:46:00,300 --> 00:46:01,900
from the war on drugs
928
00:46:01,900 --> 00:46:04,833
and having their communities
targeted due to drugs.
929
00:46:04,833 --> 00:46:08,700
Just growing up, I was always
taught, stay away from drugs.
930
00:46:08,700 --> 00:46:10,066
This is a trap.
931
00:46:10,066 --> 00:46:12,066
This is a way that people are
gonna get you
932
00:46:12,066 --> 00:46:13,433
and put you behind bars.
933
00:46:15,166 --> 00:46:16,966
NARRATOR:
Aware of abuses in the past,
934
00:46:16,966 --> 00:46:20,066
MAPS teamed up with therapists
from communities of color
935
00:46:20,066 --> 00:46:21,366
to offer them training
936
00:46:21,366 --> 00:46:24,466
in the use
of MDMA-assisted therapy.
937
00:46:24,466 --> 00:46:27,533
One of the participants,
Sara Reed,
938
00:46:27,533 --> 00:46:30,466
chose to experience
an MDMA dosing session
939
00:46:30,466 --> 00:46:32,100
as part of her training
940
00:46:32,100 --> 00:46:35,233
to become a psychedelic-assisted
therapist.
941
00:46:35,233 --> 00:46:37,800
REED:
One of my therapists
made a comment about,
942
00:46:37,800 --> 00:46:40,966
"There's a part of you that
doesn't want to be understood."
943
00:46:40,966 --> 00:46:43,033
As a Black woman,
944
00:46:43,033 --> 00:46:45,933
there is nothing more that
I want than to be understood.
945
00:46:45,933 --> 00:46:48,533
I felt that
946
00:46:48,533 --> 00:46:52,866
so deeply in that moment.
947
00:46:52,866 --> 00:46:55,133
Particularly with problems
like racism,
948
00:46:55,133 --> 00:46:57,533
I mean, one of the ways
that it hurts people so much
949
00:46:57,533 --> 00:46:59,666
is that you're experiencing it
all the time,
950
00:46:59,666 --> 00:47:01,333
but other people don't see it.
951
00:47:01,333 --> 00:47:03,266
And even when you point it out,
they're, like,
952
00:47:03,266 --> 00:47:05,000
"Oh, are you sure
that's what happened?"
953
00:47:05,000 --> 00:47:06,333
Or, "That didn't really happen,"
954
00:47:06,333 --> 00:47:08,266
or, "Maybe you're being too
sensitive,"
955
00:47:08,266 --> 00:47:10,766
so your whole experience is one
of being invalidated.
956
00:47:10,766 --> 00:47:12,666
And of being not seen
and not heard.
957
00:47:14,200 --> 00:47:16,066
NARRATOR:
Learning from this experience,
958
00:47:16,066 --> 00:47:18,200
Sara went on to provide one of
the first
959
00:47:18,200 --> 00:47:21,933
MDMA-assisted therapy sessions
for a participant of color
960
00:47:21,933 --> 00:47:24,933
experiencing racism and
post-traumatic stress disorder,
961
00:47:24,933 --> 00:47:28,300
or PTSD.
962
00:47:28,300 --> 00:47:30,700
(music playing, singing along)
963
00:47:30,700 --> 00:47:32,633
♪ I'm dropping new weights ♪
964
00:47:32,633 --> 00:47:34,533
♪ Bugs Bunny, feelin' so sunny ♪
965
00:47:34,533 --> 00:47:37,333
NARRATOR:
From a young age, Kanu Caplash
966
00:47:37,333 --> 00:47:39,300
had been the target
of racist remarks
967
00:47:39,300 --> 00:47:40,833
and bullying.
968
00:47:40,833 --> 00:47:44,700
WILLIAMS:
With racism, often
it's not necessarily
969
00:47:44,700 --> 00:47:46,300
one big problem.
970
00:47:46,300 --> 00:47:49,666
It's not necessarily, like,
oh, the Ku Klux Klan came,
971
00:47:49,666 --> 00:47:51,133
and burned a cross on your lawn.
972
00:47:51,133 --> 00:47:53,366
And now you have trauma.
973
00:47:53,366 --> 00:47:56,766
It's usually a lifetime of
smaller things that may have
974
00:47:56,766 --> 00:47:58,766
some big things here and there,
but at some point,
975
00:47:58,766 --> 00:48:02,000
the stress becomes overwhelming,
976
00:48:02,000 --> 00:48:05,266
and it tips into PTSD.
977
00:48:05,266 --> 00:48:06,500
We call that racial trauma.
978
00:48:06,500 --> 00:48:08,866
♪ ♪
979
00:48:08,866 --> 00:48:12,866
NARRATOR:
Kanu was already experiencing
racism when, as a swimmer,
980
00:48:12,866 --> 00:48:15,766
he was sexually assaulted
in the locker room,
981
00:48:15,766 --> 00:48:18,800
tipping him into PTSD.
982
00:48:18,800 --> 00:48:20,566
CAPLASH:
So the nightmares
and the symptoms
983
00:48:20,566 --> 00:48:23,633
really started to take effect
after the sexual assaults,
984
00:48:23,633 --> 00:48:25,600
which happened when I was 13.
985
00:48:25,600 --> 00:48:27,800
I was sexually assaulted,
uh, four times.
986
00:48:27,800 --> 00:48:29,266
If it wasn't for the study,
987
00:48:29,266 --> 00:48:31,266
I don't know if I'd be,
you know, alive today.
988
00:48:31,266 --> 00:48:33,366
'Cause, like, there was times
kind of right before the study,
989
00:48:33,366 --> 00:48:34,566
where I was really, really
struggling,
990
00:48:34,566 --> 00:48:35,733
where I really wanted
to kill myself.
991
00:48:37,433 --> 00:48:40,333
REED:
Our site was focused on
providing participants
992
00:48:40,333 --> 00:48:44,400
with a culturally informed
experience with MDMA therapy.
993
00:48:44,400 --> 00:48:47,733
And as one of his therapists
who is attuned to his
994
00:48:47,733 --> 00:48:51,100
racial background,
his religious background,
995
00:48:51,100 --> 00:48:56,000
his childhood upbringing,
I wanted to incorporate chants.
996
00:48:58,933 --> 00:49:00,966
During one of his dosing
sessions
997
00:49:00,966 --> 00:49:02,700
where one of those chants
played,
998
00:49:02,700 --> 00:49:05,466
I just remember it seemed like
something
999
00:49:05,466 --> 00:49:07,966
really resonated with
him in that moment.
1000
00:49:07,966 --> 00:49:10,700
♪ ♪
1001
00:49:10,700 --> 00:49:15,466
He was actually able to go
back to a childhood memory.
1002
00:49:17,700 --> 00:49:22,266
CAPLASH:
I'd be transported to,
like, a different galaxy.
1003
00:49:22,266 --> 00:49:25,933
Look down, and I see this long
set of piano keys
1004
00:49:25,933 --> 00:49:27,933
going on to infinity.
1005
00:49:27,933 --> 00:49:30,066
And it's crazy, 'cause
as I'm going down the keys,
1006
00:49:30,066 --> 00:49:31,700
I can see different parts
of my life.
1007
00:49:33,133 --> 00:49:34,500
I find that sexual assault,
1008
00:49:34,500 --> 00:49:35,966
'cause I'm, like,
that's the big one.
1009
00:49:35,966 --> 00:49:37,833
That's the one that I had
trouble remembering,
1010
00:49:37,833 --> 00:49:40,000
and kind of
trouble processing.
1011
00:49:40,000 --> 00:49:42,566
And I remember, I jumped in and
I woke up on another world.
1012
00:49:45,166 --> 00:49:47,900
I sat there and I meditated on
that planet
1013
00:49:47,900 --> 00:49:49,500
for, like, a thousand years.
1014
00:49:49,500 --> 00:49:51,600
And I was able to go through
my memory,
1015
00:49:51,600 --> 00:49:53,233
and walk through it like
a museum.
1016
00:49:53,233 --> 00:49:55,066
And, like, walk through each of
the incidents
1017
00:49:55,066 --> 00:49:57,166
and remember vividly everything
that happened.
1018
00:49:57,166 --> 00:49:59,100
I was, like, flexing my arms
really, really hard
1019
00:49:59,100 --> 00:50:03,166
and just getting out all of the,
effectively, like, pain.
1020
00:50:03,166 --> 00:50:04,333
You know, that was just kind of
1021
00:50:04,333 --> 00:50:06,366
stuck in my arms, stuck in my
body.
1022
00:50:06,366 --> 00:50:08,133
The one thing I learned through
the study
1023
00:50:08,133 --> 00:50:11,466
is, like, there's no
other way but through.
1024
00:50:11,466 --> 00:50:14,533
The only way to handle the
beast is to confront it.
1025
00:50:14,533 --> 00:50:18,133
To recognize it is what it is,
it's a part of you, um,
1026
00:50:18,133 --> 00:50:20,100
but it doesn't necessarily have
to define you.
1027
00:50:20,100 --> 00:50:22,833
And when you do that,
eventually, you know,
1028
00:50:22,833 --> 00:50:24,266
you will accept more of
yourself.
1029
00:50:24,266 --> 00:50:28,000
But also, you will
accept, like, the larger world
1030
00:50:28,000 --> 00:50:30,600
in a more kind of
positive light.
1031
00:50:32,433 --> 00:50:34,300
NARRATOR:
As of 2022,
1032
00:50:34,300 --> 00:50:36,900
MDMA-assisted
therapy for PTSD
1033
00:50:36,900 --> 00:50:40,266
is in the final stages of the
FDA approval process.
1034
00:50:42,000 --> 00:50:44,733
Psilocybin-assisted therapies
for major depression
1035
00:50:44,733 --> 00:50:48,200
and other conditions are also in
the FDA pipeline.
1036
00:50:49,433 --> 00:50:52,466
While hope runs high for
psychedelic medicine,
1037
00:50:52,466 --> 00:50:55,500
scientists are quick to point
out the inherent risks.
1038
00:50:55,500 --> 00:50:59,266
WILLIAMS:
People think about psychedelic
drugs and they think, oh,
1039
00:50:59,266 --> 00:51:01,666
you know, you're gonna kind of
zone off into
1040
00:51:01,666 --> 00:51:04,500
a world with clouds
and unicorns.
1041
00:51:04,500 --> 00:51:07,300
But I see them more as
medicines, as tools for healing.
1042
00:51:07,300 --> 00:51:09,933
And, um, and they are
powerful tools.
1043
00:51:09,933 --> 00:51:12,666
And so, I think, as such, they
require a lot of respect,
1044
00:51:12,666 --> 00:51:17,433
because I think something that
has that kind of power to heal
1045
00:51:17,433 --> 00:51:19,433
could also cause harm.
1046
00:51:19,433 --> 00:51:21,600
You gotta use it safely.
1047
00:51:21,600 --> 00:51:25,900
NARRATOR:
Scientists are cautiously moving
forward.
1048
00:51:25,900 --> 00:51:29,300
AGRAWAL:
The psilocybin therapy has been
most powerful tool I've seen.
1049
00:51:29,300 --> 00:51:31,133
It's not for everybody,
1050
00:51:31,133 --> 00:51:33,300
it's not to be, it's not a magic
bullet,
1051
00:51:33,300 --> 00:51:37,766
but it does change things
meaningfully for many patients.
1052
00:51:37,766 --> 00:51:40,933
GRIFFITHS:
It's so different than any other
intervention
1053
00:51:40,933 --> 00:51:42,733
we have within psychiatry,
1054
00:51:42,733 --> 00:51:46,533
because it's changing the very
narrative structure
1055
00:51:46,533 --> 00:51:49,266
about how people
1056
00:51:49,266 --> 00:51:50,800
tell their own story,
1057
00:51:50,800 --> 00:51:54,700
what they believe going forward.
1058
00:51:54,700 --> 00:51:57,166
YEHUDA:
We're not going to have this
whole jigsaw puzzle
1059
00:51:57,166 --> 00:51:58,866
completed for a while.
1060
00:51:58,866 --> 00:52:02,266
And I think that we want to
stay a little humble about that.
1061
00:52:02,266 --> 00:52:06,933
The less we kind of interpret,
and the more we just
1062
00:52:06,933 --> 00:52:10,533
state what
our observations are,
1063
00:52:10,533 --> 00:52:12,600
I think the better off we're
going to be.
1064
00:52:47,733 --> 00:52:55,266
♪ ♪
1065
00:53:02,566 --> 00:53:07,433
ANNOUNCER:
To order this program on DVD,
visit ShopPBS.
1066
00:53:07,433 --> 00:53:10,166
Or call 1-800-PLAY-PBS.
1067
00:53:10,166 --> 00:53:13,033
Episodes of "NOVA"
are available with Passport.
1068
00:53:13,033 --> 00:53:16,766
"NOVA" is also available
on Amazon Prime Video.
1069
00:53:16,766 --> 00:53:21,966
♪ ♪
1070
00:53:30,766 --> 00:53:37,933
♪ ♪
86373
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